[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"diarrhea-infantile\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:diarrhea-infantile":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,41,65],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100403054","whole-genome-sequencing-versus-whole-exome-sequencing-for-congenital-diarrhea-and-enteropahty-100403054",false,"NCT04528303","Whole Genome Sequencing Versus Whole Exome Sequencing for Congenital Diarrhea and Enteropahty","A Randomized, Controlled Trial of the Effectiveness of Whole Genome Sequencing Versus Whole Exome Sequencing for Screening Patients With Congenital Diarrhea and Enteropathy (CODESeq)","Inclusion Criteria:\n\n* Patients with chronic diarrhea lasting greater than 2 months\n* Patients with consent from parents or legal guardians\n* Biological relative of a patient enrolled in this study.\n\nExclusion Criteria:\n\n* Chronic diarrhea caused by specific infections, i.e. CMV, Clostridioides difficile\n* Chronic diarrhea with necrotizing enterocolitis, short bowel syndrome\n* Functional diarrhea\n* Patients with previously confirmed monogenic diarrhea\n* Patients with poor compliance","ALL","6 Years",{"count":19,"type":20},180,"ESTIMATED","INTERVENTIONAL",[23],"NA","This study will seek to determine if whole genome sequencing (WGS) improves diagnostic rates, and outcomes for congenital diarrhea and enteropathy (CODE) patients. The investigator will enroll 180 patients in a randomized controlled study to either WGS or whole exome sequencing (WES). This study is designed to evaluate whether CODE patients would benefit from WGS guided precision medicine.",[26,27],"Diarrhea, Infantile","Enteropathy","RECRUITING","2026-03-20",{"date":31,"type":32},"2026-03-24","ACTUAL",{"date":34,"type":32},"2024-05-01",{"date":36,"type":20},"2026-12-31",{"name":38,"class":39},"Children's Hospital of Fudan University","OTHER",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":4,"eligibilityCriteria":47,"healthyVolunteers":48,"sex":16,"minAge":49,"maxAge":50,"enrollmentInfo":51,"targetDuration":4,"studyType":53,"phases":4,"briefSummary":54,"conditions":55,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":57,"lastUpdatePostDateStruct":58,"startDateStruct":60,"completionDateStruct":62,"leadSponsor":64,"locationsCount":40},"100543490","phenotype-and-multi-omics-analysis-of-children-with-congenital-diarrhea-and-enteropathy-in-china-100543490","NCT06356545","Phenotype and Multi-omics Analysis of Children With Congenital Diarrhea and Enteropathy in China","A Case-control Study of Phenotype and Multi-omics Analysis of Children With Congenital Diarrhea and Enteropathy in China","Inclusion Criteria:\n\n* Patients with chronic diarrhea lasting greater than 2 months or greater than 1 month in patients younger than 2 months of age\n* Patients with consent from parents or legal guardians\n\nExclusion Criteria:\n\n* Chronic diarrhea caused by specific infections, i.e. CMV, Clostridioides difficile\n* Chronic diarrhea with necrotizing enterocolitis, short bowel syndrome\n* Functional diarrhea\n* Patients with poor compliance",true,"1 Month","3 Years",{"count":52,"type":20},60,"OBSERVATIONAL","This study will establish a clinical cohort of children with congenital diarrhea and enteropathy (CODE), mine biomarkers of CODE through multi-omics technology and construct a clinical risk prediction model.",[56],"Diarrhea Infantile","2025-09-03",{"date":59,"type":32},"2025-09-10",{"date":61,"type":32},"2024-04-15",{"date":63,"type":20},"2026-10",{"name":38,"class":39},{"id":66,"slug":67,"hasResults":11,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":71,"eligibilityCriteria":72,"healthyVolunteers":48,"sex":73,"minAge":4,"maxAge":4,"enrollmentInfo":74,"targetDuration":4,"studyType":21,"phases":76,"briefSummary":77,"conditions":78,"keywords":84,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":102},"100498174","coupons-for-safe-water-project-100498174","NCT05766826","Coupons for Safe Water Project","Scaling up Coupons for Safe Water Treatment in Kenya","Coupons","Inclusion Criteria:\n\n* Currently pregnant women\n* Women living inside Health and Demographic Surveillance Systems (HDSS) catchment areas.\n\nExclusion Criteria:\n\n\\- Women who do not consent.","FEMALE",{"count":75,"type":20},3468,[23],"Guaranteeing access to safe drinking water is still a challenge in rural households in developing countries, and unsafe water sources are responsible for millions of deaths each year around the world. Coupons for free dilute chlorine solution are a cost-effective and effective way of ameliorating child health and reducing diarrhea incidence. It is still an empirical challenge, however, to see if the positive health effects will be maintained when the program is implemented at scale. In this study, investigators conduct a randomized controlled trial (RCT) at scale to study the impacts of a chlorine coupon program implemented at health clinics on child health, including self-reported diarrhea, fever, and cough incidence in the previous two weeks. Investigators further investigate the pathway of the impact, such as self-reported and objectively measured use of chlorine and frequency of visits to health clinics.",[79,80,81,26,82,83],"Death","Death, Infant","Diarrhea","Water-Borne Infectious Disease","Water-Related Diseases",[85,86,87,88,89,71,90,91,92],"Child health","Child mortality","Chlorine","Safe water","Targeting","RCT","East Africa","Kenya","2023-03-10",{"date":95,"type":32},"2023-03-13",{"date":97,"type":32},"2023-02-21",{"date":99,"type":20},"2026-10-01",{"name":101,"class":39},"University of Chicago",2]