[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"dilation-and-evacuation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:dilation-and-evacuation":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,49,83,106],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100630405","phase-2-paracervical-block-with-combined-ketorolac-and-lidocaine-for-osmotic-dilator-placement-100630405",false,"NCT07487246","Paracervical Block With Combined Ketorolac and Lidocaine for Osmotic Dilator Placement","Effects of Paracervical Block With Combined Ketorolac and Lidocaine on Perceived Pain in Osmotic Dilator Placement for Abortion, a Randomized Controlled Trial","PCB-KinD","Inclusion criteria:\n\nAge \\>\u002F= 18 years English or Spanish speaking Ability and willingness to sign the informed consent Ability and willingness to comply with the terms of the study including possessing active cell phone with text messaging capabilities Voluntary request for pregnancy termination Ultrasound-confirmed intrauterine pregnancy with an estimated gestational age of 16+0-23+6 weeks gestational age Require osmotic dilator placement one day prior to procedural abortion according to institutional protocol Seeking outpatient abortion services at Rush University Medical Center\n\nExclusion criteria:\n\nHave taken NSAIDs less than 6 hours prior to their clinic visit Contraindications to lidocaine such as allergy to lidocaine, cardiac arrhythmia or heart block, and porphyria Allergic reaction or sensitivity to NSAIDs History of peptic ulcer or gastrointestinal bleed, history of gastric bypass (RYGB) or recent history in last 6 months of gastric sleeve; history of inflammatory bowel disease (Ulcerative colitis, Crohn's disease) Uncontrolled hypertension, heart failure, ischemic heart disease, peripheral arterial disease, cerebrovascular disease Acute renal failure or chronic renal disease Chronic liver disease History of bleeding diathesis Untreated acute cervicitis or pelvic inflammatory disease Require or request PO benzodiazepine or IV sedation for placement of osmotic dilators Require more than 1 day of osmotic dilators Chronic or current narcotic use Current recreational drug use (excluding cannabis) Require transabdominal\u002Ftransvaginal injection for induced fetal demise prior to abortion","FEMALE","18 Years",{"count":20,"type":21},76,"ESTIMATED","INTERVENTIONAL",[24],"PHASE2","The purpose of this study is to improve pain management for participantswho need osmotic dilators for cervical preparation the day before their second trimester abortion procedure.",[27,28,29,30],"Pain Management","Abortion","Second Trimester Abortion","Dilation and Evacuation",[32,33,34,35],"randomized controlled trial","osmotic dilators","ketorolac","paracervical block","NOT_YET_RECRUITING","2026-06-15",{"date":39,"type":40},"2026-06-17","ACTUAL",{"date":42,"type":21},"2026-06-29",{"date":44,"type":21},"2027-04-30",{"name":46,"class":47},"Rush University Medical Center","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":56,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":57,"targetDuration":4,"studyType":22,"phases":59,"briefSummary":61,"conditions":62,"keywords":66,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":82},"100579121","phase-4-tranexamic-acid-for-second-trimester-dilation-and-evacuation-and-bleeding-outcomes-100579121","NCT06820177","Tranexamic Acid for Second Trimester Dilation and Evacuation and Bleeding Outcomes","Prophylactic Tranexamic Acid for Second Trimester Dilation and Evacuation and Bleeding Outcomes: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Able to understand and sign informed consent\n* Speaks English or Spanish language,\n* Requesting pregnancy termination or procedural management of fetal demise - Intrauterine pregnancy, 18 weeks 0 days and 24 weeks and 0 days gestation\n\nExclusion Criteria:\n\n* History of or current thromboembolic event (deep vein thrombosis, stroke, pulmonary embolism)\n* History of coagulopathy\n* Anticoagulant use in the preceding five days\n* Severe renal impairment\n* Chorioamnionitis or sepsis\n* Suspected placenta accreta spectrum\n* Prophylactic uterotonics other than oxytocin given (or planned to be given) at the start of the D\\&E\n* Known allergic reaction or hypersensitivity to TXA",true,{"count":58,"type":21},276,[60],"PHASE4","Although procedural abortion in the second trimester is extremely safe, hemorrhage is one of the leading causes of morbidity and mortality. Tranexamic acid (TXA) is used commonly in obstetrics to prevent or manage intrapartum or postpartum hemorrhage and has been associated with decreased mortality and decreased blood loss at the time of birth. Some guidelines are recommending the use of TXA for both the prevention and management of bleeding for abortion care. However, there are currently no published studies assessing the association between TXA and bleeding outcomes for abortion procedures. This study will involve a randomized, placebo-controlled trial of pregnant patients aged 18 and older desiring dilation and evacuation (D\\&E) for abortion or fetal demise at 18-24 weeks gestation. The primary aim is to determine whether prophylactic TXA has an effect on the need for additional interventions to control bleeding at the time of D\\&E. The secondary aim is to determine whether prophylactic TXA has an effect on the mean quantitative procedural blood loss.",[28,30,63,64,65],"Hemorrhage","Prophylactic Tranexamic Acid Use","Blood Loss",[67,68,69,70,71,72],"abortion","dilation and evacuation","TXA","hemorrhage","Tranexamic acid","D&E","RECRUITING","2026-06-12",{"date":37,"type":40},{"date":77,"type":40},"2025-04-22",{"date":79,"type":21},"2027-05",{"name":81,"class":47},"University of California, San Diego",3,{"id":84,"slug":85,"hasResults":11,"nctId":86,"briefTitle":87,"officialTitle":88,"acronym":89,"eligibilityCriteria":90,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":91,"targetDuration":4,"studyType":22,"phases":93,"briefSummary":95,"conditions":96,"keywords":4,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":48},"100590204","cervical-ripening-balloons-for-same-day-cervical-prep-100590204","NCT06964373","Cervical Ripening Balloons for Same-Day Cervical Prep","Cervical Ripening Balloon for Same-Day Cervical Preparation for Second Trimester Termination","CRB","Inclusion Criteria:\n\n* Individuals who desire outpatient dilation and evacuation (D\\&E)\n* At least 18 years of age\n* Able and willing to consent\n* Gestational duration between 18 weeks 0 days and 19 weeks 6 days as determined by ultrasound\n* Able to read and understand English or Spanish\n* Able to obtain reliable post-procedure transportation\n* Able to observe fasting guidelines of 6 hours prior to the D\\&E procedure\n\nExclusion Criteria:\n\n* Medical conditions that require procedural management in the operating room\n* Preference for D\\&E procedure in the operating room",{"count":92,"type":21},70,[94],"NA","The goal of this clinical trial is to learn if a cervical ripening balloon (Foley balloon) works to prepare the cervix before same-day outpatient dilation and evacuation (D\\&E). The main questions it aims to answer are:\n\n* Is cervical preparation with cervical ripening balloon for same-day outpatient D\\&E non-inferior to cervical preparation with osmotic dilators?\n* How feasible and safe is cervical preparation with cervical ripening balloon for same-day outpatient D\\&E?\n* How acceptable is cervical preparation with cervical ripening balloon for same-day outpatient D\\&E?\n\nParticipants will:\n\n* Have cervical preparation with cervical ripening balloon (experimental group) or osmotic dilators (usual care group)\n* Complete two surveys, one about the cervical preparation and one about the D\\&E procedure",[30],"2026-05-01",{"date":99,"type":40},"2026-05-05",{"date":101,"type":40},"2025-04-08",{"date":103,"type":21},"2026-07-31",{"name":105,"class":47},"University of New Mexico",{"id":107,"slug":108,"hasResults":11,"nctId":109,"briefTitle":110,"officialTitle":111,"acronym":4,"eligibilityCriteria":112,"healthyVolunteers":56,"sex":17,"minAge":18,"maxAge":113,"enrollmentInfo":114,"targetDuration":4,"studyType":22,"phases":115,"briefSummary":116,"conditions":117,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":119,"lastUpdatePostDateStruct":120,"startDateStruct":122,"completionDateStruct":124,"leadSponsor":126,"locationsCount":4},"100552840","intracervical-block-during-laminaria-insertion-100552840","NCT06478316","Intracervical Block During Laminaria Insertion","Pain Control With Intracervical Block, During Laminaria Insertion for Late Abortions, a Double Blind Randomized Control Trial","Inclusion Criteria:\n\n* Voluntary termination of pregnancy approved by a committee or missed abortion\n* 18.0 to 22.5 gestational week (The gestational age in the case of a missed abortion is determined by the BPD - Biparietal Diameter, which is the determining measure for the ability to perform D\\&E.)\n* Singleton pregnancy\n\nExclusion Criteria:\n\n* Multiple pregnancy\n* Women undergoing the procedure urgently due to cervical insufficiency, inevitable abortion, premature rupture of membranes, or suspected chorioamnionitis\n* Allergy to lidocaine\n* Women who do not speak Hebrew or English\n* Women who have a guardian for any reason\n* Women with a history of cesarean section\n* Women with abnormal placental implantation, such as placenta previa or suspected placenta accreta\n* Women with a psychiatric illness\n* Women with a history of alcoholism or drug abuse\n* Women who required a \"two-stage\" laminaria insertion will not be included in the analysis. In cases where the cervix does not allow the insertion of the required number of laminaria, the process is carried out in two stages: in the first stage, the maximum possible number is inserted, the woman is hospitalized, and after a few hours when some initial dilation of the cervix has occurred, the laminaria are removed and new ones are inserted according to the required number","45 Years",{"count":92,"type":21},[94],"Whether intracervical block with lidocaine 1% is superior to sham procedure - intracervical injection of saline 0.9% - in terms of pain control.",[118,30],"Late Abortion","2024-06-22",{"date":121,"type":40},"2024-06-27",{"date":123,"type":21},"2024-07",{"date":125,"type":21},"2026-12",{"name":127,"class":128},"Assaf-Harofeh Medical Center","OTHER_GOV"]