[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"diastolic-dysfunction\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:diastolic-dysfunction":24},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,38,72,94,119,148,174],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":21,"conditions":22,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":27,"lastUpdatePostDateStruct":28,"startDateStruct":31,"completionDateStruct":33,"leadSponsor":35,"locationsCount":4},"100636432","changes-in-intramyocardial-fat-assessed-by-cardiac-ct-before-and-after-bariatric-surgery-and-their-relationship-with-cardiac-diastolic-function-100636432",false,"NCT07565610","Changes in Intramyocardial Fat Assessed by Cardiac CT Before and After Bariatric Surgery and Their Relationship With Cardiac Diastolic Function","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Scheduled to undergo bariatric surgery for standard clinical indications\n* Left ventricular ejection fraction (LVEF) ≥50%\n* Able to undergo cardiac computed tomography (CT)\n\nExclusion Criteria:\n\n* Left ventricular ejection fraction (LVEF) \\\u003C50%\n* Known cardiomyopathies, including sarcoidosis, amyloidosis, or myocarditis\n* Significant valvular heart disease\n* Contraindication to cardiac CT (e.g., severe renal dysfunction, contrast allergy)\n* Presence of intracardiac or cardiac-related foreign material that may interfere with imaging (e.g., prosthetic valves, pacemakers, prior transcatheter devices)","ALL","18 Years",{"count":18,"type":19},150,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to learn if weight loss surgery can lower fat inside the heart muscle and improve how the heart relaxes in adults with obesity.\n\nThe main questions it aims to answer are:\n\nDoes fat inside the heart muscle decrease after weight loss surgery? Does heart relaxation (diastolic function) improve after surgery? Are changes in heart fat linked to changes in weight, body fat, and blood markers?\n\nParticipants who are already planning to have weight loss surgery will take part in this study.\n\nParticipants will:\n\nHave a heart CT scan to measure fat in the heart muscle before surgery and about 6 months after surgery Have an ultrasound of the heart (echocardiogram) to check how the heart fills and relaxes Have body composition testing to measure fat and muscle Have blood tests, including routine tests and additional markers related to heart function and metabolism\n\nResearchers will compare each participant's results before and after surgery to see if heart fat decreases and if heart function and blood markers improve.",[23,24,25],"Obesity","Diastolic Dysfunction","Heart Failure With Preserved Ejection Fraction (HFPEF)","NOT_YET_RECRUITING","2026-04-29",{"date":29,"type":30},"2026-05-04","ACTUAL",{"date":32,"type":19},"2026-05",{"date":34,"type":19},"2028-05",{"name":36,"class":37},"Itshak Amsalem","OTHER",{"id":39,"slug":40,"hasResults":11,"nctId":41,"briefTitle":42,"officialTitle":43,"acronym":44,"eligibilityCriteria":45,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":46,"targetDuration":48,"studyType":20,"phases":4,"briefSummary":49,"conditions":50,"keywords":53,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":71},"100629868","homocysteine-and-early-diastolic-dysfunction-in-newly-diagnosed-hypertension-100629868","NCT07480265","Homocysteine and Early Diastolic Dysfunction in Newly Diagnosed Hypertension","Relationship Between Elevated Homocysteine Levels and Early Diastolic Dysfunction in Newly Diagnosed Hypertensive Patients","HHT-EDD","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Newly diagnosed essential hypertension within the previous 6 months\n* Ability and willingness to provide informed consent\n* Availability for clinical evaluation, laboratory testing, ambulatory blood pressure monitoring, electrocardiography, and transthoracic echocardiography\n\nExclusion Criteria:\n\n* Resistant hypertension\n* Secondary hypertension\n* Acute coronary syndrome within the previous 6 months\n* Major surgery within the previous 6 months\n* Known heart failure\n* Pulmonary hypertension\n* Congenital heart disease\n* Atrial fibrillation or atrial flutter\n* Moderate or severe valvular heart disease\n* Chronic kidney disease\n* Anemia\n* Current folate, vitamin B12, or vitamin B6 supplementation or treatment\n* Inadequate echocardiographic image quality for strain analysis\n* Known systemic conditions that may significantly affect plasma homocysteine levels",{"count":47,"type":19},500,"2 Years","This prospective single-center observational study aims to evaluate the relationship between elevated plasma homocysteine levels and early echocardiographic abnormalities in patients with newly diagnosed essential hypertension. Adult patients diagnosed with essential hypertension within the previous 6 months will undergo clinical assessment, ambulatory blood pressure monitoring, electrocardiography, laboratory testing, and comprehensive transthoracic echocardiography including diastolic function assessment and strain analysis when image quality is adequate. Participants will be classified according to plasma homocysteine level using, and patients with elevated and normal homocysteine levels will be compared with respect to diastolic dysfunction and left ventricular and left atrial global longitudinal strain parameters. Clinical, laboratory, and echocardiographic data will also be used to develop a machine-learning based model for prediction of H-type hypertension.",[51,52,24],"Hypertension (HTN)","Hyperhomocysteinemia",[54,55,56,57,58,59,60],"H-type hypertension","Homocysteine","Echocardiography","Diastolic dysfunction","Left ventricular global longitudinal strain","Left atrial global longitudinal strain","Machine learning","RECRUITING","2026-03-20",{"date":64,"type":30},"2026-03-24",{"date":66,"type":30},"2025-06-02",{"date":68,"type":19},"2028-03",{"name":70,"class":37},"Necmettin Erbakan University",1,{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":4,"eligibilityCriteria":78,"healthyVolunteers":11,"sex":15,"minAge":79,"maxAge":4,"enrollmentInfo":80,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":82,"conditions":83,"keywords":4,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":71},"100560669","ai-in-outpatient-practice-for-diagnosing-aortic-stenosis-and-diastolic-dysfunction-100560669","NCT06580158","AI in Outpatient Practice for Diagnosing Aortic Stenosis and Diastolic Dysfunction","The Clinical Utility of Artificial Intelligence-enabled Electrocardiograms in the Outpatient Practice - Diagnosing Aortic Stenosis and Diastolic Dysfunction","Inclusion Criteria:\n\n* ≥ 60 years of age must have a clinical scheduled ECG performed.\n\nExclusion Criteria:\n\n* \\\u003C 59 years of age\n* Is not scheduled for a clinical ECG\n* Unable to provide consent.","60 Years",{"count":81,"type":19},2000,"Two recently developed artificial intelligence-enabled electrocardiogram (AI-ECG) models have been developed to detect aortic stenosis (AS) and diastolic dysfunction (DD). AI-ECG for AS has a sensitivity of 78% and specificity of 74%, and AI-ECG for DD has a sensitivity of 83% and specificity of 80%. However, these models have never been prospectively applied to diagnose AS or DD, which may be useful for patients and providers from a diagnostic and prognostic perspective and especially in settings where access to higher- level medical care is limited. In this study, we aim to determine the clinical utility of these AI-ECG models by prospectively applying them to an outpatient cohort and then completing a focused point-of-care ultrasound to evaluate those who are AI-ECG positive for AS and DD.",[84,24],"Aortic Stenosis","2026-03-02",{"date":87,"type":30},"2026-03-04",{"date":89,"type":30},"2024-11-08",{"date":91,"type":19},"2027-03",{"name":93,"class":37},"Mayo Clinic",{"id":95,"slug":96,"hasResults":11,"nctId":97,"briefTitle":98,"officialTitle":98,"acronym":4,"eligibilityCriteria":99,"healthyVolunteers":100,"sex":15,"minAge":4,"maxAge":4,"enrollmentInfo":101,"targetDuration":79,"studyType":20,"phases":4,"briefSummary":103,"conditions":104,"keywords":105,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":110,"lastUpdatePostDateStruct":111,"startDateStruct":113,"completionDateStruct":115,"leadSponsor":117,"locationsCount":4},"100618408","a-cross-sectional-study-on-the-impact-of-shift-work-on-diastolic-dysfunction-in-healthcare-workers-100618408","NCT07331233","A Cross-sectional Study on the Impact of Shift Work on Diastolic Dysfunction in Healthcare Workers","Inclusion Criteria: Healthcare workers at our hospital",true,{"count":102,"type":19},60,"The goal of this observational cross-sectional study is to assess the prevalence of left ventricular diastolic dysfunction and identify associated risk factors in health-care workers of various ages and both sexes.\n\nThe main questions it aims to answer are:\n\nWhat is the prevalence of diastolic dysfunction among healthcare workers? Which occupational, lifestyle, or clinical factors are associated with abnormal diastolic function in this population?\n\nResearchers will compare health-care workers who dont need night shift with those who have to.\n\nParticipants will:\n\nComplete questionnaires regarding demographic information, work schedules, lifestyle factors, and medical history.\n\nUndergo echocardiographic examination to assess diastolic function. Receive basic vital sign by ambulatory blood pressure monotoring.",[24],[106,107,108,109],"diastolic dysfinction","echocardiography","health worker","shift work","2025-12-29",{"date":112,"type":30},"2026-01-09",{"date":114,"type":19},"2026-01-01",{"date":116,"type":19},"2026-12-31",{"name":118,"class":37},"National Taiwan University Hospital",{"id":120,"slug":121,"hasResults":11,"nctId":122,"briefTitle":123,"officialTitle":124,"acronym":4,"eligibilityCriteria":125,"healthyVolunteers":11,"sex":126,"minAge":127,"maxAge":79,"enrollmentInfo":128,"targetDuration":4,"studyType":129,"phases":130,"briefSummary":132,"conditions":133,"keywords":134,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":139,"lastUpdatePostDateStruct":140,"startDateStruct":142,"completionDateStruct":144,"leadSponsor":146,"locationsCount":71},"100588785","effect-of-swimming-exercise-on-diastolic-dysfunction-100588785","NCT06945913","Effect of Swimming Exercise on Diastolic Dysfunction","The Effect Of Variable Intensity Swimming Exercise On Cardiovascular Parameters And Echocardiography In Women With Diastolic Dysfunction","Inclusion Criteria\n\nParticipants who met the following criteria were included in the study:\n\n* No echocardiographic abnormalities detected except for stage 1 diastolic dysfunction based on examinations conducted in the cardiology outpatient clinic,\n* Female gender,\n* Aged between 40 and 60 years as of the study initiation date,\n* No history of substance use, including smoking and alcohol,\n* Willingness to participate by completing the informed consent form.\n\nExclusion Criteria\n\nParticipants who met at least one of the following conditions were excluded from the study:\n\n* Refusal to sign the informed consent form,\n* Failure to participate in at least one of the study measurements,\n* Inability to meet the necessary criteria for training and measurements,\n* Presence of illness or injury during training or measurements,\n* Voluntary withdrawal from the study.","FEMALE","40 Years",{"count":102,"type":19},"INTERVENTIONAL",[131],"NA","The aim of the study was to determine the rehabilitative effects of 12-week variable intensity swimming exercises on the cardiovascular system in women with diastolic dysfunction. Studies on how variable intensity swimming exercises contribute to the course of the disease in sedentary women with cardiovascular problems are limited. Previous studies generally consisted of studies on the effects of exercise applications on the cardiovascular system in different branches and their effects were determined.",[24],[24,135,136,137,138],"Exercise","High Intensity Interval Training","Moderate Intensity Continuous Training","Women Health","2025-04-22",{"date":141,"type":30},"2025-04-27",{"date":143,"type":19},"2025-05-01",{"date":145,"type":19},"2025-07-15",{"name":147,"class":37},"Uşak University",{"id":149,"slug":150,"hasResults":11,"nctId":151,"briefTitle":152,"officialTitle":153,"acronym":154,"eligibilityCriteria":155,"healthyVolunteers":100,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":156,"targetDuration":4,"studyType":129,"phases":158,"briefSummary":159,"conditions":160,"keywords":4,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":164,"lastUpdatePostDateStruct":165,"startDateStruct":167,"completionDateStruct":169,"leadSponsor":171,"locationsCount":173},"100405367","covid-19-effects-on-arterial-stiffness-and-vascular-aging-cartesian-100405367","NCT04558450","Covid-19 Effects on Arterial Stiffness and Vascular Aging (CARTESIAN)","Covid-19 Effects on ARTErial StIffness and Vascular AgiNg","CARTESIAN","Inclusion Criteria:\n\n* age \\>18 years, both sexes;\n* written informed consent;\n* affiliation to a social security regime;\n* a recent diagnosis of COVID19 (6±3 months) proven by PCR or serology (for group 1,2,3)\n* hospitalization in intensive care unit for COVID19 (for group 1)\n* hospitalization in a medicine unit for COVID19 (for group 2)\n* no hospitalization for COVID19 or hospitalization less than 24h (for group 3)\n* a negative test for SARS-nCOV2 infection (PCR or serology)(for group 4)\n\nExclusion Criteria:\n\n* Age \\\u003C18 years\n* Inability to express consent of the study\n* Diseases carrying out a life -expectancy \\\u003C1 year according to clinical judgment\n* Pregnancy and breastfeeding\n* Foreseen inability to attend scheduled visits",{"count":157,"type":19},360,[131],"The purpose of the study is to evaluate the presence of early vascular aging 6 months and 12 months after COVID-19 infection.",[161,162,163,24],"Covid19","Arterial Stiffness","Endothelial Dysfunction","2021-11-15",{"date":166,"type":30},"2021-11-22",{"date":168,"type":30},"2020-09-21",{"date":170,"type":19},"2033-03",{"name":172,"class":37},"Assistance Publique - Hôpitaux de Paris",3,{"id":175,"slug":176,"hasResults":11,"nctId":177,"briefTitle":178,"officialTitle":178,"acronym":179,"eligibilityCriteria":180,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":181,"enrollmentInfo":182,"targetDuration":4,"studyType":129,"phases":184,"briefSummary":185,"conditions":186,"keywords":4,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":188,"lastUpdatePostDateStruct":189,"startDateStruct":191,"completionDateStruct":193,"leadSponsor":195,"locationsCount":71},"100360401","danish-national-randomized-study-on-early-aortic-valve-replacement-in-patients-with-asymptomatic-severe-aortic-stenosis-100360401","NCT03972644","Danish National Randomized Study on Early Aortic Valve Replacement in Patients With Asymptomatic Severe Aortic Stenosis","DANAVR","Inclusion Criteria:\n\n* 1\\. Severe AS defined as\n\n  1. aortic valve area (AVA) ≤1 cm2, AND\n  2. Transvalvular maximum velocity (Vmax) ≥3.5 m\u002Fs AND\n  3. AS severity evaluated severe by a heart valve team conference. In cases where severity is not unambiguous an integrative approach will be utilized combining echocardiographic markers of valve severity and LV function, and if necessary aortic valve calcification estimated by non-contrast CT.\n\n     2\\. Considered to be asymptomatic (estimated by a consultant in cardiology) 3. Considered to be candidate for AVR (transcatheter AVR\u002Fsurgical AVR) 4. Sign of increased LV filling pressures18 or reduced longitudinal LV systolic function\n\n  \u003C!-- -->\n\n  1. Left atrial volume index (LAVi) \\> 34 ml\u002Fm2; OR\n  2. ratio of early diastolic peak mitral inflow velocity (E) to early mitral annulus diastolic velocity (e') ratio E\u002Fe'avg\\>13; OR\n  3. Threefold elevation in NT-proBNP compared to the upper expected age and gender value. OR\n  4. GLS\\>-15 5. Age ≥18 years 6. Signed informed consent\n\nExclusion Criteria:\n\n1. LVEF\\\u003C50%\n2. Very severe AS defined as Vmax\\>5 m\u002Fs.\n3. Concomitant severe valvular disease other than AS\n4. Previous valvular surgery\n5. Estimated glomerular filtration rate\\\u003C30 ml\u002Fmin\u002Fm2\n6. Dementia\n7. Women of childbearing potential\n8. Inability to provide informed consent\n9. Age\\>85 years.\n10. Supravalvular or subvalvular AS","85 Years",{"count":183,"type":19},1700,[131],"The purpose of this study is to examine the impact of early surgery in patients with asymptomatic severe aortic valve stenosis with signs of subclinical LV dysfunction despite preserved LVEF, with a watchfull waiting approach.",[187,24],"Aortic Valve Stenosis","2020-09-09",{"date":190,"type":30},"2020-09-14",{"date":192,"type":30},"2020-01-01",{"date":194,"type":19},"2029-09-01",{"name":196,"class":37},"Odense University Hospital"]