[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"developmental-disability\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:developmental-disability":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,16,0,[8,80,102,133,161,186,214,243,269,292,320,349,380,408,441,472],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":56,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":79},"100454745","interventions-in-mathematics-and-cognitive-skills-100454745",false,"NCT05201534","Interventions in Mathematics and Cognitive Skills","Interventions in Math Learning Disabilities: Cognitive and Neural Correlates","Inclusion Criteria:\n\n1. Elementary school aged children starting from first grade (6-12 years old)\n2. IQ: Participants with a Full Scale IQ \\> 70 on the Wechsler Abbreviated Scle of Intelligence (WASI-II).\n3. Identification of Mathematical Learning Disabilities: Scores below the 35th percentile percentile on symbolic number processing test in Numeracy Screener and two or more Wechsler Individual Achievement Test (WIAT-IV) math subtests\n4. Identification of typically developing children: Scores at or above the 35th percentile percentile on symbolic number processing test in Numeracy Screener and all WIAT-IV math subtests\n5. Normal or corrected-to-normal vision and no hearing impairments\n6. Inclusion in MRI scan session: Right-handed\n\nExclusion Criteria:\n\n1. History of neurological or psychiatric disorder (i.e., schizophrenia, psychosis, depression, or attention deficit hyperactivity disorder.)\n2. History of trauma involving head injury\n3. Consistent psychiatric medications\n4. Exclusion from MRI scan session: No major contraindication for magnetic resonance imaging (MRI) - braces, metal implants, pacemakers, vascular stents, metallic ear tubes, consistent exposure to metal, claustrophobia)",true,"ALL","6 Years","12 Years",{"count":21,"type":22},180,"ESTIMATED","INTERVENTIONAL",[25],"NA","The purpose of this study is to investigate neurocognitive mechanisms underlying response to intervention aimed at enhancing, and remediating weaknesses in, numerical skills in children, including those with mathematical learning disabilities (MLD).",[28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55],"Math Learning Disability","Child Development","Developmental Disability","Learning Disabilities","Learning Disabled","Learning Curve","Mathematics Disorder","Dyscalculia","Dyscalculia, Primary","Dyscalculia, Acquired","Specific Learning Disorder, With Impairment in Mathematics","Individuality","Behavior, Child","Behavior and Behavior Mechanisms","Behavior","Decision Making","Neuronal Plasticity","Cognition","Cognition Disorder","Cognitive Dysfunction","Cognitive Change","Cognitive Impairment, Mild","Cognitive Developmental Delay","Cognitive Orientation","Cognitive Delay, Mild","Cognitive Deficits, Mild","Cognitive Abnormality","Neuroscience",[57,58,59,60,61,62,63,64,65,66],"Numerical skills in children","Low math abilities","Mathematical Learning Disabilities","Mathematical Concepts","Mathematics","Transfer, Psychology","Generalization, Psychology","Early Intervention, Educational","Neural Pathways","Neural Networks, Computer","RECRUITING","2026-06-22",{"date":70,"type":71},"2026-06-25","ACTUAL",{"date":73,"type":71},"2023-05-05",{"date":75,"type":22},"2026-08-31",{"name":77,"class":78},"Stanford University","OTHER",1,{"id":81,"slug":82,"hasResults":11,"nctId":83,"briefTitle":84,"officialTitle":84,"acronym":4,"eligibilityCriteria":85,"healthyVolunteers":11,"sex":17,"minAge":86,"maxAge":87,"enrollmentInfo":88,"targetDuration":4,"studyType":23,"phases":90,"briefSummary":91,"conditions":92,"keywords":4,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":96,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":79},"100364526","a-center-based-early-intervention-program-for-preschoolers-with-developmental-disorders-100364526","NCT04026386","A Center Based Early Intervention Program For Preschoolers With Developmental Disorders","Inclusion Criteria:\n\n* Diagnosis of Developmental Disorder, such as Autism Spectrum Disorder, neurogenetic disorder, or intellectual disability, based on clinical interview;\n* Boys and girls between 2.0 years and 5.11 years at time of enrollment;\n* Ability to participate in the testing procedures to the extent that valid standard scores can be obtained.\n\nExclusion Criteria:\n\n* Current or lifetime diagnosis of severe psychiatric disorder (e.g., bipolar disorder, etc.);\n* Lack of availability during program hours.","2 Years","5 Years",{"count":89,"type":22},75,[25],"The purpose of this study is to examine the effectiveness of a 12-week early intervention program that will include 12 weekly hours in an intensive center-based preschool environment or in the home to treat social communication deficits in children with developmental disorders. The study will include children with developmental disorders, such as Autism Spectrum Disorder, neurogenetic disorders, or intellectual disability.",[93,30,94,95],"Development Disorder, Child","Development Delay","Autism Spectrum Disorder",{"date":70,"type":71},{"date":98,"type":71},"2019-10-19",{"date":100,"type":22},"2034-12-30",{"name":77,"class":78},{"id":103,"slug":104,"hasResults":11,"nctId":105,"briefTitle":106,"officialTitle":107,"acronym":108,"eligibilityCriteria":109,"healthyVolunteers":16,"sex":17,"minAge":110,"maxAge":4,"enrollmentInfo":111,"targetDuration":4,"studyType":23,"phases":113,"briefSummary":114,"conditions":115,"keywords":118,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":125,"lastUpdatePostDateStruct":126,"startDateStruct":127,"completionDateStruct":129,"leadSponsor":131,"locationsCount":79},"100609919","online-learning-module-to-advance-research-related-to-people-with-disabilities-100609919","NCT07220837","Online Learning Module to Advance Research Related to People With Disabilities","Randomized Control Trial (RCT) of Online Learning Module to Advance Research Related to People With Disabilities (D2\u002FR3)","D2\u002FR3","Inclusion Criteria:\n\n* Aged \\>=18\n* Conducts non-disability focused research (in the past 3 years)\n* Conducts (primarily) research with\u002Fon adults\n* Affirms their understanding that eligibility and data must pass quality assurance checks before compensation is disbursed\n\nExclusion Criteria:\n\n* Participant in Aim1\u002FAim2 of D2\u002FR3 study\n* Respondent fails to provide a valid US-based personal institutional email","18 Years",{"count":112,"type":22},200,[25],"This study will measure the effects of a brief one-time eLearning intervention on researcher Knowledge, Attitudes, and Perceptions (KAP) of including people with disabilities (PWDs) in biomedical \\& behavioral research. Researchers will be recruited from across the Einstein\u002FMontefiore network, and other medical centers with a focus on CTSAs.",[30,116,117],"Intellectual Disability","Disability",[119,120,121,122,123,124],"Bias","Attitudes","Perceptions","Inclusion","Translational Science","Representation","2026-06-17",{"date":68,"type":71},{"date":128,"type":71},"2025-12-16",{"date":130,"type":22},"2026-08",{"name":132,"class":78},"Albert Einstein College of Medicine",{"id":134,"slug":135,"hasResults":11,"nctId":136,"briefTitle":137,"officialTitle":138,"acronym":139,"eligibilityCriteria":140,"healthyVolunteers":11,"sex":17,"minAge":141,"maxAge":142,"enrollmentInfo":143,"targetDuration":4,"studyType":23,"phases":145,"briefSummary":146,"conditions":147,"keywords":149,"overallStatus":151,"whyStopped":4,"lastUpdateSubmitDate":152,"lastUpdatePostDateStruct":153,"startDateStruct":155,"completionDateStruct":157,"leadSponsor":159,"locationsCount":79},"100629472","health-engagement--access-through-learning-training-and-health-coaching-with-people-with-intellectual-andor-developmental-disabilities-100629472","NCT07475117","Health Engagement & Access Through Learning, Training, and Health-coaching With People With Intellectual and\u002For Developmental Disabilities","Comparing a Group Psychoeducational Health Intervention to Special Olympics Health Programming on Improving Access to Best Practice Health Care for Adults With Intellectual and Developmental Disabilities","HEALTH 4 ME","Inclusion Criteria - Special Olympic Athletes:\n\n* Currently participating in Special Olympics programming at a state agency in the study\n* Has a medical or educational diagnosis of intellectual and\u002For developmental disabilities\n* Between the ages of 21-65\n* Has at least weekly contact with a family member or care partner who is willing and able to participate\n* Fluent in English\n\nInclusion Criteria - Care Partner:\n\n* Care partner for the participating Special Olympic Participant\u002FAthlete\n* At least 21 years of age\n* Has at least weekly contact with Special Olympic Participant\u002FAthlete who is willing and able to participate\n* Fluent in English\n\nExclusion Criteria - all:\n\n* Inability to complete an accessible informed assent or consent process\n* Fluctuating capacity to consent","21 Years","65 Years",{"count":144,"type":22},1040,[25],"The purpose of this study is to see if a combination of an educational curriculum and health coaching embedded within Special Olympics improves health outcomes and healthcare access compared to regular Special Olympics sport and health programming for adults with intellectual and\u002For developmental disabilities.",[148,30],"Intellectual Disabilities",[150],"Special Olympics","NOT_YET_RECRUITING","2026-06-09",{"date":154,"type":71},"2026-06-11",{"date":156,"type":22},"2026-07",{"date":158,"type":22},"2031-03",{"name":160,"class":78},"University of Wisconsin, Madison",{"id":162,"slug":163,"hasResults":11,"nctId":164,"briefTitle":165,"officialTitle":166,"acronym":167,"eligibilityCriteria":168,"healthyVolunteers":16,"sex":17,"minAge":110,"maxAge":4,"enrollmentInfo":169,"targetDuration":4,"studyType":23,"phases":171,"briefSummary":172,"conditions":173,"keywords":4,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":177,"lastUpdatePostDateStruct":178,"startDateStruct":180,"completionDateStruct":182,"leadSponsor":184,"locationsCount":79},"100631799","behavioral-parent-training-to-address-early-childhood-disruptive-behavior-using-the-helping-our-toddlers-developing-our-childrens-skills-hot-docs-program-and-the-developing-our-childrens-skills-kindergarten-5th-grade-docs-k-5-program-100631799","NCT07505381","Behavioral Parent Training to Address Early Childhood Disruptive Behavior Using the Helping Our Toddlers, Developing Our Children's Skills (HOT DOCS) Program and the Developing Our Children's Skills Kindergarten-5th Grade (DOCS K-5) Program","HOT DOCS and DOCS K-5","DOCS parenting","Inclusion Criteria:\n\n* caregiver or professional caring for child ages 0-12 years, or\n* caregiver or professional caring for a child enrolled in kindergarten-5th grade.\n* Must speak English or Spanish.\n\nExclusion Criteria:\n\n* Language other than English or Spanish.\n* Caregiver\u002Fprofessional under the age of 18.",{"count":170,"type":22},800,[25],"HOT DOCS and DOCS K-5 are group-delivered behavioral parent training interventions for caregivers of children ages 0-12 years.",[174,30,175,176],"Disruptive Behavior","Developmental Delay (Disorder)","Behavior Problem of Childhood","2026-04-23",{"date":179,"type":71},"2026-04-29",{"date":181,"type":71},"2018-10-02",{"date":183,"type":22},"2028-09-30",{"name":185,"class":78},"University of South Florida",{"id":187,"slug":188,"hasResults":11,"nctId":189,"briefTitle":190,"officialTitle":191,"acronym":192,"eligibilityCriteria":193,"healthyVolunteers":16,"sex":17,"minAge":110,"maxAge":4,"enrollmentInfo":194,"targetDuration":4,"studyType":23,"phases":196,"briefSummary":197,"conditions":198,"keywords":202,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":205,"lastUpdatePostDateStruct":206,"startDateStruct":208,"completionDateStruct":210,"leadSponsor":212,"locationsCount":79},"100330747","neuropsychological-and-brain-medical-imaging-study-in-patients-with-brain-damage-2-100330747","NCT03586258","Neuropsychological and Brain Medical Imaging Study in Patients With Brain Damage 2","Anatomical Clinical Correlations. Neuropsychological and Brain Medical Imaging Study in Brain Damage Subjects 2 (CORAC2)","CORAC2","Inclusion Criteria:\n\n* Age \\> 17 years\n* French language\n* Effective contraception for women during the study\n* Informed consent\n* No alcohol intake the day before the exam\n* For patients only, focal cerebral lesion (stroke, malformation, tumor, inflammatory, infectious, traumatic), neonatal pathology, developmental or degenerative disease with cognitive deficit\n\nExclusion Criteria:\n\n* For healthy volunteers: previous neurological history (except non complicated migraine or epilepsy), previous psychiatric history (except depression with good evolution or anxiety), or severe cranial traumatism\n* For patients: vigilance disorders, severe depression or anxiety.\n* For both: psychotropic medication other than a hypnotic or an anxiolytic at low doses without dose modification for at least one month, severe visual or auditory impairment, patient without judicial or administrative liberty, measure of legal protection or no capable to express their consent, pregnancy or breastfeeding, contraindication for MRI or GVS if applicable, participation in another trial or former involvement in another trial within one month.",{"count":195,"type":22},400,[25],"Two groups of subjects will be constitute: (i) patients with circumscribed brain injury (including stroke, vascular malformations, tumor or circumscribed infectious lesions) or degenerative\u002Fdevelopmental disorders and selective cognitive disorders; (ii) healthy control subjects.\n\nThe objective of this project is to evaluate specific neuropsychological deficits and apply current brain imaging techniques (anatomical, diffusion, functional, magnetic stimulation) to patients suffering from these cognitive deficits due to brain damage, in order to elucidate the brain mechanisms underlying these deficits.",[199,200,201,30],"Cerebrovascular Disorders","Brain Lesion","Degenerative Disease",[203,204],"Neuropsychological study","Brain imaging","2026-04-09",{"date":207,"type":71},"2026-04-13",{"date":209,"type":71},"2019-01-10",{"date":211,"type":22},"2030-06",{"name":213,"class":78},"University Hospital, Caen",{"id":215,"slug":216,"hasResults":11,"nctId":217,"briefTitle":218,"officialTitle":219,"acronym":220,"eligibilityCriteria":221,"healthyVolunteers":11,"sex":17,"minAge":110,"maxAge":222,"enrollmentInfo":223,"targetDuration":4,"studyType":23,"phases":225,"briefSummary":226,"conditions":227,"keywords":229,"overallStatus":151,"whyStopped":4,"lastUpdateSubmitDate":234,"lastUpdatePostDateStruct":235,"startDateStruct":237,"completionDateStruct":239,"leadSponsor":240,"locationsCount":242},"100631779","comparing-the-impact-of-peer-support-vs-staff-delivered-transportation-interventions-for-young-adults-with-intellectual-and-developmental-disabilities-100631779","NCT07505121","Comparing the Impact of Peer Support vs. Staff-Delivered Transportation Interventions for Young Adults With Intellectual and Developmental Disabilities.","Comparing Peer Support and Staff-Delivered Transportation Interventions for Young Adults With Intellectual and Developmental Disabilities (YA-IDD) on Loneliness, Social Participation, and Transportation Skills","YA-IDD","Inclusion Criteria:\n\n* Between the ages of 18 to 27 years old during the start of the study\n* Receives services at one of the eight community service organizations participating in the study.\n* Meets the federal diagnosis of a developmental disability (DD)\n* Qualifies for services related to their DD.\n* Scores \\>28 on the Transportation Prescreening Assessment (indicating readiness for travel).\n\nExclusion Criteria:\n\n* Independently uses public transportation \\>4 times\u002Fmonth.\n* Is not able to independently mobilize through walking or use of a mobility device.\n* Has significant non-corrected visual impairments.","27 Years",{"count":224,"type":22},325,[25],"This clinical trial will look at whether young adults with intellectual and developmental disabilities (YA-IDD) have better outcomes when a travel training intervention called Ready to Ride (R2R) is taught by a specially trained Peer Supporter (PS) who shares the lived experience of having an IDD than YA-IDD who are taught Ready to Ride by staff at their community services organization. The aspects of life being looked at are loneliness, satisfaction with social activities, travel skills, service use and access, employment, and health related quality of life.\n\nThe researchers think the following things will happen.\n\n1. YA-IDD who learn from a Peer Supporter will report significantly higher satisfaction with social activities, increased social connectedness and significantly less loneliness compared to YA who are taught organization staff.\n2. Both groups will learn the same amount of travel skills.\n3. YA-IDD who learn from a Peer Supporter will show larger increases in access to community-based services, transportation use, employment and health related services after 4 months than the YA taught by organizational staff.",[228,30],"Intellectual Disability, Mild to Moderate",[230,231,116,30,232,233],"Travel Training Intervention","Young Adults","Transportation","Peer Support","2026-03-26",{"date":236,"type":71},"2026-04-01",{"date":238,"type":22},"2026-05",{"date":211,"type":22},{"name":241,"class":78},"Temple University",3,{"id":244,"slug":245,"hasResults":11,"nctId":246,"briefTitle":247,"officialTitle":248,"acronym":249,"eligibilityCriteria":250,"healthyVolunteers":11,"sex":17,"minAge":251,"maxAge":142,"enrollmentInfo":252,"targetDuration":4,"studyType":23,"phases":254,"briefSummary":256,"conditions":257,"keywords":259,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":234,"lastUpdatePostDateStruct":261,"startDateStruct":263,"completionDateStruct":265,"leadSponsor":267,"locationsCount":79},"100496457","phase-4-metformin-for-antipsychotic-induced-weight-gain-in-adults-with-intellectual-disability-100496457","NCT05744479","Metformin for Antipsychotic-induced Weight Gain in Adults With Intellectual Disability","Metformin for Antipsychotic-induced Weight Gain in Adults With Intellectual Disability: A Double-Blind Randomized Control Trial","METIDD","Inclusion Criteria:\n\n* Stable outpatients\n* Age 16-65 years\n* Diagnosed with an IDD\n* On maintenance treatment with an antipsychotic (stable dose for ≥3 months).\n* BMI must be ≥30 kg\u002Fm2, OR ≥27 kg\u002Fm2 with at least one weight-related comorbidity (treated or untreated) such as: hypertension, dyslipidaemia, obstructive sleep apnea, or impaired fasting glucose, OR \\>=25 for individuals who have gained \\> 5% body weight in association with AP use.\n* Females of child-bearing age must be on one of the following regular contraceptives:\n\n  1. Agree to abstain from sex for the duration of the trial or\n  2. A barrier method of a diaphragm with spermicide and\u002For Latex condom or\n  3. An oral contraceptive agent, implantable contraceptive or an injectable contraceptive for at least six months prior to entering the study and will continue its use throughout the study, or\n  4. An intrauterine device, or\n  5. Partner has had a vasectomy at least 3 months prior to study start\n\nExclusion Criteria:\n\n* Females who are nursing, currently pregnant, or have a positive pregnancy test\n* Clinical or laboratory evidence of uncompensated cardiovascular, endocrine, haematological, hepatic, renal, or pulmonary disease\n* Previous treatment and lack of efficacy or tolerability with metformin\n* History or diagnosis of Type 1 Diabetes (T1D) or Type 2 Diabetes (TD2) or fasting blood work, HbA1c \\> 6.5%\n* History of metabolic acidosis or lactic acidosis\n* Treatment with weight-lowering agents\n* Medications with significant renal impact\n* Major medical or surgical event in the preceding 3 months\n* Acute suicidal risk.\n* Moderate to severe substance use disorder, other than caffein or nicotine use disorder","16 Years",{"count":253,"type":22},100,[255],"PHASE4","People with IDD (intellectual and developmental disability) have very high rates of obesity and die prematurely from cardiometabolic disease. While antipsychotics contribute to this problem, their use is necessary and appropriate in a significant subgroup of individuals with IDD. Exercise and diet interventions have limitations and may not be sufficient, requiring effective adjunctive pharmacological approaches to target obesity and related comorbidities in IDD. However, persons with IDD treated with antipsychotics are systematically excluded from clinical trials hindering development of evidence to help guide safe and effective treatment of these comorbidities. Moreover, evidence from other disorders cannot be extrapolated to IDD given inherent biological differences between disorders. This trial will address the identified gaps, which extend beyond cardiovascular morbidity and negatively impact psychosocial outcomes, in a hugely underserviced population.This is the the first RCT (randomized control trial) to examine the efficacy of metformin in overweight or obese adults with IDD who have experienced antipsychotic-induced weight gain. By generating efficacy data for a very accessible and scalable intervention, allows for guideline and implementation strategies to address a recalcitrant health problem.",[116,30,258],"Obesity",[116,30,258,260],"Metformin",{"date":262,"type":71},"2026-03-31",{"date":264,"type":71},"2023-02-28",{"date":266,"type":22},"2027-03-01",{"name":268,"class":78},"Centre for Addiction and Mental Health",{"id":270,"slug":271,"hasResults":11,"nctId":272,"briefTitle":273,"officialTitle":274,"acronym":4,"eligibilityCriteria":275,"healthyVolunteers":11,"sex":17,"minAge":141,"maxAge":4,"enrollmentInfo":276,"targetDuration":4,"studyType":278,"phases":4,"briefSummary":279,"conditions":280,"keywords":4,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":283,"lastUpdatePostDateStruct":284,"startDateStruct":286,"completionDateStruct":288,"leadSponsor":290,"locationsCount":79},"100504511","evaluation-of-the-transitional-and-lifelong-care-program-100504511","NCT05849285","Evaluation of the Transitional and Lifelong Care Program","Evaluating a Model of Transitional and Lifelong Care for Adults With Childhood-Onset Disabilities","Inclusion Criteria:\n\nEach participant dyad will consist of one person, of either sex and gender, who is over the age of 21 years with a childhood-onset disability, and the primary caregiver (based on contact hours) or support person, of either sex and gender, involved in their care. In cases where the patient participant is independent with care, a spouse or family member may still participate in the caregiver portion of the study.\n\n2\\. Patient participants will have continuously resided in Ontario during the years of 2015 to 2020 to facilitate full data retrieval from the administrative dataset.\n\n3\\. Healthcare providers, of any discipline, who provide care to adults with childhood-onset conditions in the TLC program.\n\nExclusion Criteria:\n\nPatient participants will be ineligible if they are in a phase of deterioration associated with a progressive health condition identified either personally or by the caregiver participant.",{"count":277,"type":22},410,"OBSERVATIONAL","The population cared for in the Transitional and Lifelong Care (TLC) clinic is youth and adults with childhood-onset disability, of which the large majority are adults with brain-based, neurodevelopmental conditions such as cerebral palsy, spina bifida and developmental disability. The TLC program was created to address the health inequities that have long existed for this population because of the gaps in care they experience once they transition from pediatric healthcare services to the adult healthcare sector. The TLC program offers coordinated and comprehensive management of co-occurring mental, social and physical health conditions for this group of adults with neurodiverse conditions. The proposed study will provide much needed evaluation of the TLC model as an intervention to provide transitional and lifelong care that reduces the barriers experienced because of the undefined clinic path - potentially more appropriately referred to as a \"cliff\" by a Freeman et al., (2015) - for these individuals. With appropriate evidence of effectiveness, scaling of the TLC program to other Ontario Health regions and more widely across Canada would improve access healthcare providers who are knowledgeable and competent in the management of physical and mental health conditions for adults with neurodiverse conditions as well as service integration and coordination between social and health sectors. The TLC clinic was co-designed with adults with neurodiverse conditions and health care providers in 2014 and represents a significant and sustainable change in the way healthcare has been delivered for this population in the Ontario Health West region over the last 7 years. More than 750 people have accessed coordinated and comprehensive care from Physiatrists, a Nurse Practitioner, Social Worker, Physiotherapist, Occupational Therapist, Speech Language Pathologist, Registered Dietitian and Rehabilitation Therapist in the TLC program since it began, documenting the effectiveness of this care has the power to re-shape care received for adults with neurodiverse conditions that onset in childhood in Canada.",[281,282,30],"Cerebral Palsy","Spina Bifida","2026-02-25",{"date":285,"type":71},"2026-02-27",{"date":287,"type":71},"2024-01-03",{"date":289,"type":22},"2027-12",{"name":291,"class":78},"Western University, Canada",{"id":293,"slug":294,"hasResults":11,"nctId":295,"briefTitle":296,"officialTitle":297,"acronym":4,"eligibilityCriteria":298,"healthyVolunteers":11,"sex":17,"minAge":299,"maxAge":4,"enrollmentInfo":300,"targetDuration":4,"studyType":23,"phases":302,"briefSummary":303,"conditions":304,"keywords":307,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":311,"lastUpdatePostDateStruct":312,"startDateStruct":314,"completionDateStruct":316,"leadSponsor":318,"locationsCount":79},"100547380","evaluating-the-impacts-of-a-single-session-of-robot-assisted-gait-training-with-a-trexo-100547380","NCT06407219","Evaluating the Impacts of a Single Session of Robot Assisted Gait Training With a Trexo","Evaluating and Improving Robot Assisted Gait Training","Inclusion Criteria:\n\n* Able to fit into the Trexo robotic gait trainer (\\\u003C150 lbs., \\\u003C5'7\").\n* Has impaired ability to walk due to a neurological or muscular disorder.\n\nExclusion Criteria:\n\n* \\>150 lbs.\n* \\>5'6\" tall\n* Medical contraindication to weight bearing (ie. recent orthopedic surgery)","4 Years",{"count":301,"type":22},50,[25],"Early use of robotic gait trainers have shown many benefits, however why these benefits occur and how to maximize them is unknown. There are a few options for how a robotic gait trainer can be used, however, there is not much understanding of how these options impact rehabilitation and compensate for impairments. The investigators aim to evaluate the impacts of as single session of Trexo robotic gait training and the impact of different modes of the Trexo robotic gait trainer. The investigators will evaluate how the different settings impact things like physical activity, walking, brain activity, spasticity, and fatigue. Investigators will arrange for a familiarity and fitting session to start, so that study team members can fit the participant to the Trexo and so that participants can become familiar with the feeling of using the Trexo robotic gait trainer. After the initial fitting sessions, follow up sessions will be completed to evaluate different settings on the Trexo, for example in \"endurance\" mode (where the robot completes the movements for the participant) and in \"strength\" mode (where the robot requires some assistance from the participant). Investigators may also test different fitting settings, for example with and without the supportive seat in the Trexo. Only three visits are required (one fitting\u002Ffamiliarity session and two testing sessions), however participants and\u002For their families may choose to complete more testing sessions if they want to assess other aspects of the training. For example, if the first two testing sessions assessed physical activity, participants and their families may choose to return for further sessions to assess brain activity. The aim of the study is to determine how robot assisted gait training impacts rehabilitation and compensates for impairments, as well as to provide suggestions on how the robotic gait trainer might be improved or modified. This study is exploratory to find out more about how these robotic gait trainers, specifically the Trexo, impacts various aspects of rehabilitation.",[305,306,30],"Physical Disability","CP (Cerebral Palsy)",[308,309,310],"Robot Assisted Gait Training","Trexo","Rehabilitation","2026-02-03",{"date":313,"type":71},"2026-02-06",{"date":315,"type":71},"2022-03-14",{"date":317,"type":22},"2026-12",{"name":319,"class":78},"University of Calgary",{"id":321,"slug":322,"hasResults":11,"nctId":323,"briefTitle":324,"officialTitle":325,"acronym":4,"eligibilityCriteria":326,"healthyVolunteers":16,"sex":17,"minAge":327,"maxAge":87,"enrollmentInfo":328,"targetDuration":4,"studyType":23,"phases":330,"briefSummary":331,"conditions":332,"keywords":335,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":340,"lastUpdatePostDateStruct":341,"startDateStruct":343,"completionDateStruct":345,"leadSponsor":347,"locationsCount":79},"100575361","problem-behavior-assessment-and-intervention-in-idea-part-c-services-100575361","NCT06771284","Problem Behavior Assessment and Intervention in IDEA Part C Services","Problem Behavior Assessment and Intervention in IDEA Part C Services: A Single-Case Study","Child Inclusion Criteria:\n\n* age birth to 5 years old\n* has a developmental disability or delay based on caregiver report and\u002For receiving early intervention services\n* has problem behavior, as reported by the caregiver and\u002For early intervention professional\n\nCaregivers (e.g., parent, grandparent) of eligible child participants will participate with their child as the implementer of all procedures.\n\nAn early intervention professional will participate with each caregiver-child dyad to coach the caregiver, in addition to the researcher.","0 Months",{"count":329,"type":22},9,[25],"The purpose of this study is to evaluate the effect of function-based assessment and intervention to reduce problem behavior in children with developmental disability or delay in the context of IDEA Part C services. The investigators will conduct a single-case study to evaluate the efficacy of the intervention.",[333,334,30],"Problem Behavior","Developmental Delay",[336,337,338,339],"Early childhood","Problem behavior","Home-based services","IDEA Part C services","2026-01-20",{"date":342,"type":71},"2026-01-22",{"date":344,"type":71},"2025-09-30",{"date":346,"type":22},"2027-05",{"name":348,"class":78},"University of Nevada, Las Vegas",{"id":350,"slug":351,"hasResults":11,"nctId":352,"briefTitle":353,"officialTitle":354,"acronym":4,"eligibilityCriteria":355,"healthyVolunteers":11,"sex":17,"minAge":356,"maxAge":4,"enrollmentInfo":357,"targetDuration":4,"studyType":23,"phases":359,"briefSummary":360,"conditions":361,"keywords":366,"overallStatus":151,"whyStopped":4,"lastUpdateSubmitDate":372,"lastUpdatePostDateStruct":373,"startDateStruct":375,"completionDateStruct":377,"leadSponsor":378,"locationsCount":242},"100609900","implementing-powered-mobility-in-early-childhood-settings-for-children-with-cerebral-palsy-100609900","NCT07220590","Implementing Powered Mobility in Early Childhood Settings for Children With Cerebral Palsy","Bridging the Gap: Implementing A Powered Mobility Intervention Into Early Childhood Settings for Young Children With Cerebral Palsy (GMFCS IV-V)","Inclusion Criteria:\n\nChildren:\n\n1. Diagnosis of cerebral palsy or similar motor impairment\n2. Gross Motor Function Classification System (GMFCS) Levels IV-V\n3. Age 12 to 32 months at enrollment\n4. Enrolled in early intervention services\n\nCaregivers:\n\n1. Parent or legal guardian of an enrolled child participant\n2. Age 18 years or older\n3. English- or Spanish-speaking\n4. Able and willing to participate in home-based data collection, including caregiver coaching sessions, completion of surveys, and video-recorded sessions\n5. Able to provide informed consent\n\nTherapists:\n\n1. Licensed physical therapist or occupational therapist\n2. Employed at participating early intervention or early childhood special education settings\n3. Provide services to children with cerebral palsy or motor delays\n4. No prior powered mobility intervention training required\n5. Willing to complete powered mobility implementation training and participate in study assessments\n\nExclusion Criteria:\n\n1. Inability or unwillingness to provide informed consent\n2. Inability to complete required study procedures","1 Year",{"count":358,"type":22},24,[25],"The goal of this clinical trial is to learn if a therapist training program can help providers in Part C Early Childhood Settings use powered mobility (PM) with young children who have cerebral palsy (Gross Motor Function Classification System Levels IV-V). The study will also look at whether this training is practical and useful for therapists, families, and children.\n\nThe main questions it aims to answer are:\n\n1. Can therapists successfully use the training to provide powered mobility interventions in home and early childhood settings?\n2. Do families and children find the intervention acceptable and helpful?\n3. What benefits do children show in mobility, participation, and engagement after using powered mobility?\n\nIn this study, therapists and families will:\n\n1. Take part in a training program about how to use powered mobility with young children\n2. Use powered mobility devices (Permobil Explorer Mini) with children during everyday routines\n3. Complete surveys, interviews, and observations about their experiences",[362,363,30,310,364,365],"Cerebral Palsy Children","Motor Disabilities","Early Intervention","Assistive Technology",[367,368,369,370,371],"Power Mobility","Implementation Science","Community-engaged research","Caregiver coaching","Pediatric Rehabilitation","2025-12-30",{"date":374,"type":71},"2026-01-02",{"date":376,"type":22},"2026-01-01",{"date":183,"type":22},{"name":379,"class":78},"Oregon Health and Science University",{"id":381,"slug":382,"hasResults":11,"nctId":383,"briefTitle":384,"officialTitle":385,"acronym":4,"eligibilityCriteria":386,"healthyVolunteers":11,"sex":17,"minAge":141,"maxAge":4,"enrollmentInfo":387,"targetDuration":4,"studyType":278,"phases":4,"briefSummary":389,"conditions":390,"keywords":392,"overallStatus":151,"whyStopped":4,"lastUpdateSubmitDate":397,"lastUpdatePostDateStruct":398,"startDateStruct":400,"completionDateStruct":402,"leadSponsor":404,"locationsCount":407},"100600081","pgx-medication-safety-reviews-of-persons-with-idd-100600081","NCT07092852","PGx Medication Safety Reviews of Persons With IDD","Pharmacogenomic-Based Medication Safety Reviews of Persons With Intellectual and Developmental Disabilities","Inclusion Criteria:\n\n* Beneficiary with IDD\n* Reside in a CP Unlimited facility, NY state\n* At least 21 years of age\n\nExclusion Criteria:\n\n* Pregnant\n* Medical or physical abnormality that prevents cheek swab collection",{"count":388,"type":22},700,"The purpose of this study is to assess the feasibility of a comprehensive medication review and PGx initiative as part of the care process for individuals in the care of CP Unlimited. This initiative may help improve management of medications and overall health and well-being for participating individuals. Please note that in the context of the research being conducted, all information will remain confidential and deidentified for analyses.\n\nUnder the proposed study protocol, CP Unlimited, in partnership with pharmacists at GalenusRx, will implement and assess a comprehensive medication safety and PGx initiative. Almost three quarters of all clinical trials have eligibility criteria resulting in the exclusion of adults with IDD. This study will help address ongoing health practice disparity. As indicated above, the investigators are requesting the authorization of the guardian or representative, on behalf of the participant under their supervision, to enroll this individual in the proposed study because she\u002Fhe is currently prescribed medications or may eventually receive prescribed or over-the-counter medications. Hereinafter, the denomination \"he\u002Fshe, him\u002Fher, his\u002Fher or them\u002Ftheir\" will be used to refer to the individual with IDD.\n\nThe response to medication can be affected by variations in our genes and by other medications and various disease conditions. Information contained in our genes can vary from one patient to another patient and this can explain why we all can respond differently to medications. Genetic testing and a review of his\u002Fher medications can help to determine if the medication will work for him\u002Fher. PGx is how his\u002Fher genes affect the way he\u002Fshe responds to specific drugs. PGx can tell if he\u002Fshe is more or less likely to feel bad reactions to a drug, or if a drug is likely to benefit him\u002Fher and be safe for him\u002Fher to take. Knowing his\u002Fher genetic information and all medicines that he\u002Fshe is taking can help his\u002Fher pharmacist and his\u002Fher doctor find the combination of medicines that will work the best for him\u002Fher, now and in the future.",[391,228,30],"Intellectual Disability, Mild",[393,394,395,396],"Intellectual disabilities","Developmental disabilities","IDD","pharmacogenomics","2025-07-21",{"date":399,"type":71},"2025-07-30",{"date":401,"type":22},"2025-08-01",{"date":403,"type":22},"2028-01-31",{"name":405,"class":406},"GalenusRx, Inc.","INDUSTRY",2,{"id":409,"slug":410,"hasResults":11,"nctId":411,"briefTitle":412,"officialTitle":413,"acronym":395,"eligibilityCriteria":414,"healthyVolunteers":11,"sex":17,"minAge":415,"maxAge":416,"enrollmentInfo":417,"targetDuration":4,"studyType":23,"phases":419,"briefSummary":420,"conditions":421,"keywords":425,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":432,"lastUpdatePostDateStruct":433,"startDateStruct":435,"completionDateStruct":437,"leadSponsor":439,"locationsCount":79},"100576269","using-a-smart-inhaler-to-support-asthma-management-in-adolescents-with-intellectual-and-developmental-disabilities-100576269","NCT06783101","Using a Smart Inhaler to Support Asthma Management in Adolescents With Intellectual and Developmental Disabilities","A Pilot Randomized Controlled Trial: Utilizing a Digital Inhaler to Support Asthma Management in Adolescents With Intellectual and Developmental Disabilities","Inclusion Criteria: Participants must meet all of the inclusion criteria to participate in this study:\n\n* Adolescents ages 10-17 years\n* Diagnosis of mild-to-moderate intellectual disability: ICD-10: F70-F71 and\u002For diagnosis of developmental disability, including autism: ICD-10: F80-89\n* Diagnosis of moderate-to-severe asthma or moderate or severe unspecified asthma: ICD-10: J45.40-J45.909\n* Parent\u002Flegal guardian is willing to answer questions about their child.\n* Parent\u002Flegal guardian and adolescent must have the ability to understand study procedures and to comply with them for the entire length of the study\n* English or Spanish-speaking participants\n* Not involved in other studies using digital inhalers\n* Males and females of reproductive capability will be enrolled: contraception is not necessary or required.\n* Participants must use any of the following MDIs (as indicated by the 510(k): Ventolin HFA, ProAir HFA, Advair HFA, Flovent HFA, Xopenex HFA, Symbicort HFA, Atrovent HFA, Proventil HFA, Alvesco HFA, Dulera HFA, and Asmanex HFA.\n\nExclusion Criteria: All candidates meeting any of the exclusion criteria at baseline will be excluded from study participation:\n\n* Health status or any clinical conditions: Limited life expectancy, co-existing disease or other characteristics that precludes appropriate diagnosis, treatment, or follow-up in the trial.\n* Inability or unwillingness of individual or legal guardian\u002Frepresentative to give written informed consent.","10 Years","17 Years",{"count":418,"type":22},30,[25],"Correct use of daily medications containing inhaled corticosteroids is key for asthma control, yet children with intellectual and developmental disabilities (IDD) face additional barriers to proper inhaler use. Smart inhalers, a novel technology that provides guidance and immediate feedback on inhaler use techniques, have been shown to enhance correct medication administration in the typically developing pediatric population, but their effectiveness has not been evaluated on the pediatric IDD population. This study aims to investigate whether daily application of smart inhalers (1) is feasible and acceptable in the IDD population, (2) improves the rate of correct medication administration, and (3) results in improvement in lung function. This effort aims to promote better asthma management in the IDD population.",[422,423,30,424],"Asthma in Children","Intellectual Disabilities (F70-F79)","Autism Spectrum Disorder (ASD)",[426,427,428,429,430,431],"smart inhaler","asthma","inhaler proficiency","children","intellectual disability","developmental disability","2025-01-14",{"date":434,"type":71},"2025-01-20",{"date":436,"type":71},"2024-08-13",{"date":438,"type":22},"2025-04",{"name":440,"class":78},"Children's Hospital Los Angeles",{"id":442,"slug":443,"hasResults":11,"nctId":444,"briefTitle":445,"officialTitle":446,"acronym":447,"eligibilityCriteria":448,"healthyVolunteers":16,"sex":17,"minAge":299,"maxAge":449,"enrollmentInfo":450,"targetDuration":452,"studyType":278,"phases":4,"briefSummary":453,"conditions":454,"keywords":458,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":463,"lastUpdatePostDateStruct":464,"startDateStruct":466,"completionDateStruct":468,"leadSponsor":470,"locationsCount":79},"100574863","association-between-motor-skills-and-sensory-profiles-in-children-with-typical-and-atypical-development-aged-4-to-11-years-100574863","NCT06764810","Association Between Motor Skills and Sensory Profiles in Children With Typical and Atypical Development Aged 4 to 11 Years","Association Between Motor Skills and Sensory Profiles in Children With Typical and Atypical Development Aged 4 to 11 Years: A Cross-Sectional Observational Case-Control Study","MOTISEN","Inclusion Criteria:\n\n* Children aged 4 to 11 years.\n* Typical or atypical neurodevelopment, defined as follows:\n* ASD: Subclinical symptoms or Level 1 diagnosis.\n* ADHD: Predominantly inattentive, hyperactive\u002Fimpulsive, or combined presentation. For children under 6, typical symptoms of the disorder (e.g., impulsivity, hyperactivity).\n* DCD: Diagnosed or meeting the following criteria:\n\n  * Motor skills below age expectations.\n  * Significant impact on daily activities or school performance.\n  * Difficulties not attributable to another condition.\n* Parental\u002Flegal guardian consent.\n\nExclusion Criteria:\n\n* Moderate to severe intellectual disability (IQ ≤ 51).\n* Neurological disorders (e.g., cerebral palsy) or syndromes.\n* Severe visual and\u002For auditory impairments.\n* Severe behavioral disorders.\n* Severe mental health disorders (e.g., depression, severe anxiety).","11 Years",{"count":451,"type":22},40,"1 Month","Background and Justification Childhood developmental disorders, such as Autism Spectrum Disorder (ASD), Attention Deficit Hyperactivity Disorder (ADHD), and Developmental Coordination Disorder (DCD), pose significant challenges for children and their families. These disorders impact children's growth and learning, leading to difficulties in key areas such as language, communication, behavior, social interaction, and motor skills. Research in this area is limited, particularly regarding fine and gross motor skills in relation to sensory processing in children with these diagnoses.\n\nHypothesis and Objectives There is an association between motor skills and sensory processing in children aged 4 to 11 years, depending on whether they have typical or atypical neurodevelopment, such as ASD, ADHD, and DCD.\n\nMain Objective:\n\nTo evaluate the association between motor skills and sensory processing in children aged 4 to 11 years with either typical or atypical neurodevelopment (e.g., ASD, ADHD, and DCD).\n\nSecondary Objectives:\n\nTo describe and compare motor skills among children aged 4 to 11 years with typical or atypical neurodevelopment, such as ASD, ADHD, and DCD.\n\nTo describe and compare sensory processing among children aged 4 to 11 years with typical or atypical neurodevelopment, such as ASD, ADHD, and DCD.\n\nMethodology The study is a cross-sectional observational case-control study. Participants are users of the Child Development and Early Intervention Center (CDIAP) Tris Tras, Neuro Xics, or Criv in Vic.\n\nThe sample will include 30 children as controls (typical neurodevelopment) and 10 children as cases (atypical neurodevelopment: ASD, ADHD, DCD).\n\nChildren will be assessed using the Infant Motor Profile (IMP) to measure motor development and the Short Sensory Profile-2 (SSP-2) to evaluate sensory processing.\n\nStatistical Analysis Quantitative variables will be described using means and standard deviations, while categorical variables will be presented as frequencies and percentages. Statistical tests such as the Student's t-test will be used to compare means between two groups, ANOVA for comparisons among more than two groups, and the Chi-square test to analyze associations between categorical variables.\n\nExpected Results The study is expected to provide essential insights into the differences in motor development between children with typical and atypical neurodevelopment, as well as the relationship between biological and external factors and these differences. These findings could help improve clinical and educational interventions for these children by tailoring them to their specific needs, thereby enhancing their overall well-being and development.\n\nEthical Considerations The study protocol will be submitted to the Research Ethics Committee (CER) of UVic-UCC, adhering to good clinical practice guidelines in accordance with the Declaration of Helsinki. Participants will be assigned a code to ensure data pseudonymization, with data securely stored on the Microsoft 365 server of UVic-UCC. Participants will have the right to withdraw from the study at any time, and personal data will be deleted once the study is completed.\n\nResearchers will ensure confidentiality as dictated by Organic Law 3\u002F2018 of December 5 on the Protection of Personal Data and Guarantee of Digital Rights, Regulation (EU) 2016\u002F679 of April 27, 2016, on data protection, and complementary regulations, as well as Organic Law 1\u002F1982 of May 5 on the right to honor, personal and family privacy, and self-image.",[30,95,455,456,457],"Development Coordination Disorder","Attention Deficit Disorder With Hyperactivity","Typical Development",[459,460,461,462],"motor skills disorders","physical therapy modalities","pediatrics","child development","2025-01-09",{"date":465,"type":71},"2025-01-13",{"date":467,"type":71},"2024-12-01",{"date":469,"type":22},"2026-12-20",{"name":471,"class":78},"University of Vic - Central University of Catalonia",{"id":473,"slug":474,"hasResults":11,"nctId":475,"briefTitle":476,"officialTitle":477,"acronym":4,"eligibilityCriteria":478,"healthyVolunteers":11,"sex":17,"minAge":449,"maxAge":479,"enrollmentInfo":480,"targetDuration":4,"studyType":23,"phases":482,"briefSummary":483,"conditions":484,"keywords":488,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":494,"lastUpdatePostDateStruct":495,"startDateStruct":497,"completionDateStruct":499,"leadSponsor":500,"locationsCount":79},"100515150","prt-for-adolescents-with-high-functioning-autism-100515150","NCT05987761","PRT for Adolescents With High Functioning Autism","Pivotal Response Treatment for Adolescents With High Functioning Autism Intervention Study","Inclusion Criteria:\n\n* Clinical Diagnosis of Autism Spectrum Disorder, higher functioning\u002Flow support needs\n* Intelligence Quotient (IQ): Participants with a Full Scale IQ \\> 80 on the Wechsler Abbreviated Scale of Intelligence (WASI-II)\n* Right-handed\n* No metal in their body\u002Funremovable metal on their body (i.e., braces)\n* First language is English\n* Must live in the San Francisco Bay Area\n* Able and willing to receive intervention weekly for 9 weeks\n* Adolescent is interested in improving their social skills\n* MRI Compatibility: No major contraindication for MRI.\n* Diagnosis of ASD using ADOS-2 and ADI-R.\n* No evidence of a genetic, metabolic, or infectious etiology for their autism.\n* Primary diagnosis of ASD\n* No evidence of significant difficulty during pregnancy, labor, delivery, or immediate neonatal period.\n* Stable treatment (e.g., ABA), speech therapy, school placement, psychotropic medication(s) or biomedical intervention(s) for at least 1 month prior to baseline measurements with no anticipated changes during study participation.\n* Score of at least 50% or below on at least 4 out of the 9 social target areas in the SLO (administered during pre-measures)\n* No evidence of significant difficulty during pregnancy, labor, delivery, or immediate neonatal period.\n\nExclusion Criteria:\n\n* History of claustrophobia, previous head injury, serious neurological or medical illness, birth weight less than 4 lb. and\u002For gestational age \\\u003C 34 weeks\n* Left-handed\n* Braces or any metal in their body","14 Years",{"count":481,"type":22},76,[25],"The purpose of this study is to identify improvement in behavioral and social function and changes in the brain following Pivotal Response Treatment (PRT) for Adolescents in highly verbal adolescents with autism spectrum disorder (ASD).",[485,486,30,29,40,487],"Autism","Autism Spectrum Disorder High-Functioning","Behavior, Social",[485,95,489,490,491,492,493],"PRT","Pivotal Response Treatment","Autism intervention","Social skills","Adolescents","2024-03-26",{"date":496,"type":71},"2024-03-28",{"date":498,"type":71},"2023-09-01",{"date":75,"type":22},{"name":77,"class":78}]