[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"development-delay\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:development-delay":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,8,0,[8,43,76,107,134,170,201,226],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100364526","a-center-based-early-intervention-program-for-preschoolers-with-developmental-disorders-100364526",false,"NCT04026386","A Center Based Early Intervention Program For Preschoolers With Developmental Disorders","Inclusion Criteria:\n\n* Diagnosis of Developmental Disorder, such as Autism Spectrum Disorder, neurogenetic disorder, or intellectual disability, based on clinical interview;\n* Boys and girls between 2.0 years and 5.11 years at time of enrollment;\n* Ability to participate in the testing procedures to the extent that valid standard scores can be obtained.\n\nExclusion Criteria:\n\n* Current or lifetime diagnosis of severe psychiatric disorder (e.g., bipolar disorder, etc.);\n* Lack of availability during program hours.","ALL","2 Years","5 Years",{"count":19,"type":20},75,"ESTIMATED","INTERVENTIONAL",[23],"NA","The purpose of this study is to examine the effectiveness of a 12-week early intervention program that will include 12 weekly hours in an intensive center-based preschool environment or in the home to treat social communication deficits in children with developmental disorders. The study will include children with developmental disorders, such as Autism Spectrum Disorder, neurogenetic disorders, or intellectual disability.",[26,27,28,29],"Development Disorder, Child","Developmental Disability","Development Delay","Autism Spectrum Disorder","RECRUITING","2026-06-22",{"date":33,"type":34},"2026-06-25","ACTUAL",{"date":36,"type":34},"2019-10-19",{"date":38,"type":20},"2034-12-30",{"name":40,"class":41},"Stanford University","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":49,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":15,"minAge":51,"maxAge":52,"enrollmentInfo":53,"targetDuration":4,"studyType":55,"phases":4,"briefSummary":56,"conditions":57,"keywords":64,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":42},"100546822","baker-gordon-syndrome-natural-history-study-100546822","NCT06399952","Baker Gordon Syndrome Natural History Study","A Prospective, Longitudinal and Observational Natural History Study for Children and Adults With Baker Gordon Syndrome - Genetic Autism Alliance","BAGOS","Inclusion Criteria:\n\n* Genetically confirmed diagnosis of Baker Gordon syndrome.\n* 0-99 years\n* Ability to send medical records and diagnostic test results.\n* Ability to complete tests and questionnaires.\n\nExclusion Criteria:\n\n• The presence of another condition or co-morbidity unrelated to Baker Gordon syndrome, that affects neurodevelopment.\n\nIn this study, the primary caregivers\u002FLAR for each participant diagnosed Baker Gordon Syndrome will be also considered participants.\n\nCaregivers\u002FLAR will have to meet the following inclusion criteria:\n\n* \\>18 years.\n* Legal caregiver of the patient diagnosed with a Baker Gordon Syndrome.\n* Willingness to follow study procedures, as assessed by the research team.\n* Willingness to sign the consent form.\n* Ability to understand all the information regarding the study, as assessed by the research team.\n\nCaregivers\u002FLAR Exclusion Criteria:\n\n• Less than 18 years old.","0 Years","99 Years",{"count":54,"type":20},50,"OBSERVATIONAL","The goal of this study is to conduct a prospective, longitudinal assessment of the natural clinical progression of children and adults with Synaptotagmin1-Associated Neurodevelopmental Disorder also known as Baker Gordon Syndrome (BAGOS). This will be performed by acquiring baseline measurements and developing effective outcome measures and diagnostic tools for the disorder, to prepare the healthcare system for future clinical trials.",[58,59,28,60,61,62,63],"Rare Diseases","Autism or Autistic Traits","SYT-SSX Fusion Protein Expression","Sleep Disorder","Epilepsy, Generalized","Motor Delay",[65,49,66],"Baker Gordon Syndrome","Synaptotagmin 1-Associated Neurodevelopmental Disorder","2026-06-01",{"date":69,"type":34},"2026-06-03",{"date":71,"type":34},"2024-04-30",{"date":73,"type":20},"2027-05-05",{"name":75,"class":41},"University of Missouri-Columbia",{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":4,"eligibilityCriteria":82,"healthyVolunteers":83,"sex":15,"minAge":84,"maxAge":85,"enrollmentInfo":86,"targetDuration":4,"studyType":55,"phases":4,"briefSummary":88,"conditions":89,"keywords":93,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":42},"100625299","psychological-correlates-of-developmental-delays-in-preschool-children-100625299","NCT07420829","Psychological Correlates of Developmental Delays in Preschool Children","Perinatal, Cognitive, Linguistic, and Social-emotional Correlates of Developmental Delay in Polish Preschool Children From a Biopsychosocial Perspective","Inclusion Criteria:\n\n* Children aged 3 to 6 years at the time of assessment.\n* Attendance at preschool education.\n* Written informed consent provided by a parent or legal guardian.\n* Ability to participate in standardized psychological assessment.\n* Assignment to one of the predefined study cohorts based on developmental history and clinical information.\n\nExclusion Criteria:\n\n* Age below 3 years or above 6 years.\n* Severe acute medical condition preventing participation.\n* Severe uncorrected sensory impairment interfering with valid assessment.\n* Lack of parental informed consent.",true,"3 Years","6 Years",{"count":87,"type":20},500,"The goal of this observational study is to investigate perinatal, cognitive, linguistic and social-emotional correlates of developmental delays of preschool children.\n\nThe study group consist of minimal 500 children between 3 and 6 years of age who will be examined by qualified diagnosticians. Participants will be evaluated with tasks related to the studied variables: cognitive functioning, linguistic skills and social-emotional functioning. Furthermore informations regarding social-emotional functioning of children, will be collected from parents.\n\nThe main questions it aims to answer are:\n\n1. Is there a relationship between perinatal factors and risk of occurrence of developmental delay disorder?\n2. Is there a specific pattern of cognitive functioning in preschool children with indicated developmental delay disorder?\n3. Is there a specific pattern of social-emotional functioning in preschool children with indicated developmental delay disorder?\n4. Do gender and age moderates specific patterns of cognitive and socialemotional functioning in the studied groups?\n\nResearchers will compare the following groups of children between 3 and 6 years old:\n\n1. With perinatal risks factors\n2. With developmental delay disorder:\n\n   1. children with early intervention\n   2. children with delayed speech development\n3. Control group",[28,90,91,92],"Child Development","Social Functioning","Speech Delay",[94,95,96],"early intervention","development","language","2026-02-11",{"date":99,"type":34},"2026-02-19",{"date":101,"type":34},"2025-09-01",{"date":103,"type":20},"2027-01",{"name":105,"class":106},"Bartosz M. Radtke","OTHER_GOV",{"id":108,"slug":109,"hasResults":11,"nctId":110,"briefTitle":111,"officialTitle":112,"acronym":4,"eligibilityCriteria":113,"healthyVolunteers":11,"sex":15,"minAge":114,"maxAge":115,"enrollmentInfo":116,"targetDuration":4,"studyType":55,"phases":4,"briefSummary":117,"conditions":118,"keywords":120,"overallStatus":124,"whyStopped":4,"lastUpdateSubmitDate":125,"lastUpdatePostDateStruct":126,"startDateStruct":128,"completionDateStruct":130,"leadSponsor":132,"locationsCount":4},"100605784","result-of-karyotyping-in-pediatric-patients-with-congenital-anomalies-and-developmental-delay-100605784","NCT07167017","Result Of Karyotyping in Pediatric Patients With Congenital Anomalies and Developmental Delay","Result Of Karyotyping in Pediatric Patients With Congenital Anomalies and Developmental Delay at Assiut University Children Hospital","Inclusion Criteria:\n\nAll patients aged between 1 month to 12 years old who are presented with morphologic congenital anomalies associated with developmental delay either global DD or isolated developmental domain (cognitive, motor, speech and language or social) who are tested for chromosomal abnormalities\n\nExclusion Criteria:\n\nAny patient aged between 1 month and 12 years old who is presented with Developmental Delay and congenital anomalies who didn't undergo karyotyping or other genetic testing.","1 Month","12 Years",{"count":19,"type":20},"The goal of this observational cross-sectional study is to study the results of karyotyping analysis for children presented with congenital anomalies and developmental delay aged 1 month to 12 years, the need for further genetic tastings and identification of parents who are carrier of balanced chromosomal translocations. The main question it aims to answer:\n\nWhat the is the incidence of congenital anomalies tested by karyotyping and the type of chromosomal abnormalities causing the clinical features.\n\nResearcher will take detailed clinical history, physical examination and developmental assessment for children and interpret karyotyping results.\n\nFor participants data will be collected regarding:\n\n1. History will be taken including demographic data of child age, parental age, consanguinity and relevant family history and developmental history.\n2. Clinical examination for any fascial dysmorphism, congenital heart disease, skeletal deformities, renal anomalies or any associated features.\n3. Clinical assessment of developmental milestones.\n4. Investigations done including laboratory tests, ultrasound scan, x-rays, CT scan, echocardiography or any other investigation.\n5. Karyotyping results detected if aneuploidy or structural abnormality including chromosomal deletions, duplications, translocations or inversions.\n6. Other genetics tests done including Comparative microarray, FISH (Fluorescence in Situ Hybridization), and WES (Whole Exome Sequencing).\n7. If parental karyotyping for suspected translocations was done.",[119,28],"Congenital Anomalies",[121,122,123],"karyotyping","congenital anomalies","developmental delay","NOT_YET_RECRUITING","2025-09-03",{"date":127,"type":34},"2025-09-11",{"date":129,"type":20},"2025-11-01",{"date":131,"type":20},"2026-12",{"name":133,"class":41},"Assiut University",{"id":135,"slug":136,"hasResults":11,"nctId":137,"briefTitle":138,"officialTitle":139,"acronym":140,"eligibilityCriteria":141,"healthyVolunteers":11,"sex":15,"minAge":142,"maxAge":143,"enrollmentInfo":144,"targetDuration":4,"studyType":55,"phases":4,"briefSummary":146,"conditions":147,"keywords":151,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":161,"lastUpdatePostDateStruct":162,"startDateStruct":164,"completionDateStruct":166,"leadSponsor":168,"locationsCount":42},"100533737","vestibular-and-postural-function-in-children-suspected-of-balance-disorders-100533737","NCT06229704","Vestibular and Postural Function in Children Suspected of Balance Disorders","Vestibular ASsessment In Children - Balance Function in Normal Children and Specific Risk Groups (VASIC)","VASIC","Inclusion Criteria:\n\n* Children in the age of 6 months to 10 years\n* Delayed gross motor development and\u002For dizziness\u002Fbalance problems.\n* Written informed consent from the parents.\n\nExclusion Criteria:\n\n* Visual impairment to such a degree that the child is not able to maintain fixation on a dot one meter away.\n* Congenital nystagmus\n* Compromised eye muscle mobility\n* VEMP-electrode allergy\n* History of symptomatic head or neck trauma\n* Prescription of medicine which alters vestibular outputs (for instance sedative antihistamines)","6 Months","10 Years",{"count":145,"type":20},30,"The goal of this prospective cohort study is to investigate the vestibular function in children suspected of balance disorders, and to follow up on their balance progressions after rehabilitation. The main hypothesis of the study is that delayed gross motor development and symptoms of dizziness and balance problems in some children are caused by vestibular dysfunction. The investigators expect that early detection and rehabilitation by a physiotherapist will improve the balance ability for the child. The participants will be children in the age of 6 months to 10 years with delayed gross motor development and\u002For with dizziness\u002Fbalance problems. The test protocol consists of questionnaires, hearing screening and vestibular and postural assessments.",[148,149,150,28],"Children, Only","Vestibular Disorder","Vestibular Function Disorder",[152,153,154,155,156,157,158,159,160],"Vestibular dysfunction","Balance problem","Children","Dizziness","Vestibular assessment","video Head Impulse Test","Vestibular Evoked Myogenic Potential","Computerized Dynamic Posturography","Delayed gross motor development","2025-08-21",{"date":163,"type":34},"2025-08-26",{"date":165,"type":34},"2025-08-20",{"date":167,"type":20},"2028-12",{"name":169,"class":41},"Gødstrup Hospital",{"id":171,"slug":172,"hasResults":11,"nctId":173,"briefTitle":174,"officialTitle":175,"acronym":4,"eligibilityCriteria":176,"healthyVolunteers":11,"sex":15,"minAge":177,"maxAge":4,"enrollmentInfo":178,"targetDuration":4,"studyType":21,"phases":180,"briefSummary":181,"conditions":182,"keywords":186,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":191,"lastUpdatePostDateStruct":192,"startDateStruct":194,"completionDateStruct":196,"leadSponsor":198,"locationsCount":200},"100484132","paiact-programme-for-parents-of-children-with-special-healthcare-needs---phase-i-100484132","NCT05584059","Pai.ACT Programme for Parents of Children With Special Healthcare Needs - Phase I","Pai.ACT: A Deep-Learning Mental Health Advisory System Using Acceptance and Commitment Therapy for Parents of Children With Special Healthcare Needs (Phase I)","Inclusion Criteria:\n\n* Cantonese-speaking Hong Kong residents\n* living together with the child who is at preschool\u002Fschool-age (3-9 years old)\n* adopt the responsibility of taking care of the child,\n* has daily access to their iPhone and Android smartphones.\n\nIn addition, potential eligible parents who respond \"yes\" to any of the five validated screening questions in the Children with Special Health Care Needs (SHCN) Screener (see https:\u002F\u002Fwww.childhealthdata.org\u002Fdocs\u002Fcshcn\u002Ftechnical-summary-of-cshcn-screener.pdf) will then be asked the associated follow-up questions to determine whether the child possesses physical, neurodevelopmental\u002Femotional problem(s) that has lasted for at least 12 months. Only children with a positive response(s) to ≥ 1 item in each of the associated follow-up questions will be classified as children with SHCN.\n\nExclusion Criteria:\n\n* Parents with severe mental illness or developmental disabilities which impaired their ability to comprehend the content of the programme will be excluded.","21 Years",{"count":179,"type":20},150,[23],"This study aims to determine the feasibility, acceptability and potential efficacy of an individual, video-conferencing based Focused Acceptance and Commitment Therapy (FACT) on the mental well-being of parents of children with Special Health Care Needs(SHCN). The study also aims to explore the experience of parents after participating in the individual-based FACT sessions offered by the trained FACT interventionists.",[183,184,29,28,185],"Neurodevelopmental Disorders","Attention Deficit Hyperactivity Disorder","Chronic Disease",[187,188,189,190],"Focused Acceptance and Commitment Therapy","Special health care needs","Mobile App","Machine Learning","2025-08-08",{"date":193,"type":34},"2025-08-11",{"date":195,"type":34},"2022-12-01",{"date":197,"type":20},"2025-12-31",{"name":199,"class":41},"Chinese University of Hong Kong",5,{"id":202,"slug":203,"hasResults":11,"nctId":204,"briefTitle":205,"officialTitle":206,"acronym":4,"eligibilityCriteria":207,"healthyVolunteers":11,"sex":15,"minAge":17,"maxAge":115,"enrollmentInfo":208,"targetDuration":4,"studyType":21,"phases":210,"briefSummary":211,"conditions":212,"keywords":213,"overallStatus":124,"whyStopped":4,"lastUpdateSubmitDate":217,"lastUpdatePostDateStruct":218,"startDateStruct":220,"completionDateStruct":222,"leadSponsor":224,"locationsCount":4},"100594144","task-specific-vs-basketball-based-balance-training-in-children-with-developmental-delay-100594144","NCT07015619","Task Specific vs Basketball-Based Balance Training in Children With Developmental Delay","Effects of Task Specific Balance Training VS Task-oriented Basketball Training on Balance and Motor Skills in Children With Developmental Delay","Inclusion Criteria:\n\n* Children aged 5-12\n\n  * Diagnosed with DD\n  * Able to follow instruction\n  * Male and female are included\n\nExclusion Criteria:\n\n* • Neurological conditions other than DD\n\n  * Musculoskeletal deformities\n  * Visual or hearing impairments\n  * Participants who are unable to engage in the assigned interventions due to physical or cognitive limitations",{"count":209,"type":20},60,[23],"To compare the effects of task specific balance training vs task-oriented basketball training on balance and motor skills in children with developmental delay",[28],[214,215,216],"DD","TSBT","TOBT","2025-06-25",{"date":219,"type":34},"2025-06-29",{"date":221,"type":20},"2025-06-28",{"date":223,"type":20},"2025-11-29",{"name":225,"class":41},"Shalamar Institute of Health Sciences",{"id":227,"slug":228,"hasResults":11,"nctId":229,"briefTitle":230,"officialTitle":231,"acronym":232,"eligibilityCriteria":233,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":234,"enrollmentInfo":235,"targetDuration":4,"studyType":55,"phases":4,"briefSummary":237,"conditions":238,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":242,"lastUpdatePostDateStruct":243,"startDateStruct":245,"completionDateStruct":247,"leadSponsor":248,"locationsCount":250},"100496998","impact-of-sulphonylureas-on-neurodevelopmental-outcomes-in-kcnj11-related-intermediate-developmental-delay-epilepsy-and-neonatal-diabetes-idend-syndrome-100496998","NCT05751525","Impact of Sulphonylureas on Neurodevelopmental Outcomes in KCNJ11-related Intermediate Developmental Delay, Epilepsy and Neonatal Diabetes (iDEND) Syndrome","Impact of Timing of Initiation of Sulphonylurea Therapy on Neurodevelopmental Outcomes in Individuals With Intermediate Developmental Delay, Epilepsy and Neonatal Diabetes (iDEND) Syndrome Due to the V59M Mutation in the KCNJ11 Gene","iDEND","Inclusion Criteria:\n\n* Current age ≥2 years\n* Heterozygous for a V59M mutation in the KCNJ11 gene\n* Successfully transferred to oral sulphonylurea therapy\n* Willing to participate\n\nExclusion Criteria:\n\n* Never able to transfer to oral sulphonylurea therapy\n* Unwilling to participate","50 Years",{"count":236,"type":20},21,"The goal of this observational study is to learn about the impact of the diabetes drug glibenclamide (glyburide) on neurodevelopment in individuals with iDEND (developmental delay, epilepsy and neonatal diabetes) due to the V59M mutation in the KCNJ11 gene. The main question it aims to answer is whether initiating sulphonylurea (SU) therapy in the first year of life results in better neurodevelopmental outcomes in affected individuals, in comparison to starting therapy later than 12 months of age.\n\nParticipants will undergo a neurodevelopmental assessment comprising parental and teacher completion of standardised questionnaires, and where possible face to face neuropsychological testing.\n\nResearchers will compare the outcomes of these standardised tests in the individuals who started SU therapy \\\u003C12 months of age in comparison to those who started \\>12 months of age.",[183,239,28,240,29,241],"Intellectual Disability","ADHD","Epilepsy","2024-06-11",{"date":244,"type":34},"2024-06-13",{"date":246,"type":34},"2016-07-01",{"date":197,"type":20},{"name":249,"class":41},"Royal Devon and Exeter NHS Foundation Trust",4]