[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"dietary-fiber\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:dietary-fiber":38},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,58,94,124,155],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":40,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":46,"lastUpdatePostDateStruct":47,"startDateStruct":50,"completionDateStruct":52,"leadSponsor":54,"locationsCount":57},"100622820","soluble-and-osmotic-fibre-solos-diet-for-constipation-100622820",false,"NCT07388589","Soluble and Osmotic Fibre (SOLOS) Diet for Constipation","The Soluble and Osmotic Fibre (SOLOS) Diet for Functional Bowel Disorders With Constipation","SOLOS","Inclusion Criteria:\n\n* Presented with symptoms of FC, IBS-C, or SIBO-C\n* Were aged 18 to 70 years old. (Research focus is on adult patients, excluding older adults and children)\n* Date of baseline (first) and follow-up appointments ranged from January 2021 to December 2025\n* Did not attend follow-up appointments (Data would be treated as \"intention to treat\" and data points were carried forward for conservative analysis).\n\nExclusion Criteria:\n\n* Had no history of constipation-related symptoms (Does not relate to research question's population or outcome)\n* Started treatment before January 2021\n* Were not due for follow-up before the end of December 2025\n* Symptom and stool data inadequately recorded","ALL","18 Years","70 Years",{"count":21,"type":22},180,"ESTIMATED","OBSERVATIONAL","This research aims to study the dual effectiveness of incorporating soluble fibre and osmotic carbohydrates (SOLOS), with or without restricting fructans and GOS, and present novel findings in managing GI symptoms in patients with functional bowel disorders with constipation. These findings may also support researchers and clinicians in shaping new dietary approaches in the management of general constipation symptoms.",[26,27,28,29,30,31,32,33,34,35,36,37,38,39],"Constipation","Constipation - Functional","Constipation Chronic Idiopathic","Constipation Predominant Irritable Bowel Syndrome","Constipation, Signs and Symptoms, Digestive","Constipation-predominant IBS (IBS-C)","Constipation-predominant Irritable Bowel Syndrome","Constipation-predominant Irritable Bowel Syndrome (IBS-C)","Diet Therapy","Diet Modification","Diet, Food and Nutrition","Dietary and Nutritional Therapies","Dietary Fiber","Dietary Fibers",[26,41,42,43,44],"Functional constipation","Constipation-predominant irritable bowel syndrome (IBS-C)","Soluble fiber","osmotic sugar","NOT_YET_RECRUITING","2026-02-04",{"date":48,"type":49},"2026-02-06","ACTUAL",{"date":51,"type":22},"2026-02-02",{"date":53,"type":22},"2027-03-01",{"name":55,"class":56},"Singapore Institute of Technology","OTHER",1,{"id":59,"slug":60,"hasResults":11,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":64,"eligibilityCriteria":65,"healthyVolunteers":66,"sex":17,"minAge":18,"maxAge":67,"enrollmentInfo":68,"targetDuration":4,"studyType":70,"phases":71,"briefSummary":73,"conditions":74,"keywords":78,"overallStatus":82,"whyStopped":4,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":93},"100609750","aimmune-longitudinal-collaboration-study-100609750","NCT07218640","Aimmune Longitudinal Collaboration Study","Aimmune Therapeutics Manufacturing, LLC Longitudinal Collaboration Study: Evaluating the Impact of Lifestyle Factors on the Microbiome","FIBER-IMPACT","Inclusion Criteria:\n\n1. 18 years of age or greater\n2. Able to sign informed consent in English\n3. Households (2 or more adults) or individuals who are willing to provide a minimum of 3 separate stool samples per week and utilize a manual stool sampling tool. Alternatively, participants who can come to a collection site and leave stool samples a minimum of 3 days per week throughout the duration of the study.\n4. Are generally healthy\n5. Agreeable to adding chia seeds to diet\n6. Have access to a smartphone\n\nExclusion Criteria:\n\n1. Less than 18 years of age\n2. Greater than 50 years of age\n3. Unable to provide a minimum of 3 stool samples per week\n4. Active donors for a commercial product\n5. Anyone who previously made a lot of a finished product\n6. Diagnosed with a digestive, intestinal, or other condition that contraindicates consuming a daily serving size of chia seeds (\\~2.5 tbsp).",true,"50 Years",{"count":69,"type":22},60,"INTERVENTIONAL",[72],"NA","This study will include healthy households around the Irvine, CA area (based local to employees) and Tempe, AZ and Philadelphia, PA sites that will be instructed to take a daily fiber supplement (2.5 tablespoons of chia seeds \\[\\~10.3g of fiber\\] which is one serving) for two months. Participants will use a stool sampling tool to facilitate ease of stool collection, or they may donate at a study site. Half of participants will add chia seeds to their diet at the beginning of the study and then return to their baseline diet for the second half of the study; half of participants maintain their baseline diet for the first half of the study and add chia seeds to their diet at the second half of the study as a cross-over design. Households (or individual participants, if their household is not participating) will be chosen at random to decide who implements the intervention in the first half versus the second half of the study. Data measurement including metabolomics and sequencing of stool samples, blood sampling for biobanking, stool IgA analysis, stress and diet evaluations will occur initially and throughout the study. Lifestyle questionnaires including but not limited to diet surveys, stress, or depression screening may be collected through electronic forms or telephonically. During enrollment, participants may be asked to complete questionnaires focused on medical, family, dietary, and social histories.\n\nAt the end of the study, donor microbiota samples from individuals that are IgA low (undetectable) throughout the study will be evaluated from the presence of microbes that can degrade IgA. If investigators find this is the case, investigators will screen for microbes that can degrade IgA. For individuals that show persistent high fecal IgA or show a substantial improvement in IgA, investigators will transplant fecal samples or spores from fecal samples into germ-free mice to further understand the microbiome and pathophysiology relationship. For the latter, the investigator's hypothesis is that fiber exposure of a specific type will reprogram the microbiome to stimulate IgA broadly to the entire microbiome as occurs with pectin derivative treated mice. The investigator's goal will be to isolate the microbes that respond to fiber to alter levels of IgA in the gut lumen.",[75,76,38,77],"Stool Spore Colony Forming Units","Microbiome Composition","Stress",[79,80,77,81],"Spore Colony-Forming Units","Dietary fiber","Microbiome","RECRUITING","2025-10-16",{"date":85,"type":49},"2025-10-20",{"date":87,"type":22},"2025-10",{"date":89,"type":22},"2026-07",{"name":91,"class":92},"Aimmune Therapeutics, Inc.","INDUSTRY",2,{"id":95,"slug":96,"hasResults":11,"nctId":97,"briefTitle":98,"officialTitle":99,"acronym":4,"eligibilityCriteria":100,"healthyVolunteers":66,"sex":17,"minAge":18,"maxAge":101,"enrollmentInfo":102,"targetDuration":4,"studyType":70,"phases":104,"briefSummary":105,"conditions":106,"keywords":110,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":115,"lastUpdatePostDateStruct":116,"startDateStruct":118,"completionDateStruct":120,"leadSponsor":122,"locationsCount":4},"100603083","non-alcoholic-fiber-enriched-beer-and-its-effect-on-blood-glucose-concentration-100603083","NCT07131904","Non-alcoholic, Fiber-enriched Beer and Its Effect on Blood Glucose Concentration","Non-alcoholic, Fiber-enriched Beer and Its Effect on Blood Glucose Concentration: A Scientific Study","Inclusion Criteria:\n\n* Healthy adults aged 18-60 years\n* Body mass index (BMI) between 18.5 and 29.9 kg\u002Fm²\n* Signed informed consent\n\nExclusion Criteria:\n\n* Diagnosed diabetes\n* Gastrointestinal diseases\n* Hormonal or other metabolic diseases\n* Allergies or intolerances to beer ingredients\n* Professional sports (\\>10 hours\u002Fweek of intense exercise)\n* Special diets (e.g., low-carb, intermittent fasting)\n* Sleep disorders or inability to maintain regular sleep (e.g., shift work)\n* Pregnancy or breastfeeding\n* Smoking\n* Inability to speak German or English\n* Problems with alcohol, drug, or medication abuse\n* Inability to sign informed consent","60 Years",{"count":103,"type":22},25,[72],"This study examines how various non-alcoholic beverages affect blood sugar levels.\n\nThe beverages are a non-alcoholic, fiber-enriched beer, a conventional non-alcoholic beer, and a sugar solution. Participants drink one of these beverages on different days. Afterwards, a sensor on the upper arm is used to measure the sugar content in the body fluid under the skin over a period of two hours.\n\nThe aim is to find out how much blood sugar concentration rises after drinking. This will be used to check whether the non-alcoholic, fiber-enriched beer has a more favorable effect on sugar metabolism than conventional beverages. Participation is voluntary, and the data will be treated confidentially.",[107,108,38,109],"Blood Glucose Concentration","Glycemic Index","Non-alcoholic Beer",[111,112,113,114],"fiber-enriched beer","functional food","continuous glucose monitoring","postprandial glucose response","2025-08-13",{"date":117,"type":49},"2025-08-20",{"date":119,"type":22},"2025-08-12",{"date":121,"type":22},"2025-10-15",{"name":123,"class":56},"David Faeh",{"id":125,"slug":126,"hasResults":11,"nctId":127,"briefTitle":128,"officialTitle":129,"acronym":130,"eligibilityCriteria":131,"healthyVolunteers":66,"sex":17,"minAge":132,"maxAge":133,"enrollmentInfo":134,"targetDuration":4,"studyType":70,"phases":136,"briefSummary":137,"conditions":138,"keywords":139,"overallStatus":82,"whyStopped":4,"lastUpdateSubmitDate":146,"lastUpdatePostDateStruct":147,"startDateStruct":149,"completionDateStruct":151,"leadSponsor":153,"locationsCount":57},"100409417","dietary-fiber-effects-on-the-microbiome-and-satiety-100409417","NCT04611217","Dietary Fiber Effects on the Microbiome and Satiety","Mechanisms Linking Dietary Fiber, the Microbiome and Satiety","FEMS","Inclusion Criteria:\n\n* Men and women (premenopausal only)\n* Age 20-55y (Aim 1); 45-55y (Aim 2)\n* BMI ≥25 or ≤35 kg\u002Fm2 (Aim 1); ≥25 or ≤40 (Aim 2)\n* Weight stable (no fluctuations in body weight of greater than 4 kg in the last 3 months)\n* Willing to consume a research diet\n* Willing to provide blood and fecal samples\n* At least one characteristic of the metabolic syndrome (but not diabetic)\n\n  1\\. A large waistline: 35 inches or more for women 40 inches or more for men 2. High triglycerides: 150 mg\u002FdL or higher 3. Low HDLc level: \\\u003C50 mg\u002FdL for women \\\u003C40 mg\u002FdL for men 4. High blood pressure ≥130\u002F85 mmHg 5. Fasting blood sugar ≥100 mg\u002FdL\n* Pre-diabetes acceptable (glucose \\\u003C125 mg\u002FdL or HbA1c \\\u003C6.5%)\n* Stably treated with statin drugs, anti-hypertensives, and anti-depressants. These are acceptable as long as the drug category does not alter appetite, body weight, or the microbiome (if known)\n\nExclusion Criteria:\n\n* Pregnant or lactating\n* Postmenopausal (evidence suggests an interplay between the gut microbiome)\n* BMI of \\\u003C25 or \\>35 kg\u002Fm2 (Aim 1); \\\u003C25 or \\>40 kg\u002Fm2 (Aim 2)\n* Use of medications that affect the gut microbiome (e.g. antibiotics)\n* Taking medications known to affect appetite (e.g., phentermine) or gastrointestinal function (e.g., metformin)\n* On a special diet or undergoing weight loss, vegetarian, or other restricted dietary patterns\n* Ad libitum intake of fiber above 25g\u002Fday (mean intake in the US population is 17g\u002Fday) and \\\u003C 10g\u002Fd\n* Ad libitum alcohol intake of greater than 1 drink\u002Fd for women and 2 drinks\u002Fd for men\n* History of disease (example colon cancer, HIV, cardiovascular disease, psychiatric disorders, etc.)\n* Use of tobacco products\n* Having metal or implants in the body that are not MRI compatible (Aim 1 only)","20 Years","55 Years",{"count":135,"type":22},88,[72],"Strong evidence supports the association between high fiber (HiFi) diets (e.g. legumes, nuts, vegetables) and a reduced risk for chronic conditions such as cardiovascular disease (CVD), type 2 diabetes and some forms of cancer. However, the current U.S. average consumption of dietary fiber of 17g\u002Fday is significantly below the recommendation level of 25g\u002Fd for women and 38g\u002Fd for men. Furthermore, fiber fermentation to produce short chain fatty acid (SCFA) products and alterations in microbial composition and activity may be mechanisms linking a HiFi diet to improved health. Importantly, much of the data, including findings supporting a beneficial role of SCFA have been derived from animal studies. Human studies are now needed to advance the understanding of the translational significance of rodent studies and the potential benefit of fiber on microbial metabolites and cardiometabolic health, glucose regulation, appetite and satiety. The central hypothesis is that that the mechanisms by which dietary fiber provides metabolic benefit include direct physical effects in the upper gastrointestinal tract to slow nutrient absorption, and indirect effects to reduce food intake mediated by SCFA-induced secretion of intestinal hormones resulting in increased satiety. Design: Using fiber derived from peas, Aim 1 will test the effect of a HiFi diet on appetite, satiety, and cardiometabolic health and whether elevated SCFA concentration mediates improved satiety in 44 overweight\u002Fobese subjects randomly assigned to receive either a high fiber or a low fiber dietary intervention for four weeks in a parallel arm-repeated measures design. Aim 2 will quantitate the changes in microbial composition and colonic SCFA production rate during HiFi feeding and whether any changes are potential mediators of observed benefits on satiety and cardiometabolic risk factors in 26 subjects assigned to receive a high fiber intervention for 3 weeks in a repeated measures design. Relevance: These studies will significantly expand the understanding of mechanisms by which dietary fiber improves satiety and cardiometabolic health in humans.",[38],[140,141,142,143,144,145],"dietary fiber","satiety","microbiome","short chain fatty acids","functional magnetic resonance imaging","cardiometabolic risk","2025-06-20",{"date":148,"type":49},"2025-06-22",{"date":150,"type":49},"2021-04-22",{"date":152,"type":22},"2025-08-01",{"name":154,"class":56},"University of Missouri-Columbia",{"id":156,"slug":157,"hasResults":11,"nctId":158,"briefTitle":159,"officialTitle":159,"acronym":160,"eligibilityCriteria":161,"healthyVolunteers":66,"sex":17,"minAge":162,"maxAge":4,"enrollmentInfo":163,"targetDuration":4,"studyType":70,"phases":165,"briefSummary":166,"conditions":167,"keywords":173,"overallStatus":82,"whyStopped":4,"lastUpdateSubmitDate":179,"lastUpdatePostDateStruct":180,"startDateStruct":181,"completionDateStruct":183,"leadSponsor":185,"locationsCount":57},"100589558","the-effect-of-pectin-supplementation-on-geriatric-with-frailty-a-randomised-placebo-controlled-dietary-intervention-study-100589558","NCT06955975","The Effect of Pectin Supplementation on Geriatric With Frailty: A Randomised Placebo-Controlled Dietary Intervention Study","GEOFF","Inclusion Criteria:\n\n* Participant is willing and able to give informed consent for participation in the study.\n* Participant eligibility includes those aged \\>65 years who have a body mass index (BMI) between 18.5 and 39.9 kg\u002Fm2.\n* Participants who are considered as pre-frail or frail based on FRAIL (Simple Frailty Questionnaire).\n\nExclusion Criteria:\n\n* Have gastrointestinal conditions e.g. malabsorptive conditions such as IBS\u002FIBD, coeliac or functional conditions such as gastroparesis or food intolerances etc.\n* History of major surgery which potentially limit participation or completion of the study.\n* History of gastrointestinal resection surgery, including bariatric surgery.\n* Used of antibiotics, antifungal medications, probiotics or prebiotics 90 days before the start of the study.\n* Are taking the following medications: immunosuppressants, amiodarone and\u002For perhexiline.\n* Are currently following or anticipated to commence a specialised commercially available weight loss diet and\u002For program.\n* History of side effects towards probiotics or prebiotics.\n* History or current psychiatric illness.\n* History or current neurological condition (e.g. epilepsy).\n* Having taken part in a research study in the last 3 months involving invasive procedures or an inconvenience allowance.","65 Years",{"count":164,"type":22},30,[72],"The study involves the intake of Low-methoxy (LM) pectin (polysaccharides extracted from citrus peels), which are commonly found in the UK diet (not pharmacological agents), to test their effects on systematic inflammation in the body and gut microbiome composition. Study subjects will be healthy elderly with early signs of frailty or pre-frailty from the local population and will be asked to attend the laboratory on 2 occasions; before and after 4-week' supplementing the diet daily with either 10g of pectin with 10g of whey protein and 10g of cocoa powder added as flavour (active arm) or 10g of whey protein with 10g of cocoa powder added as flavour (placebo). Participants will be given the blinded products portioned in individual sachets, with instructions to add the contents of one sachet a day to 150ml of milk and to consume immediately.\n\nAt each study visit (\\~90 minutes), participants will be asked to provide a stool and blood sample, will have blood pressure, heart rate, weight, height, and waist\u002Fhip ratio measured, research team will perform physical functioning test (Time up and go test, 30-second sit to stand test) as well as participants will complete the quality-of-life questionnaire (SF-36), the Depression and Anxiety (HADS) and the Gastrointestinal Symptom Rating Scale (GSRS).",[168,169,170,171,38,172],"Frailty at Older Adults","Pre-Frailty","Frailty","Diet","Systemic Inflammatory Response",[174,175,170,169,176,177,178],"Pectin","LM Pectin","Systemic inflammation","Dietary intervention","Gut microbiome","2025-06-17",{"date":148,"type":49},{"date":182,"type":49},"2025-02-10",{"date":184,"type":22},"2026-03-31",{"name":186,"class":56},"University of Nottingham"]