[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"diquat-poisoning\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:diquat-poisoning":23},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,37,58],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":21,"conditions":22,"keywords":4,"overallStatus":24,"whyStopped":4,"lastUpdateSubmitDate":25,"lastUpdatePostDateStruct":26,"startDateStruct":29,"completionDateStruct":31,"leadSponsor":33,"locationsCount":36},"100623664","diagnostic-accuracy-of-a-diquat-quantitative-detection-kit-and-a-portable-mass-spectrometry-system-for-quantifying-diquat-concentrations-in-human-blood-samples-100623664",false,"NCT07399574","Diagnostic Accuracy of A Diquat Quantitative Detection Kit and A Portable Mass Spectrometry System for Quantifying Diquat Concentrations in Human Blood Samples","Accuracy, Safety, and Clinical Performance of a Diquat Quantitative Detection Kit (In-Situ Ionization Mass Spectrometry) and a Portable Mass Spectrometry System for Quantifying Diquat Concentrations in Human Blood Samples (Whole Blood\u002FPlasma)","Inclusion Criteria:\n\n1. Patients with suspected or clinically diagnosed acute diquat poisoning, providing whole blood and\u002For plasma samples, including qualified residual specimens retained after prior clinical testing when available.\n2. The participant or their legally authorized representative can fully understand the study purpose and procedures, voluntarily agrees to participate, and is willing and able to comply with the study requirements.\n3. Sample collection is performed according to routine clinical standards, with no apparent ethical concerns related to sample acquisition.\n\nExclusion Criteria:\n\n1. Abnormal sample appearance, such as visible flocculent material or other gross abnormalities.\n2. The participant is unable to provide a specimen, or the specimen does not meet testing requirements.\n3. Any participant considered inappropriate for inclusion by the investigator.","ALL",{"count":18,"type":19},60,"ESTIMATED","OBSERVATIONAL","This is an observational, non-interventional diagnostic accuracy study designed to evaluate a diquat quantitative detection kit (ambient ionization mass spectrometry method) and a portable mass spectrometry analysis system for measuring diquat concentrations in human blood samples (whole blood\u002Fplasma), using LC-MS\u002FMS as the clinical gold standard for comparison.",[23],"Diquat Poisoning","NOT_YET_RECRUITING","2026-05-24",{"date":27,"type":28},"2026-05-27","ACTUAL",{"date":30,"type":19},"2026-09-01",{"date":32,"type":19},"2028-12-31",{"name":34,"class":35},"The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School","OTHER",1,{"id":38,"slug":39,"hasResults":11,"nctId":40,"briefTitle":41,"officialTitle":42,"acronym":4,"eligibilityCriteria":43,"healthyVolunteers":11,"sex":16,"minAge":44,"maxAge":4,"enrollmentInfo":45,"targetDuration":4,"studyType":47,"phases":48,"briefSummary":50,"conditions":51,"keywords":4,"overallStatus":24,"whyStopped":4,"lastUpdateSubmitDate":25,"lastUpdatePostDateStruct":52,"startDateStruct":53,"completionDateStruct":55,"leadSponsor":57,"locationsCount":4},"100610961","phase-1-accelerated-hemodiafiltration-in-severe-acute-diquat-ahead-poisoning-100610961","NCT07234383","Accelerated HEmodiafiltration in Severe Acute Diquat (AHEAD) Poisoning","Accelerated HEmodiafiltration in Severe Acute Diquat (AHEAD) Poisoning: a Single-center, Single-arm, Open-label, Clinical Trial","Inclusion criteria:\n\n1. Age ≥ 18 years; and\n2. A history of oral exposure to diquat solution, reported by patient(s) or their legal proxies; and\n3. An exposure time (time form exposure to presentation at ED) ≤ 48 hours, reported by patient(s) or their legal proxies; and\n4. Plasma diquat concentration measured upon ED presentation ≥ 1,000 ng\u002FmL.\n\nExclusion criteria:\n\n1. Evidence of co-ingestion of other toxic substances alongside diquat; and\u002For\n2. Withholding of CVVHDF due to limitations on the escalation of life-sustaining therapies; and\u002For\n3. Any CKRT within the previous 2 months; and\u002For\n4. Kidney transplant within the past 365 days; and\u002For\n5. Known pre-hospitalization advanced chronic kidney disease, defined by an estimated glomerular filtration rate calculated using serum creatine (eGFRer) of less than 30 mL\u002Fmin\u002F1.73 m2 by the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation, if pre-hospitalization serum creatine is available; and\u002For (6) Treating clinician(s) believe(s) that either immediate or deferral of CVVHDF initiation is mandated; and\u002For (7) Pregnant or breast feeding.","18 Years",{"count":46,"type":19},24,"INTERVENTIONAL",[49],"PHASE1","Diquat (1,1'-ethylene-2,2'-bipyridinium) is a bipyridine herbicide that shares a similar physicochemical structure and redox cycling mechanism with paraquat. Upon ingestion, it is rapidly absorbed and distributes widely, including gastrointestinal tract, kidneys, liver, skeletal muscle, lungs, myocardium, and central nervous system. Severe diquat poisoning commonly causes toxic encephalopathy, circulatory collapse, and multiorgan dysfunction. Extracorporeal treatments, including hemoperfusion, hemodialysis, and continuous kidney replacement therapy, are frequently used in management. Continuous veno-venous hemodiafiltration (CVVHDF), the most frequently used continuous kidney replacement therapy modality, is primarily indicated for acute kidney injury. Acute kidney injury occurs in up to 73.3% of patients with acute diquat poisoning, and nearly all patients with severe acute diquat poisoning are at risk of developing acute kidney injury. In clinical practice, patients with severe acute diquat poisoning are typically defined as those with a plasma diquat concentration of ≥1000 ng\u002FmL measured at the time of presentation to the emergency department. However, the Extracorporeal Treatments in Poisoning (EXTRIP) workgroup has not issued any definitive recommendations on initiating extracorporeal treatments for diquat poisoning, and the optimal timing for starting CVVHDF has not been evaluated in clinical trials. Current practice typically delays CVVHDF until acute kidney injury occurs. A preliminary retrospective cohort study suggested that, among severe acute diquat poisoning patients treated with combined hemoperfusion and CVVHDF, an interval of \\\u003C30 minutes between hemoperfusion and CVVHDF was associated with a significantly lower risk of death compared with longer intervals (≥30 minutes). Accordingly, this study proposes a single-arm trial (SAT) to determine whether accelerated initiation of CVVHDF immediately following hemoperfusion improves outcomes in patients with severe acute diquat poisoning.",[23],{"date":27,"type":28},{"date":54,"type":19},"2027-01-01",{"date":56,"type":19},"2030-12-31",{"name":34,"class":35},{"id":59,"slug":60,"hasResults":11,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":4,"eligibilityCriteria":43,"healthyVolunteers":11,"sex":16,"minAge":44,"maxAge":4,"enrollmentInfo":64,"targetDuration":4,"studyType":47,"phases":66,"briefSummary":68,"conditions":69,"keywords":70,"overallStatus":24,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":77,"leadSponsor":79,"locationsCount":4},"100590388","phase-3-accelerated-vs-standard-approach-to-continuous-veno-venous-hemodiafiltration-post-hemoperfusion-asap-in-severe-acute-diquat-poisoning-100590388","NCT06966765","Accelerated vs Standard Approach to Continuous Veno-venous Hemodiafiltration Post-hemoperfusion (ASAP) in Severe Acute Diquat Poisoning","Accelerated vs Standard Approach to Continuous Veno-venous Hemodiafiltration Post-hemoperfusion (ASAP) in Severe Acute Diquat Poisoning: a Multi-center, Cluster, Randomized, Controlled Trial",{"count":65,"type":19},267,[67],"PHASE3","Diquat (1,1'-ethylene-2,2'-bipyridinium) is a bipyridine herbicide that shares a similar physicochemical structure and redox cycling mechanism with paraquat. Upon ingestion, it is rapidly absorbed and distributed to the gastrointestinal tract, kidneys, liver, skeletal muscle, lungs, myocardium, and central nervous system. Patients with severe diquat poisoning often develop toxic encephalopathy, circulatory collapse, and multi-organ dysfunction. Extracorporeal treatments, including hemoperfusion, hemodialysis, and continuous kidney replacement therapy (CKRT), are widely employed to manage diquat poisoning. Continuous veno-venous hemodiafiltration (CVVHDF), the most frequently used CKRT modality, is primarily indicated for acute kidney injury (AKI). AKI occurs in up to 73.3% of patients with acute diquat poisoning, and nearly all patients with severe acute diquat poisoning are at risk of developing AKI. In clinical practice, patients with severe acute diquat poisoning are typically defined as those with a plasma diquat concentration of ≥1000 ng\u002FmL measured at the time of presentation to the emergency department (ED). However, the Extracorporeal Treatments in Poisoning (EXTRIP) workgroup has not issued any definitive recommendations on initiating extracorporeal treatments for diquat poisoning, and the optimal timing for starting CVVHDF has yet to be evaluated in clinical trials. Currently, the standard practice delays initiation of CVVHDF until AKI has developed. Accordingly, this study proposes a pragmatic cluster-randomized controlled trial (RCT) to determine whether, in severe acute diquat poisoning patients, accelerated initiation of CVVHDF following hemoperfusion is preferred compared to a standard approach in which CVVHDF is initiated only in the presence of AKI or at the discretion of the treating clinician.",[23],[71,72],"diquat","continuous kidney replacement therapy","2025-11-14",{"date":75,"type":28},"2025-11-18",{"date":54,"type":19},{"date":78,"type":19},"2029-12-31",{"name":34,"class":35}]