[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"diaphragm-excursion\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:diaphragm-excursion":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":4},"100643773","phase-4-the-effect-of-doxapram-on-diaphragmatic-excursionde-during-weaning-from-mechanical-ventilation-100643773",false,"NCT07637149","the Effect of Doxapram on Diaphragmatic Excursion(DE) During Weaning From Mechanical Ventilation.","the Effect of Doxapram on Diaphragmatic Excursion(DE) During Weaning From Mechanical Ventilation :a Randomized Double Blinded Study.","Inclusion Criteria:\n\n* Adults (≥18 years) on mechanical ventilation for \\>48 hours.\n* Deemed ready for weaning by the clinical team: Defined as RSBI \\\u003C105, P\u002FF ratio \\>200, hemodynamic stability.\n* Stable hemodynamics and adequate oxygenation (PaO₂\u002FFiO₂ \\>150)\n\nExclusion Criteria:\n\n* Severe neurological impairment :Defined as GCS ≤8 or spinal cord injury above T5 .\n\n  * Known hypersensitivity to doxapram.\n  * Pregnancy or lactation.","ALL","18 Years",{"count":19,"type":20},60,"ESTIMATED","INTERVENTIONAL",[23],"PHASE4","The goal of this clincal trial is to learn if doxapram is effective in weaning in adults on mechanical ventilation.\n\nThe objectives of this study:\n\n* Evaluate the effect of doxapram on diaphragmatic function (assessed by DE)during weaning from mechanical ventilation.\n* Assess the impact of doxapram on respiratory muscle sterngth.\n* Mointor adverse effects associated with doxapram administration.\n\nResearchers will compare expermental group(intervenous doxapram during weaning)with control group(saline infusion)during weaning.\n\nThe patients who fulfull criteria of weaning will be subjected to our clincal trial and put on spontanous breathing trial for 120mins using positive end expiratory pressure (peep)5 cmh2o,pressure support 5cm h2o and fio2 0.3.By the end of the SBTthe patient will be extubated if ventilator parameters and vital signs were maintained within 20%of baseline values.\n\nThe patients will be followed up after extubation and afailed weaning will be defined as the neeed for either invasive or non invasive ventilation for 72 after extubation or failed SBT.",[26,27],"Mechanically Ventilated ICU Patients","Diaphragm Excursion","NOT_YET_RECRUITING","2026-06-05",{"date":31,"type":32},"2026-06-09","ACTUAL",{"date":34,"type":20},"2026-06-01",{"date":36,"type":20},"2027-01-01",{"name":38,"class":39},"Kasr El Aini Hospital","OTHER"]