[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"dietary-nitrate\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:dietary-nitrate":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,46],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100605396","effect-of-dietary-nitrate-on-immobilization-induced-changes-in-skeletal-muscle-in-young-healthy-men-100605396",false,"NCT07161973","Effect of Dietary Nitrate on Immobilization-induced Changes in Skeletal Muscle in Young Healthy Men","Effect of Dietary Nitrate on Immobilization-induced Changes in Skeletal Muscle","Inclusion Criteria:\n\n* Men age 18-44\n* Above the minimum threshold of the IPAQ questionnaire\n* Below the maximum threshold of the IPAQ questionnaire\n\nExclusion Criteria:\n\n* Men and women \\\u003C18 or \\>44 years of age\n* Unable to provide informed consent\n* Known clotting disorder\n* Previous history of deep vein thrombosis\n* Injury to either leg resulting in reduced mobility in the previous year\n* Currently dieting or weight instability for the past 3 months\n* Epileptic\n* Pacemaker or other implantable heart device\n* Currently taking antibiotics\n* Current smoker\n* Stage II hypertension (resting blood pressure \\>140\u002F\\>90)\n* Previously undergone a revascularization procedure involving a vascular graft or stenting of the femoral or popliteal arteries\n* Those taking phosphodiesterase inhibitors (e.g., Viagra), proton pump inhibitors, antacids, xanthine oxidase inhibitors, hormonal contraceptives or on hormone replacement therapy\n* An answer of yes to any of the seven questions on the first page of the Physical Activity Readiness Questionnaire (PAR-Q. These exclusions include the following:\n\n  * If participant's doctor has ever said that he\u002Fshe has a heart condition and that he\u002Fshe should only do physical activity recommended by a doctor\n  * Pain in chest when doing physical activity\n  * In past month, chest pain when not doing physical activity\n  * If participant has ever lost balance because of dizziness or has ever lost consciousness\n  * Muscle, bone, or joint problem that could be made worse by physical activity\n  * Currently on prescribed drugs for blood pressure or heart condition.\n  * If the participant knows of any other reason he\u002Fshe should not do physical activity.",true,"MALE","18 Years","44 Years",{"count":21,"type":22},24,"ESTIMATED","INTERVENTIONAL",[25],"NA","Diminished use of skeletal muscle, such as occurs with many chronic diseases (e.g., heart failure or cancer cachexia), denervation, bedrest, immobilization (e.g., limb casting or bracing), etc., is a common clinical condition affecting untold millions of individuals each year. Such disuse leads to a rapid decline in muscle fiber area and hence whole muscle size, contributing to a decrease in strength, speed, and power as well as alterations in energy metabolism. Collectively, these changes lead to reduced physical function and contribute to the seriousness of any disease, illness (e.g., pneumonia), surgery (e.g., joint replacement), or injury (e.g., broken bone) accompanied by decreased muscular activity. Currently, there are no effective pharmacological treatments to prevent disuse-associated muscle wasting in humans.\n\nThe above-described effects of disuse appear to be due, at least in part, to a decrease in nitric oxide (NO) bioavailability. Reduced synthesis of NO and\u002For increased NO destruction (due to increased production of oxygen free radicals) likely contributes to the mitochondrial changes, energetic abnormalities, and muscle atrophy resulting from immobilization. The objective of this study is to investigate the potential benefits of dietary nitrate supplementation on immobilization-induced changes in muscle contractile function and mitochondrial respiratory capacity in young healthy men. Our disuse-induced muscle atrophy model will involve wearing a knee brace for a period of 14 d.",[28,29,30],"Mitochondrial Energetics","Dietary Nitrate","Disuse Atrophy (Muscle) of Lower Leg",[29,32],"Immobilization","RECRUITING","2026-02-20",{"date":36,"type":37},"2026-02-23","ACTUAL",{"date":39,"type":37},"2026-01-30",{"date":41,"type":22},"2026-12-31",{"name":43,"class":44},"Indiana University","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":16,"sex":53,"minAge":18,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":23,"phases":57,"briefSummary":58,"conditions":59,"keywords":61,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":45},"100589607","evaluating-the-impact-of-various-dietary-nitrate-supplements-on-oral-health-100589607","NCT06956612","Evaluating the Impact of Various Dietary Nitrate Supplements on Oral Health","Evaluating the Impact of Various Dietary Nitrate Supplementation Forms on Microbiological Markers of Oral Health and Acceptability Among Adult Participants","Inclusion Criteria:\n\n* Healthy volunteers\n* Aged 18 - 65 years.\n\nExclusion Criteria:\n\n* Aged less than 18 or more than 65 years old.\n* Current smoking\n* Alcohol consumption of greater than14 units per week.\n* Diagnosis of a chronic disease (e.g., cardiovascular disease, diabetes, cancer, or gastrointestinal disorders), including oral diseases.\n* Use of antibiotics within the past three months or medications\u002Fnutritional supplements that may affect the oral cavity (e.g., prebiotics, probiotics, or hormone replacement therapy).\n* Regular use of antibacterial mouthwash or xylitol-containing products (e.g., gum or toothpaste) or the use of proton pump inhibitors.\n* Presence of braces\u002Finvisalign or dentures.\n* Known allergy to any food, including beets\n* Adherence to dietary restrictions (e.g., weight loss diet)\n* Eating disorders that may limit participation in the study.\n* Currently pregnant, breastfeeding or trying to become pregnant.\n* Participation in other studies.","ALL","65 Years",{"count":56,"type":22},60,[25],"This study aims to investigate the effects of different dietary nitrate supplements, versus placebo, on microbiological and immunological markers associated with oral health in people aged 18-65 years.\n\nThe main research questions are:\n\n* How do different dietary nitrate supplements (beetroot crystals vs. beetroot juice) affect oral health markers, including salivary pH and oral microbiome composition?\n* What is the acceptability and ease of integrating one of dietary nitrate supplements, made from beetroot but processed as freeze dried crystals or juice, into the daily diet?\n\nTo answer these questions, the study will compare results from three groups of participants, who will be randomly assigned to one of the following study arms:\n\nGroup 1: The control group will consume a placebo beetroot supplement completely free of nitrate in juice form.\n\nGroup 2: The beetroot juice group will consume a beetroot supplement standardised to contain \\~ 400 mg of nitrate in juice form.\n\nGroup 3: The beetroot crystals group will consume a beetroot supplement standardised to contain \\~400 mg of nitrate in freeze dried crystal form.\n\nThe study will follow a randomised, single-blind, placebo-controlled, parallel design, and the intervention will last for four weeks. Data will be collected by providing pre- and post-intervention saliva samples tongue swabs, and various questionnaires will be completed at baseline and at the end of the study. In addition, at the end of the second week of the intervention period, participants will be asked to collect a saliva sample over three consecutive days at home.",[60,29],"Oral Health",[62,63,64,65],"Dietary nitrate","oral health","salivary acidity","oral microbiome","2025-05-27",{"date":68,"type":37},"2025-05-28",{"date":70,"type":37},"2025-05-23",{"date":72,"type":22},"2026-04",{"name":74,"class":44},"Shatha Alhulaefi"]