[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"development-child\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:development-child":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,8,0,[8,49,94,111,141,168,199,224],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":30,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100622423","the-inicio-guatemala-study-100622423",false,"NCT07383428","The INICIO-Guatemala Study","IGHID 12601 - Improving Neurodevelopment With an Intestinal Health and Caregivers' Intervention in the surOeste, Guatemala: The INICIO-Guatemala Study","INICIO","The investigators will offer enrollment to pregnant in the Trifinio region of southwest Guatemala and will enroll their newborns after birth.\n\nInclusion Criteria:\n\n* Pregnant woman in the second trimester of pregnancy\n* Pregnant woman =\\>15 years of age\n* Plan to live in the study area during pregnancy and up to 24 months after giving birth\n* Newborns born to enrolled women will join the study at birth\n\nExclusion Criteria:\n\n* Pregnant woman less than 15 years of age\n* Planning to move during the study\n* Not willing or able to participate in the interventions, including following instructions for preparing the food, completing the adherence forms, participating in the caregiving sessions\n* Women who do not sign the consent form for their or their child's participation\n* Infants who require a hospital stay after birth of 21 days or longer",true,"ALL","0 Days","50 Years",{"count":22,"type":23},400,"ESTIMATED","INTERVENTIONAL",[26],"NA","The goal of this randomized controlled trial (RCT) is to evaluate an intestinal health-targeted nutritional intervention and a caregiver training program, individually and combined, on childhood neurodevelopment (ND) in rural southwest Guatemala.\n\nThe main questions it aims to answer are: what is the impact of an intestinal-targeted nutritional intervention on child ND and what is the added benefit of a caregiver intervention on child ND.\n\nThe primary endpoint is the Mullen Scales of Early Learning (MSEL) Early Learning Composite (ELC) Score at 24 months. Secondary endpoints include MSEL subdomain scores (gross motor, fine motor, expressive language, receptive language, visual reception).\n\nResearchers will compare child ND between the four study arms using a factorial design: (1) intestinal health-targeted nutritional intervention, (2) caregiving training program, (3) combined intestinal health-targeted nutritional intervention and caregiving training program, and (4) active control.\n\nParticipants will be randomized as mother-child dyads at 6 months of age and followed until 24 months of age.",[29],"Development, Child",[31,32,33,34,35],"Nutritional intervention","Microbiome","Caregiving","Rice bran","Bean flour","NOT_YET_RECRUITING","2026-01-26",{"date":39,"type":40},"2026-02-03","ACTUAL",{"date":42,"type":23},"2026-06-15",{"date":44,"type":23},"2030-06-15",{"name":46,"class":47},"University of North Carolina, Chapel Hill","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":17,"sex":57,"minAge":58,"maxAge":59,"enrollmentInfo":60,"targetDuration":4,"studyType":24,"phases":62,"briefSummary":64,"conditions":65,"keywords":76,"overallStatus":84,"whyStopped":4,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":48},"100559957","phase-3-vitamin-d-in-pregnancy-for-prevention-of-early-childhood-asthma-100559957","NCT06570889","VItamin D in pregnanCy for prevenTion Of eaRlY Childhood Asthma","VItamin D in pregnanCy for prevenTion Of eaRlY Childhood Asthma (VICTORY)","VICTORY","* Pregnant Danish women before week 26 with blood levels of EPA+DHA above 4.7% of total fatty acids\n* No current vitamin D intake above the recommended 400 IU\u002Fday\n* No endocrine-, heart-, kidney- or auto-immune disorders\n* No disorders requiring treatment with blood thinning medication","FEMALE","18 Years","45 Years",{"count":61,"type":23},2000,[63],"PHASE3","The overall aim of the study is to develop a nutritional preventive vitamin D supplementation strategy in pregnancy for early childhood asthma\u002Fpersistent wheeze during the first three years of life as we hypothesize that supplementation in higher doses than recommended could reduce the risk of disease development.",[66,67,68,69,70,71,72,73,29,74,75],"Asthma","Respiratory Tract Infections","Gastrointestinal Infection","Croup","Eczema","Allergy","Wheezing","Fractures, Bone","Cognition Disorders in Children","Psychiatric Diagnosis",[77,66,78,70,71,79,80,81,82,83],"Childhood","Infections","Development","Psychiatry","Bone development","Cognition","Growth","RECRUITING","2025-09-24",{"date":87,"type":40},"2025-09-30",{"date":89,"type":40},"2024-12-20",{"date":91,"type":23},"2033-03",{"name":93,"class":47},"Professor Klaus Bønnelykke",{"id":95,"slug":96,"hasResults":11,"nctId":97,"briefTitle":98,"officialTitle":99,"acronym":100,"eligibilityCriteria":101,"healthyVolunteers":17,"sex":57,"minAge":58,"maxAge":59,"enrollmentInfo":102,"targetDuration":4,"studyType":24,"phases":103,"briefSummary":104,"conditions":105,"keywords":106,"overallStatus":84,"whyStopped":4,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":107,"startDateStruct":108,"completionDateStruct":109,"leadSponsor":110,"locationsCount":48},"100559140","phase-3-fish-oil-in-pregnancy-for-personalized-prevention-of-early-childhood-asthma-100559140","NCT06560255","Fish Oil in pREgnancY for Personalized Prevention of Early Childhood Asthma","Fish Oil in pREgnancY for Personalized Prevention of Early Childhood Asthma (FREYA)","FREYA","* Pregnant Danish women before week 26 with blood levels of EPA+DHA below 4.7% of total fatty acids\n* No planned use of fish oil supplementations\n* No endocrine-, heart-, kidney- or auto-immune disorders\n* No disorders requiring treatment with blood thinning medication",{"count":61,"type":23},[63],"The overall aim of the study is to develop a nutritional preventive fish oil supplementation strategy in pregnancy for early childhood asthma\u002Fpersistent wheeze during the first three years of life as we hypothesize that both supplementations in higher doses than recommended could reduce the risk of disease development.",[66,67,68,69,70,71,72,73,29,74,75],[77,66,78,70,71,79,80,81,82,83],{"date":87,"type":40},{"date":89,"type":40},{"date":91,"type":23},{"name":93,"class":47},{"id":112,"slug":113,"hasResults":11,"nctId":114,"briefTitle":115,"officialTitle":116,"acronym":4,"eligibilityCriteria":117,"healthyVolunteers":17,"sex":18,"minAge":118,"maxAge":4,"enrollmentInfo":119,"targetDuration":4,"studyType":24,"phases":121,"briefSummary":122,"conditions":123,"keywords":127,"overallStatus":84,"whyStopped":4,"lastUpdateSubmitDate":131,"lastUpdatePostDateStruct":132,"startDateStruct":134,"completionDateStruct":136,"leadSponsor":138,"locationsCount":140},"100503411","hands-and-hearts-together-100503411","NCT05834907","Hands and Hearts Together","Prevention of Attachment Insecurity, Physiological Dysregulation, and Child Behavior Problems","Inclusion Criteria:\n\n* Parents whose children (age 8 to 36 months) are enrolled or are eligible to be enrolled in Harrisburg PA and Lehigh Valley PA Early Head Start programs\n\nExclusion Criteria:\n\n* Parents who are not sufficiently fluent in the language in which COS-P intervention will be conducted (Spanish or English)","8 Months",{"count":120,"type":23},249,[26],"Growing evidence demonstrates that secure attachment in childhood predicts children's healthy social, biological, and behavioral functioning, whereas insecure attachment predicts behavior problems and physiological dysregulation; thus, efforts to foster secure attachment are crucial for promoting the healthy development of children and families. This proposal describes a randomized controlled trial (RCT) of an innovative intervention program that can be widely implemented designed to foster children's secure attachment, promote healthy physiological regulation, and reduce the risk for behavior problems: The Circle of Security ® Parenting (COS-P) intervention. To this end, investigators will conduct an RCT with 249 parent-child dyads enrolled or are eligible but not yet enrolled in two diverse Early Head Start (EHS) programs.",[124,125,126,29],"Parent-Child Relations","Development, Infant","Parenting",[124,125,126,29,128,129,130],"Attachment","Home Visiting","Early Intervention","2025-06-30",{"date":133,"type":40},"2025-07-03",{"date":135,"type":40},"2023-03-27",{"date":137,"type":23},"2027-06-30",{"name":139,"class":47},"University of Maryland, College Park",2,{"id":142,"slug":143,"hasResults":11,"nctId":144,"briefTitle":145,"officialTitle":146,"acronym":147,"eligibilityCriteria":148,"healthyVolunteers":11,"sex":57,"minAge":58,"maxAge":20,"enrollmentInfo":149,"targetDuration":4,"studyType":24,"phases":150,"briefSummary":151,"conditions":152,"keywords":155,"overallStatus":84,"whyStopped":4,"lastUpdateSubmitDate":159,"lastUpdatePostDateStruct":160,"startDateStruct":162,"completionDateStruct":164,"leadSponsor":166,"locationsCount":140},"100528202","social-transfers-for-exclusive-breastfeeding-in-brazil-100528202","NCT06157697","Social Transfers for Exclusive Breastfeeding in Brazil","Social Transfers for Exclusive Breastfeeding in São Paulo, Brazil","STEBB","Inclusion Criteria:\n\n* Gave birth in the last 72 hours\n* Exclusively breastfeeding at time of recruitment and intend to continue to exclusively breastfeed\n* Part of or eligible Bolsa Familia or on the Bolsa Familia list (CAD Unico)\n* Lives in São Paulo\n* No illnesses that contraindicates breastfeeding\n* Had a healthy singleton infant of 37 weeks or more gestation with a birth weight of at least 2500 grams\n* Agrees to participate and sign an informed consent; if under age (12-17 years), a legal representative will also have to agree to sign the informed consent\n\nExclusion Criteria:\n\n* Plans to move permanently outside study area\n* Has a medical, intellectual or psychological disability\n* Contraindication for breastfeeding\n* Preterm births\n* Children born with \\\u003C 2500 grams",{"count":22,"type":23},[26],"The goal of this study is to assess the effectiveness of social transfers on exclusive breastfeeding rates in São Paulo, Brazil. The main research questions are:\n\n1. Are social transfers effective at increasing exclusive breastfeeding rates\n2. Are social transfers effective in prolonging the duration of exclusive breastfeeding\n3. Are social transfers effective in prolonging the duration of complementary breastfeeding\n4. What are the long-term impacts of social transfers for breastfeeding on child health and development\n\nParticipants will be randomly assigned to one of three groups: 1) control, no social transfer 2) non-conditional social transfer at 6-months postpartum, and 3) conditional social transfer at six months postpartum; conditional upon the mothers exclusive breastfeeding status.\n\nAll participants receive education about the benefits of exclusive breastfeeding and current international recommendations.\n\nResearchers will compare the intervention groups to the control group to see if social transfers are effective at increasing exclusive breastfeeding rates at six months postpartum.",[153,154,29,125],"Breast Feeding, Exclusive","Breastfeeding",[156,157,158],"exclusive breastfeeding","child development","social transfer","2025-06-18",{"date":161,"type":40},"2025-06-24",{"date":163,"type":40},"2025-03-06",{"date":165,"type":23},"2027-10",{"name":167,"class":47},"Swiss Tropical & Public Health Institute",{"id":169,"slug":170,"hasResults":11,"nctId":171,"briefTitle":172,"officialTitle":173,"acronym":174,"eligibilityCriteria":175,"healthyVolunteers":17,"sex":18,"minAge":4,"maxAge":4,"enrollmentInfo":176,"targetDuration":4,"studyType":24,"phases":178,"briefSummary":179,"conditions":180,"keywords":183,"overallStatus":84,"whyStopped":4,"lastUpdateSubmitDate":190,"lastUpdatePostDateStruct":191,"startDateStruct":193,"completionDateStruct":195,"leadSponsor":197,"locationsCount":48},"100355322","preventing-vulnerable-child-syndrome-in-the-nicu-with-cognitive-behavioral-therapy-prevnt-trial-100355322","NCT03906435","Preventing Vulnerable Child Syndrome in the NICU With Cognitive Behavioral Therapy (PreVNT Trial)","Parental Perception of Child Vulnerability in the NICU and Development Outcomes: A Randomized Control Trial Preventative Intervention With Cognitive Behavioral Therapy","PreVNT","Inclusion Criteria:\n\n* Born at Parkland Hospital\n* English or Spanish speaking mother +\u002F- father\n* ≤ 30.6 weeks gestation at birth\n* Survival to 33 weeks gestation\n\nExclusion Criteria:\n\n* Significant congenital anomalies\n* Child Protective Services (CPS) involvement or foster care placement -- Prior enrollment in this PreVNT study for an older sibling.",{"count":177,"type":23},100,[26],"This study is being done to see if outcomes for both a premature infant's parents and the infant born prematurely who have spent time in the neonatal intensive care unit (NICU) can be improved through parent cognitive behavioral therapy (CBT) sessions.",[181,182,29,124],"Premature Infant","Mental Health Issue (E.G., Depression, Psychosis, Personality Disorder, Substance Abuse)",[184,185,186,187,188,189],"Vulnerable Child Syndrome","Neonatal Intensive Care Unit","Cognitive Behavioral Therapy","Parental Perception of Child Vulnerability","Child Developmental Outcomes","Parent Mental Health","2025-06-10",{"date":192,"type":40},"2025-06-13",{"date":194,"type":40},"2019-04-15",{"date":196,"type":23},"2026-12-01",{"name":198,"class":47},"University of Texas Southwestern Medical Center",{"id":200,"slug":201,"hasResults":11,"nctId":202,"briefTitle":203,"officialTitle":204,"acronym":205,"eligibilityCriteria":206,"healthyVolunteers":17,"sex":18,"minAge":207,"maxAge":208,"enrollmentInfo":209,"targetDuration":4,"studyType":24,"phases":211,"briefSummary":212,"conditions":213,"keywords":4,"overallStatus":84,"whyStopped":4,"lastUpdateSubmitDate":215,"lastUpdatePostDateStruct":216,"startDateStruct":218,"completionDateStruct":220,"leadSponsor":222,"locationsCount":48},"100550549","reference-values-for-the-muscle-power-sprint-test-100550549","NCT06448520","Reference Values for the Muscle Power Sprint Test","Reference Values for the Muscle Power Sprint Test in Children Aged 5-12 Years","Ref MPST","Inclusion Criteria:\n\n* Age 5-12 years\n* Attending primary education at one of the participating schools or attending participating after-school childcare centers.\n\nExclusion Criteria:\n\n* Contra-indication for maximal exercise due to cardiac or respiratory morbidities\n* Injuries limiting maximal exercise capacity\n* Known with motor function impairment which may hamper maximal exercise (e.g. neurologic comorbidities)","5 Years","12 Years",{"count":210,"type":23},480,[26],"The goal of this prospective, cross-sectional study is to develop updated reference values for the Muscle Power Sprint Test (MPST) in children aged 5-12 years.\n\nThe main question it aims to answer is:\n\n• What are reference ('normal') values for the MPST in children aged 5-12 years?\n\nParticipants will be asked to perform six short sprints of fifteen meters each, with a ten-second rest between each effort.",[29,214],"Activity, Motor","2025-02-24",{"date":217,"type":40},"2025-02-25",{"date":219,"type":40},"2024-12-01",{"date":221,"type":23},"2025-09",{"name":223,"class":47},"Erasmus Medical Center",{"id":225,"slug":226,"hasResults":11,"nctId":227,"briefTitle":228,"officialTitle":228,"acronym":229,"eligibilityCriteria":230,"healthyVolunteers":17,"sex":18,"minAge":231,"maxAge":232,"enrollmentInfo":233,"targetDuration":4,"studyType":24,"phases":235,"briefSummary":236,"conditions":237,"keywords":4,"overallStatus":84,"whyStopped":4,"lastUpdateSubmitDate":248,"lastUpdatePostDateStruct":249,"startDateStruct":251,"completionDateStruct":252,"leadSponsor":254,"locationsCount":48},"100509349","orchestra-in-class-a-novel-booster-for-executive-functions-and-brain-development-in-young-primary-school-children-100509349","NCT05912270","Orchestra in Class, a Novel Booster for Executive Functions and Brain Development in Young Primary School Children","ORBIT","Inclusion Criteria:\n\n* School grade 3P\u002F4P (3rd and 4th year of elementary school (6-8-year-old children)\n* Right-handedness\n* Sufficient Mastery of the French Language\n* Able to give oral informed consent (child)\n* Able to give written informed consent (parent)\n\nExclusion Criteria:\n\n* Non-consent (children and or parents)\n* Repeated or skipped a class with respect to standard curriculum\n* Not corrected\u002Fsevere hearing deficits\n* Not corrected\u002Fsevere vision deficits\n* Severe neurodevelopmental disorders (eg. severe dyslexia, severe ADHD)\n* Older than 7 at the beginning of the school year if 3P\n* Older than 8 at the beginning of the school year if 4P\n* Protocolled music instrumental practice in the preceding year\n* Protocolled visual arts courses in the preceding year\n* MRI incompatibility (physical or psychological)\n* Psychometric battery incompatibility (psychological)","6 Years","8 Years",{"count":234,"type":23},150,[26],"How to optimally stimulate the developing brain is still unclear. Executive functions (EF) exhibited substantially stronger far transfer effects in children who learned to play a musical instrument than in children who acquired other arts.\n\nWhat is crucially lacking is a large-scale, long-term genuine randomized controlled trial (RCT) in cognitive neuroscience, comparing musical instrumental training (MIP) to another art form and a control group. Collected data of this proposal will allow, using machine learning, to build a data-driven multivariate model of children's interconnected brain and EF development over the first 2 years of their academic curriculum (6-8 years), with or without music or other art training.",[29,238,239,240,241,242,243,244,245,246,247],"Executive Functions","Interventions","Music","Arts","Brain Plasticity","Behavior","Brain Imaging","Magnetic Resonance Imaging","Functional Magnetic Resonance Imaging","Structural Brain Connectivity","2023-12-12",{"date":250,"type":40},"2023-12-18",{"date":250,"type":23},{"date":253,"type":23},"2027-04-30",{"name":255,"class":47},"School of Health Sciences Geneva"]