[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"diffusion-mri\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:diffusion-mri":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,43],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":17,"targetDuration":20,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":26,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100612107","mr-microstructural-imaging-for-prostate-cancer-diagnosis-100612107",false,"NCT07249281","MR Microstructural Imaging for Prostate Cancer Diagnosis","Development of MR Microstructural Imaging Markers for Prostate Cancer Diagnosis and Investigation of the Associated Molecular Mechanisms","Inclusion Criteria:\n\n* Clinical suspicion of prostate cancer (elevated PSA, abnormal digital rectal examination, or other clinical indication).\n* Undergoing prostate MRI including TDDMRI as part of diagnostic evaluation. Able and willing to provide written informed consent.\n\nExclusion Criteria:\n\n* Contraindications to MRI (e.g., pacemaker, ferromagnetic implants, severe claustrophobia).\n* Prior treatment for prostate cancer (surgery, radiation, hormonal therapy, chemotherapy).\n* Severe comorbid conditions precluding MRI or biopsy.\n* Inability to provide informed consent.\n* Poor image quality due to motion or technical artifacts (assessed at imaging QC).","MALE",{"count":18,"type":19},2000,"ESTIMATED","6 Months","OBSERVATIONAL","The goal of this multi-center clinical study is to evaluate whether time-dependent diffusion MRI (TDDMRI) can provide reliable microstructural imaging markers for the diagnosis of prostate cancer. The main questions this study aims to answer are:\n\n* Do TDDMRI-derived microstructural parameters (such as cell size and density) improve diagnostic accuracy for prostate cancer compared with conventional MRI?\n* How well do the microstructural parameters correlate with whole-slide pathology findings?\n* Can the investigators determine diagnostic models combining multiple features for presurgical diagnosis across multiple centers?\n\nParticipants with suspected prostate cancer will undergo 3T MRI including TDDMRI. Microstructural parameters will be quantified and compared with standard multiparametric MRI. All participants will also receive prostate biopsy or prostatectomy, and imaging findings will be validated against histopathology.\n\nThis study will:\n\n* Collect TDDMRI and conventional MRI data from six hospitals.\n* Derive and validate imaging markers of prostate cancer based on microstructural parameters.\n* Compare diagnostic performance across centers and against pathology as the reference standard.",[24,25],"Prostate Cancer","Diffusion MRI",[24,27,28,29],"Time-dependent Diffusion MRI (TDDMRI)","Diagnostic Accuracy","Multi-center Study","RECRUITING","2025-11-22",{"date":33,"type":34},"2025-11-25","ACTUAL",{"date":36,"type":34},"2020-09-01",{"date":38,"type":19},"2028-12-31",{"name":40,"class":41},"First Affiliated Hospital of Zhejiang University","OTHER",6,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":50,"minAge":51,"maxAge":52,"enrollmentInfo":53,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":55,"conditions":56,"keywords":58,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":4},"100570122","role-of-diffusion-mri-in-differentiation-of-various-bone-marrow-lesions-100570122","NCT06703138","Role of Diffusion MRI in Differentiation of Various Bone Marrow Lesions","Role of MRI Diffusion in Differentiation Between Various Vertebral Bone Marrow Pathological Lesions. .","Inclusion Criteria:\n\n* All adult patients with vertebral lesions Clinically suspected or diagnosed by other modalities as X-ray or CT were included in the study.\n\nExclusion Criteria:\n\n* Patients with metallic prosthesis which are not MRI compatible .\n* patients with previous Vertebral surgery.\n* patients with Vertebral Congenital anomalies\n* Patients refused the examination.\n* Patients who suffer from claustrophobia","ALL","20 Years","60 Years",{"count":54,"type":19},70,"Bone marrow lesions are common, and imaging findings are associated with various aetiologies, as compared to conventional radiography and computed tomography (CT), MRI is a better non-invasive imaging modality to evaluate vertebral bone marrow, due to better soft-tissue contrast, so the aim of our study is the use of MRI diffusion in differentiating various vertebral bone marrow pathological lesions.",[25,57],"Bone Marrow Disease",[59,60],"MRI","Bone marrow pathologies","NOT_YET_RECRUITING","2024-11-26",{"date":64,"type":34},"2024-11-29",{"date":66,"type":19},"2024-12-15",{"date":68,"type":19},"2026-01",{"name":70,"class":41},"Assiut University"]