[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"difficult-airway\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:difficult-airway":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,16,0,[8,46,78,103,133,158,194,222,250,276,297,325,352,373,395,416],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100622505","high-flow-nasal-cannula-versus-conventional-oxygen-during-awake-tracheal-intubation-with-difficult-airways-100622505",false,"NCT07384494","High-flow Nasal Cannula Versus Conventional Oxygen During Awake Tracheal Intubation With Difficult Airways","High-Flow Nasal Cannula Versus Conventional Oxygen to Prevent Hypoxaemia During Awake Tracheal Intubation: A Multicentre, Open-Label, Randomised Controlled Trial (OXYOPTI-ATI)","Inclusion Criteria:\n\n* Presence of an anticipated difficult airway;\n* Planned awake tracheal intubation;\n* Age ≥ 18 years;\n* Willingness to participate in the study and provision of written informed consent.\n\nExclusion Criteria:\n\n* Contraindications to HFNC use, such as severe nasal obstruction or deformity, recent (within 3 months) nasal or skull base surgery, skull base fracture, or active epistaxis;\n* Hemodynamic instability, defined as a mean arterial pressure (MAP) \\\u003C 65 mmHg or the need for vasoactive medications to maintain blood pressure;\n* Pregnancy;\n* Current participation in another interventional clinical trial.","ALL","18 Years",{"count":19,"type":20},336,"ESTIMATED","INTERVENTIONAL",[23],"NA","Study Background Airway management is one of the most fundamental and critical technical procedures in anesthesiology, critical care, and emergency medicine. Difficult airway management remains a major challenge in these fields, particularly when a \"cannot intubate, cannot ventilate\" scenario occurs during the induction of general anesthesia. Such events can rapidly lead to hypoxemia, resulting in brain injury or even death, and have become a significant source of anesthesia-related severe complications and medical disputes.\n\nAwake tracheal intubation (ATI) is considered the gold standard for airway management in patients with anticipated difficult airways, as it preserves spontaneous breathing and thereby reduces the risk of catastrophic airway failure during anesthesia induction. However, despite routine supplemental oxygen administration, hypoxemia remains one of the most common and potentially serious complications during ATI. When low-flow oxygen therapy (\\\u003C30 L\u002Fmin) is used, the reported incidence of hypoxemia (SpO₂ ≤ 90%) ranges from 12% to 29%. Once hypoxemia occurs during ATI, it may not only interrupt the procedure, increase the number of intubation attempts, and reduce the likelihood of successful intubation, but also trigger serious cardiovascular events, thereby compromising patient safety.\n\nHigh-flow nasal cannula (HFNC) oxygen therapy can deliver heated and humidified gas at flow rates of up to 70 L\u002Fmin and improve oxygenation and ventilation through mechanisms such as anatomical dead space washout, reduction of work of breathing, and generation of continuous positive airway pressure. HFNC has been shown to improve oxygenation in a variety of medical and procedural settings. However, evidence regarding the role of HFNC during awake tracheal intubation remains controversial and of low quality. There is an urgent need for well-designed multicenter randomized controlled trials specifically focused on the ATI setting, using hypoxemic events as the primary outcome and applying strictly standardized procedures, to provide high-quality evidence on the effectiveness and safety of HFNC during ATI. Such evidence is essential to inform clinical practice and support future updates of airway management guidelines.\n\nStudy Hypothesis This study hypothesizes that, in patients with anticipated difficult airways undergoing ATI, HFNC is more effective in preventing intubation-related hypoxemic events than conventional low-flow nasal cannula oxygen therapy.\n\nStudy Objectives\n\nPrimary Objective:\n\nTo evaluate the effectiveness of high-flow nasal cannula oxygen therapy compared with conventional low-flow nasal cannula oxygen therapy in preventing hypoxemia during ATI in patients with anticipated difficult airways.\n\nSecondary Objectives:\n\nTo assess the effects of high-flow nasal cannula oxygen therapy versus conventional low-flow nasal cannula oxygen therapy on procedural outcomes of awake tracheal intubation, including the rate of interventions required after hypoxemia, first-attempt intubation success rate, number of intubation attempts, overall ATI success rate, intubation time, and the incidence of adverse events.\n\nStudy Methods This study is a multicenter, randomized controlled clinical trial. Adult patients undergoing ATI will be recruited from six tertiary hospitals in China. Participants will be randomly assigned to receive either high-flow nasal cannula oxygen therapy or conventional low-flow nasal cannula oxygen therapy throughout the intubation procedure. The study will compare the incidence of hypoxemia between the two groups and further evaluate intubation success rates, intubation time, the need for rescue interventions following hypoxemia, and the incidence of adverse events.",[26,27],"Awake Tracheal Intubation","Difficult Airway",[29,30,31,32],"Awake tracheal intubation","High-flow nasal cannula","Difficult airway","hypoxemia","RECRUITING","2026-06-08",{"date":36,"type":37},"2026-06-10","ACTUAL",{"date":39,"type":37},"2026-02-04",{"date":41,"type":20},"2026-12-31",{"name":43,"class":44},"Wenxian Li","OTHER",6,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":54,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":21,"phases":57,"briefSummary":58,"conditions":59,"keywords":63,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":73,"leadSponsor":75,"locationsCount":77},"100639898","mental-rehearsal-in-emergency-cricothyroidotomy-training-100639898","NCT07625072","Mental Rehearsal in Emergency Cricothyroidotomy Training","Effect of Mental Rehearsal Training on the Effectiveness of Emergency Cricothyroidotomy Training Among Medical Personnel.","MERIT","Inclusion Criteria:\n\n* Medical personnel, including anesthesiology and intensive care specialists, residents, and nursing staff employed within Anesthesiology and Intensive Care Departments of the Medical University of Warsaw network.\n* No prior experience with the use of Mental Rehearsal techniques in performing emergency cricothyroidotomy.\n* Informed consent.\n\nExclusion Criteria:\n\n* Medical personnel involved in the training process of study participants in emergency cricothyroidotomy, including instructors, assisting staff, and examiners.\n* Previous experience with the use of Mental Rehearsal techniques for acquiring competencies in performing emergency cricothyroidotomy.\n* Lack of informed consent.",true,{"count":56,"type":20},60,[23],"Medical staff at the clinic will participate in standard cricothyroidotomy training supplemented with structured mental rehearsal exercises in order to evaluate the usefulness and effectiveness of this approach as a training tool.",[27,60,61,62],"Medical Training","Airway Management","Cricothyroidotomy",[64,65,66,62,61,67],"Mental Rehearsal","Mental Training","eFONA (Emergency Front of Neck Airway)","Critical care","NOT_YET_RECRUITING","2026-06-01",{"date":71,"type":37},"2026-06-04",{"date":34,"type":20},{"date":74,"type":20},"2028-05-01",{"name":76,"class":44},"Medical University of Warsaw",1,{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":84,"eligibilityCriteria":85,"healthyVolunteers":54,"sex":16,"minAge":17,"maxAge":86,"enrollmentInfo":87,"targetDuration":4,"studyType":89,"phases":4,"briefSummary":90,"conditions":91,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":4},"100638681","effect-of-left-head-rotation-on-glottic-view-during-video-laryngoscopy-in-obese-adults-100638681","NCT07590739","Effect Of Left Head Rotation On Glottic View During Video Laryngoscopy In Obese Adults","Effect of Left Head Rotation Manoeuvre on Glottic View as Assessed With Percentage of Glottic Opening (POGO) Score During Video Laryngoscopy in Obese Adult Patients: A Prospective Observational Study","LeHeR","Inclusion Criteria\n\n* Adult patients aged 18-65 years\n* Body mass index (BMI) ≥30 kg\u002Fm²\n* ASA physical status I-III\n* Scheduled for elective surgical procedures under general anesthesia requiring endotracheal intubation\n\nExclusion Criteria:\n\n* Anticipated need for nasal intubation\n* Facial or upper airway pathology preventing laryngoscope insertion\n* Cervical spine instability or contraindication to head movement\n* Pregnant patients","65 Years",{"count":88,"type":20},50,"OBSERVATIONAL","This study aims to evaluate whether the Left Head Rotation (LeHeR) maneuver improves visualization of the vocal cords during video laryngoscopy in obese adult patients undergoing general anesthesia. Obesity is associated with increased difficulty in airway management due to excess upper airway soft tissue and altered anatomy, which may impair visualization during intubation.\n\nIn this prospective observational study, 50 adult patients with a body mass index (BMI) ≥30 kg\u002Fm² will undergo video laryngoscopy using a C-MAC D-blade. The glottic view will be assessed using the Percentage of Glottic Opening (POGO) score in the standard sniffing position and after rotating the head 45 degrees to the left (LeHeR maneuver). A difference in POGO score between the two positions will be analyzed.\n\nSecondary outcomes include ease of intubation, number of attempts, time to successful intubation, and occurrence of complications such as desaturation or airway trauma. The study is expected to determine whether the LeHeR maneuver is a simple and effective technique to improve airway visualization in obese patients.",[27,92],"Obesity Difficult Airway Airway Management","2026-05-08",{"date":95,"type":37},"2026-05-15",{"date":97,"type":20},"2026-05",{"date":99,"type":20},"2027-01",{"name":101,"class":102},"Royal Hospital, Oman","OTHER_GOV",{"id":104,"slug":105,"hasResults":11,"nctId":106,"briefTitle":107,"officialTitle":108,"acronym":4,"eligibilityCriteria":109,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":110,"targetDuration":4,"studyType":89,"phases":4,"briefSummary":112,"conditions":113,"keywords":119,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":125,"lastUpdatePostDateStruct":126,"startDateStruct":127,"completionDateStruct":129,"leadSponsor":131,"locationsCount":4},"100640762","effect-of-high-flow-nasal-oxygen-on-laryngoscopic-view-100640762","NCT07575776","Effect of High-Flow Nasal Oxygen on Laryngoscopic View","Effect of Different Flows Using High-Flow Nasal Oxygen (HFNO) on Laryngoscopic View Quality During Videolaryngoscopy","Inclusion Criteria:\n\n* Age ≥18 years\n* Scheduled for endotracheal intubation under general anesthesia\n* Use of videolaryngoscopy\n\nExclusion Criteria:\n\n* Anticipated difficult airway\n* Emergency intubation\n* Contraindications to HFNO\n* Inability to obtain adequate video recording",{"count":111,"type":20},150,"This prospective, multicenter observational study aims to evaluate the effect of different flow rates of high-flow nasal oxygen (HFNO) on the quality of the laryngoscopic view during videolaryngoscopy in adult patients undergoing general anesthesia. Each patient will serve as their own control, with repeated measurements obtained at three different HFNO flow settings (0, 40, and 60 L\u002Fmin). The study will assess objective and subjective parameters of glottic visualization using standardized scoring systems.",[114,115,116,117,27,118],"High Flow Nasal Canula","Laryngoscopy","Airway Anesthesia","Airway Complication of Anaesthesia","Difficult \u002F Failed Intubation",[120,121,122,123,124],"high flow nasal canula","thrive","difficult airway","airway management","anaesthesia","2026-05-04",{"date":93,"type":37},{"date":128,"type":20},"2026-09-01",{"date":130,"type":20},"2027-12-01",{"name":132,"class":44},"Masarykova Nemocnice v Usti nad Labem, Krajska Zdravotni a.s.",{"id":134,"slug":135,"hasResults":11,"nctId":136,"briefTitle":137,"officialTitle":138,"acronym":139,"eligibilityCriteria":140,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":141,"targetDuration":4,"studyType":89,"phases":4,"briefSummary":143,"conditions":144,"keywords":145,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":150,"lastUpdatePostDateStruct":151,"startDateStruct":153,"completionDateStruct":154,"leadSponsor":156,"locationsCount":77},"100635073","tmh-and-ultrasound-for-difficult-airway-prediction-100635073","NCT07547943","TMH And Ultrasound For Difficult Airway Prediction","Comparative Evaluation Of Thyromental Height And Ultrasonographic Airway Measurements In Predicting Difficult Airway: A Prospective Observational Study","TMH-USG","Inclusion Criteria:\n\nAdult patients aged 18 years and older Patients scheduled for elective surgery under general anesthesia Patients requiring endotracheal intubation Patients who provide written informed consent\n\nExclusion Criteria:\n\n* Patients with known upper airway pathology (e.g., tumor, trauma, infection) Patients with previous head and neck surgery or anatomical deformity affecting airway evaluation Patients with limited mouth opening (\\\u003C3 cm) or severe cervical spine restriction Patients with contraindications to ultrasonographic examination Patients requiring rapid sequence induction or emergency surgery Patients who refuse to participate",{"count":142,"type":20},240,"This prospective observational study aims to evaluate the predictive value of thyromental height (TMH) and ultrasonographic airway measurements in predicting difficult airway in adult patients undergoing elective surgery under general anesthesia.\n\nPreoperative airway assessment will include standard clinical evaluation, TMH measurement, and ultrasonographic measurements of anterior neck soft tissue. Perioperative airway management data, including intubation difficulty, number of attempts, and Cormack-Lehane classification, will be recorded.\n\nThe relationship between preoperative measurements and difficult airway will be analyzed to determine their predictive accuracy and clinical usefulness.",[27,61],[146,147,148,149],"Thyromental Height","Airway Ultrasound","Difficult Intubation","Cormack-Lehane","2026-04-17",{"date":152,"type":37},"2026-04-23",{"date":95,"type":20},{"date":155,"type":20},"2027-05-15",{"name":157,"class":102},"Bursa City Hospital",{"id":159,"slug":160,"hasResults":11,"nctId":161,"briefTitle":162,"officialTitle":163,"acronym":4,"eligibilityCriteria":164,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":86,"enrollmentInfo":165,"targetDuration":4,"studyType":89,"phases":4,"briefSummary":167,"conditions":168,"keywords":172,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":185,"lastUpdatePostDateStruct":186,"startDateStruct":188,"completionDateStruct":190,"leadSponsor":192,"locationsCount":77},"100633591","ultrasound-vs-clinical-parameters-for-difficult-airway-prediction-in-obesity-100633591","NCT07528677","Ultrasound vs Clinical Parameters for Difficult Airway Prediction in Obesity","Comparison of Airway Ultrasonography and Conventional Difficult Airway Parameters for Predicting Difficult Airway in Obese Patients: A Prospective Observational Study","Inclusion Criteria:\n\n* Age 18-65 years\n* BMI \\>30 kg\u002Fm2\n* ASA physical status I, II, or III\n* Scheduled for elective surgery requiring orotracheal intubation under general anesthesia\n* Written informed consent obtained\n\nExclusion Criteria:\n\n* Emergency surgery\n* History of previous head and neck surgery or radiotherapy\n* Known or anticipated difficult airway (history of difficult intubation)\n* Presence of cervical spine pathology or limited neck mobility\n* Presence of oropharyngeal or laryngeal pathology\n* Pregnancy\n* Patients with tracheostomy\n* Refusal to participate",{"count":166,"type":20},70,"Obesity is associated with anatomical changes in the upper airway that increase the risk of difficult laryngoscopy and difficult mask ventilation during anesthesia. Conventional airway assessment parameters such as Mallampati score, neck circumference, and STOP-BANG scale are widely used but have limited predictive accuracy in obese patients. Airway ultrasonography has emerged as a promising non-invasive tool for difficult airway prediction; however, ultrasonographic criteria have not yet been standardized.\n\nThis prospective observational study aims to evaluate the utility of airway ultrasonography in predicting difficult airway in adult obese patients (BMI \\>30 kg\u002Fm²) scheduled for elective surgery under general anesthesia. Ultrasonographic measurements will include the distance from skin to hyoid bone (DSHB) at the level of the hyoid bone, the anterior neck soft tissue thickness at the thyrohyoid membrane level, and the hyomental distance ratio (HMDR). These parameters will be compared with conventional airway assessment tools and correlated with intraoperative Cormack-Lehane laryngoscopy grade and Han Scale mask ventilation score to determine their predictive value for difficult airway.",[169,27,170,171],"Obesity (BMI > 35)","Difficult Airway Intubation","Difficult Mask Ventilation",[173,174,175,176,177,178,179,180,181,182,183,184],"Airway ultrasonography","Difficult airway prediction","Obese patients","Cormack-Lehane classification","Han Scale","Hyomental distance ratio","Distance from skin to hyoid bone","Neck circumference","Mallampati score","STOP-BANG scale","General anesthesia","Orotracheal intubation","2026-04-09",{"date":187,"type":37},"2026-04-14",{"date":189,"type":20},"2026-04-10",{"date":191,"type":20},"2026-11",{"name":193,"class":44},"Fatih Sultan Mehmet Training and Research Hospital",{"id":195,"slug":196,"hasResults":11,"nctId":197,"briefTitle":198,"officialTitle":199,"acronym":4,"eligibilityCriteria":200,"healthyVolunteers":54,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":201,"targetDuration":4,"studyType":21,"phases":203,"briefSummary":204,"conditions":205,"keywords":209,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":213,"lastUpdatePostDateStruct":214,"startDateStruct":216,"completionDateStruct":218,"leadSponsor":220,"locationsCount":77},"100629137","comparative-study-between-combined-video-laryngoscope-and-video-stylet-intubation-versus-combined-video-laryngoscope-and-fiberoptic-intubation-in-a-simulated-difficult-airway-100629137","NCT07470736","Comparative Study Between Combined Video Laryngoscope and Video Stylet Intubation Versus Combined Video Laryngoscope and Fiberoptic Intubation in a Simulated Difficult Airway","Comparative Study Between Combined Video Laryngoscope and Video Stylet Intubation Versus Combined Video Laryngoscope and Fiberoptic Intubation","Inclusion Criteria:\n\n* the anaesthesiology medical officers who have at least more than two years of experience.\n\nExclusion Criteria:\n\n* Thsoe who has severe hand tremors.",{"count":202,"type":20},75,[23],"This study titled \"Comparative Study Between Combined Video Laryngoscope and Video Stylet Intubation Versus Combined Video Laryngoscope and Fibreoptic Intubation in a Simulated Difficult Airway\" aims to evaluate and compare two advanced intubation techniques used in managing difficult airways. Currently, there is no study in Malaysia that compares the combination of a video laryngoscope (VL) with a video stylet (VS) and the combination of VL with a fibreoptic bronchoscope (FOB). Although both methods have been investigated separately, direct comparisons in simulated difficult airway settings are limited. The findings of this study will help guide airway management protocols and improve clinical outcomes in challenging airway situations.\n\nThis is a single-centre, randomized comparative crossover trial conducted at the Department of Anaesthesiology and Intensive Care, HCTM, UKM. Ethical approval will be obtained from the departmental and university ethics committees prior to commencement. The study population will consist of anaesthesiology medical officers with at least two years of experience and anaesthesiology trainees in their second to fourth year of training at HCTM, UKM. Participants with severe hand tremors or those who decline participation will be excluded.\n\nThe main objectives are to compare the first-pass intubation success rate, time to successful intubation, and operator-rated ease of intubation between the two combined techniques. Each participant will perform both VL with VS and VL with FOB intubations in a simulated difficult airway scenario. The study hypothesizes that the combined VL with VS technique will provide superior performance, a higher first-pass success rate, shorter intubation time, and greater ease of use compared to the VL with FOB technique.\n\nParticipants who fail to complete all procedures or withdraw after participation will be considered dropouts. The results from this study are expected to provide useful insights into the effectiveness and practicality of these two combination techniques for airway management training and clinical application.",[206,207,27,208],"Video Laryngoscope","Airway","Fiberoptic Guided Intubation",[210,211,212,207],"Video laryngoscope","Video sylet intubation","Simulated difficult airway","2026-03-13",{"date":215,"type":37},"2026-03-17",{"date":217,"type":37},"2026-02-26",{"date":219,"type":20},"2028-03-14",{"name":221,"class":44},"National University of Malaysia",{"id":223,"slug":224,"hasResults":11,"nctId":225,"briefTitle":226,"officialTitle":227,"acronym":4,"eligibilityCriteria":228,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":86,"enrollmentInfo":229,"targetDuration":4,"studyType":89,"phases":4,"briefSummary":231,"conditions":232,"keywords":237,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":241,"lastUpdatePostDateStruct":242,"startDateStruct":244,"completionDateStruct":246,"leadSponsor":248,"locationsCount":77},"100617250","predicting-difficult-intubation-in-bariatric-surgery-comparison-of-el-ganzouri-risk-index-and-airway-ultrasound-100617250","NCT07316179","Predicting Difficult Intubation in Bariatric Surgery: Comparison of El Ganzouri Risk Index and Airway Ultrasound","A Prospective Observational Study Comparing the El Ganzouri Risk Index and Airway Ultrasonography in Predicting Difficult Intubation in Patients Undergoing Bariatric Surgery","Inclusion Criteria:\n\n* Adult patients aged 18 to 65 years.\n* ASA physical status classification II or III.\n* Scheduled to undergo elective bariatric surgery under general anesthesia.\n* Patients who voluntarily agree to participate in the study and sign the informed consent form.\n\nExclusion Criteria:\n\n* Patients younger than 18 years or older than 65 years\n* Presence of upper airway anatomical pathology\n* History of tracheal or thyroid surgery.\n* History of radiotherapy to the head and neck region.\n* Cervical spine anomalies.\n\nIndividuals unwilling to participate in the study.",{"count":230,"type":20},52,"This study is designed as a prospective observational study and will be conducted at the Health Sciences University Antalya Training and Research Hospital. Adult patients scheduled to undergo bariatric surgery will be included.\n\nThe aim of this study is to compare the El Ganzouri Risk Index (EGRI) and airway ultrasonography (USG) parameters in predicting difficult intubation and to evaluate their relationship with the Cormack-Lehane (CL) score obtained during direct laryngoscopy.\n\nBefore surgery, each participant will be evaluated using both the EGRI scoring system and airway USG. During general anesthesia, tracheal intubation will be performed using direct laryngoscopy, and data including the CL score, intubation time, number of attempts, and the need for videolaryngoscopy will be recorded based on the anesthesiologist's observations.\n\nThe collected data will be analyzed by classifying participants according to the presence or absence of difficult intubation, and statistical comparisons will be performed between EGRI scores and airway ultrasonography parameters. The results of this study may contribute to improved preoperative airway assessment and enhanced patient safety in bariatric surgery.",[233,92,234,27,235,236],"Obesity & Overweight","Obesity (Disorder)","Difficult Intubation in Obesity","Difficult Laryngoscopy",[238,31,239,240,61],"El Ganzouri Risk Index","Obesity","Airway Ultrasonography","2026-03-06",{"date":243,"type":37},"2026-03-09",{"date":245,"type":37},"2025-12-25",{"date":247,"type":20},"2026-07-28",{"name":249,"class":102},"Antalya Training and Research Hospital",{"id":251,"slug":252,"hasResults":11,"nctId":253,"briefTitle":254,"officialTitle":255,"acronym":256,"eligibilityCriteria":257,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":258,"targetDuration":4,"studyType":89,"phases":4,"briefSummary":260,"conditions":261,"keywords":264,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":268,"lastUpdatePostDateStruct":269,"startDateStruct":271,"completionDateStruct":273,"leadSponsor":274,"locationsCount":77},"100591881","difficult-airway-incidence-in-cardiovascular-surgery-and-a-prediction-model-development-100591881","NCT06986187","Difficult Airway Incidence in Cardiovascular Surgery and a Prediction Model Development","Investigation of Difficult Airway and Difficult Intubation Incidence and Associated Factors in Patients Undergoing Cardiovascular Surgery and a Prediction Model Development","DAPCAP","Inclusion Criteria:\n\n* Undergoing cardiovascular surgery\n* ASA I-IV physical status\n* Over 18 years of age\n\nExclusion Criteria:\n\n* Known difficult airway\n* Head-neck and upper airway pathology\n* Patients at risk of aspiration",{"count":259,"type":20},2000,"A difficult airway is a clinical condition that occurs when one or more of the components of difficult mask ventilation, difficult laryngoscopy, difficult endotracheal intubation, difficult supraglottic airway device (SGA) placement, and inability to intubate-oxygenate are present. Data concerning incidence of difficult airway in patients undergoing cardiovascular surgery is controversial. Unwanted hemodynamic changes that may occur in patients undergoing cardiovascular surgery, combined with hemodynamic changes caused by underlying cardiac pathologies, may also lead to a physiologically difficult airway situation. Since all these interactions, combined with the hemodynamic changes caused by difficult airway interventions, may lead to catastrophic outcomes, it is vital to predict difficult airway in this patient population.",[170,27,148,262,263],"Cardiac Surgery","Cardiac Surgery in Adult Patient",[265,122,266,267],"difficult intubation","difficult airway prediction","difficult airway prediction model","2026-02-03",{"date":270,"type":37},"2026-02-05",{"date":272,"type":37},"2025-06-01",{"date":130,"type":20},{"name":275,"class":44},"Diskapi Teaching and Research Hospital",{"id":277,"slug":278,"hasResults":11,"nctId":279,"briefTitle":280,"officialTitle":281,"acronym":4,"eligibilityCriteria":282,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":283,"targetDuration":284,"studyType":89,"phases":4,"briefSummary":285,"conditions":286,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":288,"lastUpdatePostDateStruct":289,"startDateStruct":291,"completionDateStruct":293,"leadSponsor":295,"locationsCount":4},"100617876","validation-of-end-to-end-difficult-airway-pathway-planning-algorithm-eap-lc-100617876","NCT07324317","Validation of End-to-End Difficult Airway Pathway Planning Algorithm (EAP-LC)","A Prospective Clinical Validation Study of an End-to-End Difficult Airway Pathway Planning Algorithm (EAP-LC) in Patients With Laryngeal Cancer: A Spatial Consistency Assessment Based on Awake Flexible Bronchoscopic Intubation Videos","Inclusion Criteria:\n\n* Patients scheduled to undergo laryngeal cancer surgery under general anesthesia, including supraglottic, glottic, and subglottic laryngeal cancers, as well as lesions involving the hypopharynx-larynx junction, who are assessed preoperatively as requiring awake flexible bronchoscopic intubation. Eligible participants must meet all of the following criteria: age ≥ 18 years, with no restriction on sex; a confirmed diagnosis of laryngeal cancer or laryngeal tumor based on previous or preoperative imaging and\u002For pathological findings; a planned laryngeal surgical procedure; a preoperative anesthetic assessment indicating the need for awake flexible bronchoscopic intubation to ensure airway safety; completion of contrast-enhanced laryngeal and\u002For cervical computed tomography (CT) within 2 weeks prior to surgery, with image quality adequate for analysis by the EAP-LC algorithm; clear consciousness, the ability to understand the study procedures, and voluntary provision of written informed consent.\n\nExclusion Criteria:\n\n* Patients will be excluded if they meet any of the following conditions: inability to cooperate with awake intubation due to severe anxiety, cognitive impairment, or psychiatric disorders; a history of total laryngectomy or loss of normal laryngeal anatomical structures that precludes oral or nasal flexible bronchoscopic intubation; severe coagulation disorders or an uncontrollable risk of bleeding; or any other condition deemed by the investigators to make participation inappropriate, such as refusal of video recording or special confidentiality requirements.",{"count":166,"type":20},"1 Day","Patients with laryngeal cancer often present with varying degrees of airway narrowing or anatomical distortion, making airway management particularly challenging. Awake flexible bronchoscopic intubation is a widely accepted and important strategy to ensure airway safety in this population. Currently, the selection of the intubation pathway mainly relies on visual assessment of preoperative computed tomography (CT) images and the clinical experience of anesthesiologists, lacking objective and quantifiable tools for airway pathway planning.\n\nOur research group has developed an end-to-end airway pathway planning algorithm for laryngeal cancer patients (EAP-LC), which can automatically generate predicted nasal or oral intubation pathways based on preoperative pharyngeal and upper airway CT images. Preliminary simulation analyses based on retrospective CT data demonstrated that the algorithm is capable of identifying airway narrowing and generating trajectories that are close to clinically feasible intubation paths (preliminary data, under review). However, to date, no study has directly compared the algorithm-predicted pathways with actual intubation trajectories obtained during awake flexible bronchoscopic intubation. Therefore, a prospective clinical validation study is required to evaluate the spatial consistency and clinical feasibility of the EAP-LC algorithm.\n\nWithout altering routine clinical treatment or anesthetic management, this study aims to evaluate the clinical accuracy, safety, and feasibility of the EAP-LC algorithm by comparing the intubation pathways predicted from preoperative CT images with the real-world trajectories recorded during awake flexible bronchoscopic intubation. The results of this study are expected to provide a more precise and objective decision-support tool for airway management in patients with laryngeal cancer.",[287,27],"Laryngeal Cancer","2025-12-24",{"date":290,"type":37},"2026-01-07",{"date":292,"type":20},"2026-01-01",{"date":294,"type":20},"2026-06-30",{"name":296,"class":44},"Eye & ENT Hospital of Fudan University",{"id":298,"slug":299,"hasResults":11,"nctId":300,"briefTitle":301,"officialTitle":302,"acronym":303,"eligibilityCriteria":304,"healthyVolunteers":11,"sex":16,"minAge":305,"maxAge":306,"enrollmentInfo":307,"targetDuration":4,"studyType":21,"phases":308,"briefSummary":309,"conditions":310,"keywords":312,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":315,"lastUpdatePostDateStruct":316,"startDateStruct":318,"completionDateStruct":320,"leadSponsor":322,"locationsCount":324},"100568620","sealion-study-on-supplemental-oxygenation-via-nasal-cannula-for-young-children-during-intubation-100568620","NCT06683599","SEALion: Study on Supplemental Oxygenation Via Nasal Cannula for Young Children During Intubation","SEALion: a Study on the Effectiveness of Additional Oxygenation in Little Children During Intubation Using Oxygenation Delivered by Nasal Cannula","SEALION","Inclusion Criteria:\n\n* Pediatric patients requiring oral or nasal tracheal intubation for elective, semi-elective, or urgent surgical and non-surgical procedures.\n* Neonates and infants up to 52 weeks post-conceptual age.\n* Written informed consent provided by legal guardians prior to the intervention.\n\nExclusion Criteria:\n\n* Prediction of difficult intubation based on physical examination or a history of previous difficult intubation.\n* Requirement for an alternative technique to direct laryngoscopy to secure the airway.\n* Specific conditions, such as congenital heart disease requiring FiO₂ \\\u003C 1.0, or cardiopulmonary collapse necessitating advanced life support and intubation for emergency surgical or non-surgical interventions.","1 Minute","52 Weeks",{"count":142,"type":20},[23],"Tracheal intubation in neonates can be technically challenging, even for experienced pediatric anesthesiologists, with a high first-attempt success rate crucial to ensure safety. Intubation, while life-saving for children with circulatory shock or respiratory failure, carries risks of severe desaturation that can lead to hypoxic encephalopathy, cardiac arrest, or death. Neonates, especially, are prone to hypoxemia due to high oxygen consumption, low functional residual capacity, small closing capacity, and increased risk of airway collapse, which is exacerbated under anesthesia and neuromuscular paralysis. Rapid desaturation occurs after cessation of ventilation, with neonates facing shorter apnea times before desaturation. Studies show that about two-thirds of neonates undergoing non-emergency nasotracheal intubation experience desaturation (SpO₂ \\\u003C80% for over 60 seconds), although low-flow oxygen supplementation (0.2 L\u002Fkg\u002Fmin) can extend safe apnea time.\n\nThis study aims to investigate apneic oxygenation with VL (using Miller or Macintosh blades size 0 or 1) in operating rooms or intensive care units. We hypothesize that supplemental oxygen and standardized VL use will improve first-pass success rates and reduce adverse events.",[27,170,311],"Neonate",[313,314,311],"Difficult intubation","Apneic oxygenation","2025-11-24",{"date":317,"type":37},"2025-11-25",{"date":319,"type":37},"2024-12-10",{"date":321,"type":20},"2026-12-01",{"name":323,"class":44},"Vinícius C Quintão, MD, MSc, PhD",3,{"id":326,"slug":327,"hasResults":11,"nctId":328,"briefTitle":329,"officialTitle":330,"acronym":4,"eligibilityCriteria":331,"healthyVolunteers":54,"sex":16,"minAge":17,"maxAge":86,"enrollmentInfo":332,"targetDuration":334,"studyType":89,"phases":4,"briefSummary":335,"conditions":336,"keywords":341,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":344,"lastUpdatePostDateStruct":345,"startDateStruct":347,"completionDateStruct":348,"leadSponsor":350,"locationsCount":77},"100584073","determination-of-the-frequency-and-predictors-of-difficult-intubation-in-septoplasty-operations-100584073","NCT06884592","Determination of the Frequency and Predictors of Difficult Intubation in Septoplasty Operations","Determination of the Incidence of Difficult Intubation and Predictive Factors in Patients Undergoing Nasal Septum Deviation Surgery.","Inclusion Criteria:\n\n* Consenting patients,\n* ASA-I-II\n* Between the ages of 18 and 65,\n* Difficult intubation and no history of facial trauma or congenital craniofacial deformity\n* Patients with easy mask ventilation during the procedure\n* Nasal obstruction due to deviated nasal septum,\n* Patients who will receive general anaesthesia and undergo septoplasty surgery\n\nExclusion Criteria:\n\n* Patients without consent\n* Not in the appropriate age range,\n* Patients who do not receive general anaesthesia and will not undergo septoplasty surgery,\n* ASA-IV-V with ,\n* Difficult intubation and a history of facial trauma or congenital craniofacial deformity\n* Patients with easy mask ventilation during the procedure",{"count":333,"type":20},300,"2 Days","Deviated septum is among the most prevalent etiologies of nasal obstruction. Congenital or acquired deformities of the nasal septum have been demonstrated to result in partial obstruction of the airflow, thereby causing respiratory distress. Furthermore, studies have indicated a potential correlation between nasal congestion and Obstructive Sleep Apnoea Syndrome (OSAS). It is a well-documented phenomenon that patients suffering from nasal obstruction often exhibit an open mouth during sleep, a condition that has been shown to result in the narrowing of the pharyngeal lumen and the subsequent development of sleep-related breathing disorders, including snoring and sleep apnoea. Surgical intervention to correct a deviated nasal septum (commonly referred to as septoplasty) has been shown to reduce upper airway resistance by enhancing airflow, leading to a reduction in the severity of both snoring and OSAS. Numerous studies have demonstrated a robust correlation between a deviated nasal septum and asymmetric facial growth, including maxillary and mandibular abnormalities. While septoplasty is considered a minor surgical procedure with a low anaesthetic risk, concomitant obstructive sleep apnoea syndrome (OSAS) and facial asymmetry have been demonstrated to be associated with an increased risk of difficult intubation. Consequently, the development of preoperative assessment tests to predict difficult intubation is imperative for effective planning of the necessary preoperative preparation when such complications are anticipated. The present study therefore sought to evaluate the incidence of difficult airway in patients undergoing septoplasty. The secondary aim was to determine the predictive factors associated with difficult airway in patients undergoing septoplasty.",[337,338,27,339,340],"Nasal Septum, Irregular","Nasal Septal Defect","Difficult Endotracheal Intubation","Predicted Difficult Airway",[342,343,27,340],"Septoplasty","Nasal Septum Deviation","2025-05-28",{"date":346,"type":37},"2025-05-31",{"date":344,"type":37},{"date":349,"type":20},"2026-05-30",{"name":351,"class":102},"Başakşehir Çam & Sakura City Hospital",{"id":353,"slug":354,"hasResults":11,"nctId":355,"briefTitle":356,"officialTitle":356,"acronym":4,"eligibilityCriteria":357,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":358,"targetDuration":4,"studyType":89,"phases":4,"briefSummary":360,"conditions":361,"keywords":362,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":366,"lastUpdatePostDateStruct":367,"startDateStruct":369,"completionDateStruct":370,"leadSponsor":371,"locationsCount":77},"100591570","ai-based-prediction-model-of-difficult-tracheal-intubation-using-medical-image-parameters-100591570","NCT06982144","AI-based Prediction Model of Difficult Tracheal Intubation Using Medical Image Parameters","Inclusion Criteria:\n\n1. age ≥18 years old;\n2. surgical patients undergoing general anesthesia with endotracheal intubation;\n3. with head and neck CT examination results\n4. Consent to participate in the study.\n\nExclusion Criteria:\n\n1. The presence of laryngeal edema;\n2. The presence of airway stenosis, including internal airway stenosis (such as foreign body or tumor) or stenosis caused by external tracheal mass compression;\n3. tracheo-esophageal fistula;\n4. severe gastroesophageal reflux;\n5. previous upper airway surgery, such as laryngeal cancer radical surgery, snoring surgery, etc.\n\n6）participating in other research projects",{"count":359,"type":20},228,"Difficult airway is a life-threatening event during anesthesia. Prediction model is helpful to detect high-risk patients and decrease the risk of un-anticipated difficult airway. Present models are usually based on Mallampati grade and the width of mouth open. However, the prediction accuracy is only about 0.7-0.8 in different populations. Present study is designed to investigate if AI-based prediction model using medical imaging parameters (such as CT and MRI) can increase the accuracy of prediction model.",[27],[122,363,364,365],"AI-based method","medical imaging","prediction model","2025-05-20",{"date":368,"type":37},"2025-05-21",{"date":366,"type":20},{"date":349,"type":20},{"name":372,"class":44},"Mu Dong Liang",{"id":374,"slug":375,"hasResults":11,"nctId":376,"briefTitle":377,"officialTitle":377,"acronym":4,"eligibilityCriteria":378,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":379,"targetDuration":4,"studyType":89,"phases":4,"briefSummary":381,"conditions":382,"keywords":384,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":386,"lastUpdatePostDateStruct":387,"startDateStruct":389,"completionDateStruct":391,"leadSponsor":393,"locationsCount":77},"100495822","comparison-of-two-sedation-regimens-for-awake-fiberoptic-intubation-100495822","NCT05736198","Comparison of Two Sedation Regimens for Awake Fiberoptic Intubation","Inclusion Criteria:\n\n* Subjects with potentially difficult airways who require awake fiberoptic intubations will be identified from the OR schedule and the pre-operative clinic workups.\n\nExclusion Criteria:\n\n* Anyone who does not meet the inclusion criteria",{"count":380,"type":20},96,"The purpose of this study is to examine the effects of different sedation drugs used for the awake fiberoptic intubation procedure. Benzodiazapines and narcotics (such as midazolam and fentanyl) are standard drugs used for sedation during awake fiberoptic intubation. Dexmedetomidine, midazolam, and fentanyl are approved by the Food and Drug Administration (FDA) procedural sedation. These drugs might be given to the patient regardless of their participation in the study.\n\nIn addition to midazolam and fentanyl study subjects will also receive either dexmedetomidine or a placebo (a salt solution that contains no drug). It is believed that dexmedetomidine will not slow down breathing as much as the combination of the valium-like drug and narcotic. In our study, we are trying to determine if this is the best drug for sedation during an awake fiberoptic procedure.",[383,27],"Awake Fiberoptic Intubation",[385],"Dexmedetomidine","2024-11-26",{"date":388,"type":37},"2024-11-29",{"date":390,"type":37},"2024-08-12",{"date":392,"type":20},"2034-03-01",{"name":394,"class":44},"University of Illinois at Chicago",{"id":396,"slug":397,"hasResults":11,"nctId":398,"briefTitle":399,"officialTitle":399,"acronym":4,"eligibilityCriteria":400,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":401,"enrollmentInfo":402,"targetDuration":4,"studyType":21,"phases":403,"briefSummary":404,"conditions":405,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":408,"lastUpdatePostDateStruct":409,"startDateStruct":411,"completionDateStruct":412,"leadSponsor":414,"locationsCount":77},"100562274","sevoflurane-sedation-as-an-alternative-for-awake-fiberoptic-intubation-in-difficult-airway-patients-100562274","NCT06601036","Sevoflurane Sedation as an Alternative for Awake Fiberoptic Intubation in Difficult Airway Patients","Inclusion Criteria:\n\n* Age from 18 to 50 years.\n* Both sexes.\n* American Society of Anesthesiology (ASA) physical status I-II.\n* Patients with difficult airway (Mallampati grade 3 and 4 with mouth opening less than 5 cm).\n\nExclusion Criteria:\n\n* Patient refusal.\n* Patients with bleeding disorders and nasal mass.\n* Allergy or intolerance to one of the study medications.\n* Patients with uncontrolled systemic diseases.\n* patients with gastro-esophageal reflex.\n* history of nasopharyngeal surgery or drug abuse.","50 Years",{"count":166,"type":20},[23],"The aim of this study is to compare patient satisfaction and intubating conditions with fiber optic intubation under sevoflurane sedation versus airway blocks in difficult airway patients",[406,407,383,27],"Sevoflurane","Sedation","2024-09-17",{"date":410,"type":37},"2024-09-19",{"date":408,"type":37},{"date":413,"type":20},"2025-02-01",{"name":415,"class":44},"Tanta University",{"id":417,"slug":418,"hasResults":11,"nctId":419,"briefTitle":420,"officialTitle":421,"acronym":4,"eligibilityCriteria":422,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":423,"targetDuration":4,"studyType":89,"phases":4,"briefSummary":425,"conditions":426,"keywords":429,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":432,"lastUpdatePostDateStruct":433,"startDateStruct":435,"completionDateStruct":437,"leadSponsor":439,"locationsCount":441},"100555638","postoperative-memories-and-level-of-sedation-for-tracheal-intubation-using-fiberoptic-bronchoscopyvideolaryngoscopy-100555638","NCT06514690","Postoperative Memories and Level of Sedation for Tracheal Intubation Using Fiberoptic Bronchoscopy\u002FVideolaryngoscopy","Postoperative Memories and Optimal Level of Sedation for Tracheal Intubation Using Fiberoptic Bronchoscopy\u002FVidolaryngoscopy in Patients With Anticipated Difficult Airway Undergoing Surgery","Inclusion Criteria:\n\n* Patients older than 18 years\n* Patients undergoing surgery\n* Patients with predicted difficult airway\n\nExclusion Criteria:\n\n* Patients under 18 years of age\n* Patients without cognitive disorders",{"count":424,"type":20},100,"Antecedentes In patients with expected difficult airways undergoing surgery, tracheal intubation must be performed with a fiberoptic bronchoscope or video laryngoscope while keeping the patient awake and under the effects of anesthetic sedation.\n\nObjective: To determine and compare the existence of postoperative memories of the patients and the different levels of sedation (Ramsay scale) obtained during the intubation procedure.\n\nMethods Prospective observational study that includes 100 patients older than 18 years who are going to undergo surgery, who need fiberoptic bronchoscopy\u002Fvideolaryngoscopy for tracheal intubation due to the planned difficult airway and intravenous sedation. Patients with an unexpected difficult airway, under 18 years of age and\u002For with cognitive impairment will be excluded. After checking the tracheal intubation, the general anesthesia indicated for each patient will be used.\n\nTwenty-four hours after tracheal extubation, the patient will be questioned about the pain presented during the fiberoptic bronchoscopic\u002Fvideolaryngoscopic procedure and postoperative memories based on a modified Brice questionnaire. At 30 days after surgery, the postoperative memories of the patients will be evaluated again by telephone interview.",[27,427,428],"Postoperative Memories","Tracheal Intubation",[430,431,122],"postoperative memories","tracheal intubation","2024-08-11",{"date":434,"type":37},"2024-08-13",{"date":436,"type":37},"2023-04-29",{"date":438,"type":20},"2025-05-29",{"name":440,"class":44},"Hospital Universitari Vall d'Hebron Research Institute",2]