[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"diaphragm-issues\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:diaphragm-issues":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,41,69,95,122],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":4},"100618977","comparison-of-the-interscalene-block-alone-versus-combined-with-superior-truncus-block-during-shoulder-surgery-in-diaphragmatic-function-100618977",false,"NCT07338630","Comparison of the Interscalene Block Alone Versus Combined With Superior Truncus Block During Shoulder Surgery in Diaphragmatic Function","Phrenic Nerve Sparing of the Interscalene Block Alone Versus Combined With Superior Truncus Block During Shoulder Surgery , Prospective Comparative Randomized Study","Inclusion Criteria:\n\n* ASA (American Society of Anesthesiologists) I, II physical status.\n* Aged between 20 and 65 years.\n* Male or female.\n* Body Mass index (BMI): 18-30 kg\u002Fm3.\n* Scheduled for shoulder surgery.\n\nExclusion Criteria:\n\n* Allergy to local anesthetics.\n* Infection at the injection site.\n* Coagulation disorders.\n* Respiratory diseases ( Acute or Chronic) or Chest trauma.\n* Multiple traumatized patients.\n* Phrenic nerve injury\n* Heart failure, Cardiomyopathy.\n* Severe organ dysfunction\n* Patient refusal",true,"ALL","20 Years","65 Years",{"count":21,"type":22},60,"ESTIMATED","INTERVENTIONAL",[25],"NA","Primarily, This study aims to compare between interscalene block alone versus combined with superior truncus block in producing diaphragmatic paralysis and Secondarily aims to evaluate\n\n1. Effect on the pulmonary function.\n2. Duration of the sensory and motor block.\n3. Postoperative analgesic consumption.\n4. Any complications or side effects during shoulder surgery.",[28],"Diaphragm Issues","NOT_YET_RECRUITING","2026-02-04",{"date":32,"type":33},"2026-02-06","ACTUAL",{"date":35,"type":22},"2026-04-01",{"date":37,"type":22},"2027-06-01",{"name":39,"class":40},"Sohag University","OTHER",{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":47,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":17,"minAge":49,"maxAge":50,"enrollmentInfo":51,"targetDuration":4,"studyType":53,"phases":4,"briefSummary":54,"conditions":55,"keywords":4,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":60,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":68},"100455523","diaphragm-atrophy-and-dysfunction-in-mechanical-ventilation-100455523","NCT05211661","Diaphragm Atrophy and Dysfunction in Mechanical Ventilation","Development of Diaphragm Atrophy, Dysfunction and Inhibited Cortical Control in Mechanical Ventilation","DAM","Inclusion Criteria:\n\n* Initiation of invasive mechanical ventilation in the Intensive Care Unit within 48 hours.\n* Expected duration of invasive mechanical ventilation of at least 5 days.\n\nExclusion Criteria:\n\n* Body-mass-index (BMI) \\>40\n* Expected absence of active participation of the patient in study-related measurements after extubation\n* Alcohol or drug abuse\n* Non MRI compatible implant in the body\n* Slipped disc\n* Epilepsy\n* Patients in an interdependence or with an employment contract with the principal investigator, Co-PI or his deputy.","18 Years","75 Years",{"count":52,"type":22},15,"OBSERVATIONAL","The gold standard of twitch transdiaphragmatic pressure recordings would ultimately clear the fog around the rate of development of Ventilator induced Diaphragm Dysfunction (VIDD) in mechanically ventilated patients over time.\n\nThrough measurements made even after mechanical ventilation (MV) it could be clarified to what extent patients recover from VIDD.\n\nPaired with cortical stimulation and electromyographic recordings of diaphragm muscle potentials, it could be explored to what extent decreased diaphragm excitability due to long term MV contributes to VIDD on the level of motor cortex.\n\nAgainst that background the present project aims at determining the rate of decline in diaphragm function, strength and control in patients undergoing MV (including measurements after extubation).",[28,56,57,58],"Mechanical Ventilation Complication","Respiratory Failure","Intensive Care (ICU) Myopathy","RECRUITING",{"date":61,"type":33},"2026-02-09",{"date":63,"type":33},"2022-10-10",{"date":65,"type":22},"2028-06-01",{"name":67,"class":40},"RWTH Aachen University",1,{"id":70,"slug":71,"hasResults":11,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":4,"eligibilityCriteria":75,"healthyVolunteers":11,"sex":17,"minAge":76,"maxAge":4,"enrollmentInfo":77,"targetDuration":4,"studyType":23,"phases":79,"briefSummary":80,"conditions":81,"keywords":82,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":94},"100507113","stimit-activator-1-ide-study-100507113","NCT05883163","STIMIT Activator 1 IDE Study","STIMIT Activator 1 Pivotal Study","Inclusion Criteria:\n\n1. Are 21 years or older, and,\n2. Have recently been placed on invasive MV (enroll and randomized as soon as possible after intubation), and have received no more than 7 days of MV\n3. Are predicted to remain on mechanical ventilation for an additional 48 hours or longer post randomization\n\nExclusion Criteria:\n\n1. Patients that are actively treated with continuous infusion of neuromuscular blocking agents beyond the enrollment period.\n2. Medical condition known to affect the phrenic nerve or respiratory muscles (examples of possible medical conditions that could affect the phrenic nerve provided in Annex 1 below).\n3. Any patients with ICP probe.\n4. Patients with metallic device implants or body penetrating metallic devices in the upper body area within 30cm (12inches) from the coils; known anatomy or devices in the neck area (e.g., ECMO cannulas in the neck area, collars or cranial appliances) that would interfere with headset placement or stimulation.\n5. Any non-removable electrical \u002F electronic device (device internal or external) that may be prone to interaction with, or interference from the STIMIT Activator, such as pacemakers, implantable defibrillators, implanted medication pumps, bio-stimulators, deep brain stimulators, implanted nerve stimulator, deep brain stimulators or cochlear device implants.\n6. BMI \\>40.\n7. Cardiogenic or septic shock with ongoing severe hemodynamic instability that cannot be stabilized within the enrollment period.\n8. Physician thinks that the patient will not tolerate initial installation of the STIMIT respiratory sensor.\n9. Anticipating withdrawal of life support and\u002For shift to palliation as the goal of care.\n10. Known to be pregnant.\n11. Participating in another clinical trial studying an experimental Intervention that could affect the study primary outcome.\n12. Patients whose ultrasonographic assessment of right-sided diaphragmatic thickness would be too difficult (e.g. local subcutaneous emphysema surrounding the zone of apposition, large dressings in the zone of apposition that cannot be removed).\n13. Patients with neck condition that would not allow placing the coils on the neck (e.g. open wounds that cannot be covered, skin at risk for burns).\n14. Patients with significant spontaneous efforts (P0.1 \\\u003C - 2) that would not be at risk for diaphragmatic atrophy\u002F dysfunction.","21 Years",{"count":78,"type":22},40,[25],"The study is a prospective, multi-center, randomized, controlled study using adaptive design to assess the evidence of safety and performance of the STIMIT Activator 1 System in the treatment of patients who have been mechanically ventilated for up to 7 days and are predicted to require additional minimum 48 hours of mechanical ventilation or longer.",[28],[83],"Non-Invasive Phrenic Nerve Stimulation","2025-11-13",{"date":86,"type":33},"2025-11-14",{"date":88,"type":33},"2024-01-24",{"date":90,"type":22},"2026-07",{"name":92,"class":93},"Stimit AG","INDUSTRY",4,{"id":96,"slug":97,"hasResults":11,"nctId":98,"briefTitle":99,"officialTitle":100,"acronym":4,"eligibilityCriteria":101,"healthyVolunteers":11,"sex":17,"minAge":102,"maxAge":103,"enrollmentInfo":104,"targetDuration":4,"studyType":53,"phases":4,"briefSummary":106,"conditions":107,"keywords":111,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":113,"lastUpdatePostDateStruct":114,"startDateStruct":116,"completionDateStruct":118,"leadSponsor":120,"locationsCount":68},"100607781","the-effect-of-bipap-on-diaphragmatic-function-100607781","NCT07193017","The Effect of BIPAP on Diaphragmatic Function","The Effects of Biphasic Positive Airway Pressure (BIPAP) Use on Diaphragm Functions in Patients With Chronic Obstructive Pulmonary Disease (COPD)","Inclusion Criteria:\n\n* Being between 40-80 years of age,\n* Having a diagnosis of stable COPD for at least 1 year,\n* Being in a stable phase (no acute exacerbation within the last 4 weeks),\n* Meeting the GOLD 2025 A-B-E classification according to symptoms and exacerbation history,\n* Having been initiated on BiPAP therapy with a clinical indication,\n* Being willing to participate in the study and providing informed consent.\n\nExclusion Criteria:\n\n* Pregnancy,\n* Diaphragmatic paralysis,\n* Neuromuscular and neurological diseases,\n* Decompensated heart failure,\n* Chest deformity,\n* Acute exacerbation within the last month,\n* Pneumothorax,\n* Body mass index greater than 35 kg\u002Fm²,\n* Long-term corticosteroid use,\n* Chemotherapy,\n* Active malignancy,\n* Inability to cooperate,\n* Thoracoabdominal surgery within the last 3 months.","40 Years","80 Years",{"count":105,"type":22},30,"This research is designed to evaluate how long-term treatment with Bilevel Positive Airway Pressure (BiPAP) influences diaphragm function in patients with Chronic Obstructive Pulmonary Disease (COPD) who suffer from chronic hypercapnic respiratory failure. The diaphragm is the primary muscle of breathing, and its dysfunction is linked to unfavorable clinical outcomes such as higher mortality rates and frequent hospitalizations. In this prospective cohort study, COPD patients starting BiPAP therapy based on clinical indication will be monitored through repeated ultrasound assessments of diaphragm structure and function together with pulmonary function testing, respiratory muscle strength evaluation, dyspnea. The main outcome of interest is the change in diaphragm thickness in inspiration, thickness in expiration, diaphragm thickening fraction (DTF), diaphragm maximum contraction velocity and maximum relaxation velocity across a 6 weeks as a early time and 12 months for long time follow-up period. Secondary measures include hospital admissions, and one-year survival. The study is expected to generate valuable evidence about the link between non-invasive ventilation and diaphragm function, which may contribute to optimizing treatment strategies for COPD patients with advanced respiratory failure.",[108,28,109,110],"BIPAP Biphasic Intermittent Positive Airway Pressure","Ultrasound Diagnostics","COPD (Chronic Obstructive Pulmonary Disease)",[112],"bıpap, diaphragm function, diaphragm ultrasound, copy","2025-09-24",{"date":115,"type":33},"2025-09-25",{"date":117,"type":22},"2025-10-15",{"date":119,"type":22},"2027-06-15",{"name":121,"class":40},"Istanbul Demiroglu Bilim University",{"id":123,"slug":124,"hasResults":11,"nctId":125,"briefTitle":126,"officialTitle":127,"acronym":4,"eligibilityCriteria":128,"healthyVolunteers":16,"sex":17,"minAge":49,"maxAge":129,"enrollmentInfo":130,"targetDuration":4,"studyType":23,"phases":132,"briefSummary":133,"conditions":134,"keywords":4,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":138,"lastUpdatePostDateStruct":139,"startDateStruct":141,"completionDateStruct":143,"leadSponsor":145,"locationsCount":68},"100553832","the-relationship-between-pes-planus-diaphragm-postural-control-and-plantar-pressure-100553832","NCT06491212","The Relationship Between Pes Planus, Diaphragm, Postural Control, and Plantar Pressure","Examination of Diaphragm Function, Postural Control, and Plantar Pressure in Individuals With Pes Planus","Inclusion Criteria:\n\nInclusion criteria for individuals with Pes Planus Deformity\n\n* Willing to participate in the study voluntarily\n* Having a Navicular drop test value of 10mm or above\n* Being between the ages of 18-30\n* Having the physical capacity to perform assessments and tests\n* Having a body mass index of 18-25 kg\u002Fm²\n\nExclusion Criteria:\n\n* Exclusion criteria for individuals with Pes Planus Deformity:\n* Termination of voluntariness\n* Those with rigid flatfoot, pes cavus, hallux valgus, hallux rigidus, or calcaneal spur deformity\n* Those with chronic systematic and metabolic diseases (e.g., diabetes mellitus, rheumatoid arthritis, etc.) and musculoskeletal problems (e.g., pes planus) that may affect foot functions and gait\n* Those with any surgical history likely to affect balance, lower extremity strength, and postural control\n* Those with any visual\u002Fvestibular, musculoskeletal, or neurological problems\"\n\nInclusion criteria for healthy participants:\n\n* Willing to participate in the study voluntarily\n* Being between the ages of 18-30\n* Having the physical capacity to perform assessments and tests\n* Having a body mass index of 18-25 kg\u002Fm²\n* Having the ideal height of the medial longitudinal arch of the foot (not having pes planus)\n\nExclusion criteria for healthy participants:\n\n* Termination of voluntariness\n* Those with chronic systematic and metabolic diseases (e.g., diabetes mellitus, rheumatoid arthritis, etc.) and musculoskeletal problems (e.g., pes planus) that may affect foot functions and gait\n* Those with any surgical history likely to affect balance, lower extremity strength, and postural control\n* Those with any visual\u002Fvestibular, musculoskeletal, or neurological problems\"","30 Years",{"count":131,"type":22},34,[25],"Our primary aim is to compare diaphragm function (resting thickness, activity\u002Fresting thickness ratio indicating contractility), postural control, and plantar pressure between individuals with pes planus and healthy controls without pes planus.",[135,28,136,137],"Pes Planus","Plantar Pressure","Postural Control","2024-06-30",{"date":140,"type":33},"2024-07-09",{"date":142,"type":33},"2024-05-01",{"date":144,"type":22},"2024-10-15",{"name":146,"class":40},"Alanya Alaaddin Keykubat University"]