[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"diet-modification\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:diet-modification":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,12,0,[8,49,73,101,125,166,203,238,272,295,321,352],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":31,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100571008","drivers-and-barriers-for-adopting-healthy-and-sustainable-food-swaps-in-young-100571008",false,"NCT06714656","Drivers and Barriers for Adopting Healthy and Sustainable Food Swaps in Young","Drivers and Barriers for Adopting Healthy and Sustainable Food Swaps in Young. The FOOD SWAPS Study","FOOD-SWAPS","Inclusion Criteria:\n\n* men and women\n* aged 18-30 years,\n* having a high baseline consumption of red meat (More than 70 grams per day or 280 grams per 4 days)\n* who are willing to make their diet healthier and more sustainable but do not know how or are facing barriers\n\nExclusion Criteria:\n\n* Having a lower red meat consumption (less than 70 grams per day or 240 grams per 4 days)\n* being vegetarian or vegan\n* having a clinical diagnosis of hypertension or high cholesterol, having unstable or untreated thyroid disorder\n* taking blood pressure and\u002For cholesterol-lowering medications (e.g. beta blockers or statins)\n* having food allergies, being on a weight loss diet or having lost \\>5kg in the last 6 months\n* having a history of an eating disorder.",true,"ALL","18 Years","30 Years",{"count":22,"type":23},30,"ESTIMATED","INTERVENTIONAL",[26],"NA","Food represents one of the greatest health and environmental challenges of the 21st century. Consuming less of the most environmentally damaging foods, such as meat, is considered an effective method to reduce food-related greenhouse gas emissions. The aim of these N-of-1 FOOD SWAP intervention studies is to investigate whether and which physiological, psychological and environmental factors, at an individual level, modify the adoption and adherence of food swaps aiming to reduce the intake of red meat and replace this with fish or plant-based foods, in young adults. The series of N-of-1 studies will also assess whether an 8-week food swap intervention will improve general health markers such as blood pressure, plasma lipids and glucose, and blood\u002Furinary metabotype. This approach will provide insight into physiological, behavioural and environmental factors that can help explain individual fluctuations in adherence and physiological outcomes common in nutrition studies. In the future, this should enable us to tailor how we deliver effective individualised interventions and better consider and control for factors affecting adherence and response to dietary interventions.",[29,30],"Diet Modification","Sustainable Food Consumption",[32,33,34,35],"diet","sustainable food choices","food swaps","N of 1 study","RECRUITING","2026-04-30",{"date":39,"type":40},"2026-05-01","ACTUAL",{"date":42,"type":40},"2024-12-09",{"date":44,"type":23},"2027-12-30",{"name":46,"class":47},"University of Aberdeen","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":18,"minAge":56,"maxAge":19,"enrollmentInfo":57,"targetDuration":4,"studyType":24,"phases":59,"briefSummary":60,"conditions":61,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":48},"100586502","study-of-the-effect-of-capsinoid-supplementation-on-brown-adipose-tissue-in-obese-adolescents-100586502","NCT06916208","Study of the Effect of Capsinoid Supplementation on Brown Adipose Tissue in Obese Adolescents","ADOBAT","Inclusion Criteria:\n\n* member or beneficiary of a health insurance scheme\n* aged between 11 and 18\n* Body Mass Index Z score corresponding to stage 2 obesity according to the curves of Rolland-Cachera et al., 1991 and an absence of weight loss of more than 5% of the total weight over the last 3 months.\n* effective contraception (in pubescent females)\n\nExclusion Criteria:\n\n* known allergy to capsinoids and\u002For soya\n* inflammatory digestive pathology and\u002For history of digestive tract surgery\n* participation in another study or in a period of exclusion determined by a previous study\n* pregnant, parturient or breastfeeding\n* The holder(s) of parental authority or the adolescent refuse(s) to sign the authorisation or acceptance form, respectively.\n* It proves impossible to provide the adolescent or parental guardian(s) with informed information.","11 Years",{"count":58,"type":23},38,[26],"Among the new strategies being considered for the treatment of obesity and its metabolic complications, the activation of brown adipose tissue (BAT) from white adipose tissue looks promising. Interest in the study of BAT has increased over the last 5-10 years in response to the discovery of functional BAT in humans. The BAT is a tissue specialized in regulating energy expenditure by producing heat through the oxidation of fatty acids contained in the multiple lipid droplets of brown adipocytes. This adipose tissue does not play a storage role, but rather an anti-obesogenic one, thanks to its high metabolic and energetic activity.\n\nIn addition to exposure to cold, which is the major physiological inducer of brown adipocytes, it seems that exercise and the intake of \"adrenergic\" foods can activate the TAB and potentially induce a change from white to brown tissue via the production of adrenalin and myokines. Acute and\u002For chronic effects of thermogenic food supplements have been reported on BAT activation and energy metabolism. The most conclusive of these involve the capsinoids found in sweet peppers and chillies. Weight loss also improves BAT activation.\n\nThe BAT has already been identified in children. A decrease in its volume and activity from childhood to adolescence and during puberty has been reported.\n\nThe main objective of this randomized controlled double-blind study is to investigate the effects of capsinoid dietary supplementation on BAT activity in obese adolescents.\n\nOur general working hypothesis is that capsinoid supplementation, combined with dietary management, leads to an increase in BAT activity.",[62,63,29,64],"Obese Adolescents","Exercise","Dietary Supplement","2026-04-29",{"date":37,"type":40},{"date":68,"type":40},"2025-03-03",{"date":70,"type":23},"2027-03",{"name":72,"class":47},"University of Avignon",{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":4,"eligibilityCriteria":79,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":80,"targetDuration":4,"studyType":24,"phases":82,"briefSummary":83,"conditions":84,"keywords":87,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":48},"100393329","fermented-food-supplemented-diet-in-ulcerative-colitis-100393329","NCT04401605","Fermented Food-Supplemented Diet in Ulcerative Colitis","Effects of a Fermented Food-Supplemented on Patients With Ulcerative Colitis","Inclusion Criteria:\n\n* Written informed consent\n* Male or female subjects, ≥18 years of age\n* Confirmed diagnosis of UC\n* Symptomatic disease defined as partial Mayo Score 2 to 7 (inclusive)\n* Elevated fecal calprotectin\n\nExclusion Criteria:\n\n* Women who are pregnant, nursing or expect to be pregnant\n* Intolerance to fermented food\n* Individuals with a body mass index (BMI) lower than 18\n* Individuals diagnosed with a serious medical condition (unless approved in writing by a physician)\n* Individuals who have been severely weakened by a disease or medical procedure\n* Individuals with more than mild-moderate cardiovascular disease or life-threatening cancer (as determined by patient's physician) unless approved by a physician\n* Individuals with history of severe cardiac disease (particularly uncompensated congestive heart failure NYHA grade 2 or more or LVEF \\\u003C 40%)\n* History of relevant intestinal surgery such as total or hemi-colectomy, proctocolectomy, stoma.\n\nComplications of disease such as extraintestinal manifestations (EIMs) are not automatically considered exclusion criteria. Appropriate medical treatment for UC and\u002For EIMs will not be withheld.",{"count":81,"type":23},21,[26],"The purpose of this study is to see how a diet that supplements fermented foods effects inflammation and quality of life in patients with mild to moderate Ulcerative Colitis (UC). There is a paucity of research and an enormous need for better understanding of diet and intestinal inflammation. Fermented food have been shown to positively influence inflammatory cytokines and intestinal microbial diversity in healthy volunteers.",[85,29,86],"Inflammatory Bowel Diseases","Ulcerative Colitis",[88,86,89,90,91],"IBD","UC","Diet","Fermented Food","2026-02-23",{"date":94,"type":40},"2026-02-27",{"date":96,"type":40},"2020-09-14",{"date":98,"type":23},"2027-06",{"name":100,"class":47},"Stanford University",{"id":102,"slug":103,"hasResults":11,"nctId":104,"briefTitle":105,"officialTitle":105,"acronym":4,"eligibilityCriteria":106,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":107,"enrollmentInfo":108,"targetDuration":4,"studyType":24,"phases":110,"briefSummary":111,"conditions":112,"keywords":114,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":119,"startDateStruct":120,"completionDateStruct":122,"leadSponsor":124,"locationsCount":48},"100333007","the-influence-of-a-fasting-mimicking-diet-on-ulcerative-colitis-100333007","NCT03615690","The Influence of a Fasting Mimicking Diet on Ulcerative Colitis","Inclusion Criteria:\n\n* Mild to moderate Ulcerative Colitis on the partial Mayo Score out of 9 (score between 2 to 7)\n* Age of 18-70 at start of study (inclusive)\n\nExclusion Criteria:\n\n* Women who are pregnant or nursing or expect to be pregnant\n* Individuals allergic to nuts\n* Individuals with a body mass index (BMI) lower than 18\n* Individuals diagnosed with a serious medical condition as defined by the patient's physician, unless approved in writing by a physician\n* Individuals who have been severely weakened by a disease or medical procedure,\n* Individuals who are taking medication which may not be safely consumed with a calorie restricted diet\n* Individuals with diabetes who are taking anti-diabetic drugs associated with risk of hypoglycemia\n* Individuals with more than mild-moderate cardiovascular disease or life-threatening cancer (as determined by patient's physician) unless approved by a physician\n* Individuals with history of severe cardiac disease (particularly uncompensated congestive heart failure NYHA grade 2 or more or LVEF \\\u003C 40%)\n* Individuals with a history of syncope\n* Individuals with dietary needs incompatible with the FMD meal plan\n* Individuals with liver or kidney disorders that may be affected by very low glucose and protein content of the diet.\n* Patients on a caloric restricted diet will also be excluded.\n* Patients with relevant prior gastrointestinal surgery and consequences such as short bowel syndrome, ostomy of small or large intestine, hemi- or total colectomy, proctocolectomy, ileoanal pouch will be excluded.","70 Years",{"count":109,"type":23},75,[26],"The purpose of this study is to see how a diet that mimics fasting effects inflammation in patients with mild to moderate Ulcerative Colitis (UC). The diet may allow users to receive the benefits of fasting while also being able to enjoy food (the ingredients of which are GRAS (generally recognized as safe) by the Food and Drug Administration (FDA). Research on dietary interventions and UC are very limited. Fasting mimicking diets (FMD) have been studied with support of the National Institute of Health and published in leading journals. This research investigates whether markers of inflammation decrease and\u002For quality of life increases after three cycles of a five-day period of the fasting mimicking diet, and may provide rationale for its use to treat UC.",[113,29,86],"Inflammatory Bowel Disease",[115,88,32,116,117,89,118],"ulcerative colitis","fasting","fasting mimicking diet","intermittent fasting",{"date":94,"type":40},{"date":121,"type":40},"2020-12-15",{"date":123,"type":23},"2028-12",{"name":100,"class":47},{"id":126,"slug":127,"hasResults":11,"nctId":128,"briefTitle":129,"officialTitle":130,"acronym":131,"eligibilityCriteria":132,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":107,"enrollmentInfo":133,"targetDuration":4,"studyType":135,"phases":4,"briefSummary":136,"conditions":137,"keywords":151,"overallStatus":156,"whyStopped":4,"lastUpdateSubmitDate":157,"lastUpdatePostDateStruct":158,"startDateStruct":160,"completionDateStruct":162,"leadSponsor":164,"locationsCount":48},"100622820","soluble-and-osmotic-fibre-solos-diet-for-constipation-100622820","NCT07388589","Soluble and Osmotic Fibre (SOLOS) Diet for Constipation","The Soluble and Osmotic Fibre (SOLOS) Diet for Functional Bowel Disorders With Constipation","SOLOS","Inclusion Criteria:\n\n* Presented with symptoms of FC, IBS-C, or SIBO-C\n* Were aged 18 to 70 years old. (Research focus is on adult patients, excluding older adults and children)\n* Date of baseline (first) and follow-up appointments ranged from January 2021 to December 2025\n* Did not attend follow-up appointments (Data would be treated as \"intention to treat\" and data points were carried forward for conservative analysis).\n\nExclusion Criteria:\n\n* Had no history of constipation-related symptoms (Does not relate to research question's population or outcome)\n* Started treatment before January 2021\n* Were not due for follow-up before the end of December 2025\n* Symptom and stool data inadequately recorded",{"count":134,"type":23},180,"OBSERVATIONAL","This research aims to study the dual effectiveness of incorporating soluble fibre and osmotic carbohydrates (SOLOS), with or without restricting fructans and GOS, and present novel findings in managing GI symptoms in patients with functional bowel disorders with constipation. These findings may also support researchers and clinicians in shaping new dietary approaches in the management of general constipation symptoms.",[138,139,140,141,142,143,144,145,146,29,147,148,149,150],"Constipation","Constipation - Functional","Constipation Chronic Idiopathic","Constipation Predominant Irritable Bowel Syndrome","Constipation, Signs and Symptoms, Digestive","Constipation-predominant IBS (IBS-C)","Constipation-predominant Irritable Bowel Syndrome","Constipation-predominant Irritable Bowel Syndrome (IBS-C)","Diet Therapy","Diet, Food and Nutrition","Dietary and Nutritional Therapies","Dietary Fiber","Dietary Fibers",[138,152,153,154,155],"Functional constipation","Constipation-predominant irritable bowel syndrome (IBS-C)","Soluble fiber","osmotic sugar","NOT_YET_RECRUITING","2026-02-04",{"date":159,"type":40},"2026-02-06",{"date":161,"type":23},"2026-02-02",{"date":163,"type":23},"2027-03-01",{"name":165,"class":47},"Singapore Institute of Technology",{"id":167,"slug":168,"hasResults":11,"nctId":169,"briefTitle":170,"officialTitle":170,"acronym":171,"eligibilityCriteria":172,"healthyVolunteers":11,"sex":18,"minAge":173,"maxAge":174,"enrollmentInfo":175,"targetDuration":4,"studyType":24,"phases":177,"briefSummary":178,"conditions":179,"keywords":185,"overallStatus":156,"whyStopped":4,"lastUpdateSubmitDate":193,"lastUpdatePostDateStruct":194,"startDateStruct":196,"completionDateStruct":198,"leadSponsor":200,"locationsCount":48},"100603330","targeting-lifestyle-to-improve-colorectal-cancer-screening-100603330","NCT07135115","Targeting Lifestyle to Improve Colorectal Cancer Screening","KoloPrev","Inclusion Criteria:\n\n* Invited to the first round of immunochemical faecal blood testing in the national colorectal cancer screening program via a digital platform.\n\nExclusion Criteria:\n\n* Not invited to the national colorectal cancer screening program.","55 Years","56 Years",{"count":176,"type":23},16000,[26],"The goal of this study is to learn whether receiving personalized, digital lifestyle advice during colorectal cancer screening leeds to changes in lifestyle over a two-year follow-up period. Changes will be measured using a composite score including diet, alcohol consumption, physical activity, body mass index and smoking habits. The main questions it aims to answer are:\n\n* Do participants who receive short, personalized digital feedback on their lifestyle - either once or through repeated rounds -change their lifestyle during the two-year study period, compared to those who do not receive any feedback?\n* Does the inclusion of additional contact, such as telephone consultation with healthcare providers, result in further lifestyle changes?\n\nResearchers will compare three groups which receive digital feedback at different intensities and a control group which does not get any feedback to see if lifestyle changes differ between the groups.\n\nParticipants in four different groups will fill in a digital diet and lifestyle questionnaire at the start of the study and 2-4 times after this during the following 2 years.\n\n* Participants in three of the groups will receive a short digital feedback report on their lifestyle related to health recommendations after each completion of the questionnaire.\n* One of these groups will also be offered to go through the feedback report together with a healthcare provider in a telephone call.\n* This group will also receive invitations to motivational webinars every half year during the 2-year study period. The topics in the webinars address cancer preventive lifestyle.\n\nA secondary goal of the study is to understand whether the invitation to fill in the diet and lifestyle questionnaire affects participation in colorectal cancer screening. Therefore, a fifth group of individuals invited to colorectal cancer screening but not to be invited to fill in the questionnaire will be included for extra comparison. Participation in colorectal cancer screening will be compared between this group and the four groups that are additionally invited to complete the questionnaire.\n\nAnother secondary goal is to learn which groups in the society consent to the current study. Therefore, sociodemographic characteristics will be compared between the invited individuals who consent and those who do not consent to the study.",[180,181,29,182,183,184],"Lifestyle Alteration","Tobacco","Physical Activity","Alcohol Consumption","Body Weight Control",[186,187,90,188,189,190,191,192],"Lifestyle intervention","Colorectal cancer screening","Alcohol consumption","Smoking","Body mass index","Physical activity","Digital questionnaire","2025-08-26",{"date":195,"type":40},"2025-09-03",{"date":197,"type":23},"2025-10-15",{"date":199,"type":23},"2041-12-31",{"name":201,"class":202},"Norwegian Institute of Public Health","OTHER_GOV",{"id":204,"slug":205,"hasResults":11,"nctId":206,"briefTitle":207,"officialTitle":207,"acronym":208,"eligibilityCriteria":209,"healthyVolunteers":11,"sex":18,"minAge":210,"maxAge":211,"enrollmentInfo":212,"targetDuration":4,"studyType":24,"phases":214,"briefSummary":215,"conditions":216,"keywords":223,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":229,"lastUpdatePostDateStruct":230,"startDateStruct":232,"completionDateStruct":234,"leadSponsor":236,"locationsCount":48},"100596179","lifestyle-for-the-brain-health---time-restricted-eating-and-mindfulness-100596179","NCT07042087","Lifestyle for the BRAin Health - Time Restricted Eating and Mindfulness","LIBRA REMIND","Inclusion Criteria:\n\n* Age 60-80 years\n* Diagnosis of Subjective Cognitive Impairment (SCI) or Mild Cognitive Impairment (MCI)\n* mini-mental-scale (MMSE) score between 24-30\n* Positive plasma pTau217 biomarker\n* Stable dose of iAChE therapy (if applicable)\n* Ability to participate in a 9-month intervention\n\nExclusion Criteria:\n\n* Stroke or myocardial infarction within the past year\n* Decompensated internal conditions (e.g., severe heart failure, kidney failure, unstable diabetes, GLP1 agonist therapy)\n* Long-term psychiatric treatment (except well-managed depression)\n* Neurological conditions affecting mobility or cognition (e.g., Parkinson's disease, severe tremor, epilepsy)\n* Severe sensory or motor impairment preventing protocol participation\n* Active cancer treated within the past 5 years\n* Poor anticipated compliance (e.g., transport issues, time constraints, non-cooperation)\n* Concurrent participation in another clinical study\n* Unstable iAChE medication regimen\n* Substance or alcohol dependence","60 Years","80 Years",{"count":213,"type":23},48,[26],"The study aims to evaluate the effects of a 9-month intervention combining yoga-based mindfulness techniques, cognitive training, and nutritional counseling on cognitive function, plasma markers of neurodegeneration (tau protein), physical fitness, and metabolism in older adults at increased risk of developing Alzheimer's disease.",[217,218,219,220,221,222,29],"Alzheimer Disease","Aging","Lifestyle Factors","Cognitive Impairment","Yoga","Time Restricted Eating",[224,225,226,227,228],"Alzheimer's Disease Prevention","Mindfulness-Based Intervention","Cognitive Training","Time-Restricted Eating","Dietary consultation","2025-06-19",{"date":231,"type":40},"2025-06-27",{"date":233,"type":40},"2024-11-01",{"date":235,"type":23},"2026-12",{"name":237,"class":47},"St. Anne's University Hospital Brno, Czech Republic",{"id":239,"slug":240,"hasResults":11,"nctId":241,"briefTitle":242,"officialTitle":242,"acronym":4,"eligibilityCriteria":243,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":244,"targetDuration":4,"studyType":24,"phases":246,"briefSummary":247,"conditions":248,"keywords":256,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":262,"lastUpdatePostDateStruct":263,"startDateStruct":265,"completionDateStruct":267,"leadSponsor":269,"locationsCount":271},"100418985","personalized-responses-to-dietary-composition-trial-3-100418985","NCT04735835","Personalized Responses to Dietary Composition Trial 3","Inclusion Criteria:\n\n* Enrolled in the commercial ZOE testing program\n* Any sex\n* Minimum 18 years of age (minimum 19 years of age in Alabama and Nebraska due to state laws)\n* Body mass index (BMI) of greater than or equal to 16.5 kg\u002Fm2.\n* Living in the continental US states, other than in New York (excluded from the ZOE testing product also as they are unable to access the dried blood spot service provided by Quest), or living in the UK\n* Able and willing to comply with the study protocol and provide informed consent.\n* Under care for chronic medical conditions (including eating disorders, type 1 diabetes, type 2 diabetes), and confirm they have checked with their primary care physician that this study is safe for them (US cohort only)\n\nExclusion Criteria:\n\n* Cannot safely eat the pre-made test meals which contain standard US ingredients, e.g. due to allergy or recent gastrointestinal surgery, or are unwilling to consume these foods.\n* Are pregnant.\n* Have had a heart attack (myocardial infarction), stroke\u002Ftransient ischemic attack (TIA), or major surgery in the last two months.\n* Are unable to read and write in English, as the ZOE app is only available in English.",{"count":245,"type":23},250000,[26],"The PREDICT 3 study will build on previous research in over 2,000 individuals to further refine machine learning models that predict individual responses to foods, with the aim of advancing precision nutrition science and individualized dietary advice. The study incorporates both standardized and controlled dietary intervention, for the purpose of testing postprandial responses to specific mixed meals, in addition to a free-living period with a dietary record for measuring responses to a large variety of meals consumed in a realistic context, where the role of external factors (e.g. exercise, sleep, time of day) on postprandial responses may be determined. For the first time this PREDICT study is built on top of a commercial product which will allow access to a much larger group of participants who are already collecting large amounts of data through digital and biochemical devices that can contribute to science.",[249,250,251,29,252,253,254,255],"Diabetes","Heart Diseases","Diet Habit","Healthy","Obesity","Metabolism","Microbial Colonization",[257,258,259,260,261],"Gut microbiome","Personalised nutrition","Machine learning","Postprandial metabolism","Metabolic health","2025-04-11",{"date":264,"type":40},"2025-04-16",{"date":266,"type":40},"2020-07-20",{"date":268,"type":23},"2030-01-01",{"name":270,"class":47},"Zoe Global Limited",2,{"id":273,"slug":274,"hasResults":11,"nctId":275,"briefTitle":276,"officialTitle":277,"acronym":4,"eligibilityCriteria":278,"healthyVolunteers":17,"sex":18,"minAge":279,"maxAge":280,"enrollmentInfo":281,"targetDuration":4,"studyType":24,"phases":283,"briefSummary":284,"conditions":285,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":286,"lastUpdatePostDateStruct":287,"startDateStruct":289,"completionDateStruct":291,"leadSponsor":293,"locationsCount":48},"100583893","increasing-lean-protein-intake-in-preschool-age-children-and-assessing-effects-on-cognition-and-select-health-outcomes-100583893","NCT06882252","Increasing Lean Protein Intake in Preschool-age Children and Assessing Effects on Cognition and Select Health Outcomes","Increasing Lean Protein Intake in Preschool-age Children","Inclusion Criteria:\n\n* child 2-5 years old\n\nParent participants:\n\n* Parents of at least one child aged 2-5 years old\n* Parents can communicate in English.\n* Parents in households who do not have a cultural\u002F religious reason to abstain from to consuming pork\n\nExclusion Criteria:\n\n* Child participants:\n* Food allergies\n* Taking medication that affects food intake (such as stimulant medications),\n* Children with diabetes or impaired glucose control.\n* Children with digestive disease (such as Crohn's)\n* Dietary\u002Freligious preferences that exclude consumption of pork\n\nParent participants:\n\n\\- Dietary\u002Freligious preferences that exclude consumption of pork","2 Years","5 Years",{"count":282,"type":23},20,[26],"The proposed project addresses the goal of exploring preschooler's ability to recognize changes in feelings of hunger\u002Fsatiety based on consuming a snack and a meal (lunch\u002Fdinner) that are either based on the usual childcare center fare (control) or are based on lean meats (intervention), which will have a lower glycemic index.",[29],"2025-03-11",{"date":288,"type":40},"2025-03-18",{"date":290,"type":40},"2025-02-08",{"date":292,"type":23},"2025-12-31",{"name":294,"class":47},"Sibylle Kranz, PhD, RDN",{"id":296,"slug":297,"hasResults":11,"nctId":298,"briefTitle":299,"officialTitle":300,"acronym":4,"eligibilityCriteria":301,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":302,"enrollmentInfo":303,"targetDuration":4,"studyType":24,"phases":304,"briefSummary":305,"conditions":306,"keywords":308,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":312,"lastUpdatePostDateStruct":313,"startDateStruct":315,"completionDateStruct":317,"leadSponsor":319,"locationsCount":48},"100354850","low-energy-diet-and-familial-partial-lipodystrophy-100354850","NCT03900286","Low Energy Diet and Familial Partial Lipodystrophy","Evaluating the Therapeutic Efficacy and Metabolic Impact of a Low Energy Diet (LED) in People With Familial Partial Lipodystrophy and Diabetes","Inclusion Criteria:\n\n* Familial Partial Lipodystrophy\n* Age \\>= 18 yrs\n* T2DM\n* Willingness to check daily blood sugars\n* HbA1c between 53mmol(7%)- 108 mmol(12%)\n* Weight stable for 3 months\n* Capacity to consent\n\nExclusion Criteria:\n\n* Pregnancy\n* Untreated thyroid dysfunction (patients who have been euthyroid on medication for at least 3 months can be included)\n* Use of medication adversely that affects diabetes control (e.g. steroids\u002F immunosuppressants\u002F certain antipsychotics)\n* Incapacity to give informed consent\n* History of an eating disorder\u002F purging behaviour\n* Previous gastric bypass\u002F banding\n* Use of Leptin Therapy\n* Untreated retinopathy","99 Years",{"count":282,"type":23},[26],"To evaluate the therapeutic efficacy and metabolic impact of a low energy diet (LED) in people with familial partial lipodystrophy and diabetes. Participants will be provided with a LED (total diet replacement) for 12 weeks, before the introduction of a stepped food transition. Metabolic effects will continue to be assessed for 1 year. In order to better understand why this intervention changes insulin sensitivity, we will also collect adipose and muscle tissue samples at baseline and 12 weeks into the intervention in participants willing to have these procedures performed. These samples will be used for histological, metabolite, gene expression and protein expression analyses.",[307,249,29],"Lipodystrophy",[309,310,90,311,249],"Familial Partial Lipodystrophy","FPLD","Total Diet Replacement","2024-12-03",{"date":314,"type":40},"2024-12-05",{"date":316,"type":40},"2020-01-16",{"date":318,"type":23},"2025-05",{"name":320,"class":47},"Cambridge University Hospitals NHS Foundation Trust",{"id":322,"slug":323,"hasResults":11,"nctId":324,"briefTitle":325,"officialTitle":325,"acronym":4,"eligibilityCriteria":326,"healthyVolunteers":17,"sex":18,"minAge":327,"maxAge":328,"enrollmentInfo":329,"targetDuration":4,"studyType":24,"phases":331,"briefSummary":332,"conditions":333,"keywords":339,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":344,"lastUpdatePostDateStruct":345,"startDateStruct":347,"completionDateStruct":349,"leadSponsor":351,"locationsCount":48},"100451992","longitudinal-multi-omic-profiles-to-reveal-mechanisms-of-obesity-mediated-insulin-resistance-100451992","NCT05165706","Longitudinal Multi-Omic Profiles to Reveal Mechanisms of Obesity-Mediated Insulin Resistance","Inclusion Criteria:\n\n* Age 35-65\n* BMI 25-35 kg\u002Fm2\n* Stable body weight\n* Nondiabetic\n\nExclusion Criteria:\n\nPatients with;\n\n* diabetes\n* major organ disease\n* history of liposuction or bariatric surgery\n* active eating or psychiatric disorder\n* pregnancy or lactation, heavy alcohol use\n* recent change in weight (over the past 12 weeks)\n* use of weight loss medication, statins, or oral steroids\n\nClinical screening exclusions;\n\n* hematocrit \\\u003C 33%\n* fasting glucose \\>\u002F= 126 mg\u002FdL\n* blood pressure \\>160\u002F100 mmHg","35 Years","65 Years",{"count":330,"type":23},110,[26],"This 12-week controlled diet and weight intervention study seeks to define the molecular pathways that link excess body weight to the development of insulin resistance (IR). Blood, adipose and stool are sampled at three timepoints; baseline, peak weight (4 weeks) and post weight loss to monitor changes in cellular processes. Additionally, direct insulin sensitivity testing, and radiological measurement of visceral fat and intrahepatic fat content is measured at three timepoints to correlate clinical indices with cellular changes.",[334,335,336,253,337,338,29],"Diabetes Mellitus, Type 2","PreDiabetes","Insulin Resistance","Nonalcoholic Steatohepatitis","Nonalcoholic Fatty Liver",[340,341,342,343],"Metabolomics","Low Fat Diet","Low Carbohydrate Diet","Microbiome","2024-12-02",{"date":346,"type":40},"2024-12-04",{"date":348,"type":40},"2019-01-31",{"date":350,"type":23},"2026-12-30",{"name":100,"class":47},{"id":353,"slug":354,"hasResults":11,"nctId":355,"briefTitle":356,"officialTitle":357,"acronym":4,"eligibilityCriteria":358,"healthyVolunteers":17,"sex":18,"minAge":359,"maxAge":360,"enrollmentInfo":361,"targetDuration":4,"studyType":24,"phases":363,"briefSummary":364,"conditions":365,"keywords":367,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":373,"lastUpdatePostDateStruct":374,"startDateStruct":376,"completionDateStruct":377,"leadSponsor":379,"locationsCount":48},"100551042","impact-of-regular-consumption-of-eggs-and-nutrients-fortified-eggs-on-eczema-condition-in-singapore-individuals-100551042","NCT06454942","Impact of Regular Consumption of Eggs and Nutrients Fortified Eggs on Eczema Condition in Singapore Individuals","Impact of Regular Consumption of Eggs and Nutrients Fortified Eggs on Eczema Condition in Singapore Individuals With Eczema","Inclusion Criteria:\n\n1. English-literate and able to give informed consent in English\n2. Male and female participants, aged between 21 and 59 inclusive\n3. Healthy individuals with no underlying condition or on regular medication\n4. BMI between 18.5-25 kg\u002Fm2\n5. Mild to moderate severity of eczema, which will also be determined using our questionnaires during the screening visit\n\nExclusion Criteria:\n\n1. Significant change in body weight (3 kg or more) in the past 3 months\n2. Significant exercise pattern over the past 3 months defined as high-intensity exercise of more than 3 hours per week\n3. Known food allergy to eggs\n4. Taking dietary supplements which may impact the study results\n5. Having gastrointestinal disorders not suitable for the study\n6. Current smokers\n7. Consumes more than 2 alcoholic drinks per day i.e. one drink is defined as either 150ml of wine, 340ml of beer\u002Fcider, or 45ml of distilled spirit\n8. Taking lipid-lowering and blood pressure-controlling medications for less than 3 years\n9. Pregnant or lactating women, or planning to conceive in the next 6 months\n10. Unwilling to stop the medication of eczema during the study, either topical creams or oral medications\n11. Hierarchical link (professional and familial ties) with the research team members\n12. Participating in another clinical study\n13. Having blindness in one eye or more, eye diseases, retinal\u002Flens\u002Foptical nerve surgery, or other eye conditions that may impact the study results\n14. Low-quality macular pigment optical density results were determined during the screening visit.","21 Years","59 Years",{"count":362,"type":23},44,[26],"The study aims to assess the effects of daily consumption of nutrients-fortified eggs on eczema condition in Singapore individuals with eczema. The investigators hypothesize that egg consumption will improve eczema condition and nutrients fortified egg consumption will improve further improvements when compared to standard egg consumption in individuals with eczema",[366,218,29],"Atopic Dermatitis Eczema",[368,369,370,371,372],"Atopic Dermatitis","Eczema","Young and Middle-aged adults","Eye health","Antioxidants","2024-07-17",{"date":375,"type":40},"2024-07-19",{"date":373,"type":40},{"date":378,"type":23},"2026-05",{"name":380,"class":47},"National University of Singapore"]