[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"dimensional-changes\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:dimensional-changes":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,49,72],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":31,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100595386","early-phase-1-topic-simvastatin-for-bone-regeneration-100595386",false,"NCT07031778","Topic Simvastatin for Bone Regeneration","Efficacy of Topical Application of Simvastatin in Bone Regeneration","SM","Inclusion Criteria:\n\n* Anesthetic risk ASA I-II.\n* Patients with the adjacent tooth in the mouth (37 or 47).\n* Third molars with fully developed roots.\n* Mandibular third molars included or semi-included.\n* With indication for extraction.\n* Signed informed consent.\n\nExclusion Criteria:\n\n* Pregnant or lactating women.\n* Chronic smokers.\n* Patients with decompensated metabolic disease.\n* Patients with motor difficulties that prevent or hinder hygiene.\n* Patients who are using statins to treat hypercholesterolemia.\n* Patients under treatment with drugs that could affect the osseointegration process such as chemotherapy drugs, bisphosphonates, corticosteroids or immunosuppressants.\n* Patients with metabolic bone diseases or who have undergone radiotherapy in the last five years.",true,"ALL","18 Years","40 Years",{"count":22,"type":23},90,"ESTIMATED","INTERVENTIONAL",[26],"EARLY_PHASE1","The goal of this clinical trial is to evaluate the efficacy of topical application of simvastatin in bone regeneration in the maxillae, in the reduction of dimensional bone changes, using mandibular third molar surgery as a model and assessing bone healing at 12 weeks. We will also compare the two forms of intralveolar topical administration currently used to assess which is the best form of administration. The main questions it aims to answer are:\n\n* Can the topical application of simvastatin, used as a preservation material, improve the variations with respect to bone dimensions and density that occur after tooth extraction.\n* Can topical application of SM improve soft tissue healing.\n* Does the topical application of SM produce changes with respect to postoperative variables of pain, inflammation or trismus.\n* What is the best vehicle for topical SM administration?\n\nFor this purpose, the investigators will randomly place 4 topical treatment options in the postextraction alveoli:\n\n* SM in gel form\n* collagen sponge impregnated with saline solution containing 10 mg of SM\n* collagen sponge with placebo gel. All patients will undergo postoperative CBCT, which will be repeated at 12 weeks.\n\nIn addition, inflammation, trismus and pain variables will be measured preoperatively, at 24 hours, 3 and 7 days.",[29,30],"Dimensional Changes","Bone Density",[32,33,34,35],"simvastatin","bone density","dimensional changes","cbct scan","RECRUITING","2025-06-12",{"date":39,"type":40},"2025-06-22","ACTUAL",{"date":42,"type":40},"2025-01-07",{"date":44,"type":23},"2025-12-31",{"name":46,"class":47},"Universidad de Granada","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":18,"minAge":55,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":24,"phases":58,"briefSummary":60,"conditions":61,"keywords":4,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":4},"100585231","analyzing-the-effect-of-disinfection-additives-on-the-linear-dimensional-stability-of-dental-alginate-impressions-a-quasi-experimental-comparative-study-100585231","NCT06899672","Analyzing the Effect of Disinfection Additives on the Linear Dimensional Stability of Dental Alginate Impressions: A Quasi-Experimental Comparative Study","Inclusion Criteria:\n\n* Dental stone casts free from excessive porosity, fractures, or other visible defects that could affect dimensional stability measurements.\n* Typodont models with intact maxillary arch configurations.\n\nExclusion Criteria:\n\n* Distorted impressions, under-extended impressions, impressions that detach from the tray before pouring, and impressions with voids, on visual inspection.\n* Dental cast with a fracture component, incomplete pouring, and those with voids or bubbles.","60 Minutes",{"count":57,"type":23},96,[59],"NA","This quasi-experimental comparative study investigates the effects of incorporating various self-disinfecting agents-0.2% Chlorhexidine (CHX), 1% Chitosan solution, 0.2% Silver Nitrate (AgNO3), green-synthesized Silver Nanoparticles (AgNPs), and 15% PVP-Iodine-on the linear dimensional stability of dental alginate impressions. Alginate is widely used in dentistry but is prone to dimensional changes and contamination. This study aims to assess whether integrating these disinfectants can reduce microbial risks without compromising the material's dimensional accuracy, thereby improving infection control and the precision of dental prostheses",[29],"NOT_YET_RECRUITING","2025-03-26",{"date":65,"type":40},"2025-03-28",{"date":67,"type":23},"2025-04-01",{"date":69,"type":23},"2025-10-01",{"name":71,"class":47},"Altamash Institute of Dental Medicine",{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":78,"eligibilityCriteria":79,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":80,"targetDuration":4,"studyType":24,"phases":82,"briefSummary":83,"conditions":84,"keywords":85,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":91,"completionDateStruct":92,"leadSponsor":93,"locationsCount":4},"100567121","early-phase-1-osteoimplant-and-bone-healing-100567121","NCT06664060","Osteoimplant and Bone Healing","Efficacy of Two Nutritional Supplements on Healing and Bone Density in the Jaws","Osteocic","Inclusion Criteria:\n\n* Patients presenting both lower third molars.\n* Adult patients between 18 and 40 years of age.\n* Anaesthetic risk ASA I-II (American Society of Anaesthesiologists classification) \\[14\\].\n* Absence of drug or food allergies that could compromise our study (e.g. egg).\n* Signed informed consent.\n\nExclusion Criteria:\n\n* Age not between 18-40 years.\n* Pregnant or breastfeeding women.\n* Presenting decompensated metabolic disease.\n* Poor periodontal status (≥10% plaque index and bleeding index).\n* Patients who have undergone radiotherapy in the last five years.\n* Patients who will not comply with the study guidelines.\n* Unsigned informed consent.\n* History of allergy to any study medication or related drugs (e.g. egg).\n* Patients with a history of renal colic.",{"count":81,"type":23},60,[26],"In view of the above and the possible improvements in terms of postoperative morbidity and tissue repair in oral surgery, this study is justified, the general objective of which would be:\n\n'To evaluate the efficacy of perioperative oral administration of two nutritional supplements based on vitamins and antioxidants (Osteoimplant Complex® and Osteoimplant®), using mandibular third molar surgery as a study model, assessing postoperative symptomatology and bone density'.\n\nThe null hypothesis of this study is: 1) the administration of the perioperative nutritional complex (Osteoimplant Complex® and Osteoimplant®) did not improve postoperative symptoms and 2) neither did it increase bone density after lower third molar extraction.",[29,30],[86,87,33,34],"vitamin d","vitamin c","2024-10-27",{"date":90,"type":40},"2024-10-29",{"date":42,"type":23},{"date":44,"type":23},{"name":46,"class":47}]