[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"dietary-supplements\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:dietary-supplements":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,43,80],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100526696","developing-a-nutritional-supplement-to-increase-collagen-synthesis-in-people-100526696",false,"NCT06138106","Developing a Nutritional Supplement to Increase Collagen Synthesis in People","Inclusion Criteria:\n\n* Young healthy adults (18-30 y)\n\nExclusion Criteria:\n\n* Pregnancy\n* Smoking\n* Receiving any medication that may interfere with the study outcomes",true,"ALL","18 Years","30 Years",{"count":20,"type":21},20,"ESTIMATED","INTERVENTIONAL",[24],"NA","The purpose of this study is to test whether a natural product supplement can potentiate the increase in collagen synthesis following the ingestion of collagen protein. The investigators have developed a model of natural (GRAS certified) products that stimulate collagen synthesis, in vitro. The investigators will determine whether the natural product supplement can potentiate the collagen synthetic response to the ingestion of collagen protein. Basal and fed serum will be isolated and these samples will be used to treat human engineered ligaments.",[27,28,29],"Dietary Supplements","Connective Tissue","Exercise","RECRUITING","2026-06-26",{"date":33,"type":34},"2026-06-29","ACTUAL",{"date":36,"type":34},"2023-11-21",{"date":38,"type":21},"2026-12-01",{"name":40,"class":41},"University of California, Davis","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":50,"targetDuration":4,"studyType":52,"phases":4,"briefSummary":53,"conditions":54,"keywords":58,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":42},"100567563","influencing-a-vegan-diet-and-the-intake-of-dietary-supplements-during-pregnancy-and-childhood-100567563","NCT06669819","Influencing a Vegan Diet and the Intake of Dietary Supplements During Pregnancy and Childhood","Can Dietary Supplements be Linked to a Vegan Diet and Health Risk Modulation During Vegan Pregnancy, Infancy and Early Childhood","Inclusion Criteria:\n\nA. For vegans:\n\n1. Females\u002Fgender-diverse participants (ages 18 and over) who follow\u002Ffollowed a vegan diet during their pregnancy\u002Fpregnancies (If there is\u002Fwas more than one pregnancy, at least during one of their pregnancies)\n2. Parents (females\u002Fmales\u002Fgender-diverse - ages 18 and over) who feed\u002Ffed their child\u002Fchildren (If there is more than one child, at least one of them) a vegan diet within the age of 0-5 years\n3. Vegan mothers\u002Fgender-diverse participants (ages 18 and over) who breastfeed\u002Fbreastfed their infant(s)\u002Fchild(ren). Answering questions regarding their infant(s)\u002Fchild(ren) up to an age of 5 years will be included\n4. Pregnant and breastfeeding women\u002Fgender diverse participants\u002Fparents (f\u002Fm\u002Fd) who make rare exceptions to their vegan diet and a vegan diet of their child(ren) - up to an age of 5 years. Inclusion in the survey depends on the frequency of exceptions → determined through questions\u002Fgiven answers within the survey. Participants that consume animal products maximum twice a month will be included - hence participants who do not make vegetarian or pescetarian exceptions more than twice a month will be included 5.Confirmation of the consent form and participant information ( online - addressing the subjects, purpose and process of the study, opportunities for discussion of further questions, duration of the questionnaire, who is conducting the study, possibility for further inquiries)\n\nB. For medical experts:\n\n1. Gynaecologists, paediatricians, general practitioners, pharmacists, dieticians with or without a consulting focus on vegans\n2. Confirmation of the participant information\u002Fwritten consent\n\nExclusion Criteria:\n\nA. For vegans:\n\n1. Females\u002Fgender-diverse participants who change\u002Fchanged their vegan diet (eat\u002Fate a vegetarian or omnivorous diet) during their pregnancy\u002Fpregnancies\n2. Parents who do not feed\u002Fhave never fed their children a vegan diet at least up to an age of 5 years (If vegan mothers followed a vegan diet during their pregnancy, exclusion only relates to questions concerning their children)\n3. No confirmation of the consent form and participant information (online) For the inclusion into the study at least one inclusion criteria (plus participant information) must be fulfilled. Exclusion (or not inclusion) will happen if only exclusion 3 is fulfilled. If only 1 or 2 is fulfilled - and 3 is not, participants will be included in the survey. All criteria will be proven by the study physician.\n\nB. For medical experts:\n\n1. Other medical specialists than mentioned in inclusion criteria\n2. No confirmation of the participant information\u002Fno written consent For the inclusion into the study all criteria must be fulfilled. Exclusion (or not inclusion) will happen if only one exclusion criteria is fulfilled. All criteria will be proven by the study physician.\n\nAll participants have do understand the German language in order to answer the questionnaire.",{"count":51,"type":21},1000,"OBSERVATIONAL","The main goals of the exploratory, cross-sectional survey among vegans are to reveal influencing factors, sources of information gathering, reasons for choosing certain dietary supplements of pregnant vegans and parents, difficulties in administering dietary supplements to children, and the compliance of dietary supplements of vegans, because there is no data available yet. Results serve as a starting point for comprehensive information provision for surveyed vegans and provide insight into the nutritional knowledge of vegans. The advisory role of the medical experts is essential to provide vegans with reliable information on a balanced vegan diet and dietary supplements. The opinion of medical experts has a decisive influence on the health of vegans. For this reason the content of their advice will be assessed.\n\nThe main questions the study aims to answer are: Do vegan pregnant women and parents know about possible nutrient deficiencies during pregnancy and childhood and who do they turn to for information about nutritional supplements? What is the quality of the information received?",[55,56,27,57],"Vegan Diet","Pregnancy","Childhood",[59,60,61,62,63,64,65,66,67,68,69,70],"vegan","pregnancy","pregnant","childhood","dietary supplements","parents","medical experts","paediatrician","gynaecologist","general practitioner","pharmacist","dietician","2025-03-26",{"date":73,"type":34},"2025-04-01",{"date":75,"type":34},"2023-10-01",{"date":77,"type":21},"2025-12",{"name":79,"class":41},"Wolfgang Huber-Schneider",{"id":81,"slug":82,"hasResults":11,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":4,"eligibilityCriteria":86,"healthyVolunteers":11,"sex":16,"minAge":18,"maxAge":87,"enrollmentInfo":88,"targetDuration":4,"studyType":22,"phases":90,"briefSummary":91,"conditions":92,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":42},"100545291","oral-supplementation-compared-with-hyaluronic-acid-infiltration-in-rotator-cuff-tendinopathies-100545291","NCT06379997","Oral Supplementation Compared With Hyaluronic Acid Infiltration in Rotator Cuff Tendinopathies","Efficacy of Oral Hyaluronic Acid and Collagen Supplementation Compared With Hyaluronic Acid Infiltration Treatment in Rotator Cuff Tendinopathies: A Prospective Study","Inclusion Criteria:\n\n* Persistent shoulder pain lasting for at least 2 months unresponsive to conservative treatment (nonsteroidal anti-inflammatory drugs \\[NSAIDs\\] and rehabilitation)\n* Ultrasound or MRI evidence of a rotator cuff lesion without complete tendon rupture\n* Limited active range of motion (ROM) in the shoulder\n\nExclusion Criteria:\n\n* Traumatic shoulder injury as the cause of pain\n* History of shoulder dislocation, fracture, or previous shoulder surgery\n* Presence of signs indicating ligamentous instability\n* Severe shoulder arthrosis, adhesive capsulitis, or calcific tendinitis\n* Previous infiltrative treatment with corticosteroids, hyaluronic acid, or collagen within the past 6 months\n* Diagnosis of rheumatic or neoplastic diseases\n* Ongoing therapy with anticoagulants\n* Cervical radiculopathy\n* Pregnancy\n* History of heart, kidney, or liver failure\n* Cognitive impairment","80 Years",{"count":89,"type":21},50,[24],"The present study aims to investigate the effectiveness of oral supplementation with a nutraceutical containing Collagen, Hyaluronic Acid, Vitamin C, and Manganese in functional outcome and pain reduction in cases of shoulder rotator cuff tendinopathy compared to a cycle of intra-articular hyaluronic acid injections.\n\nThe project involves the recruitment of 50 adult individuals presenting with shoulder pain and instrumental evidence of rotator cuff tendinopathy. All participants will receive one intra-articular injection of 1 ml of triamcinolone acetonide 40 mg. After the injection, participants will be divided into two groups according to Good Clinical Practice guidelines. One group will begin taking one vial per day for 56 days of an oral supplement containing Hyaluronic Acid, Collagen, Vitamin C, and Manganese (HA-COL) (Tendogenial®, B2Pharma) starting from the day following enrollment (Group 1). The other group will undergo a cycle of 3 intra-articular injections with hyaluronic acid (HA) (Hyalotend®, Fidia) (Group 2).\n\nThe hypothesis is that oral supplementation with HA-COL may have the same efficacy as intra-articular hyaluronic acid treatment in reducing pain and improving shoulder functionality.\n\nFunctional assessments will be conducted by a clinician unaware of the participants' group assignment. The following assessment scales will be used:\n\nNumeric Rating Scale (NRS) for pain (from 0 to 10), evaluating 3 aspects of pain: 1) pain at rest, 2) nocturnal pain, 3) pain during movement.\n\nShoulder Disability Questionnaire (SDQ) for functionality.\n\nAssessments will be conducted at the following time points:\n\nT0) Before the administration of corticosteroid intra-articular injection (baseline).\n\nT1) Seven days after the start of HA-COL intake for Group 1 and before the first intra-articular HA injection for Group 2 (T1, seven days from T0).\n\nT2) At mid-cycle of oral HA-COL supplementation for Group 1 (28 days of intake) and seven days after the last HA injection for Group 2 (T2, 21 days from T1).\n\nT3) Follow-up at 28 days from T2, at the end of the 56-day oral treatment cycle for Group 1, and 28 days after the last injection for Group 2 (T3, 56 days from T0).",[93,94,27,95],"Tendinitis of Shoulder","Hyaluronic Acid","Shoulder Pain","2024-08-27",{"date":98,"type":34},"2024-08-29",{"date":100,"type":34},"2024-08-10",{"date":102,"type":21},"2025-12-31",{"name":104,"class":41},"I.R.C.C.S. Fondazione Santa Lucia"]