[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"diarrhea-caused-by-antitumor-drugs\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:diarrhea-caused-by-antitumor-drugs":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":5},"100608042","phase-1-kan-004-for-immune-related-diarrhea-or-colitis-100608042",false,"NCT07196410","KAN-004 for Immune-Related Diarrhea or Colitis","A Phase I Study of KAN-004 in Patients With Immune-Related Diarrhea or Colitis","Inclusion Criteria:\n\n* Diagnosis of solid tumor treated with immune checkpoint inhibitor (≥1 cycle, ≤180 days since last cycle).\n* Clinical diagnosis of irColitis (CTCAE \\>grade 2).\n* Age ≥18 years\n* Able to ingest capsules.\n* Consent to provide blood and stool samples.\n* Accessible for treatment and follow-up.\n* Agreement to use highly effective contraception if of childbearing potential.\n\nExclusion Criteria:\n\n* Prior\u002Fconcurrent malignancy that could interfere with safety\u002Fefficacy assessment.\n* Colostomy.\n* Prior diagnosis of malabsorption.\n* Untreated chronic hepatitis B or C.\n* Solid organ transplant recipients.\n* HIV-positive status.\n* Pregnancy or breastfeeding.","ALL","18 Years",{"count":19,"type":20},21,"ESTIMATED","INTERVENTIONAL",[23],"PHASE1","The goal of this clinical trial is to evaluate the safety and tolerability of KAN-004 in patients with immune-related colitis.",[26,27],"Colitis","Diarrhea Caused by Antitumor Drugs","RECRUITING","2026-04-08",{"date":31,"type":32},"2026-04-13","ACTUAL",{"date":34,"type":32},"2026-03-01",{"date":36,"type":20},"2030-12-31",{"name":38,"class":39},"Centre hospitalier de l'Université de Montréal (CHUM)","OTHER"]