[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"difficult-airway-intubation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:difficult-airway-intubation":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,52,91,113,142,165,194],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":51},"100631035","video-versus-direct-laryngoscopy-for-tracheal-intubation-in-pediatric-surgery-100631035",false,"NCT07495436","Video Versus Direct Laryngoscopy for Tracheal Intubation in Pediatric Surgery","Videolaryngoscopy Versus Direct Laryngoscopy for Tracheal Intubation in Pediatric Surgery: The VIDEOKIDS Pragmatic Multicentre Randomized Trial","VIDEOKIDS","Inclusion Criteria:\n\n* Paediatric patients (age 0-16 years),\n* Undergoing elective or scheduled surgery under general anaesthesia requiring orotracheal intubation,\n* Planned tracheal intubation using either videolaryngoscopy or direct laryngoscopy as the initial technique,\n* Informed or general consent given, according to the relevant ethics committee statement,.\n\nExclusion Criteria:\n\n* Known upper airway anatomical abnormalities or clinical conditions requiring a specific intubation technique (e.g., fibreoptic intubation),\n* Requirement for emergent tracheal intubation that does not allow adequate randomisation,\n* Refusal of parents or legal guardians to participate in the study.","ALL","0 Days","16 Hours",{"count":21,"type":22},5562,"ESTIMATED","INTERVENTIONAL",[25],"NA","Tracheal intubation in paediatric patients is a high-risk procedure in which failure to achieve successful intubation on the first attempt is associated with an increased risk of complications, including hypoxaemia and airway trauma. Videolaryngoscopes have been increasingly adopted in clinical practice because they improve glottic visualisation; however, evidence of their benefit in paediatric patients remains inconsistent.\n\nThe VIDEOKIDS trial is a large, pragmatic, international, multicentre, randomised controlled trial designed to compare videolaryngoscopy with direct laryngoscopy as the initial technique for tracheal intubation in paediatric patients undergoing surgery under general anaesthesia. The primary objective is to determine whether videolaryngoscopy increases the rate of successful intubation on the first attempt compared with direct laryngoscopy.",[28,29,30,31],"Tracheal Intubation","Videolaryngoscopy","General Anesthesia","Difficult Airway Intubation",[33,34,35,36,37,38],"tracheal intubation","videolaryngoscopy","laryngoscopy","Paediatric airway","Airway management","Randomised controlled trial","NOT_YET_RECRUITING","2026-04-17",{"date":42,"type":43},"2026-04-22","ACTUAL",{"date":45,"type":22},"2026-05-01",{"date":47,"type":22},"2027-12-30",{"name":49,"class":50},"Hospital Clinico Universitario de Santiago","OTHER",1,{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":4,"eligibilityCriteria":58,"healthyVolunteers":11,"sex":17,"minAge":59,"maxAge":60,"enrollmentInfo":61,"targetDuration":4,"studyType":63,"phases":4,"briefSummary":64,"conditions":65,"keywords":69,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":51},"100633591","ultrasound-vs-clinical-parameters-for-difficult-airway-prediction-in-obesity-100633591","NCT07528677","Ultrasound vs Clinical Parameters for Difficult Airway Prediction in Obesity","Comparison of Airway Ultrasonography and Conventional Difficult Airway Parameters for Predicting Difficult Airway in Obese Patients: A Prospective Observational Study","Inclusion Criteria:\n\n* Age 18-65 years\n* BMI \\>30 kg\u002Fm2\n* ASA physical status I, II, or III\n* Scheduled for elective surgery requiring orotracheal intubation under general anesthesia\n* Written informed consent obtained\n\nExclusion Criteria:\n\n* Emergency surgery\n* History of previous head and neck surgery or radiotherapy\n* Known or anticipated difficult airway (history of difficult intubation)\n* Presence of cervical spine pathology or limited neck mobility\n* Presence of oropharyngeal or laryngeal pathology\n* Pregnancy\n* Patients with tracheostomy\n* Refusal to participate","18 Years","65 Years",{"count":62,"type":22},70,"OBSERVATIONAL","Obesity is associated with anatomical changes in the upper airway that increase the risk of difficult laryngoscopy and difficult mask ventilation during anesthesia. Conventional airway assessment parameters such as Mallampati score, neck circumference, and STOP-BANG scale are widely used but have limited predictive accuracy in obese patients. Airway ultrasonography has emerged as a promising non-invasive tool for difficult airway prediction; however, ultrasonographic criteria have not yet been standardized.\n\nThis prospective observational study aims to evaluate the utility of airway ultrasonography in predicting difficult airway in adult obese patients (BMI \\>30 kg\u002Fm²) scheduled for elective surgery under general anesthesia. Ultrasonographic measurements will include the distance from skin to hyoid bone (DSHB) at the level of the hyoid bone, the anterior neck soft tissue thickness at the thyrohyoid membrane level, and the hyomental distance ratio (HMDR). These parameters will be compared with conventional airway assessment tools and correlated with intraoperative Cormack-Lehane laryngoscopy grade and Han Scale mask ventilation score to determine their predictive value for difficult airway.",[66,67,31,68],"Obesity (BMI > 35)","Difficult Airway","Difficult Mask Ventilation",[70,71,72,73,74,75,76,77,78,79,80,81],"Airway ultrasonography","Difficult airway prediction","Obese patients","Cormack-Lehane classification","Han Scale","Hyomental distance ratio","Distance from skin to hyoid bone","Neck circumference","Mallampati score","STOP-BANG scale","General anesthesia","Orotracheal intubation","2026-04-09",{"date":84,"type":43},"2026-04-14",{"date":86,"type":22},"2026-04-10",{"date":88,"type":22},"2026-11",{"name":90,"class":50},"Fatih Sultan Mehmet Training and Research Hospital",{"id":92,"slug":93,"hasResults":11,"nctId":94,"briefTitle":95,"officialTitle":95,"acronym":4,"eligibilityCriteria":96,"healthyVolunteers":11,"sex":17,"minAge":59,"maxAge":97,"enrollmentInfo":98,"targetDuration":4,"studyType":63,"phases":4,"briefSummary":100,"conditions":101,"keywords":4,"overallStatus":103,"whyStopped":4,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":111,"locationsCount":51},"100616774","assessment-of-difficult-airway-predictors-a-prospective-comparison-of-upper-airway-ultrasound-and-conventional-anthropometric-measures-100616774","NCT07309978","Assessment Of Difficult Airway Predictors: A Prospective Comparison Of Upper Airway Ultrasound And Conventional Anthropometric Measures","Inclusion Criteria:\n\n* Adults aged 18-99 years\n* Patients scheduled for elective surgery under general anesthesia\n* ASA Physical Status I-III\n* Able to provide informed consent\n* Undergoing preoperative airway evaluation\n\nExclusion Criteria:\n\n* \\- Emergency surgery cases\n* Age \\\u003C18 years\n* ASA Physical Status IV-V\n* Pregnant or breastfeeding patients\n* Patients with limited cooperation or inability to provide consent\n* Known anatomical airway anomalies or previous major neck surgery","99 Years",{"count":99,"type":22},200,"This prospective observational study aims to evaluate whether upper airway ultrasound measurements can improve the prediction of difficult airway compared with conventional anthropometric assessments. Adult patients undergoing elective procedures requiring airway management will be included. Ultrasound parameters such as tongue thickness, anterior neck soft tissue thickness, and hyomental distance will be measured before airway intervention. Standard clinical predictors (Mallampati score, thyromental distance, neck circumference, etc.) will also be recorded. The primary objective is to determine the diagnostic accuracy of ultrasound-based measurements in predicting difficult laryngoscopy and intubation. The study seeks to provide evidence supporting the integration of upper airway ultrasound into routine pre-anesthetic airway evaluation.",[102,31],"Prediction of Difficult Airway","RECRUITING","2026-03-06",{"date":106,"type":43},"2026-03-10",{"date":108,"type":43},"2025-12-25",{"date":110,"type":22},"2027-12-25",{"name":112,"class":50},"Saglik Bilimleri Universitesi Gulhane Tip Fakultesi",{"id":114,"slug":115,"hasResults":11,"nctId":116,"briefTitle":117,"officialTitle":118,"acronym":119,"eligibilityCriteria":120,"healthyVolunteers":11,"sex":17,"minAge":59,"maxAge":4,"enrollmentInfo":121,"targetDuration":4,"studyType":63,"phases":4,"briefSummary":123,"conditions":124,"keywords":128,"overallStatus":103,"whyStopped":4,"lastUpdateSubmitDate":133,"lastUpdatePostDateStruct":134,"startDateStruct":136,"completionDateStruct":138,"leadSponsor":140,"locationsCount":51},"100591881","difficult-airway-incidence-in-cardiovascular-surgery-and-a-prediction-model-development-100591881","NCT06986187","Difficult Airway Incidence in Cardiovascular Surgery and a Prediction Model Development","Investigation of Difficult Airway and Difficult Intubation Incidence and Associated Factors in Patients Undergoing Cardiovascular Surgery and a Prediction Model Development","DAPCAP","Inclusion Criteria:\n\n* Undergoing cardiovascular surgery\n* ASA I-IV physical status\n* Over 18 years of age\n\nExclusion Criteria:\n\n* Known difficult airway\n* Head-neck and upper airway pathology\n* Patients at risk of aspiration",{"count":122,"type":22},2000,"A difficult airway is a clinical condition that occurs when one or more of the components of difficult mask ventilation, difficult laryngoscopy, difficult endotracheal intubation, difficult supraglottic airway device (SGA) placement, and inability to intubate-oxygenate are present. Data concerning incidence of difficult airway in patients undergoing cardiovascular surgery is controversial. Unwanted hemodynamic changes that may occur in patients undergoing cardiovascular surgery, combined with hemodynamic changes caused by underlying cardiac pathologies, may also lead to a physiologically difficult airway situation. Since all these interactions, combined with the hemodynamic changes caused by difficult airway interventions, may lead to catastrophic outcomes, it is vital to predict difficult airway in this patient population.",[31,67,125,126,127],"Difficult Intubation","Cardiac Surgery","Cardiac Surgery in Adult Patient",[129,130,131,132],"difficult intubation","difficult airway","difficult airway prediction","difficult airway prediction model","2026-02-03",{"date":135,"type":43},"2026-02-05",{"date":137,"type":43},"2025-06-01",{"date":139,"type":22},"2027-12-01",{"name":141,"class":50},"Diskapi Teaching and Research Hospital",{"id":143,"slug":144,"hasResults":11,"nctId":145,"briefTitle":146,"officialTitle":146,"acronym":4,"eligibilityCriteria":147,"healthyVolunteers":11,"sex":17,"minAge":148,"maxAge":149,"enrollmentInfo":150,"targetDuration":152,"studyType":63,"phases":4,"briefSummary":153,"conditions":154,"keywords":155,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":156,"lastUpdatePostDateStruct":157,"startDateStruct":159,"completionDateStruct":161,"leadSponsor":163,"locationsCount":51},"100614333","research-on-a-machine-learning-based-predictive-model-for-difficult-intubation-using-specific-vocal-characteristics-100614333","NCT07278232","Research on a Machine Learning-Based Predictive Model for Difficult Intubation Using Specific Vocal Characteristics","Inclusion Criteria:\n\n* Patients scheduled for elective general anesthesia with tracheal intubation.\n\nExclusion Criteria:\n\n* Patients with speech and pronunciation disorders (vocal cord diseases, cleft palate, craniofacial deformities, extensive tooth defects, cleft lip).\n* Hearing impairment (difficulty in communication, inaccurate repetition).\n* Patients with central nervous system diseases causing significant pronunciation abnormalities.\n* Patients contraindicated for direct laryngoscopy (e.g., post-chemotherapy in the pharynx, diseases prone to mucosal bleeding, etc.) that affect group allocation, as well as those unable to complete the recording or temporarily reassigned to other anesthesia methods.","15 Years","70 Years",{"count":151,"type":22},300,"1 Day","1. Study Purpose This research aims to develop a novel, non-invasive, and simple method to predict difficult intubation before surgery. The core idea is that the anatomy of a person's throat and mouth, which determines the ease of intubation, also uniquely shapes their voice.\n\n   By analyzing the acoustic features of specific vowel sounds using machine learning, we seek to identify voice patterns associated with difficult airways. The ultimate goal is to create a tool that allows for a quick, painless pre-operative risk assessment, enhancing patient safety by better preparing anesthesiologists.\n2. Study Design This is a prospective, observational, single-center study. It is purely observational and does not involve any changes to standard medical care or anesthesia procedures.\n3. Participants We plan to enroll 300 patients. Who can join: Patients aged 15-70 scheduled for elective surgery requiring general anesthesia with tracheal intubation. Who cannot join: Individuals with speech\u002Fhearing impairments, significant neurological diseases affecting speech, or conditions contraindicating standard laryngoscopy.\n4. Study Procedures For participants, the study involves one key procedure in addition to standard care:Voice Recording: Before surgery, participants will be asked to lie down and pronounce the vowels \"a,\" \"e,\" and \"i\" steadily for 1-2 seconds. This will be done twice: once with the head in a normal position and once with the head tilted back. A high-quality recorder will capture the sounds. This process is painless and takes only a few minutes. Standard anesthesia and intubation will then proceed as usual. The anesthesiologist will record the laryngeal view obtained during intubation, which will be used to classify the case as \"difficult\" or \"non-difficult\" for analysis.\n5. Data Analysis The primary goal is to determine if there are statistically significant differences in the key voice resonance frequencies (F1, F2, F3) between the difficult and non-difficult intubation groups. Advanced machine learning models will be built to create the predictive algorithm.\n6. Risks and Benefits Benefits: There is no direct medical benefit to participants. The contribution is to future medical knowledge and patient safety.\n\n   Risks: The study involves minimal risk. The voice recording is non-invasive and safe. The main risk is the potential loss of confidentiality, which is mitigated by strict data protection protocols.\n7. Confidentiality \\& Ethics All patient data will be de-identified and stored securely. The study protocol and informed consent form have been approved by the Institutional Ethics Committee of Shanghai Sixth People's Hospital. Participation is voluntary, and participants may withdraw at any time without affecting their medical care. Written informed consent will be obtained from every participant before any study procedures.",[31],[31],"2025-12-15",{"date":158,"type":43},"2025-12-19",{"date":160,"type":22},"2025-12-20",{"date":162,"type":22},"2026-12-31",{"name":164,"class":50},"Shanghai Jiao Tong University Affiliated Sixth People's Hospital",{"id":166,"slug":167,"hasResults":11,"nctId":168,"briefTitle":169,"officialTitle":170,"acronym":171,"eligibilityCriteria":172,"healthyVolunteers":11,"sex":17,"minAge":173,"maxAge":174,"enrollmentInfo":175,"targetDuration":4,"studyType":23,"phases":177,"briefSummary":178,"conditions":179,"keywords":181,"overallStatus":103,"whyStopped":4,"lastUpdateSubmitDate":184,"lastUpdatePostDateStruct":185,"startDateStruct":187,"completionDateStruct":189,"leadSponsor":191,"locationsCount":193},"100568620","sealion-study-on-supplemental-oxygenation-via-nasal-cannula-for-young-children-during-intubation-100568620","NCT06683599","SEALion: Study on Supplemental Oxygenation Via Nasal Cannula for Young Children During Intubation","SEALion: a Study on the Effectiveness of Additional Oxygenation in Little Children During Intubation Using Oxygenation Delivered by Nasal Cannula","SEALION","Inclusion Criteria:\n\n* Pediatric patients requiring oral or nasal tracheal intubation for elective, semi-elective, or urgent surgical and non-surgical procedures.\n* Neonates and infants up to 52 weeks post-conceptual age.\n* Written informed consent provided by legal guardians prior to the intervention.\n\nExclusion Criteria:\n\n* Prediction of difficult intubation based on physical examination or a history of previous difficult intubation.\n* Requirement for an alternative technique to direct laryngoscopy to secure the airway.\n* Specific conditions, such as congenital heart disease requiring FiO₂ \\\u003C 1.0, or cardiopulmonary collapse necessitating advanced life support and intubation for emergency surgical or non-surgical interventions.","1 Minute","52 Weeks",{"count":176,"type":22},240,[25],"Tracheal intubation in neonates can be technically challenging, even for experienced pediatric anesthesiologists, with a high first-attempt success rate crucial to ensure safety. Intubation, while life-saving for children with circulatory shock or respiratory failure, carries risks of severe desaturation that can lead to hypoxic encephalopathy, cardiac arrest, or death. Neonates, especially, are prone to hypoxemia due to high oxygen consumption, low functional residual capacity, small closing capacity, and increased risk of airway collapse, which is exacerbated under anesthesia and neuromuscular paralysis. Rapid desaturation occurs after cessation of ventilation, with neonates facing shorter apnea times before desaturation. Studies show that about two-thirds of neonates undergoing non-emergency nasotracheal intubation experience desaturation (SpO₂ \\\u003C80% for over 60 seconds), although low-flow oxygen supplementation (0.2 L\u002Fkg\u002Fmin) can extend safe apnea time.\n\nThis study aims to investigate apneic oxygenation with VL (using Miller or Macintosh blades size 0 or 1) in operating rooms or intensive care units. We hypothesize that supplemental oxygen and standardized VL use will improve first-pass success rates and reduce adverse events.",[67,31,180],"Neonate",[182,183,180],"Difficult intubation","Apneic oxygenation","2025-11-24",{"date":186,"type":43},"2025-11-25",{"date":188,"type":43},"2024-12-10",{"date":190,"type":22},"2026-12-01",{"name":192,"class":50},"Vinícius C Quintão, MD, MSc, PhD",3,{"id":195,"slug":196,"hasResults":11,"nctId":197,"briefTitle":198,"officialTitle":199,"acronym":200,"eligibilityCriteria":201,"healthyVolunteers":11,"sex":17,"minAge":202,"maxAge":59,"enrollmentInfo":203,"targetDuration":4,"studyType":63,"phases":4,"briefSummary":205,"conditions":206,"keywords":210,"overallStatus":103,"whyStopped":4,"lastUpdateSubmitDate":216,"lastUpdatePostDateStruct":217,"startDateStruct":218,"completionDateStruct":220,"leadSponsor":222,"locationsCount":51},"100611817","comparison-of-vidiac-pediac-and-intubation-difficulty-scale-in-pediatric-patients-undergoing-videolaryngoscopic-intubation-100611817","NCT07245511","Comparison of VIDIAC, PeDiAC and Intubation Difficulty Scale in Pediatric Patients Undergoing Videolaryngoscopic Intubation","A Prospective Observational Study Comparing the VIDIAC, PeDiAC, and Intubation Difficulty Scale (IDS) in Pediatric Patients Aged 5-18 Years Undergoing Tracheal Intubation With Videolaryngoscopy","VIDIPEDIDS","Eligible participants will be pediatric patients aged 5 to 18 years who are undergoing general anesthesia for any surgical procedure. All included patients must undergo tracheal intubation using a videolaryngoscope (C-MAC). Patients must have an ASA physical status classification of I to IV and written informed consent must be obtained from a parent or legal guardian prior to participation.\n\nInclusion Criteria:\n\n* Pediatric patients between 5 and 18 years of age\n* Undergoing general anesthesia for any type of surgical procedure\n* ASA physical status classification I to IV\n* Written informed consent obtained from parents or legal guardians\n\nExclusion Criteria:\n\n* Patients undergoing awake fiberoptic intubation\n* History of tracheal resection or reconstruction surgery\n* Refusal to participate or absence of informed consent","5 Years",{"count":204,"type":22},450,"This prospective observational study aims to evaluate three scoring systems (VIDIAC (Video Laryngoscopic Intubation and Difficult Airway Classification), PeDiAC (Pediatric Difficult Airway Classification), and the Intubation Difficulty Scale (IDS)).\n\nA total of 450 children undergoing general anesthesia with videolaryngoscopic intubation will be included in the study. Demographic data, intraoperative parameters, and glottic imaging, as well as detailed intubation-related variables such as total intubation time, number of attempts, complications, and subjective intubation ease scores will be recorded.",[29,207,208,31,209],"Intubation Difficulty Scale","Vidiac Score","Pediatric Anesthesia",[211,212,213,214,34,215],"intubation difficulty scale (IDS)","VIDIAC","PeDiAC","Pediatric anesthesia","airway management","2025-11-17",{"date":184,"type":43},{"date":219,"type":43},"2025-10-16",{"date":221,"type":22},"2026-04-15",{"name":223,"class":50},"Ankara City Hospital Bilkent"]