[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"diaphragm-injury\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:diaphragm-injury":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,60,87,110,134,161,184],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":21,"conditions":22,"keywords":37,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":48,"lastUpdatePostDateStruct":49,"startDateStruct":52,"completionDateStruct":54,"leadSponsor":56,"locationsCount":59},"100434493","developing-a-decision-instrument-to-guide-abdominal-pelvic-ct-imaging-of-blunt-trauma-patients-100434493",false,"NCT04937868","Developing a Decision Instrument to Guide Abdominal-pelvic CT Imaging of Blunt Trauma Patients","NEXUS AP CT","Inclusion Criteria:\n\nBlunt trauma patients who undergo abdominal-pelvic CT imaging during their initial trauma evaluation in the emergency department.\n\nExclusion Criteria:\n\nNone","ALL",{"count":18,"type":19},12000,"ESTIMATED","OBSERVATIONAL","Unrecognized abdominal and pelvic injuries can result in catastrophic disability and death. Sporadic reports of \"occult\" injuries have generated concern, and physicians, fearing that they may miss such an injury, have adopted the practice of obtaining computed tomography on virtually all patients with significant blunt trauma. This practice exposes large numbers patients to dangerous radiation at considerable expense, while detecting injuries in a small minority of cases.\n\nExisting data suggest that a limited number of criteria can reliably identify blunt injury victims who have \"no risk\" of abdominal or pelvic injuries, and hence no need for computed tomography (CT), without misidentifying any injured patient. It is estimated that nationwide implementation of such criteria could result in an annual reduction in radiographic charges of $75 million, and a significant decrease in radiation exposure and radiation induced malignancies.\n\nThis study seeks to determine whether \"low risk\" criteria can reliably identify patients who have sustained significant abdominal or pelvic injuries and safely decrease CT imaging of blunt trauma patients. This goal will be accomplished in the following manner:\n\nAll blunt trauma victims undergoing computed tomography of the abdomen\u002Fpelvis in the emergency department will undergo routine clinical evaluations prior to radiographic imaging. Based on these examinations, the presence or absence of specific clinical findings (i.e. abdominal\u002Fpelvic\u002Fflank pain, abdominal\u002Fpelvic\u002Fflank tenderness, bruising abrasions, distention, hip pain, hematuria, hypotension, tachycardia, low or falling hematocrit, intoxication, altered sensorium, distracting injury, positive FAST imaging, dangerous mechanism, abnormal x-ray imaging) will be recorded for each patient, as will the presence or absence of abdominal or pelvic injuries. The clinical findings will serve as potential imaging criteria. At the completion of the derivation portion of the study the criteria will be examined to find a subset that predicts injury with high sensitivity, while simultaneously excluding injury, and hence the need for imaging, in the remaining patients. These criteria will then be confirmed in a separate validation phase of the study.\n\nThe criteria will be considered to be reliable if the lower statistical confidence limit for the measured sensitivity exceeds 98.0%. Potential reductions in CT imaging will be estimated by determining the proportion of \"low-risk\" patients that do not have significant abdominal or pelvic injuries.",[23,24,25,26,27,28,29,30,31,32,33,34,35,36],"Abdominal Injury","Pelvic Fracture","Genital Hemorrhage","Lumbar Spine Injury","Hip Injuries","Liver Injury","Spleen Injury","Renal Injury","Diaphragm Injury","Aortic Rupture","Aortic Dissection","Bowel Disease","Vascular System Injuries","Sacral Fracture",[38,39,40,41,42,43,44,45,46],"Blunt trauma","Abdominal injury","Pelvic injury","Spine injury","Genital injury","Vascular injury","Hip injury","Computed tomography","Decision instrument","RECRUITING","2026-01-09",{"date":50,"type":51},"2026-01-13","ACTUAL",{"date":53,"type":51},"2018-01-15",{"date":55,"type":19},"2027-06-15",{"name":57,"class":58},"University of California, Los Angeles","OTHER",1,{"id":61,"slug":62,"hasResults":11,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":66,"eligibilityCriteria":67,"healthyVolunteers":11,"sex":16,"minAge":68,"maxAge":4,"enrollmentInfo":69,"targetDuration":4,"studyType":71,"phases":72,"briefSummary":74,"conditions":75,"keywords":4,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":59},"100488647","feasibility-of-reducing-respiratory-drive-using-the-through-flow-system-100488647","NCT05642832","Feasibility of Reducing Respiratory Drive Using the Through-flow System","Feasibility of Reducing Respiratory Drive in Patients with Acute Hypoxemic Respiratory Failure Using the Through-flow System","Throughflow","Inclusion Criteria:\n\n* PaO2\u002FFiO2 less than or equal to 300 at time of screening\n* Oral endotracheal intubation with ETT 7.5 or 8.0 and on invasive mechanical ventilation\n* Bilateral airspace opacities on chest radiograph or chest CT scan\n\nExclusion Criteria:\n\n* Contraindication to esophageal catheterization (upper gastrointestinal tract surgery within preceding 6 weeks, bleeding esophageal\u002Fgastric varices)\n* Intubation for traumatic brain injury or stroke\n* Intracranial hypertension (suspected or diagnosed by medical team)\n* Anticipated liberation from mechanical ventilation within 24 hours","18 Years",{"count":70,"type":19},15,"INTERVENTIONAL",[73],"NA","Mechanical ventilation can lead to diaphragm and lung injury. During mechanical ventilation, the diaphragm could be completely rested or it could be overworked, either of which may cause diaphragm injury. Mechanical stress and strain applied by mechanical ventilation or by the patient's own respiratory muscles can also cause injury to the lungs. Diaphragm and lung injury are associated with increased morbidity and mortality. Throughflow is a novel system that can reduce dead space without the need to increase the tidal ventilation, reducing the ventilatory demands and respiratory drive.",[76,31,77],"Respiratory Insufficiency","Lung Injury","2024-12-06",{"date":80,"type":51},"2024-12-11",{"date":82,"type":51},"2024-01-01",{"date":84,"type":19},"2025-08-31",{"name":86,"class":58},"University Health Network, Toronto",{"id":88,"slug":89,"hasResults":11,"nctId":90,"briefTitle":91,"officialTitle":91,"acronym":92,"eligibilityCriteria":93,"healthyVolunteers":11,"sex":16,"minAge":68,"maxAge":4,"enrollmentInfo":94,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":96,"conditions":97,"keywords":100,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":104,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":59},"100336945","diaphragm-structure-and-pathobiology-in-patients-being-bridged-to-lung-transplant-100336945","NCT03667027","Diaphragm Structure and Pathobiology in Patients Being Bridged to Lung Transplant","DIASPORA","Inclusion Criteria (Cases):\n\n* Receiving a respiratory support modality as a bridge to lung transplantation\n* Formally listed for transplantation\n\nInclusion Criteria (Control Group 1):\n\n\\- Undergoing lung transplantation for either obstructive or restrictive lung disease\n\nInclusion Criteria (Control Group 2):\n\n\\- Undergoing elective thoracic surgery without any prior history of chronic pulmonary parenchymal disease\n\nExclusion Criteria (Cases and Controls):\n\n* Previously diagnosed with neuromuscular disorder\n* Received invasive mechanical ventilation for \\>48 hours in the preceding four weeks\n* Thoracic cage deformity",{"count":95,"type":19},40,"This study is designed to characterize the changes in diaphragm structure, function and biology during bridging to lung transplant by mechanical ventilation or extracorporeal life support.",[31,98,99],"Respiratory Failure","Mechanical Ventilation Complication",[101,102,103],"Diaphragm Dysfunction","Acute Respiratory Failure","Mechanical Ventilation",{"date":80,"type":51},{"date":106,"type":51},"2019-04-01",{"date":108,"type":19},"2025-12-30",{"name":86,"class":58},{"id":111,"slug":112,"hasResults":11,"nctId":113,"briefTitle":114,"officialTitle":115,"acronym":4,"eligibilityCriteria":116,"healthyVolunteers":11,"sex":16,"minAge":68,"maxAge":4,"enrollmentInfo":117,"targetDuration":4,"studyType":71,"phases":119,"briefSummary":121,"conditions":122,"keywords":123,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":125,"lastUpdatePostDateStruct":126,"startDateStruct":128,"completionDateStruct":130,"leadSponsor":132,"locationsCount":59},"100338040","phase-2-janus-kinase-inhibition-to-prevent-ventilator-induced-diaphragm-dysfunction-100338040","NCT03681275","Janus Kinase Inhibition to Prevent Ventilator-induced Diaphragm Dysfunction","A Clinical Trial of JAK Inhibition to Prevent Ventilator-induced Diaphragm Dysfunction","Inclusion Criteria:\n\n* Patients undergoing esophagectomy\n\nExclusion Criteria:\n\n* Patients with more than mild pulmonary dysfunction\n* Patients with any neuromuscular disease that might compromise diaphragm function\n* Patients with abnormal liver or kidney function\n* Patients taking any immunosuppressant medication (including prednisone) or antifungal medications\n* History of tuberculosis\n* Weight loss of \\>5% of body weight over previous 6 months\n* Pregnancy",{"count":118,"type":19},70,[120],"PHASE2","We intend, with this study, to prove that blocking the molecular mechanisms whose blockade prevents VIDD in animals, will indeed prevent the development of VIDD in humans as well. We believe that this evidence will serve as the required basis for proceeding with large, ICU-based clinical trial(s) of a drug to prevent VIDD.",[31],[124],"Ventilator-induced Diaphragm Dysfunction","2024-11-21",{"date":127,"type":51},"2024-11-25",{"date":129,"type":51},"2019-09-03",{"date":131,"type":19},"2026-11-30",{"name":133,"class":58},"Stanford University",{"id":135,"slug":136,"hasResults":11,"nctId":137,"briefTitle":138,"officialTitle":139,"acronym":4,"eligibilityCriteria":140,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":141,"targetDuration":4,"studyType":71,"phases":143,"briefSummary":144,"conditions":145,"keywords":148,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":152,"lastUpdatePostDateStruct":153,"startDateStruct":155,"completionDateStruct":157,"leadSponsor":159,"locationsCount":59},"100560064","non-invasive-phrenic-nerve-stimulation-in-ards-patient-100560064","NCT06572280","Non-invasive Phrenic Nerve Stimulation in ARDS Patient","Non-invasive Phrenic Nerve Stimulation in ARDS Patients - a Feasibility Study","Inclusion Criteria:\n\n1. Adult ARDS patients undergoing controlled mechanical ventilation\n2. The duration of endotracheal intubation \\\u003C 48 hrs\n\nExclusion Criteria:\n\n1. Neurological condition affecting motor neuron or muscle (e.g. ALS)\n2. Paralysis of the phrenic nerve\n3. Proven or suspected spinal cord injury\n4. Conditions that limit diaphragm movement\n5. Patients with Implanted cardiac support systems (pacemaker, implanted defibrillator)\n6. Patients with implanted medical pumps\n7. Pregnancy\n8. Patients with skin lesions, infections or strictures in throat\u002Fneck area\n9. Patients with metallic implants\n10. Refusal to sign informed consent",{"count":142,"type":19},10,[73],"Reduced diaphragmatic activity during mechanical ventilation can lead to diaphragmatic disuse atrophy, atelectasis, increased lung stress and strain, and hemodynamic impairment. This, in turn, may prolong the duration of mechanical ventilation, make weaning more difficult, and even increase mortality. Synchronizing phrenic nerve stimulation to promote diaphragmatic activity may prevent ventilator-induced lung injury and ventilator-induced diaphragm dysfunction, thereby improving patient outcomes. Surgically implanted phrenic nerve stimulation has been used in certain neurological disorders, but the effects of percutaneous non-invasive synchronized phrenic nerve stimulation in patients with ARDS undergoing mechanical ventilation remain unclear and require further investigation.",[146,147,31],"ARDS, Human","Ventilator-Induced Lung Injury",[149,150,151],"ARDS","diaphragm injury","mechanical ventilation","2024-08-25",{"date":154,"type":51},"2024-08-27",{"date":156,"type":51},"2024-08-01",{"date":158,"type":19},"2025-01-30",{"name":160,"class":58},"Southeast University, China",{"id":162,"slug":163,"hasResults":11,"nctId":164,"briefTitle":165,"officialTitle":166,"acronym":4,"eligibilityCriteria":167,"healthyVolunteers":168,"sex":16,"minAge":68,"maxAge":4,"enrollmentInfo":169,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":171,"conditions":172,"keywords":4,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":176,"lastUpdatePostDateStruct":177,"startDateStruct":179,"completionDateStruct":180,"leadSponsor":182,"locationsCount":59},"100548693","exploration-of-mechanisms-for-weaning-failure-100548693","NCT06424314","Exploration of Mechanisms for Weaning Failure","Changes in Respiratory Mechanics in Patients With Failed Ventilator Withdrawal","Inclusion Criteria:\n\n* Invasive mechanical ventilation for at least 48 hours\n\nExclusion Criteria:\n\n* neuromuscular disease；Postoperative patients or patients with traumatic brain injury",true,{"count":170,"type":19},30,"This study is a prospective physiologic study. The primary study population will be adult invasive tracheal intubated patients with COPD, and investigators will collect relevant demographic data, vital signs, and baseline physiologic parameters of the patients prior to the spontaneous breathing test（SBT).\n\nThe participants will be divided into a successful withdrawal group and a failed withdrawal group according to the SBT outcome, and the changes in the above parameters during SBT will be compared between the two groups .",[173,174,31,175],"Weaning Failure","Central Respiratory Depression","Phrenic Nerve Disorder","2024-07-08",{"date":178,"type":51},"2024-07-09",{"date":178,"type":51},{"date":181,"type":19},"2025-12-01",{"name":183,"class":58},"The First Affiliated Hospital of Guangzhou Medical University",{"id":185,"slug":186,"hasResults":11,"nctId":187,"briefTitle":188,"officialTitle":188,"acronym":189,"eligibilityCriteria":190,"healthyVolunteers":11,"sex":16,"minAge":68,"maxAge":4,"enrollmentInfo":191,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":193,"conditions":194,"keywords":4,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":196,"lastUpdatePostDateStruct":197,"startDateStruct":199,"completionDateStruct":201,"leadSponsor":203,"locationsCount":59},"100505163","respiratory-muscle-structure-and-function-in-mechanically-ventilated-patients-and-long-term-outcomes-100505163","NCT05857774","Respiratory Muscle Structure and Function in Mechanically Ventilated Patients and Long-term Outcomes","RESPIRE","Cases Inclusion Criteria:\n\n• Adult patients ≥18 years of age undergoing invasive mechanical ventilation in the ICU for any reason within 36 hours of intubation\n\nControl condition A Inclusion Criteria:\n\n• Non-invasively ventilated patients in the ICU within 36 hours of initiating non-invasive ventilation\n\nControl condition B Inclusion Criteria\n\n• Non-ventilated patients admitted to the ICU receiving no respiratory support or oxygen therapy alone, including high flow nasal cannula\n\nExclusion Criteria:\n\n* Patients expected to be extubated within 24 hours of screening for eligibility\n* Patients who have already undergone a SBT at time of screening\n* Patients with a previously diagnosed neuromuscular disorder\n* Patients receiving long-term invasive mechanical ventilation (prior to current hospitalization)\n* Patients who have required previously (during current hospitalization) a period of invasive ventilation in ICU of more than 24 hours\n* Patients who have previously been enrolled in the study\n* Patients for whom post-hospital follow-up may be challenging, e.g. those who reside overseas or who have no fixed address",{"count":192,"type":19},230,"Air is normally pumped in and out of the lungs by the muscles that contribute to inhalation and exhalation, called the respiratory muscles. The abdominal muscles help by forcing air out of your lungs during exhalation; whereas the diaphragm, the main muscle used for breathing, contracts to get air into the lungs during inhalation. With mechanical ventilation, respiratory muscles are able to rest and recover while the breathing machine takes over; however, this may cause respiratory muscle weakness. Patients who develop weakness of these muscles may require more assistance from the ventilator and take longer to recover their ability to breathe without assistance. The impact of this phenomenon on long-term outcomes is uncertain.\n\nThe RESPIRE study is designed to characterize how respiratory muscles change during mechanical ventilation and to evaluate the impact on long term quality of life. An additional objective of this study is to examine novel measures obtained from automated functions of a ventilator, that may better predict success from weaning from mechanical ventilation.",[99,31,77,76,195],"Abdominal Muscle Strained","2024-05-18",{"date":198,"type":51},"2024-05-21",{"date":200,"type":51},"2023-04-27",{"date":202,"type":19},"2026-06-30",{"name":86,"class":58}]