[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"dextrose\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:dextrose":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,45,76],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100622646","impact-of-bupivacaine-dilution-with-dextrose-or-saline-on-infraclavicular-block-outcomes-100622646",false,"NCT07386327","Impact of Bupivacaine Dilution With Dextrose or Saline on Infraclavicular Block Outcomes","The Effect of Diluting Bupivacaine With 5% Dextrose and 0.9% NaCl on Block Success and Duration of Analgesia in Infraclavicular Block","Inclusion Criteria:\n\n* Patients who agree to participate in the study and provide written informed consent\n* Patients scheduled for elective upper extremity surgery for whom infraclavicular block is considered appropriate for anesthetic management\n* Age between 18 and 65 years\n* American Society of Anesthesiologists (ASA) physical status I-III\n* Patients with a normal neurological examination in the extremity scheduled for peripheral nerve block\n\nExclusion Criteria:\n\n* Patients who decline to participate in the study or refuse to provide informed consent\n* History of allergy or hypersensitivity to study medications\n* Body mass index (BMI) ≥ 30 kg\u002Fm²\n* Body weight less than 40 kg\n* Age below 18 years or above 65 years\n* History of significant cardiac disease (e.g., arrhythmia, conduction disorders)\n* Presence of coagulopathy (international normalized ratio \\[INR\\] \\> 1.5 and\u002For platelet count \\\u003C 100,000\u002Fmm³)\n* Hepatic failure or significant liver dysfunction\n* Pregnant patients\n* Infection at the planned peripheral block site\n* Presence of neurological deficit in the extremity planned for peripheral nerve block\n* Patients with uncontrolled diabetes mellitus and\u002For established diabetic neuropathy\n* American Society of Anesthesiologists (ASA) physical status IV","ALL","18 Years","65 Years",{"count":20,"type":21},90,"ESTIMATED","INTERVENTIONAL",[24],"NA","D5W) has long been used as an intravenous fluid for hydration and energy supplementation and has recently gained increasing clinical interest in perineural injection therapies and ultrasound-guided hydrodissection. D5W has been shown to improve pain and functional outcomes in entrapment neuropathies by mechanically releasing perineural adhesions and potentially modulating neurogenic inflammation. In contrast, 0.9% sodium chloride (normal saline) is routinely used as a dilution medium for local anesthetics in peripheral nerve blocks; however, emerging evidence suggests that alternative diluents such as D5W may influence block onset and efficacy.\n\nThe infraclavicular block is a commonly used ultrasound-guided technique for brachial plexus anesthesia, providing reliable anesthesia and postoperative analgesia for upper extremity surgery. This study aims to compare the effects of diluting bupivacaine with either D5W or 0.9% NaCl on block success and duration of analgesia in patients undergoing infraclavicular block. Secondary outcomes include block onset characteristics, sensory and motor block profiles, and perioperative analgesic requirements. The findings may help determine whether D5W represents a safe and effective alternative diluent to saline in routine regional anesthesia practice.",[27,28,29,30,31],"Infraclavicular Brachial Plexus Block","Dextrose","Bupivacaine","Block Success","Postoperative Analgesia","RECRUITING","2026-06-22",{"date":35,"type":36},"2026-06-23","ACTUAL",{"date":38,"type":36},"2026-03-09",{"date":40,"type":21},"2026-07-15",{"name":42,"class":43},"Burçin Alaçam, MD","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":16,"minAge":51,"maxAge":52,"enrollmentInfo":53,"targetDuration":4,"studyType":22,"phases":55,"briefSummary":56,"conditions":57,"keywords":62,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":44},"100617852","efficacy-of-combining-ultrasound-guided-needle-release-of-transverse-carpal-ligament-and-median-nerve-dextrose-water-hydrodissection-for-carpal-tunnel-syndrome-100617852","NCT07324005","Efficacy of Combining Ultrasound-Guided Needle Release of Transverse Carpal Ligament and Median Nerve Dextrose Water Hydrodissection for Carpal Tunnel Syndrome","Inclusion Criteria:\n\n* age between 20 to 80 years old\n* diagnosed with CTS on the basis of clinical condition and an electrophysiological analysis\n* the NRS of pain or paresthesia≧3\n* with symptoms lasting for a minimum of 3 months.\n\nExclusion Criteria:\n\n* history of polyneuropathy, thoracic outlet syndrome, brachial plexopathy, or inflammatory arthropathy\n* onset of CTS during pregnancy, hypothyroidism, or systemic infection\n* previous corticosteroid injection or wrist surgery for CTS\n* hypersensitivity to dextrose injection\n* the anatomic structure of the wrist is not suitable for needle release of TCL.","20 Years","80 Years",{"count":54,"type":21},102,[24],"Carpal tunnel syndrome (CTS) is a common musculoskeletal disorder, which is caused by compression of the median nerve as it travels through the wrist. There are several treatments for CTS, including conservative and surgical options. Though local corticosteroid injection has been considered more effective than physical therapy for treatment of CTS and has significant short-term benefits, long term benefits are not evidenced. Several studies in recent years reported significantly superior longer-term benefit of D5W and PRP compared with corticosteroid injections and other conservative managements. In addition, percutaneous release of the transverse carpal ligament (TCL) was developed to treat CTS in recent years. Because the effectiveness of the recently developed techniques in treating CTS has not been well established, the investigators aim to investigate whether combining US-guided partial release of the transverse carpal ligament with a needle plus D5W hydrodissection is more beneficial for CTS comparing to either treatment alone.",[58,28,59,60,61],"Carpal Tunnel Syndrome","Carpal Tunnel Release","Ultrasound","Nerve Hydrodissection Therapy",[58,63,64,65,66],"dextrose","carpal tunnel release","ultrasound","nerve hydrodissection therapy","2026-04-21",{"date":69,"type":36},"2026-04-23",{"date":71,"type":36},"2026-01-01",{"date":73,"type":21},"2030-12-31",{"name":75,"class":43},"Shin Kong Wu Ho-Su Memorial Hospital",{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":4,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":83,"targetDuration":4,"studyType":22,"phases":85,"briefSummary":86,"conditions":87,"keywords":91,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":44},"100631309","glucocorticoid-ozone-and-5-dextrose-local-injection-for-pain-relief-in-carpal-tunnel-syndrome-100631309","NCT07498998","Glucocorticoid, Ozone and 5% Dextrose Local Injection for Pain Relief in Carpal Tunnel Syndrome","A Comparative Study Between Glucocorticoid, Ozone and 5% Dextrose Local Injection for Pain Relief in Carpal Tunnel Syndrome","Inclusion Criteria:\n\n* Adults aged 18-65 years with a clinical diagnosis of mild to moderate Carpal Tunnel Syndrome .\n* Clinical diagnosis of mild to moderate Carpal Tunnel Syndrome , as classified by Bland neurophysiological classification scale: Mild Carpal Tunnel Syndrome : Slow Distal Sensory Latency(≥3.6 ms), Normal Distal Motor Latency(\\\u003C 4.5 ms)\n* Moderate Carpal Tunnel Syndrome : Slow Distal Sensory Latency (≥ 3.6 ms), Slow Distal Motor Latency (4.5 - 6.4 ms)\n* Failure to respond to conservative treatments (e.g., splinting, activity modification, or oral medications) for at least 6 weeks.\n\nExclusion Criteria:\n\n* Patient refusal.\n* Severe Carpal Tunnel Syndrome requiring surgical intervention, as defined by the Bland neurophysiological classification scale: Severe Carpal Tunnel Syndrome: Absent Distal Sensory Latency and Slow Distal Motor Latency (4.5 - 6.4 ms)\n* Previous corticosteroid injection for Carpal Tunnel Syndrome within the last 6 months.\n* History of wrist trauma, surgery or anatomical abnormalities.\n* Systemic conditions such as diabetes mellitus, thyroid dysfunction or rheumatoid arthritis.\n* Pregnancy or lactation.\n* Contraindications to any of the study interventions (e.g., allergy to glucocorticoids or ozone).\n* Infection at wrist.",{"count":84,"type":21},105,[24],"This study aims to compare the efficacy and outcomes of perineural injection with 5% dextrose, local ozone and glucocorticoid injection in the management of carpal tunnel syndrome.",[88,89,90,28],"Carpal Tunnel Syndrome (CTS)","Glucocorticoid","Pain",[92,93,94,95],"glucocorticoid","Ozone","5% dextrose","carpal tunnel syndrome","NOT_YET_RECRUITING","2026-03-24",{"date":99,"type":36},"2026-03-27",{"date":101,"type":21},"2026-07-30",{"date":103,"type":21},"2026-08-30",{"name":105,"class":43},"Tanta University"]