[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"development-and-health\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:development-and-health":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,47,86],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":4},"100641295","developmental-support-program-a-intervention-study-100641295",false,"NCT07656272","Developmental Support Program: A Intervention Study","The Effect of a Developmental Support Program for Parents of Children Aged 1-3 Years in a Family Health Center: An Interventional Study","Inclusion Criteria:\n\n* Parents with children aged 12-36 months\n* Children with a percentile value between the 3rd and 97th percentile\n* Able to speak and understand Turkish\n* No previous participation in a similar program\n* Having internet access and the ability to use a computer\u002Flaptop, tablet, or smartphone\n* At least primary school graduates\n* Able to read and comprehend written information\n* Willing to participate in the study\n\nExclusion Criteria:\n\n* Adolescent parents\n* Parents of children with congenital anomalies, chronic diseases, or a history of prematurity\n* Individuals with a diagnosed mental health disorder",true,"FEMALE","15 Years","65 Years",{"count":21,"type":22},60,"ESTIMATED","INTERVENTIONAL",[25],"NA","This study aims to evaluate the effectiveness of an online video-based developmental support program for parents of children aged 1-3 years receiving care at a Family Health Center. Approximately 60 parents will be randomly assigned to either an intervention group, which will receive a four-week online developmental support program, or a control group, which will continue to receive usual healthcare services. Data will be collected at baseline, two weeks after the intervention, and at one- and three-month follow-up assessments. The study will examine the effects of the online video-based developmental support program on parents' attitudes toward child development, developmental awareness, parenting self-efficacy, and the quality of the home environment that supports child development.",[28],"Development and Health",[30,31,32,33,34],"Developmental Support Program","Self-Efficacy in Parenting Tasks","Mindful Awareness in Parenting","Parents' Attitudes Towards Psychosocial Development","Stimulating Home Environment","NOT_YET_RECRUITING","2026-06-15",{"date":38,"type":39},"2026-06-18","ACTUAL",{"date":41,"type":22},"2026-09-01",{"date":43,"type":22},"2028-06-30",{"name":45,"class":46},"TC Erciyes University","OTHER",{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":16,"sex":55,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":60,"phases":4,"briefSummary":61,"conditions":62,"keywords":69,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":85},"100578382","the-effect-of-mobile-devices-on-the-development-and-health-of-young-children-100578382","NCT06810570","The Effect of Mobile Devices on the Development and Health of Young Children","Understanding the Impact of Interactive Electronic Devices on Young Children's Development and Health: the iKids Study","iKids","Inclusion Criteria:\n\n* Children between 36 and 48 months old at the time of enrolment, who have received parent\u002Fcarer consent for participation and provided verbal assent\n\nExclusion Criteria:\n\n* Parents or child do not speak and\u002For understand English.\n* Child who is clinically diagnosed with a developmental disorder by a medical professional prior to either baseline or follow-up assessments.","ALL","36 Months","48 Months",{"count":59,"type":22},874,"OBSERVATIONAL","Interactive electronic devices (IEDs) have become a common part of young children's lives, yet research on this topic remains limited. Most studies utilise cross-sectional designs and present inconsistent evidence regarding the benefits and harms of IED use. Some findings suggest that IEDs may negatively impact sleep quality, be linked to visual impairment, and lead to reduced and more negative interactions between parents and children. However, it might also have a positive effect in helping language learning in young children when IEDs are co-viewed with parents and improving literacy, mathematics and science skills.\n\nDue to this conflicting evidence, health guidelines for young children do not provide specific recommendations on using these devices, leading policymakers to request more information in this area. In conversation with parents and nursery practitioners, they told us they were confused about the benefits and hams of using these devices and wanted further guidance.\n\nThe primary aim of this study is to investigate the long-term association between IED use (duration and mode) and development outcomes in 3-to-5-year-old children. The researchers will also explore the longitudinal association between IED use (duration) and other outcomes, including BMI z-score, movement behaviour, motor skills, parent-child interaction and school readiness.\n\nChildren and their parents or caregivers from both low, mid and high-income areas in England will be invited to take part. Children can participate if they are between 3 and 4 years old when they join the study, have received consent from their parent or caregiver, and have provided verbal agreement to participate. However, children will not be eligible if their parents or caregivers do not speak or understand English or if the child has been diagnosed with a developmental disorder by a medical professional before the baseline or follow-up measurements.\n\nData collection will occur at the start of the study and one year later when children are 4 to 5 years old. Parents will be asked to download an app called EARS on the smartphone and\u002For tablet that the child uses. The app will measure how long they use the device (IED duration) and the specific apps accessed during device usage (IED mode).\n\nChild development will be assessed through the following measures: 1) working memory, including visual-spatial and phonological aspects; 2) ability to control, referred to as inhibition; 3) the ability to control and redirect attention, defined as shifting; 4) self-regulation; 5) social development; 6) numeracy skills; and 7) expressive vocabulary. Child development will be measured using the Early Years Toolbox app and recorded on an iPad.\n\nThe researchers will also measure a set of secondary outcomes, including 1) BMI z-score; 2) 24-hour movement behaviour (i.e. physical activity, sedentary behaviour and sleep); 3) motor development (i.e., gross motor skills and fine motor skills); 4) parent-child interaction; 5) school readiness.\n\nThe researchers will also measure other things that might influence IED use or emerging abilities, such as participants' demographics (i.e., sex, age, ethnicity and caregiver education), parenting styles, parents' smartphone addiction, the presence of screen viewing policy at the early year's settings.\n\nTo thank the early years settings for participating, each will receive £100 for every data collection session. Parents will receive a £30 high street e-voucher for each data collection session in which they participate. There are no risks of physical injury or harm involved in this study. All researchers entering the nursery will have been subject to an enhanced Disclosure and Barring Service (DBS) check and are permitted to engage in controlled activity. If the research team observes a significant developmental delay in the child while conducting the health and development measures, they will notify the nursery staff, who will then communicate this information to the parents. Parents may feel uncomfortable downloading the app (EARS) onto their electronic devices to track how long the device is being used and the type of apps in use. The app has been designed for research purposes and approved by Sheffield Hallam University Digital Technology Services. Participants will download the app through the official Apple or Google Stores, which offers additional security and convenience. Participants will be advised to delete the app after each data collection point.\n\nThe investigators will have regular group meetings throughout the project with parents, carers, nursery teachers and policymakers to gather ideas and opinions and share our findings. These discussions will help researchers improve the project.\n\nThe findings will help inform public health guidance on children's device usage. The researchers will share the knowledge gained from this study with all participants, write policy briefs and scientific papers, and present the findings at conferences.",[28,63,64,65,66,67,68],"Behavior and Behavior Mechanisms","Cognition","Physical Health","Parent-Child Relations","Education","Technology Use",[70,71,72,73,74],"early years","mobile devices","cognitive development","socio emotional development","physical development","RECRUITING","2025-12-12",{"date":78,"type":39},"2025-12-19",{"date":80,"type":39},"2025-01-13",{"date":82,"type":22},"2027-01-31",{"name":84,"class":46},"Sheffield Hallam University",2,{"id":87,"slug":88,"hasResults":11,"nctId":89,"briefTitle":90,"officialTitle":91,"acronym":92,"eligibilityCriteria":93,"healthyVolunteers":16,"sex":55,"minAge":4,"maxAge":94,"enrollmentInfo":95,"targetDuration":4,"studyType":60,"phases":4,"briefSummary":97,"conditions":98,"keywords":102,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":108,"startDateStruct":110,"completionDateStruct":112,"leadSponsor":114,"locationsCount":116},"100574085","evaluation-of-blood-protein-o-glcnacylation-levels-in-children-100574085","NCT06754696","Evaluation of Blood Protein O-GlcNAcylation Levels in Children","Evaluation of Blood Protein O-GlcNAcylation Levels in Children - CHANCE Study (Child Heart O-glcnAc Nantes)","CHANCE","1. Healthy group\n\n   Inclusion Criteria :\n   * Age from 0 to 17 years at the time of sampling (including premature infants)\n   * Children coming to hospital for a blood sample to be taken as part of a pre-operative check-up, an allergy check-up or a check-up as part of a pathology other than sepsis.\n   * Premature infants benefiting from a blood sample as part of their monitoring and management of prematurity\n   * Collection of umbilical cord blood\n   * Signed consent\n\n   Exclusion Criteria :\n   * Children with an infection\n   * Children with fever\n   * Children with an immune deficiency\n   * Children with autoimmune disease\n   * Children with metabolic disease\n   * Children with haematological diseases\n   * Children with a genetic disease\n   * Unsigned consent\n   * Refusal by parents or child\n2. Septic group\n\nInclusion Criteria :\n\n* Age from 0 to 17 years at the time of sampling (including preterm infants)\n* Children with suspected sepsis or diagnosed sepsis according to the 2016 definition\n* Premature infants having blood drawn for suspected or diagnosed sepsis\n* All responsible bacteria, viruses or fungi\n* Signed bio-collection consent\n\nExclusion Criteria :\n\n* Children with an immune deficiency\n* Children with autoimmune disease\n* Children with a metabolic disease\n* Children with haematological diseases\n* Children with a genetic disease\n* Unsigned bio-collection consent\n* Refusal by parents or child","17 Years",{"count":96,"type":22},240,"Stimulation of O-GlcNAcylation has been shown to be beneficial in several acute pathologies and different animal models, such as haemorrhagic and septic shock, and ischaemia-reperfusion (cerebral and cardiac). It could therefore be interesting to use this approach in children in order to limit the impact of various pathologies inducing SIRS, such as extracorporeal circulation for major surgery, septic shock or various traumas. The investigators demonstrated in 2 different animal models (endotoxemia by injection of Lipopolysaccharides and caecal puncture ligation model) with 3 different pharmacological molecules (Glucosamine, ThiametG and NButGT) that stimulation of O-GlcNAcylation was beneficial in the early phase of septic shock with a marked effect on cardiac function and survival. The investigators thus demonstrated that stimulation of O-GlcNAcylation was beneficial in young rats in septic shock. However, none of this work has yet been reproduced in humans, either children or adults.",[99,100,28,101],"Sepsis","Septic Shock","Metabolism Changes",[103,99,104,105,106],"O-GlcNAcylation","Septic shock","metabolism","children","2025-02-11",{"date":109,"type":39},"2025-02-13",{"date":111,"type":39},"2025-01-30",{"date":113,"type":22},"2036-01-31",{"name":115,"class":46},"Nantes University Hospital",1]