[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"diet-intervention\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:diet-intervention":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,48,70],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100537115","effect-of-changes-in-carbohydrate-intake-patterns-on-glucose-control-in-patients-with-type-1-diabetes-100537115",false,"NCT06273631","Effect of Changes in Carbohydrate Intake Patterns on Glucose Control in Patients With Type 1 Diabetes","Inclusion Criteria:\n\n1. Those who agree to participate in the study and sign informed consent;\n2. Diagnosis of type 1 diabetes mellitus (ADA2024);\n3. Age of 18\\~70 years;\n4. Dependent on exogenous insulin therapy, the treatment plan remains unchanged within 2 months (the type of insulin cannot be changed, and the dose can be adjusted according to plasma glucose);\n5. Body mass index (BMI) of 18\\~25kg\u002Fm2;\n6. HbA1c ≤11%;\n\nExclusion Criteria:\n\n1. Honeymooners with type 1 diabetes mellitus;\n2. Women who are pregnant or plan to become pregnant;\n3. Patients who are vegetarians or are undergoing weight loss;\n4. Patients who are users of oral hypoglycemic drugs (alpha-glucosidase inhibitors, DPP-IV inhibitors, etc.);\n5. Patients who are users of glucocorticoids within 30 days;\n6. History of severe food allergy;\n7. Patients with acute complications such as DKA or HHS within six months;\n8. Patients with gastroparesis, inflammatory bowel disease and other complications;\n9. Patients with large albuminuria(albumin-to-creatinine ratio\\>34.09mg\u002Fmmol) and renal insufficiency(creatinine\\>200umol\u002FL);\n10. Patients with uncontrolled hyperthyroidism and hypothyroidism(Uncontrolled hyperthyroidism is defined as abnormal TSH and T4. Uncontrolled hypothyroidism is defined as TSH \\> 10mIU\u002FL.);\n11. History of heart disease, coronary heart disease and arrhythmia;\n12. Serious of liver dysfunction (ALT or AST\\>3 times the upper limit of normal);\n13. History of malignant tumors; History of tumors or surgeries affecting digestion and nutrient absorption; Patients with a history of benign tumors, which is judged by the physician to be not suitable;\n14. Patients with uncontrolled other immune system diseases or uncontrolled infections;\n15. Alcohol abuse, drug abuse, mental disorders or other conditions unfit to be an observer in drug tests;\n16. Patients with any disease likely to interfere with study participation or evaluation.","ALL","18 Years","70 Years",{"count":19,"type":20},80,"ESTIMATED","INTERVENTIONAL",[23],"NA","The blood glucose fluctuates greatly in T1DM patients, especially in the middle and late stages of the disease, and carbohydrate (CHO) is the main determinant of postprandial glucose response (PGR). Based on the previous investigation to understand how nutritional habits affect blood glucose control, we will conduct dietary intervention studies in T1DM patients to explore whether the adjustment of dietary pattern is beneficial to blood glucose control, and further explore the relevant mechanism through the detection of related metabolic indicators.",[26,27,28],"Type 1 Diabetes","Diet Intervention","Glucose Control",[30,31,32,33,34],"dietary fiber","autoimmunity","metabolomics","intestinal microbiota","time in range","RECRUITING","2026-04-15",{"date":38,"type":39},"2026-04-20","ACTUAL",{"date":41,"type":39},"2024-08-01",{"date":43,"type":20},"2027-12-31",{"name":45,"class":46},"Yang Tao","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":54,"sex":15,"minAge":16,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":21,"phases":58,"briefSummary":59,"conditions":60,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":47},"100549369","effects-of-lean-beef-consumption-on-cardiometabolic-health-and-gut-microbiome-100549369","NCT06433115","Effects of Lean Beef Consumption on Cardiometabolic Health and Gut Microbiome","Inclusion Criteria:\n\n* Age: 18-45 years of age\n* BMI: 18-35 kg\u002Fm2\n* Willingness to consume study foods.\n* Willing to comply with study protocol.\n* Consistent diet and activity patterns for 4 weeks\n* Weight stable (≤5 kg change over the last 3 months)\n* Non-smoker \\>1 year or more\n\nExclusion Criteria:\n\n* Allergies to foods provided in the study\n* Diabetes\n* Gastrointestinal disease and\u002For bariatric surgery\n* Uncontrolled hypertension and blood pressure ≥ 180\u002F110\n* Illicit drug use\n* Recent consumption of antibiotics or probiotics\n* Recent start of medications that affect metabolism or appetite.\n* Recent blood donation\n* Drug therapy for coronary artery disease, peripheral artery disease, congestive - heart failure, or dyslipidemia\n* Pregnant or lactating individuals\n* Taste or smell disorders\n* High consumers of red meat or plant-based meat (≥ 4 times\u002Fweek)",true,"45 Years",{"count":57,"type":20},90,[23],"This study is investigating the benefits of lean beef consumption on cardiometabolic health and gut microbiome.",[27],"2025-07-29",{"date":63,"type":39},"2025-08-01",{"date":65,"type":39},"2024-06-11",{"date":67,"type":20},"2027-12-01",{"name":69,"class":46},"University of Missouri-Columbia",{"id":71,"slug":72,"hasResults":11,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":76,"eligibilityCriteria":77,"healthyVolunteers":11,"sex":15,"minAge":78,"maxAge":79,"enrollmentInfo":80,"targetDuration":4,"studyType":21,"phases":81,"briefSummary":82,"conditions":83,"keywords":86,"overallStatus":93,"whyStopped":4,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":103},"100581129","obesity-prevention-in-children-and-young-people-treated-for-acute-lymphoblastic-leukaemia-with-alltogether-100581129","NCT06846294","Obesity Prevention in Children and Young People Treated for Acute Lymphoblastic Leukaemia with ALLTogether","OBesity PREVention in Children and Young People Treated with ALLtogetheR: Prehabilitation Feasibility Intervention","BREVARY","Inclusion Criteria:\n\n* CYP aged between 5 - 21 years.\n* Newly diagnosed or relapsed CYP\\_ALL treated in University Hospital Bristol and Weston NHS Foundation Trust and Hospital Infantil Universitario Nino Jesus, Madrid\n* Within two weeks of being recruited to ALLTogether.\n* Treated with curative intent.\n\nExclusion Criteria:\n\n* CYP not partaking in ALLTogether.\n* CYP treated with palliative intent.\n* Those excluded by healthcare professionals or clinical reasons","5 Years","21 Years",{"count":57,"type":20},[23],"Background Leukaemia is the most common cancer in children with 800 diagnoses per year in England. To survive, children need strong treatments like chemotherapy and steroids given usually through clinical trials. The current trial used by the NHS is called ALLTogether. Fifty percent of children become obese during treatment due to increased hunger, cravings for junk foods and lack of physical activity. Obesity raises the chance of cancer relapse by 31%, makes treatment side-effects worse and makes it harder to kill off leukaemia cells, which affects how well children do during treatment, as indicated by minimal residual disease, a key predictor of prognosis.\n\nAims and Objectives This study (called BREVARY) aims to see if we can successfully provide personalised diet and physical activity with behaviour support for children and young people with leukaemia who are being treated with the ALLTogether trial. It will help us figure out if we can perform a bigger study, if this programme could reduce obesity and side-effects and improve survival and wellbeing.\n\nHow it will be done We plan to randomly assign participants to one of three groups; one group will get both a diet and physical activity plan, another will get only a diet plan, and the last group will receive standard care. This will take place in Hospital Infantil Universitario Nino Jesus, Madrid and Bristol Royal Hospital for Children and Southwest England NHS-sites. The diet and exercise plans will be created in partnership with the children and their families and delivered online or during regular hospital visits. The diet will follow healthy eating guidelines, consider personal food preferences (including cultural and religious needs), treatment side-effects and personal finances. Assessments of fitness and strength will be taken to plan personalised activities. During the study, the following data will also be collected: weight, height, body fat, diet, biomarkers, microbiome, muscle strength and wellbeing at three different times. \"One to one\" interviews will be conducted at the end to obtain feedback on their experiences with BREVARY.\n\nThis study aims to find out if children and their families\u002Fcarers are willing to participate in BREVARY, if enough people sign up and stay until the end and if our interventions and health measurements are appropriate.\n\nPotential Impact The results will help determine if a larger study can be performed, if changes are needed and what the cost will be. The study will be disseminated through networks, targeting underserved communities, healthcare professionals and affected families using accessible platforms to spread the word.",[27,84,85],"Physical Activity Intervention","Standard Care Control",[87,88,89,90,91,92],"Diet","Physical Activity","Obesity","Acute Lymphoblastic Leukaemia","Children and Young People","ALLTogether","NOT_YET_RECRUITING","2025-02-22",{"date":96,"type":39},"2025-02-26",{"date":98,"type":20},"2025-04-01",{"date":100,"type":20},"2029-12-31",{"name":102,"class":46},"University of Exeter",2]