[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"diaphragmatic-breathing\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:diaphragmatic-breathing":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,49,85,107,141],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100641289","effects-of-diaphragmatic-breathing-during-equipment-based-pilates-in-women-100641289",false,"NCT07652229","Effects of Diaphragmatic Breathing During Equipment-Based Pilates in Women","The Effects of Diaphragmatic Breathing Exercises on Core Stabilization Muscle Strength, Peak Expiratory Flow, and Chest Expansion in Women Performing Equipment-Based Pilates: A Randomized Controlled Trial","Inclusion Criteria:\n\nFemale participants aged 20-50 years. Healthy individuals regularly performing equipment-based Pilates exercises. Willingness to participate voluntarily and provide informed consent. Ability to attend Pilates sessions twice weekly for 8 weeks.\n\nExclusion Criteria:\n\nHistory of spinal trauma or surgery within the previous 6 months. Pregnancy. Diabetes mellitus or other systemic diseases. Respiratory or musculoskeletal disorders that may affect participation or outcome measurements.\n\nCognitive or physical limitations preventing compliance with the study protocol.\n\nFailure to attend scheduled sessions or complete the intervention protocol. Development of pain, injury, or any medical condition requiring discontinuation during the study.",true,"FEMALE","20 Years","50 Years",{"count":21,"type":22},44,"ESTIMATED","INTERVENTIONAL",[25],"NA","This randomized controlled study aims to investigate the effects of diaphragmatic breathing exercises on core stabilization muscle strength, peak expiratory flow (PEF), and chest expansion in women performing equipment-based Pilates.\n\nA total of 44 healthy women aged 20 to 50 years who regularly participate in equipment-based Pilates exercises will be recruited and randomly assigned to one of two groups. The intervention group will receive equipment-based Pilates training combined with diaphragmatic breathing exercises, while the control group will receive equipment-based Pilates training only.\n\nBoth groups will participate in supervised exercise sessions twice weekly for 8 weeks. Core stabilization muscle strength, peak expiratory flow, and chest expansion measurements will be assessed before and after the intervention period.\n\nThe findings of this study may contribute to a better understanding of the additional effects of diaphragmatic breathing exercises on respiratory function and core stabilization in women performing Pilates.",[28,29,30],"Core Stability","Respiratory Function","Diaphragmatic Breathing",[32,33,30,28,34,35,29],"Pilates","Equipment-Based Pilates","Peak Expiratory Flow","Chest Expansion","NOT_YET_RECRUITING","2026-06-16",{"date":39,"type":40},"2026-06-18","ACTUAL",{"date":42,"type":22},"2026-06-15",{"date":44,"type":22},"2026-08-15",{"name":46,"class":47},"Istanbul Aydın University","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":56,"minAge":57,"maxAge":4,"enrollmentInfo":58,"targetDuration":4,"studyType":23,"phases":60,"briefSummary":61,"conditions":62,"keywords":68,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":4},"100621908","effects-of-controlled-breathing-on-cardiorespiratory-variables-in-multiple-myeloma-100621908","NCT07376733","Effects of Controlled Breathing on Cardiorespiratory Variables in Multiple Myeloma","Efficacy of a Controlled Breathing and Therapeutic Exercise Program on Cardiorespiratory Variables in Patients With Multiple Myeloma","Inclusion Criteria:\n\n* Age ≥ 18 years.\n* Confirmed diagnosis of multiple myeloma, currently undergoing active treatment with daratumumab, and under clinical follow-up by the Hematology Department of HU12O.\n* Explicit medical indication for supervised physical activity issued by the responsible hematologist and documented in the medical record.\n* No scheduled hematopoietic stem cell transplantation within the 60 days following the planned start date of the intervention (verified through medical record review).\n* Functional status of ECOG 0-2 (Eastern Cooperative Oncology Group), assessed by a healthcare professional from the Hematology Department, ensuring the ability to perform at least basic and light instrumental activities of daily living, including independent ambulation.\n* Access to a smartphone with stable internet connection, required for monitoring and recording adherence to the intervention.\n* Ability to provide written informed consent, demonstrating understanding of the study's nature, purpose, and procedures.\n\nExclusion Criteria:\n\n* Medical risk contraindicating exercise or breathing techniques:\n\n  * Clinically significant cardiovascular disease, including:decompensated heart failure, acute myocardial infarction within the past 3 months, clinically uncontrolled arrhythmias, unstable angina, acute-phase deep vein thrombosis or pulmonary embolism, pacemakers or cardiac devices whose monitoring parameters contraindicate supervised exercise according to cardiology.\n  * Severe decompensated respiratory disease, such as acute exacerbation of COPD, severe respiratory insufficiency, or persistently low resting oxygen saturation \\\u003C 90% (not correctable).\n* High musculoskeletal or bone risk:\n\n  * Extensive lytic bone lesions, high risk of pathological fracture, or unstable vertebral fracture, documented by imaging or based on the assessment of the Hematology\u002FTraumatology specialist.\n  * Uncontrolled pain that prevents safe participation in an exercise program.\n* Hematologic or systemic conditions contraindicating exercise:\n\n  * Severe anemia: hemoglobin \\\u003C 9 g\u002FdL in women or \\\u003C 8 g\u002FdL in men (latest laboratory test ≤ 14 days).\n  * Active systemic infection contraindicating exercise, fever ≥ 38 °C, or neutropenia \\\u003C 0.5 × 10⁹\u002FL.\n  * Severe cytopenias that, in the opinion of the hematologist, preclude moderate exercise.\n* Functional or procedural limitations:\n\n  * Inability to remain in the supine position for ≥ 5 minutes, required for part of the breathing intervention.\n  * Confirmed pregnancy or reasonable suspicion of pregnancy.\n  * Severe cognitive impairment, major psychiatric disorders, or neurological diseases that limit understanding of the procedures or safe participation.\n  * Significant difficulty understanding the language (spoken or written) that prevents following essential instructions or completing validated questionnaires.","ALL","18 Years",{"count":59,"type":22},26,[25],"A randomized, parallel, double-blind, controlled, clinical trial. Two groups of participants will be included, both receiving a therapeutic exercise intervention and an educational session on the importance of proper breathing over a 6-week period. One of the groups will additionally perform a home-based controlled breathing exercise protocol. Pre- and post-intervention assessments (6 weeks) will be conducted, along with a follow-up evaluation 4 weeks after completion of the intervention. The goal is to determine the effectiveness of adding a controlled breathing exercise program to a therapeutic exercise intervention on cardiorespiratory variables in individuals with multiple myeloma.",[63,64,65,66,30,67],"Multiple Myeloma (MM)","Breathing Techniques","Breathing Exercises","Exercise Activity","Heart Rate Variability (HRV)",[69,70,71,72,73,74,75],"multiple myeloma","Breathing","Diaphragmatic breathing","Slow breathing","exercise activity","Breathing exercises","heart rate variability","2026-01-21",{"date":78,"type":40},"2026-01-29",{"date":80,"type":22},"2026-01",{"date":82,"type":22},"2026-09",{"name":84,"class":47},"Universidad Complutense de Madrid",{"id":86,"slug":87,"hasResults":11,"nctId":88,"briefTitle":89,"officialTitle":90,"acronym":4,"eligibilityCriteria":91,"healthyVolunteers":11,"sex":56,"minAge":57,"maxAge":4,"enrollmentInfo":92,"targetDuration":4,"studyType":23,"phases":94,"briefSummary":95,"conditions":96,"keywords":98,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":103,"completionDateStruct":104,"leadSponsor":106,"locationsCount":4},"100617001","effects-of-controlled-breathing-added-to-therapeutic-exercise-in-multiple-myeloma-100617001","NCT07312942","Effects of Controlled Breathing Added to Therapeutic Exercise in Multiple Myeloma","Effects of Adding a Controlled Breathing Protocol to a Therapeutic Exercise Program in Adults With Multiple Myeloma","Inclusion Criteria:\n\n* Age ≥ 18 years.\n* Confirmed diagnosis of multiple myeloma, currently undergoing active treatment with daratumumab, and under clinical follow-up by the Hematology Department of HU12O.\n* Explicit medical indication for supervised physical activity issued by the responsible hematologist and documented in the medical record.\n* No scheduled hematopoietic stem cell transplantation within the 60 days following the planned start date of the intervention (verified through medical record review).\n* Functional status of ECOG 0-2 (Eastern Cooperative Oncology Group), assessed by a healthcare professional from the Hematology Department, ensuring the ability to perform at least basic and light instrumental activities of daily living, including independent ambulation.\n* Access to a smartphone with stable internet connection, required for monitoring and recording adherence to the intervention.\n* Ability to provide written informed consent, demonstrating understanding of the study's nature, purpose, and procedures.\n\nExclusion Criteria:\n\n* Medical risk contraindicating exercise or breathing techniques:\n\n  +Clinically significant cardiovascular disease, including: decompensated heart failure, acute myocardial infarction within the past 3 months, clinically uncontrolled arrhythmias, unstable angina, acute-phase deep vein thrombosis or pulmonary embolism, pacemakers or cardiac devices whose monitoring parameters contraindicate supervised exercise according to cardiology.\n  * Severe decompensated respiratory disease, such as acute exacerbation of COPD, severe respiratory insufficiency, or persistently low resting oxygen saturation \\\u003C 90% (not correctable).\n* High musculoskeletal or bone risk:\n\n  * Extensive lytic bone lesions, high risk of pathological fracture, or unstable vertebral fracture, documented by imaging or based on the assessment of the Hematology\u002FTraumatology specialist.\n  * Uncontrolled pain that prevents safe participation in an exercise program.\n* Hematologic or systemic conditions contraindicating exercise:\n\n  * Severe anemia: hemoglobin \\\u003C 9 g\u002FdL in women or \\\u003C 8 g\u002FdL in men (latest laboratory test ≤ 14 days).\n  * Active systemic infection contraindicating exercise, fever ≥ 38 °C, or neutropenia \\\u003C 0.5 × 10⁹\u002FL.\n  * Severe cytopenias that, in the opinion of the hematologist, preclude moderate exercise.\n* Functional or procedural limitations:\n\n  * Inability to remain in the supine position for ≥ 5 minutes, required for part of the breathing intervention.\n  * Confirmed pregnancy or reasonable suspicion of pregnancy.\n  * Severe cognitive impairment, major psychiatric disorders, or neurological diseases that limit understanding of the procedures or safe participation.\n  * Significant difficulty understanding the language (spoken or written) that prevents following essential instructions or completing validated questionnaires.",{"count":93,"type":22},32,[25],"A randomized, parallel, double-blind, controlled, multicenter clinical trial with two intervention arms. Two groups of participants will be included, both receiving a therapeutic exercise intervention and an educational session on the importance of proper breathing over a 6-week period. One of the groups will additionally perform a home-based controlled breathing exercise protocol. Pre- and post-intervention assessments (6 weeks) will be conducted, along with a follow-up evaluation 4 weeks after completion of the intervention.\n\nThe goal is to determine the effectiveness of adding a controlled breathing exercise program to a therapeutic exercise intervention on somatic symptoms in individuals with multiple myeloma",[97,64,65,66,30],"Multiple Myeloma",[99,70,71,72,73,74],"Multiple myeloma","2026-01-15",{"date":102,"type":40},"2026-01-20",{"date":80,"type":22},{"date":105,"type":22},"2026-07",{"name":84,"class":47},{"id":108,"slug":109,"hasResults":11,"nctId":110,"briefTitle":111,"officialTitle":112,"acronym":4,"eligibilityCriteria":113,"healthyVolunteers":11,"sex":56,"minAge":18,"maxAge":114,"enrollmentInfo":115,"targetDuration":4,"studyType":23,"phases":117,"briefSummary":118,"conditions":119,"keywords":123,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":132,"lastUpdatePostDateStruct":133,"startDateStruct":135,"completionDateStruct":137,"leadSponsor":139,"locationsCount":4},"100606722","effect-of-breathing-training-on-symptoms-of-gastroesophageal-reflux-disease-100606722","NCT07179250","Effect of Breathing Training on Symptoms of Gastroesophageal Reflux Disease","Effect of Breathing Training on Symptoms of Gastroesophageal Reflux Disease: A Parallel Randomized Controlled Trial","Inclusion Criteria:\n\n* Adults aged 20 to 80 years\n* Endoscopic finding of reflux esophagitis (LA grade A) with proton pump inhibitor (PPI) use \\> 2 months, or 24-hour pH monitoring showing acid exposure time (AET) \\> 6%, or endoscopic diagnosis of reflux esophagitis LA grade B or higher\n* Willingness to comply with the full training and follow-up protocol\n\nExclusion Criteria:\n\n* Pregnant or breastfeeding women\n* History of anti-reflux surgery\n* Severe cardiopulmonary dysfunction or respiratory disease\n* Inability to perform the training exercises or attend follow-up visits","80 Years",{"count":116,"type":22},51,[25],"The goal of this clinical trial is to evaluate whether two types of breathing training can improve symptoms of gastroesophageal reflux disease (GERD) in adults.\n\nThe main research questions are:\n\n* Do volume-oriented incentive spirometry (VIS) or diaphragmatic breathing exercise (DBE) improve GERD symptoms compared with usual care?\n* Do these breathing exercises reduce the symptoms of GERD?\n* Does volume-oriented incentive spirometry (VIS) produce greater improvement in GERD symptoms compared with DBE?\n* Do these exercises increase the strength of the lower esophageal sphincter (LES)?\n\nResearchers will compare VIS training, DBE training, and usual care to determine whether breathing training can serve as a safe and effective non-pharmacological treatment option for GERD.\n\nParticipants will:\n\n* Be randomly assigned to VIS training, DBE training, or usual care\n* Perform their assigned breathing training (if in the intervention group) twice daily for 6 weeks\n* Attend study visits at baseline and at week 7 for questionnaires and esophageal function tests\n* Keep a diary of their symptoms and breathing practice",[120,30,121,122],"Incentive Spirometer","Gastroesophageal Reflux Disease (GERD)","Breath Exercise",[124,125,126,30,127,120,128,129,130,131],"GERD","Gastroesophageal Reflux Disease","Acid Reflux","Breathing Training","Volume-Oriented Incentive Spirometry","GERDQ","Gastroesophageal Reflux Disease Questionnaire","breath exercise","2025-09-23",{"date":134,"type":40},"2025-09-26",{"date":136,"type":22},"2025-09",{"date":138,"type":22},"2026-05",{"name":140,"class":47},"Changhua Christian Hospital",{"id":142,"slug":143,"hasResults":11,"nctId":144,"briefTitle":145,"officialTitle":146,"acronym":4,"eligibilityCriteria":147,"healthyVolunteers":16,"sex":56,"minAge":57,"maxAge":148,"enrollmentInfo":149,"targetDuration":4,"studyType":23,"phases":151,"briefSummary":152,"conditions":153,"keywords":155,"overallStatus":158,"whyStopped":4,"lastUpdateSubmitDate":159,"lastUpdatePostDateStruct":160,"startDateStruct":162,"completionDateStruct":164,"leadSponsor":166,"locationsCount":48},"100602750","scalable-intervention-for-stress-management-100602750","NCT07127575","Scalable Intervention for Stress Management","A Scalable Intervention for Stress Management Practices","Inclusion Criteria:\n\n* Be at least 18 years old\n* Be currently enrolled in a college or university\n* Be able to read, speak, and comprehend English\n* Be able and willing to complete a 60-minute study involving heart rate monitoring, survey completion, training, a stress test, and device utilization\n\nExclusion Criteria:\n\n-Individuals diagnosed with anxiety or stress and require professional support to cope with these clinical levels of stress or anxiety should not enroll in the study in place of professional assistance.","30 Years",{"count":150,"type":22},60,[25],"The purpose of this research is to measure the acceptance of a resistance breathing intervention and to assess whether it produces physiological and subjective effects in a laboratory setting.",[154,30],"Stress",[156,157],"resistance breathing","stress management","RECRUITING","2025-08-13",{"date":161,"type":40},"2025-08-17",{"date":163,"type":40},"2025-08-01",{"date":165,"type":22},"2025-09-30",{"name":167,"class":168},"Livotion, LLC","INDUSTRY"]