[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"disability-physical\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:disability-physical":28},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,27,0,25,[9,47,77,112,137,203,231,256,281,305,332,354,382,409,437,468,492,525,562,593,624,665,690,716,744],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":16,"eligibilityCriteria":17,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100605090","phase-4-of-designed-with-you-100605090",false,"NCT07157995","Phase 4 of Designed With You","Building Active Living and Addressing Needs for Caregiver Empowerment (BALANCE) Study - Phase 4 of Designed With You","BALANCE","Inclusion Criteria:\n\n* 18 years of age and older,\n* Community dwelling in the state of Maryland,\n* Self report of physical or sensory disability and\n* self-report of serving as a family caregiver for a person for at least 10 hours\u002Fweek.\n\nExclusion Criteria:\n\n* have a terminal diagnosis (\\\u003C1 year expected survival), and\n* \\> severe cognitive impairment (5-7 errors) based on the Short Portable Mental Status Questionnaire (SPMQ)","ALL","18 Years",{"count":21,"type":22},20,"ESTIMATED","INTERVENTIONAL",[25],"NA","The purpose of this study is to provide evaluate the feasibility of a structured 8-10-week, multi-component intervention that integrates individualized resource navigation, personalized self-care planning, emergency and end of life (EOL) preparedness, and peer support to improve the well-being, resource access and social connectedness of caregivers with disabilities. For this study we are interested in caregivers over the age of 18 who have some form (e.g. mobility or sensory) disability and are caring for a person with a disability and\u002For a chronic illness.",[28],"Disability Physical",[30,31,32,33],"Caregivers","Disability","Sensory Disability","Mobility Disability","RECRUITING","2026-06-30",{"date":37,"type":38},"2026-07-02","ACTUAL",{"date":40,"type":38},"2026-01-01",{"date":42,"type":22},"2026-10-30",{"name":44,"class":45},"Johns Hopkins University","OTHER",1,{"id":48,"slug":49,"hasResults":12,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":23,"phases":57,"briefSummary":58,"conditions":59,"keywords":63,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":71,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":46},"100541211","capable-transplant-100541211","NCT06326905","CAPABLE Transplant","Addressing Inactive Kidney Transplant Waitlist Status Through Adapting a Tailored Psycho-Social-Environmental Program","Inclusion Criteria:\n\n* Deceased Donor Waitlist\n* ≥18 years old\n* Community dwelling\n* Current Inactive status or active and had been inactive in the last 18 months for cardiovascular disease, frailty, obesity, social support, mental health, incomplete testing OR Active on the waitlist and low-income\n\nExclusion Criteria:\n\n* Living Donor Waitlist\n* Severe cognitive impairment\n* Inactivity expected to last \\> 3 months (eg cancer treatment)\n* \\>4 hospitalizations in the last 12 months\n* Current home nursing, physical or occupational therapy","99 Years",{"count":56,"type":22},43,[25],"The purpose of this mixed methods study is to adapt CAPABLE as CAPABLE Transplant to accomplish two things: 1) To resolve barriers to being classified as active on the Kidney Transplant (KT) waitlist, 2) as a surgical prehabilitation intervention targeting the pre-frail\u002F frail KT waitlist population. It consists of two phases- an open label pilot and a randomized waitlist control trial, and 3) pilot test the feasibility and acceptability for CAPABLE Transplant in symptom and waitlist specific metrics amongst low-income active kidney transplant waitlist candidates.",[60,61,62,28],"Quality of Life","Depression","End Stage Renal Disease",[64,65,66,67,68,69,70,62],"Activities of Daily Living","Instrumental Activities of Daily Living","Physical Function","Executive Function","Home","Intervention","Kidney Transplant",{"date":37,"type":38},{"date":73,"type":38},"2025-01-25",{"date":75,"type":22},"2026-07-01",{"name":44,"class":45},{"id":78,"slug":79,"hasResults":12,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":83,"eligibilityCriteria":84,"healthyVolunteers":12,"sex":85,"minAge":86,"maxAge":87,"enrollmentInfo":88,"targetDuration":4,"studyType":23,"phases":90,"briefSummary":91,"conditions":92,"keywords":97,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":46},"100644875","remote-virtual-inspiration-vitality-and-energy-100644875","NCT07675681","REmote Virtual Inspiration: Vitality and Energy","Improving Cardiometabolic Health With Meditative Movement in Mobility Impaired Women","REVIVE","Inclusion Criteria:\n\n* Self-identify as a woman.\n* Age 35-64 years.\n* Mobility impairment lasting at least 1 year.\n* Regular use of a mobility aid (e.g., wheelchair, scooter, walker, cane, crutches, or other assistive device).\n* Community dwelling.\n* Able to demonstrate sufficient upper-extremity mobility to participate in seated Tai Chi\u002FQigong activities.\n* Access to a smartphone, tablet, or computer with internet access.\n* Willing to wear a study-provided wearable device and complete study assessments.\n* Reside in the United States.\n* Waist circumference ≥ 33 inches (84 cm).\n* Perceived Stress Scale (PSS) score ≥ 15.\n* Insomnia Severity Index (ISI) score ≥ 8.\n* Emotional eating indicated by a score \\\u003C 3 on the Mindful Eating Questionnaire (MEQ) Emotional Response subscale.\n* Able to understand written and spoken English.\n* Able to provide informed consent.\n* Able to provide healthcare provider approval for participation.\n\nExclusion Criteria:\n\n* Medical conditions that would make participation unsafe, as determined during screening.\n* Inability to safely perform seated upper-body movements.\n* Current participation in a structured Tai Chi, Qigong, or similar meditative movement program.\n* Pregnancy, lactation, or plans to become pregnant during the study period.\n* Cognitive, visual, auditory, or other impairments that would preclude completion of study procedures.\n* Implanted cardiac devices or implanted electronic devices that interfere with physiologic measurements.\n* Severe arrhythmia, left ventricular assist device (LVAD), or other conditions that interfere with heart rate variability assessment.\n* Use of sleep medications three or more times per week.\n* Medical conditions or medications that substantially affect autonomic nervous system activity, sleep, or stress-related outcomes.\n* Uncontrolled cardiovascular, neurological, psychiatric, or other serious medical conditions that would preclude safe participation.","FEMALE","35 Years","64 Years",{"count":89,"type":22},280,[25],"REVIVE is a randomized controlled trial designed to evaluate the effects of a remotely delivered seated Tai Chi\u002FQigong (TCQ) intervention on cardiometabolic health, stress, sleep, and psychological well-being among women with mobility impairments.\n\nWomen with mobility impairments experience higher rates of obesity, cardiometabolic disease, chronic stress, sleep disturbances, and mental health concerns compared with women without disabilities. Limited access to accessible physical activity programs and barriers to participation in traditional exercise interventions contribute to these health disparities. Tai Chi and Qigong are gentle mind-body practices that may improve physical and psychological health through movement, breathing, and mindfulness techniques and can be adapted for individuals with limited mobility.\n\nParticipants will be randomized to either a seated Tai Chi\u002FQigong intervention or a health education video control condition. During the 12-week intervention phase, participants will receive daily video-based content delivered remotely. Participants assigned to the Tai Chi\u002FQigong group will engage in seated meditative movement practices, while participants assigned to the control group will receive health and wellness education videos unrelated to physical activity or nutrition behavior change.\n\nOutcomes will be assessed remotely at baseline, post-intervention, and follow-up. Primary outcomes include waist circumference and indicators of physiological stress regulation, including heart rate variability and salivary cortisol. Secondary outcomes include perceived stress, emotion regulation, depression, anxiety, emotional eating, sleep quality, and sleep disturbance. Additional measures collected through wearable technology, sleep diaries, questionnaires, and biological samples will be used to examine potential behavioral, psychological, and physiological mechanisms underlying intervention effects.\n\nThe findings from this study will contribute to the development of accessible, scalable, and evidence-based health promotion interventions designed to improve cardiometabolic health and overall well-being among women with mobility impairments.",[93,94,28,95,96],"Implementation Science","Women Health","Meditation","Tai Chi",[98,99,100,101,102,103],"Mobility Impairment","Tai Chi\u002FQigong","Cardiometabolic Health","Women with Disabilities","Stress Regulation","Sleep Health","2026-06-23",{"date":35,"type":38},{"date":107,"type":22},"2026-07",{"date":109,"type":22},"2030-08",{"name":111,"class":45},"Arizona State University",{"id":113,"slug":114,"hasResults":12,"nctId":115,"briefTitle":116,"officialTitle":117,"acronym":4,"eligibilityCriteria":118,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":119,"enrollmentInfo":120,"targetDuration":4,"studyType":23,"phases":122,"briefSummary":123,"conditions":124,"keywords":125,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":129,"startDateStruct":131,"completionDateStruct":133,"leadSponsor":135,"locationsCount":46},"100644535","adapted-table-tennis-for-disabilities-100644535","NCT07671807","Adapted Table Tennis for Disabilities","Health Promotion Through Adapted Table Tennis for Individuals With Disabilities","Inclusion Criteria:\n\n* Individuals aged 18 to 75 years who hold a disability identification certificate issued by the Taiwan government and have been assessed by a physician and a professional coach as suitable for participating in adapted table tennis, with a willingness to take part in the study; Participants must respond \"No\" to all questions in the first section of the Physical Activity Readiness Questionnaire for Everyone (PAR-Q+ 2024 edition) or, if they respond \"Yes\" to one or more questions in the first section, must respond \"No\" to all questions in the second section.\n\nExclusion Criteria:\n\n* Individuals with uncontrolled cardiovascular diseases or relevant neurological history.\n* Hearing impairment.\n* Cognitive dysfunction.\n* Individuals with uncontrolled psychiatric disorders who are unable to comply with the assessments.\n* Individuals with color vision deficiencies or visual impairments.\n* Pregnant women (self-reported).\n* Individuals who have undergone lower limb musculoskeletal surgery or experienced musculoskeletal injuries within the past 6 months.\n* Individuals with a history of significant head trauma.\n* Individuals unable to comply with the testing schedule.\n* Individuals advised by a physician to avoid moderate to high-intensity exercise or those deemed unsuitable for physical activity.","75 Years",{"count":121,"type":22},40,[25],"In recent years, sports participation among individuals with disabilities has increased, driven by medical advancements, growing societal awareness, and improved accessibility. However, a significant proportion-about 60%-still do not engage in regular physical activity, often due to limited awareness and environmental barriers. Organizations like the International Paralympic Committee (IPC) have played a key role in promoting disability sports, as evidenced by the growth in Paralympic participation from 400 athletes in 1960 to an expected 4,400 in 2024. Physical activity offers both physical and psychological benefits for people with disabilities, including improved cardiovascular health, motor function, and emotional well-being. Although adapted table tennis is a promising, accessible sport for this population, research on its health effects remains limited. This study aims to evaluate the impact of a 12-week adapted table tennis program on the physical and mental health of individuals with disabilities and to explore its potential as a sustainable health-promotion strategy.",[28],[126,127,128],"table tennis","disabilities","adapted exercise",{"date":130,"type":38},"2026-06-26",{"date":132,"type":38},"2025-07-08",{"date":134,"type":22},"2028-12-31",{"name":136,"class":45},"Kaohsiung Medical University Chung-Ho Memorial Hospital",{"id":138,"slug":139,"hasResults":12,"nctId":140,"briefTitle":141,"officialTitle":142,"acronym":143,"eligibilityCriteria":144,"healthyVolunteers":145,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":146,"targetDuration":4,"studyType":148,"phases":4,"briefSummary":149,"conditions":150,"keywords":168,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":193,"lastUpdatePostDateStruct":194,"startDateStruct":196,"completionDateStruct":198,"leadSponsor":200,"locationsCount":46},"100641995","human-observatory-study-100641995","NCT07646782","Human Observatory Study","The Human Observatory: A Prospective Individual and Population-Level Study of Aging, Health, and Longevity","HOS","Inclusion Criteria:\n\n* Enrolled in the 100-Year Human Aging Study at any fixed or mobile clinical site; OR completion of online health screener with provision of geographic anchor data and consent.\n\nExclusion Criteria:\n\n* Age under 18 years (current protocol; pediatric amendment planned).",true,{"count":147,"type":22},1000000,"OBSERVATIONAL","The Human Observatory Study is a prospective observational and ecological surveillance study building a continuously-updating world model for human health, disease, and death at the individual and population level. Individual multi-system clinical data from enrolled participants are linked to a continuously-ingested ecological data infrastructure spanning environmental exposures, social determinants, genealogical and family history records, mortality data, and population health databases at geographic resolutions from home address to global scale and beyond. The resulting model generates individual screening recommendations informed by population-level causal estimates, and population-level causal forecasts anchored by present-timepoint individual clinical biology. Thus creating a feedback architecture designed to improve both simultaneously.",[151,152,153,154,155,156,157,158,159,160,161,162,64,163,28,164,165,166,167],"Aging","Mortality","All-cause Mortality","Life Expectancy","Cardiovascular Diseases","Neoplasms","Cognitive Dysfunction","Metabolic Syndrome","Frailty","Musculoskeletal Disease","Neurodegenerative Disease","Dementia","Health Related Quality of Life","Environmental Exposure","Occupational Diseases","Health Equity","Social Determinants of Health",[169,170,171,172,173,174,175,176,177,178,179,180,181,166,182,183,184,185,186,187,188,189,190,191,192],"longevity","biological aging","causal inference","life expectancy","exposome","Environmental Health","Social Determinants","Genealogy","Family History","Human Family Tree","Population Health","Neighborhood Health","Geographic Health Disparities","Mortality Prediction","Biomarker Validation","Cardiopulmonary Exercise Testing","Body Composition","Preventive Medicine","Healthspan","Functional Decline","Centenarian","Space Medicine","Aerospace Medicine","World Model","2026-06-09",{"date":195,"type":38},"2026-06-15",{"date":197,"type":38},"2026-04-25",{"date":199,"type":22},"2099-12-31",{"name":201,"class":202},"Longevity Metrics, Inc.","INDUSTRY",{"id":204,"slug":205,"hasResults":12,"nctId":206,"briefTitle":207,"officialTitle":208,"acronym":4,"eligibilityCriteria":209,"healthyVolunteers":145,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":210,"targetDuration":4,"studyType":148,"phases":4,"briefSummary":211,"conditions":212,"keywords":218,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":193,"lastUpdatePostDateStruct":225,"startDateStruct":227,"completionDateStruct":229,"leadSponsor":230,"locationsCount":46},"100636291","100-year-human-aging-study-100636291","NCT07563777","100-Year Human Aging Study","100-Year Human Aging Study: Prospective Longitudinal Validation of Multi-System Health Measurements Against Mortality and Aging Outcomes","Inclusion Criteria:\n\n* Age 18 years or older\n* Willing and able to provide written informed consent, or enrollment with consent of a legally authorized representative\n* Willing to participate in longitudinal follow-up\n\nExclusion Criteria:\n\n* Age under 18 years",{"count":147,"type":22},"The 100-Year Human Aging Study is a prospective, pragmatic, observational trial enrolling participants across fixed and mobile clinical sites to undergo comprehensive multi-system health screening and longitudinal follow-up until death. Participants are followed to determine whether measurements taken at enrollment and repeated across the lifespan - individually and in combination - predict all-cause mortality, cause-specific mortality, incident serious disease, and functional disability. The study is designed to generate the surrogate endpoint validation data that longevity medicine currently lacks.",[151,213,214,152,158,155,157,215,156,159,64,216,28,217,162],"Aging Well","All-Cause Mortality","Musculoskeletal Diseases","Health-Related Quality of Life","Neuro-Degenerative Disease",[219,184,185,186,220,182,188,187,154,221,222,223,183,224,179,189],"Longevity","Surrogate Endpoint Validation","Biological Aging","Preventive Screening","Longitudinal Cohort","Human Performance",{"date":226,"type":38},"2026-06-11",{"date":228,"type":38},"2025-02-09",{"date":199,"type":22},{"name":201,"class":202},{"id":232,"slug":233,"hasResults":12,"nctId":234,"briefTitle":235,"officialTitle":236,"acronym":4,"eligibilityCriteria":237,"healthyVolunteers":145,"sex":18,"minAge":238,"maxAge":4,"enrollmentInfo":239,"targetDuration":4,"studyType":23,"phases":241,"briefSummary":242,"conditions":243,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":248,"lastUpdatePostDateStruct":249,"startDateStruct":251,"completionDateStruct":253,"leadSponsor":255,"locationsCount":46},"100602422","capable-care--connect-100602422","NCT07123298","CAPABLE Care + Connect","CAPABLE Care + Connect: Pilot Feasibility of Implementing CAPABLE Into Homebased Primary Care","Inclusion Criteria:\n\n* Any patient currently in JHOME\n* At risk for or experiencing social isolation as defined by the Lubben Social Network Scale 6 item score less than or equal 12 points or loneliness as defined by the UCLA Loneliness Scale 3 item score of 6 to 9 points\n* Cognitive inclusion criteria Montreal Cognitive Assessment (MOCA) \\>23 as determined by referring JHOME study team member provider\n* English speaking (measures are standardized in English)\n* Ability to participate in an approximately 45-60 min virtual or in person meeting\n* Eligible for CAPABLE\n* 50 years or older\n* Not hospitalized over night more than 4 times in the last 12 months\n* Have some difficulty with any ADL\n* Cognitively intact\n* Live in Baltimore County or Baltimore City\n* Not receiving active cancer treatment\n* Interested in participating in CAPABLE Care partners will be included if the care partners provide \\> 10 hours of care\u002Fweek\n\nExclusion Criteria:\n\n* Terminally ill\n* live in long term care setting\n* receiving active cancer treatment\n\nStandard of Care\u002FComparison group Inclusion Criteria:\n\n• Any patient currently in JHOME who did not receive the CAPABLE intervention","50 Years",{"count":240,"type":22},450,[25],"In this evaluation scale-up research project, the investigators seek to test an implementation of CAPABLE on the infrastructure of home-based primary care for individuals who may experience social isolation and\u002For loneliness. These two home-based care programs may improve each other and provide opportunity to further improve quality of life for people living with disabilities and the caregivers. The purpose of this mixed methods study is to adapt and test CAPABLE, an existing evidence-based program, to a new target population with the scalable infrastructure of home-based primary care.",[244,245,246,60,28,247],"Social Isolation in Older Adults","Social Isolation or Loneliness","Social Isolation","Homebound Persons","2026-06-01",{"date":250,"type":38},"2026-06-02",{"date":252,"type":38},"2025-08-14",{"date":254,"type":22},"2027-05",{"name":44,"class":45},{"id":257,"slug":258,"hasResults":12,"nctId":259,"briefTitle":260,"officialTitle":261,"acronym":4,"eligibilityCriteria":262,"healthyVolunteers":12,"sex":85,"minAge":19,"maxAge":263,"enrollmentInfo":264,"targetDuration":4,"studyType":148,"phases":4,"briefSummary":266,"conditions":267,"keywords":4,"overallStatus":271,"whyStopped":4,"lastUpdateSubmitDate":272,"lastUpdatePostDateStruct":273,"startDateStruct":275,"completionDateStruct":277,"leadSponsor":279,"locationsCount":46},"100640028","assessment-of-venous-insufficiency-and-clinical-features-in-lipedema-100640028","NCT07603076","Assessment of Venous Insufficiency and Clinical Features in Lipedema","Evaluation of Venous Insufficiency and Its Association With Clinical Features in Patients With Lipedema: A Cross-Sectional Study","Inclusion Criteria:\n\n* Female participants aged 18 years or older\n* Clinically diagnosed lipedema according to established diagnostic criteria\n* Ability to provide written informed consent\n* Ability to complete clinical assessments and questionnaires\n\nExclusion Criteria:\n\n* History of lower extremity venous surgery or sclerotherapy\n* Known peripheral arterial disease\n* Secondary lymphedema or other causes of lower extremity edema\n* Active infection, cellulitis, or inflammatory disease affecting the lower extremities\n* Pregnancy or postpartum period\n* Neurological, rheumatological, or musculoskeletal disorders significantly affecting lower extremity function\n* Malignancy or severe systemic disease\n* Inability to undergo venous Doppler ultrasonography\n* Inability to understand or complete study assessments and questionnaires","65 Years",{"count":265,"type":22},82,"Lipedema is a chronic adipose tissue disorder characterized by disproportionate fat accumulation, pain, tenderness, edema, and functional impairment. Venous symptoms such as heaviness, swelling, and discomfort are frequently reported in individuals with lipedema; however, the relationship between venous Doppler ultrasonography findings and lipedema-related clinical manifestations remains insufficiently investigated. This cross-sectional controlled study aims to evaluate venous insufficiency parameters in patients with lipedema using Doppler ultrasonography and to examine their associations with pain severity, lower extremity function, disease severity, and quality of life.",[268,269,270,28],"Lipedema","Venous Insufficiency","Venous Disease","NOT_YET_RECRUITING","2026-05-17",{"date":274,"type":38},"2026-05-22",{"date":276,"type":22},"2026-05-20",{"date":278,"type":22},"2026-08-01",{"name":280,"class":45},"Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey",{"id":282,"slug":283,"hasResults":12,"nctId":284,"briefTitle":285,"officialTitle":285,"acronym":4,"eligibilityCriteria":286,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":287,"enrollmentInfo":288,"targetDuration":4,"studyType":148,"phases":4,"briefSummary":290,"conditions":291,"keywords":294,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":296,"lastUpdatePostDateStruct":297,"startDateStruct":299,"completionDateStruct":301,"leadSponsor":303,"locationsCount":46},"100494295","pain-and-disability-outcomes-in-post-amputation-patients-100494295","NCT05716321","Pain and Disability Outcomes in Post Amputation Patients","Inclusion Criteria:\n\n1. Ages between 18 and 89 years old, inclusive\n2. Patients scheduled for surgical limb amputation at Penn State Hershey Medical Center\n\nExclusion Criteria:\n\n1. Patients who cannot cooperate or consent\n2. Patients who cannot understand or speak English\n3. Patients with a history of chronic regional pain syndromes\n4. Patients suffering from alcohol and\u002For drug abuse -based on previous Dx listed in the MRN\n5. BMI \\>50","89 Years",{"count":289,"type":22},350,"The objective of this study is to evaluate efficacy of varied medical and procedural therapies used to treat pain after surgical amputation of a limb. The primary outcome will be assessment of pain severity at rest and with movement as measured by pain scores on Numerical Rating Scale (NRS) 0 to 10, where 0 is not pain and 10 is the worst pain possible, taken on post-operative day 1, day 7, 30 days, 90 days, 6 months, and 1 year (+\u002F- 3 days at each time point).",[292,293,28],"Limb Pain, Phantom","Residual Limbs Pain",[295],"Amputation","2026-05-01",{"date":298,"type":38},"2026-05-07",{"date":300,"type":38},"2023-04-05",{"date":302,"type":22},"2028-11",{"name":304,"class":45},"Milton S. Hershey Medical Center",{"id":306,"slug":307,"hasResults":12,"nctId":308,"briefTitle":309,"officialTitle":310,"acronym":4,"eligibilityCriteria":311,"healthyVolunteers":145,"sex":18,"minAge":312,"maxAge":313,"enrollmentInfo":314,"targetDuration":4,"studyType":23,"phases":315,"briefSummary":316,"conditions":317,"keywords":319,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":323,"lastUpdatePostDateStruct":324,"startDateStruct":326,"completionDateStruct":328,"leadSponsor":330,"locationsCount":46},"100540637","technology-in-play-for-children-with-physical-disabilities-the-dice-model-of-play-100540637","NCT06319430","Technology in Play for Children With Physical Disabilities: the Dice Model of Play","The Role of Technology in Facilitating Play for Children With Physical Disabilities: Development of the Dice Model of Play","Inclusion Criteria:\n\n* Having a disability or typically developed\n* Between 3 to 9 years old\n* Speaking and understanding English or Persian\n* Living in Winnipeg\n\nExclusion Criteria:\n\n* Not receiving play therapy within the last three months","3 Years","9 Years",{"count":21,"type":22},[25],"Play is an important activity for children. Almost all children play, but what is play? It is not easy to define play. In the past, people believed that children played to burn their energy. Now, it is known that play is important for children's growth. Some kids with disabilities cannot play. Many experts use play to teach children specific skills. People often forget that play is a child's right. It is important to help all children play. The first step is to define play and find what features are important in helping a child with a disability play.\n\nThere are some models of play. But they are not complete. They do not look at play as a whole. Some models are just about playfulness, and some are about playing with others. Having a model that defines play helps researchers and clinicians think about play and the different parts of it. Then, when a child cannot play, experts can fix the part that is not working. Investigators want to introduce a model of play in this project. Investigators want to edit and complete it in three steps. First, Investigators will ask parents and children with disabilities about things that help or do not help them play; then, investigators will give Lego robots to children that they will build with help and play with them for a few weeks. And at the end, investigators will ask therapists and other experts about our model of play. This model will be edited during the study.",[28,318],"Disabilities Mental",[320,321,322],"play and playthings","Assistive technology","Pediatric ALL","2026-04-28",{"date":325,"type":38},"2026-05-05",{"date":327,"type":38},"2025-02-06",{"date":329,"type":22},"2026-05-28",{"name":331,"class":45},"University of Manitoba",{"id":333,"slug":334,"hasResults":12,"nctId":335,"briefTitle":336,"officialTitle":337,"acronym":338,"eligibilityCriteria":339,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":340,"targetDuration":4,"studyType":23,"phases":342,"briefSummary":343,"conditions":344,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":346,"lastUpdatePostDateStruct":347,"startDateStruct":348,"completionDateStruct":350,"leadSponsor":352,"locationsCount":46},"100555374","the-strive-before-surgery-trial-100555374","NCT06511258","The STRIVE Before Surgery Trial","The STRIVE Before Surgery Pilot Trial: a Vanguard Pragmatic Multicenter Randomized Trial of Structured TRaining to Improve Fitness in a Virtual Environment (STRIVE) Before Surgery","STRIVE","Inclusion Criteria:\n\n1. Age ≥18 years\n2. Scheduled, or on the pathway, for inpatient abdominal, thoracic, pelvic, head-and-neck or vascular surgery\n3. Expected surgery date between 3 and 12 weeks from enrollment\n4. Valid provincial health insurance number\n5. Access to internet-enabled device\n6. Email address\n\nExclusion Criteria:\n\n1. Inability to read and communicate in English\n2. Cognitive impairment preventing ability to provide informed consent independently\n3. No telephone\u002Fcell phone\n4. Cardiac, neurological or orthopedic procedure\n5. Surgery with no curative intent (palliative surgery)\n6. Patient not interested in participating in the context of their TAPA score\n7. Any of the following cardiovascular conditions:\n\n   1. Severe valvular heart disease that limits a patient's ability to ambulate on level ground, or is associated with syncope or dyspnea\n   2. Severe cardiac dysrhythmias that limit a patient's ability to ambulate on level ground, or is associated with syncope or dyspnea\n   3. Recent myocardial infarction (within 6 weeks prior to enrollment - based on the Heart and Stroke Foundation's HeartWalk program)",{"count":341,"type":22},902,[25],"The STRIVE Before Surgery Trial evaluates patient-reported disability at 90 days after surgery following participating in a home-based multimodal prehabilitation program supported through an online platform. Half of the participants will be randomized into the prehabilitation group, while the other half will be randomized into the control group.",[345,28],"Surgery-Complications","2026-04-27",{"date":296,"type":38},{"date":349,"type":38},"2024-09-05",{"date":351,"type":22},"2031-12-01",{"name":353,"class":45},"Ottawa Hospital Research Institute",{"id":355,"slug":356,"hasResults":12,"nctId":357,"briefTitle":358,"officialTitle":359,"acronym":4,"eligibilityCriteria":360,"healthyVolunteers":145,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":361,"targetDuration":4,"studyType":23,"phases":363,"briefSummary":364,"conditions":365,"keywords":371,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":373,"lastUpdatePostDateStruct":374,"startDateStruct":376,"completionDateStruct":378,"leadSponsor":380,"locationsCount":46},"100634680","using-virtual-reality-to-improve-medical-training-100634680","NCT07542834","Using Virtual Reality to Improve Medical Training","Enhancing Osteopathic Medical Education Through Cinematic Virtual Reality","Inclusion Criteria: able to read and speak English, are age 18 years and older, and are a medical student enrolled at the Ohio University Heritage College of Osteopathic Medicine enrolled in the 2025-2026 academic year.\n\n\\-\n\nExclusion Criteria: unable to read and speak English, 17 years or younger, and are not a medical student enrolled at the Ohio University Heritage College of Osteopathic Medicine enrolled in the 2025-2026 academic year.\n\n\\-",{"count":362,"type":22},100,[25],"As the U.S. population ages, future physicians must be prepared to care for older adults with multiple health conditions and complex needs. This study will test whether cinematic virtual reality (VR)-an immersive, interactive learning tool-is more effective than traditional lectures in helping medical students learn about geriatric care. Students who complete the VR training will experience realistic patient scenarios that show what can go wrong in medical care and learn how to apply osteopathic principles to improve outcomes. Researchers will compare students' performance on a clinical skills assessment and explore their experiences with the VR training. The goal is to determine whether cinematic virtual reality can better prepare students for residency and improve their ability to provide compassionate, high-quality care for older adults.",[366,367,368,28,369,370],"Type 2 Diabetes (T2DM)","Geriatric Syndromes","Disability Hearing","Urinary Tract Infection(UTI)","Delirium Confusional State",[372],"virtual reality, type 2 diabetes, geriatric syndromes, disability, elder abuse and neglect","2026-04-14",{"date":375,"type":38},"2026-04-21",{"date":377,"type":22},"2026-04-15",{"date":379,"type":22},"2027-06-30",{"name":381,"class":45},"Ohio University",{"id":383,"slug":384,"hasResults":12,"nctId":385,"briefTitle":386,"officialTitle":387,"acronym":4,"eligibilityCriteria":388,"healthyVolunteers":12,"sex":18,"minAge":263,"maxAge":4,"enrollmentInfo":389,"targetDuration":4,"studyType":23,"phases":391,"briefSummary":392,"conditions":393,"keywords":394,"overallStatus":271,"whyStopped":4,"lastUpdateSubmitDate":401,"lastUpdatePostDateStruct":402,"startDateStruct":404,"completionDateStruct":405,"leadSponsor":407,"locationsCount":46},"100548785","using-technology-to-improve-function-for-older-latinos-with-disabilities-in-underserved-areas-100548785","NCT06425510","Using Technology to Improve Function for Older Latinos With Disabilities in Underserved Areas","Tech Enabled Functional Health: Bridging Primary Care Gaps for Older Latinos With Functional Disabilities in Underserved Communities","Inclusion Criteria:\n\n* Spanish speaking Latino adults ≥65 years\n* With a physical function impairment (PROMIS-HAQ T-Score ≤45)\n* Living independently in the community (not requiring supervision to perform their daily living activities)\n* Self-reported ability to participate in a 6 weeks of group intervention\n* Having no plans to move for the next 12 months\n\nExclusion Criteria:\n\n* Currently residing in a nursing or group home\n* Receiving home healthcare services\n* Having a significant cognitive impairment as evidenced by a score ≤23 in the Mini Mental State Examination (MMSE)",{"count":390,"type":22},76,[25],"This project aims to test a culturally appropriate assistive technology (AT) intervention called VIVE-AT to help older Latinos with disabilities improve their function and quality of life. The researchers will first refine the VIVE-AT program based on feedback from a Community Advisory Board and focus groups with older Latinos with disabilities. Then, 76 older Latinos with disabilities will be recruited from a primary care clinic serving low-income communities in Puerto Rico. They will be randomly assigned to either receive the VIVE-AT intervention in the primary care clinic or be placed on a waitlist with regular phone calls. All participants will continue to receive standard care at the clinic.",[151,28],[395,396,397,398,399,400],"self help devices","behavioral intervention","assistive technology","primary health care","community health workers","older Latinos","2026-04-10",{"date":403,"type":38},"2026-04-13",{"date":278,"type":22},{"date":406,"type":22},"2027-12-31",{"name":408,"class":45},"University of Puerto Rico",{"id":410,"slug":411,"hasResults":12,"nctId":412,"briefTitle":413,"officialTitle":414,"acronym":4,"eligibilityCriteria":415,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":416,"enrollmentInfo":417,"targetDuration":418,"studyType":148,"phases":4,"briefSummary":419,"conditions":420,"keywords":425,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":428,"lastUpdatePostDateStruct":429,"startDateStruct":431,"completionDateStruct":433,"leadSponsor":435,"locationsCount":46},"100610916","presence-of-dural-pulsation-in-patients-diagnosed-with-lumbar-spinal-stenosis-100610916","NCT07233798","Presence of Dural Pulsation in Patients Diagnosed With Lumbar Spinal Stenosis","Correlation of the Presence of Dural Pulsation With Clinical and Radiological Parameters in Patients Diagnosed With Lumbar Spinal Stenosis","Inclusion criteria\n\n* Aged between 18 and 85 years\n* Patients experiencing low back and\u002For leg pain attributable to lumbar spinal stenosis\n* Presence of lumbar spinal stenosis at least at one level consistent with clinical symptoms on lumbar MRI\n* Willingness to participate in the study Exclusion criteria\n* Body Mass Index (BMI) ≥ 35 kg\u002Fm²\n* Patients with radiculopathy due to lumbar disc herniation\n* Patients with axial low back pain caused by facet syndrome, sacroiliac dysfunction, or discogenic pain\n* History of lumbar spine surgery\n* Individuals with mental retardation\n* Patients with major psychiatric comorbidities\n* Patients with congenital spinal anomalies\n* Inflammatory rheumatic diseases characterized by osteophyte formation and ligament calcification, such as ankylosing spondylitis and diffuse idiopathic skeletal hyperostosis (DISH)\n* Pregnancy\n* Patients with heart failure","85 Years",{"count":362,"type":22},"1 Year","Lumbar spinal stenosis is defined as the narrowing of the spinal canal resulting from degenerative changes in the spinal joints, intervertebral discs, and the ligamentum flavum.\n\nPressure fluctuations within the cerebral and spinal vascular systems lead to the formation of pulsations. The periodic occurrence of these pulsations in the dura mater is referred to as spinal dural pulsation.The vibratory movements of the dura mater have been interpreted as an indicator that the spinal cord is freely mobile within the subarachnoid space and not subjected to any external compression.This study aims to investigate whether the presence of dural pulsation is associated with clinical and radiological parameters in patients diagnosed with lumbar spinal stenosis",[421,422,28,423,424],"Lumbar Spinal Stenosis","Numerical Rating Scale","Magnetic Resonance","Claudication",[426,427],"Dural Pulsation","oswestry disability index","2026-03-09",{"date":430,"type":38},"2026-03-11",{"date":432,"type":38},"2025-12-07",{"date":434,"type":22},"2026-12-30",{"name":436,"class":45},"Marmara University",{"id":438,"slug":439,"hasResults":12,"nctId":440,"briefTitle":441,"officialTitle":442,"acronym":4,"eligibilityCriteria":443,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":444,"targetDuration":4,"studyType":23,"phases":446,"briefSummary":447,"conditions":448,"keywords":451,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":459,"lastUpdatePostDateStruct":460,"startDateStruct":462,"completionDateStruct":464,"leadSponsor":466,"locationsCount":46},"100603809","fast-in-bed-tracking-fit-system-lifestyle-intervention-is-a-clinical-trial-of-a-bed-scale-device-overweight-wheelchair-users-will-participate-in-a-weight-loss-program-half-will-receive-bed-scales-and-participants-who-receive-the-bed-scales-are-expected-to-have-increased-weight-loss-100603809","NCT07141342","Fast In-Bed Tracking (FIT) System Lifestyle Intervention is a Clinical Trial of a Bed Scale Device. Overweight Wheelchair Users Will Participate in a Weight Loss Program, Half Will Receive Bed Scales, and Participants Who Receive the Bed Scales Are Expected to Have Increased Weight Loss.","The Fast In-Bed Tracking (FIT) System Lifestyle Intervention","Inclusion Criteria:\n\n* Age18 +\n* Live within approximately 75 miles of Pittsburgh\n* Uses a wheelchair as primary means of locomotion\n* Currently transfers in and out of bed every night (or most nights)\n* Has been diagnosed as obese or overweight\n* Are interested in losing weight\n* BMI in the range of approximately 25 to 40; BMI range will be determined from published evidence for the primary diagnosis of the participant. For example, spinal cord injury \u002Fquadriplegic BMI range of approximately 22 to 40; for amputees it will be based on location and level of amputation, or if no diagnosis specific evidence exists, a BMI of approximately 25 to 40 will be used as a general guideline.\n* Own a smart phone, and have reliable internet and wifi connection\n* Are comfortable using exercise equipment like resistance bands or hand pedal exercisers\n* Are able and willing to engage in exercise of moderate intensity\n* Weight in bed including sleep partner is an estimated combined weight of 600 pounds or less\n* Does not have a regular way to weigh themselves, such as a roll-on scale in the home or gym, or have regular access to a device to weigh themselves regularly and are willing to avoid weighing themselves during the trial.\n* Indication that the participant has autonomy in decision-making as determined by the \"Everyday Autonomy Self-Determination Scale.\"\n* Indication that their current bedroom setup is compatible with the FIT bed scales as determined by the \"Bed Determination Survey.\"\n\nDue to the medical complexity of this population, inclusion of this study based on BMI, in-bed transfer frequency, or geographic location will be at the discretion of the expert members of our study team and will be considered on a case-by-case basis.\n\nExclusion Criteria:\n\n* Extended vacations or absences planned in the next year (more that 2 - 4 weeks) or plans to move approximately 75 miles or greater from the Pittsburgh region\n* BMI outside of the desired range as based on condition and as determined by the study team.\n* Currently taking weight loss medication, medications that affect appetite, or have had weight loss surgery in the last 2 years.\n* History disordered eating in the last 2 years, such as Anorexia Nervosa, Bulimia Nervosa or Binge Eating Disorder\n* Currently pregnant or intend to become pregnant in the next 12 months\n* Regularly have 4 or more alcoholic drinks a day\n* Have any cognitive conditions that limit decision making or self-governing.\n* Indication that the participant does not have autonomy in decision-making as determined by the \"Everyday Autonomy Self-Determination Scale.\"\n* Indication that their current bedroom setup is not compatible with the FIT bed scales as determined by the \"Bed Determination Survey.\"\n\nDue to the medical complexity of this population, exclusion from this study based on BMI, geographic location, and what is considered a \"medication that affects appetite\" will be at the discretion of the expert members of our study team and will be considered on a case-by-case basis.",{"count":445,"type":22},92,[25],"This project will complete the final design and development steps to commercialize the Fast In-Bed Tracking (FIT) Platform, which is an e-Health and wellness Internet of Things (IoT) monitoring system that can be integrated into a user's bed and provide person-centered, real-world outcomes to support health and wellness. The technical feasibility of FIT was proven over the past several years and has demonstrated the platform can support the treatment of several chronic conditions across different populations, including obesity, congestive heart failure, and pressure injuries. The project goals will be to (1) complete design refinements for FIT and (2) demonstrate the platform's efficacy to support weight loss goals of wheelchair users. Wheelchair users are twice as likely as the general population to be overweight or obese and excess weight not only exacerbates mobility and participation limitations but increases risk for secondary health problems. Evidence reveals that frequent weight monitoring is a key driver for weight management, which puts wheelchair users at a significant disadvantage, because they have no convenient way to measure their body weight. As a recent example, lack of participant's ability to self-weigh was a noted limitation to a weight loss program for wheelchair users, known as the Group Lifestyle Balance weight loss program Adapted for Individuals with Impaired Mobility (GLB-AIM). FIT solves this challenge by passively monitoring a user's weight when they get on and off their bed. The investigators lab and community-based feasibility trials demonstrated that FIT successfully tracks weight for individuals and couples sharing a bed and that users find FIT highly usable. This proposed project will allow the investigators to complete the design refinements participants recommended during our community-based feasibility trial and subsequently examine the efficacy of FIT in supporting the weight-loss goals of community-dwelling wheelchair users through a randomized controlled trial using the GLB-AIM.",[28,449,450],"Wheelchair","Obesity; Overweight",[449,452,453,454,455,456,457,458],"Wheelchair Users","Weigh loss","Weight loss device","Weight loss program","device research","bed scale","Wheelchair Scale","2026-02-20",{"date":461,"type":38},"2026-02-23",{"date":463,"type":38},"2026-02-16",{"date":465,"type":22},"2027-09",{"name":467,"class":45},"Jonathan Pearlman",{"id":469,"slug":470,"hasResults":12,"nctId":471,"briefTitle":472,"officialTitle":473,"acronym":4,"eligibilityCriteria":474,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":475,"targetDuration":4,"studyType":23,"phases":477,"briefSummary":478,"conditions":479,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":463,"lastUpdatePostDateStruct":484,"startDateStruct":486,"completionDateStruct":488,"leadSponsor":490,"locationsCount":46},"100492690","brief-cognitive-behavioral-therapy-for-people-with-physical-disabilities-100492690","NCT05695430","Brief Cognitive Behavioral Therapy for People With Physical Disabilities","Telehealth-delivered Brief Cognitive Behavioral Therapy to Prevent Suicides in People With Physical Disabilities","Inclusion Criteria:\n\n* 18 years of age\n* Disability impacting vision, hearing, or mobility\n* Past-week suicidal ideation or past-month suicide attempt\n\nExclusion Criteria:\n\n* Inability to provide informed consent\n* Lack of internet connection and web camera",{"count":476,"type":22},60,[25],"The purpose of this study is to examine the effectiveness of a psychotherapy (non-medication) treatment, Brief Cognitive Behavioral Therapy for Suicide Prevention, in reducing suicide ideation and attempts for people with physical disabilities.",[480,481,482,28,368,483],"Suicide","Suicide, Attempted","Suicidal Ideation","Disability, Vision",{"date":485,"type":38},"2026-02-19",{"date":487,"type":38},"2022-03-01",{"date":489,"type":22},"2026-03",{"name":491,"class":45},"Ohio State University",{"id":493,"slug":494,"hasResults":12,"nctId":495,"briefTitle":496,"officialTitle":497,"acronym":498,"eligibilityCriteria":499,"healthyVolunteers":12,"sex":18,"minAge":4,"maxAge":4,"enrollmentInfo":500,"targetDuration":4,"studyType":23,"phases":502,"briefSummary":503,"conditions":504,"keywords":510,"overallStatus":271,"whyStopped":4,"lastUpdateSubmitDate":516,"lastUpdatePostDateStruct":517,"startDateStruct":519,"completionDateStruct":521,"leadSponsor":523,"locationsCount":4},"100623939","improving-step-in-stroke-patients-100623939","NCT07403149","Improving STEP in Stroke Patients","Evaluating the Improvement of Stepping Quality by Using Adapted Shoes","I-STEP","Inclusion Criteria:\n\n1. Aged over 18 years\n2. With health insurance card \" carte vitale \" (being affiliated to the French security system) on \"ALD\" (Affection de longue durée) meaning reimbursement at a 100% rate\n3. With a past history of stroke (ischemic or hemorrhagic) with a Rankin score 2 to 4, once stabilized (no more improvement), at least 6 months after stroke onset\n4. Spasticity on one side of the body, with spastic walking, with tip-toeing gait, resulting in a \"mowing wheats-like\" movement of the leg as described in the French literature\n5. Patient had full medical examination prior to this research\n6. Informed and written consent of the participant.\n\nExclusion Criteria:\n\n1. Impossible to walk (wheel chair or bedridden)\n2. Diabetic foot\n3. Unhealed and\u002For painful foot injury\n4. Acquired deformity of a foot (osteophytosis, parrot beak on metatarso-phalangeal joint of the first ray, a bunion or hallux valgus, or hallux rigidus or stiffness of the big toe)\n5. Intercurrent disease that may interfere with the evaluation of the primary outcome (Parkinson's disease, peripheral neuropathy, Little's disease, significant hip or knee injury)",{"count":501,"type":22},58,[25],"Stroke is the leading cause of acquired disability in adults. Stroke causes death in 10% of patients, disability and functional handicap in 60% of cases. Sequelea of hemiplegia include spasticity resulting in great difficulty and slowness in walking, gait instability, increasing the risk of falls.\n\nDeambulation may need help (cane, crutch, tripod cane, walker). Lower limb spasticity includes hypertonia of extensors (gluteus maximus, quadriceps, posterior gastrocnemius) resulting in equinovarus. A neurology deficit may be present on ipsilateral lower limb flexors. Hence the patient walks with rubbing of the tip of the foot (tip-toeing gait), resulting in a \"mowing wheatslike\" movement of the leg as described in the French literature. Walking is then slowed down, unstable, with increased risk of falls.\n\nIn post stroke, during the period of rehabilitation and beyond, it is advisable to wear sports shoes although custom-made shoes improve walking and are reimbursed by the French social security system after prior agreement. Most of patients only wear conventional shoes.",[505,506,28,507,508,509],"Stroke","Hemiplegia Following Ischemic Stroke","Spasticity as Sequela of Stroke","Gluteus Maximus Muscle Atrophy","Equinovarus Foot",[505,511,512,513,514,515],"Hemiplegia","equinovarus","orthopedic shoes","REMARCHE® shoes","Walking performance","2026-02-04",{"date":518,"type":38},"2026-02-11",{"date":520,"type":22},"2026-03-01",{"date":522,"type":22},"2026-04-01",{"name":524,"class":45},"Assistance Publique - Hôpitaux de Paris",{"id":526,"slug":527,"hasResults":12,"nctId":528,"briefTitle":529,"officialTitle":530,"acronym":531,"eligibilityCriteria":532,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":287,"enrollmentInfo":533,"targetDuration":4,"studyType":23,"phases":535,"briefSummary":536,"conditions":537,"keywords":549,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":553,"lastUpdatePostDateStruct":554,"startDateStruct":556,"completionDateStruct":558,"leadSponsor":560,"locationsCount":46},"100531998","the-fit-with-us-study-100531998","NCT06207084","The Fit With Us Study","Precision-based Teleexercise Trial to Increase Adherence in People With Disabilities","FITWITHUS","Eligible participants must meet the following criteria to be included: (1) live with a permanent physical disability that limits their mobility; (2) be 18 to 89 years of age; (3) have broadband internet access; (4) be able to speak and read English; and (5) be able to attend coaching and training sessions during the weekdays.\n\nParticipants are excluded from participation if they (1) possess significant visual acuity that prevents seeing a computer screen to follow a home exercise program; (2) have been regularly engaging in exercise for the previous 3 months; (3) are unable to use their arms and their legs at all to exercise; (4) are unsafe to exercise; (5) self-report that they are currently pregnant",{"count":534,"type":22},257,[25],"The purpose of this 32-week study is to use an innovative experimental design known as SMART (Sequential Multiple Assignment Randomized Trial), which will allow us to determine the best way to sequence the delivery of teleexercise (referred to as an adaptive intervention), combined with predictive analytics on participant adherence in a stepped program of physical activity interventions. All 257 participants will have access to a library of recorded video exercise content, and a weekly wellness article. Some participants will receive health coaching calls (1st randomization). Analytic data will be used to determine which participants are responding or not responding to the intervention. Participants not responding after 4 weeks will receive either live one-on-one or group exercise training (2nd randomization). After 8 weeks, the participant will receive only pre-recorded exercise content and articles for a 24-week maintenance phase (weeks 9-32). The study outcomes are: The effectiveness of the adaptive interventions; Exploring mediating and moderating variables; Sensitivity analysis of the predictive analytics.",[538,28,539,540,541,542,543,544,545,546,547,548],"Mobility Limitations","Telehealth","Health Coaching","Physical Activity","Behavior, Health","eHealth","Health Literacy","Self Efficacy","Fatigue","Usability","Predictive Model",[550,551,552],"telehealth","health coaching","disability","2026-01-07",{"date":555,"type":38},"2026-01-09",{"date":557,"type":38},"2024-09-01",{"date":559,"type":22},"2029-02-01",{"name":561,"class":45},"University of Alabama at Birmingham",{"id":563,"slug":564,"hasResults":12,"nctId":565,"briefTitle":566,"officialTitle":566,"acronym":567,"eligibilityCriteria":568,"healthyVolunteers":12,"sex":85,"minAge":569,"maxAge":4,"enrollmentInfo":570,"targetDuration":4,"studyType":23,"phases":571,"briefSummary":572,"conditions":573,"keywords":577,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":584,"lastUpdatePostDateStruct":585,"startDateStruct":587,"completionDateStruct":589,"leadSponsor":591,"locationsCount":46},"100561821","breast-cancer-fitness-and-exercise-for-heart-health-the-be-fitter-study-100561821","NCT06595147","Breast cancEr, FITness and ExeRcise for Heart Health: The BE-FITTER Study","BE-FITTER","Inclusion Criteria:\n\n* Age ≥60 years\n* Previously diagnosed with early-stage (I-III) BC\n* Completed (≥1 year post) primary cardiotoxic treatment (anthracycline-based chemotherapy or trastuzumab-based biological therapy).\n\nExclusion Criteria:\n\n* Have a history of coronary artery disease, heart failure, persistent and permanent arrhythmia (e.g. currently in atrial fibrillation), stroke, or chronic obstructive pulmonary disease\n* Develop signs or symptoms of myocardial ischemia (≥1mm horizontal or down-sloping ST segment depression on electrocardiogram) during the cardiopulmonary (VO2peak) test\n* Have any research MRI contraindications (e.g. any type of pacemaker), or any orthopedic limitation preventing exercise testing\n* Currently performing structured exercise training (defined as ≥30 mins\u002Fday of moderate-to-vigorous aerobic and\u002For resistance exercise training on ≥4 days\u002Fweek)\n* Are unwilling to be randomized to either ExT or STRETCH","60 Years",{"count":476,"type":22},[25],"The chemotherapy medications used for breast cancer treatment are important for achieving a cure, but a potential side effect is that they can cause a decline in functional capacity (reduced exercise tolerance and impaired physical function) and increase the risk of cardiovascular disease. The risks of decreased functional capacity and cardiovascular disease are highest in breast cancer survivors as they grow older. The factors causing the decline in functional capacity are not well understood, however they may be related to a reduction in cardiac function (e.g. decreased pumping ability of the heart) or skeletal muscle function (reduced muscle blood flow and oxygenation). Exercise training is used for other populations at risk for cardiovascular disease (such as cardiac rehabilitation), but is not routinely offered to breast cancer survivors. Therefore this research study wants to test whether exercise training can improve heart and muscle health, and increase functional capacity in up to 60 older breast cancer survivors aged \\>60 years old who previously received chemotherapy drugs that can affect the heart.\n\nThe purpose of this study is to compare two rehabilitation approaches: a 12-week structured exercise training program or a 12-week stretching-yoga program. The investigators want to compare whether these programs can improve functional capacity, and heart and skeletal muscle function. To do this, some of the participants in this study will be randomly enrolled in the structured exercise training program and others will be randomly enrolled in the stretching-yoga program.",[574,28,575,576],"Breast Cancer","Heart Failure","Cardiotoxicity",[578,579,580,581,582,583],"Exercise Training","Fitness","Heart","Muscle","Cancer","Survivorship","2026-01-05",{"date":586,"type":38},"2026-01-08",{"date":588,"type":38},"2024-07-01",{"date":590,"type":22},"2026-12-20",{"name":592,"class":45},"University of Alberta",{"id":594,"slug":595,"hasResults":12,"nctId":596,"briefTitle":597,"officialTitle":598,"acronym":599,"eligibilityCriteria":600,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":54,"enrollmentInfo":601,"targetDuration":4,"studyType":148,"phases":4,"briefSummary":603,"conditions":604,"keywords":610,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":615,"lastUpdatePostDateStruct":616,"startDateStruct":618,"completionDateStruct":620,"leadSponsor":622,"locationsCount":46},"100612468","prospective-evaluation-of-atrial-fibrillation-related-stroke-patients-in-rehabilitation-program-pearl-an-observational-cohort-study-100612468","NCT07253974","Prospective Evaluation of Atrial Fibrillation-Related Stroke Patients in Rehabilitation Program (PEARL), an Observational Cohort Study","Prospective Evaluation of Atrial Fibrillation-Related Stroke Patients in Rehabilitation Program (PEARL), an Observational Cohort Study. TARGET: Health Virtual Twins for the Personalised Management of Stroke Related to Atrial Fibrillation\".","PEARL","Inclusion Criteria:\\> 18 a, first-ever intracerebral ischemic stroke\n\n\\-\n\nExclusion Criteria:\n\n* intracranial haemorrhage, symptomatic hemorrhagic transformation, new infarcts after the initial stroke or other neurological or psychiatric conditions.",{"count":602,"type":22},213,"The goal of this observational study is to determine if rehabilitation program intensity impacts functional recovery and specific needs in adult ischemic stroke patients who require inpatient rehabilitation. The main questions it aims to answer are:\n\nDo patients with stroke of Atrial-related subtypes (AFRS) have distinct rehabilitation needs and functional outcomes compared to non-AFRS patients? Does higher-intensity inpatient rehabilitation (3-5 sessions\u002Fday) result in better functional recovery at six months (measured by the Barthel Index) than moderate-intensity programs (1 session\u002Fday)? The study is non-invasive, does not interfere with usual care. The investigators' ultimate goal is to enhance the understanding of recovery after following different rehabilitation usual programs.",[605,606,607,608,609,28],"STROKE","Rehabilitation Outcome","Brain Disease","Cardiovascular Disease Acute","Hemiplegia and\u002For Hemiparesis Following Stroke",[611,612,552,613,614],"functional outcomes","stroke","rehabilitation","high intensity rehabilitation program","2025-12-11",{"date":617,"type":38},"2025-12-15",{"date":619,"type":38},"2024-11-11",{"date":621,"type":22},"2027-12-01",{"name":623,"class":45},"Parc de Salut Mar",{"id":625,"slug":626,"hasResults":12,"nctId":627,"briefTitle":628,"officialTitle":628,"acronym":629,"eligibilityCriteria":630,"healthyVolunteers":145,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":631,"targetDuration":4,"studyType":23,"phases":633,"briefSummary":634,"conditions":635,"keywords":640,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":655,"lastUpdatePostDateStruct":656,"startDateStruct":658,"completionDateStruct":660,"leadSponsor":662,"locationsCount":664},"100501810","red-blood-cell-transfusion-in-ecmo---a-feasibility-trial-100501810","NCT05814094","Red Blood Cell Transfusion in ECMO - A Feasibility Trial","ROSETTA","Inclusion Criteria:\n\n* Patients receiving ECMO\n* Age: 18 years or older\n\nExclusion Criteria:\n\n* Contraindication to RBC transfusion (including known patient preference)\n* Limitations of care put in place either through patient wishes or the treating medical teams\n* ECMO treatment for more than 12 hours. The start of ECMO is defined as the time of initiation of extracorporeal blood flow unless ECMO was initiated during a surgical intervention in which case the start is defined as the arrival time into the initial ICU.\n* The treating physician anticipates that ECMO treatment will cease before the end of tomorrow\n* Where the treating physician deems the study is not in the patient's best interest\n* Where the treating physician has concern regarding patient ability to tolerate restrictive or liberal transfusion trigger thresholds\n* Patients actively listed for a solid organ transplant\n* Patients who are suspected or confirmed to be pregnant\n* Previous ECMO treatment during the same hospital admission",{"count":632,"type":22},120,[25],"Extracorporeal Membrane Oxygenation (ECMO) is an invasive and resource intense treatment used to support critically ill patients who have suffered severe cardiac arrest, cardiac failure or respiratory failure (including severe cases of COVID-19). ECMO acts as a mechanical circulatory support temporarily replacing the function of the heart or lungs by oxygenating blood and removing carbon dioxide, allowing time for these organs to recover. Many critically ill patients, including those on ECMO, have an increased risk of bleeding and reduced production\u002Fincreased destruction of red blood cells (RBCs). This can lead to anaemia (haemoglobin levels \\\u003C120 g\u002Fl), a condition where the body lacks enough healthy RBCs to carry enough oxygen to the body's tissues. Therefore, patients on ECMO frequently require RBC transfusion, with clinicians having to decide if administering an RBC transfusion (with its associated risks) is higher than tolerating complications of anaemia.\n\nROSETTA is a feasibility study that aims to determine the safety and feasibility of randomizing patients on ECMO to a restrictive RBC transfusion strategy (maintain Hb concentration above 70g\u002FL) or to a more liberal transfusion strategy (maintain Hb concentration above 90g\u002FL). Feasibility is defined as the ability to achieve a mean separation of at least 10g\u002FL between the average lowest daily haemoglobin values in the two study groups.",[636,637,28,638,639],"Blood Loss Anemia","Extracorporeal Membrane Oxygenation Complication","Cognitive Ability, General","Functional Status",[641,642,643,644,645,646,647,648,649,650,651,652,653,654],"Hb","RBC transfusion","ECMO","feasibility","safety","blood transfusion","Australia","blood products","ICU","critical care","intensive care","bleeding","transfusion","Hb values","2025-05-27",{"date":657,"type":38},"2025-05-31",{"date":659,"type":38},"2023-09-20",{"date":661,"type":22},"2025-12-30",{"name":663,"class":45},"Australian and New Zealand Intensive Care Research Centre",2,{"id":666,"slug":667,"hasResults":12,"nctId":668,"briefTitle":669,"officialTitle":670,"acronym":671,"eligibilityCriteria":672,"healthyVolunteers":12,"sex":18,"minAge":673,"maxAge":4,"enrollmentInfo":674,"targetDuration":4,"studyType":23,"phases":676,"briefSummary":677,"conditions":678,"keywords":679,"overallStatus":271,"whyStopped":4,"lastUpdateSubmitDate":683,"lastUpdatePostDateStruct":684,"startDateStruct":686,"completionDateStruct":688,"leadSponsor":689,"locationsCount":4},"100579762","evaluation-of-orthopus-partner-arm-in-people-with-disabilities-needing-for-robotic-assistance-to-compensate-for-upper-limb-deficiency-100579762","NCT06828510","Evaluation of ORTHOPUS Partner Arm in People With Disabilities Needing for Robotic Assistance to Compensate for Upper Limb Deficiency","Evaluation of the ORTHOPUS Partner Arm in People With Disabilities Needing for Robotic Assistance to Compensate for Upper Limb Deficiency","MS PARTNER","Inclusion Criteria:\n\n* Have a loss of mobility in the upper limb (UL).\n* Have minimal functional capacities in the upper limb, defined by a score between 1 and 4 on the Lovett scale for all muscle groups of the arm, except for the hand and wrist.\n* Demonstrate effective distal motor skills in the upper limb to be fitted.\n* Be an informed patient who has provided signed consent, or in the case of minors, have given assent along with the signed consent of legal guardians.\n* A relative must be available for the installation visit, and either the patient or the relative must have the necessary equipment to record videos in ecological conditions (smartphone or tablet).)\n\nExclusion Criteria:\n\n* Patients with cognitive or behavioral dysfunctions that may compromise adherence to instructions and procedures required for the trial (at the discretion of the investigator clinician).\n* Patients already enrolled in an interventional clinical trial.\n* History of fractures in the upper limb to be fitted within the six months preceding the inclusion visit in the trial.\n* Any conditions or injuries that may interfere with functional assessments.\n* Patients under legal guardianship or curatorship.\n* Lack of health insurance coverage.","6 Years",{"count":675,"type":22},12,[25],"The study is a prospective, multicenter, interventional, open clinical trial, in Single Case Experimental Design (SCED) in multiple introduction withdrawal, controlled, randomized.",[28],[552,680,681,682],"robotic","impairment","upper limb","2025-02-10",{"date":685,"type":38},"2025-02-14",{"date":687,"type":22},"2025-03",{"date":107,"type":22},{"name":524,"class":45},{"id":691,"slug":692,"hasResults":12,"nctId":693,"briefTitle":694,"officialTitle":695,"acronym":4,"eligibilityCriteria":696,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":697,"targetDuration":4,"studyType":23,"phases":699,"briefSummary":700,"conditions":701,"keywords":702,"overallStatus":271,"whyStopped":4,"lastUpdateSubmitDate":707,"lastUpdatePostDateStruct":708,"startDateStruct":710,"completionDateStruct":712,"leadSponsor":714,"locationsCount":4},"100576535","nurse-led-rehabilitation-to-improve-self-care-among-stroke-patients-in-bangladesh-100576535","NCT06786559","Nurse-led Rehabilitation to Improve Self-care Among Stroke Patients in Bangladesh","Post Discharge Nurse-led Rehabilitation to Improve Self-care Among Stroke Patients in Bangladesh: A Pilot Randomized Controlled Trial","Inclusion Criteria:\n\n* For Patient\n\n  1. who is 18 years old and above, both males \\& females,\n  2. is irrespective of type of stroke and time of stroke,\n  3. is within 5 days to 2 weeks of onset of the current stroke\n  4. Physician advice rehabilitation, and who needs assistive devices for ADL,\n  5. has family caregivers,\n  6. lives in the study area, and\n  7. who will provide written consent \\& willing to participate in the study.\n\nFor family care giver\n\n1. Primary caregivers irrespective of sex and aged 18 years old and above, living with the patient who take care of an above patient and who meets all the inclusion criteria.\n2. Who will provide written consent \\& willing to participate in the study\n\nExclusion Criteria:\n\n* For patient\n\n  1. Participation in other clinical trials,\n  2. not having a smartphone at home, For family care giver No exclusion criteria",{"count":698,"type":22},64,[25],"Stroke causes various levels of disability, which decreases physical function for a prolonged period. The purpose of this study is to test the feasibility and efficacy of a nurse-led rehabilitation program focused on improving the activity of daily living (ADL) among post-stroke patients in Bangladesh. A feasibility study, including descriptive and randomized controlled trial (RCT), will be conducted at the National Institute of Neuroscience \\& Hospital (NINS\\&H) in Dhaka, Bangladesh, from March 2025 to August 2025. Participants will be the post-stroke patients who got discharged from NINS\\&H from 5th days to 2 weeks after the onset of stroke and the family caregivers of the patients and meet the inclusion criteria. The sample size will be calculated based on G-Power analysis with a medium effect size and will be 64. The intervention will be designed to provide the 3-month nurse-led rehabilitation program regarding self-care and the use of assistive devices. Assessment for rehabilitation will be performed by the multidisciplinary team with research nurses (RA nurses), physiotherapists (PT), and occupational therapists (OT). The control group will receive the usual care. The Functional Independence Measure (FIM) measures the primary outcome as improved self-care. The secondary outcomes are self-efficacy and participation in social activities for patients and the care burden of family caregivers. We also qualitatively describe changes and improvements of cognitive, emotional, and behavioral aspects among patients and their families. The endpoints will be compared at baseline and the 3rd month. Rehabilitation with proper assistive devices may improve self-dependence, ADL, and social participation. The caregiver's burden will decrease through the implementation of self-care education and assistive devices for daily life adjustment.",[505,28],[505,31,703,704,705,706],"Rehabilitation","Assistive device","Self-Care","Care Burden","2025-01-15",{"date":709,"type":38},"2025-01-22",{"date":711,"type":22},"2025-03-01",{"date":713,"type":22},"2025-08-30",{"name":715,"class":45},"Hiroshima University",{"id":717,"slug":718,"hasResults":12,"nctId":719,"briefTitle":720,"officialTitle":721,"acronym":722,"eligibilityCriteria":723,"healthyVolunteers":12,"sex":18,"minAge":119,"maxAge":4,"enrollmentInfo":724,"targetDuration":4,"studyType":23,"phases":726,"briefSummary":727,"conditions":728,"keywords":730,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":735,"lastUpdatePostDateStruct":736,"startDateStruct":738,"completionDateStruct":740,"leadSponsor":742,"locationsCount":46},"100542239","immersive-virtual-reality-and-physical-exercise-on-cognitive-and-functional-performance-in-hospitalized-older-patients-100542239","NCT06340282","Immersive Virtual Reality and Physical Exercise on Cognitive and Functional Performance in Hospitalized Older Patients","Effects of Immersive Virtual Reality and\u002For Multicomponent Physical Exercise on Cognitive and Functional Performance in Hospitalized Older Patients With Severe Functional Dependency: Study Protocol for a Randomized Clinical Trial","MOTOMED","Inclusion Criteria:\n\nAge ≥ 75 years Clinica Stability Expected length of stay ≥ 5 days Being able to communicate and collaborate with the research team\n\nExclusion Criteria:\n\nBarthel Index score ≥ 60 at admission Refusal to sign the informed consent by the patient\u002Flegal guardian or inability to obtain it Life expectancy less than three months End-stage disease Severe level of major neurocognitive disorder (GDS 7)",{"count":725,"type":22},212,[25],"This study will be conducted in a hospital in Spain to investigate how a special intervention using immersive virtual reality technology can benefit hospitalized older adults with difficulties in their daily functionality.\n\nThe main objective of this study is to evaluate whether a cognitive stimulation intervention through immersive virtual reality, along with specific physical exercises, can improve the cognitive and physical function of hospitalized older patients. It is expected that this innovative intervention will have a positive impact on the quality of life of these patients.\n\nParticipants eligible for the study must be over 75 years old, have severe functional dependency upon hospital admission, and be willing to participate. Those with severe dementia or other terminal illnesses will be excluded.\n\nParticipants will be randomly assigned to one of four study groups: a control group without intervention and three intervention groups, including viewing Spanish landscapes through virtual reality, performing specific physical exercises, or a combination of both interventions.\n\nAt the end of the study, various aspects such as cognitive and physical function, mood, quality of life, muscle strength, and acceptance of virtual reality technology by patients will be evaluated.\n\nThis study aims to provide new insights into the care of hospitalized older adults and explore innovative ways to improve their well-being during their hospital stay",[28,729],"Cognition",[731,732,733,734,552],"hospital-associated functional decline","cognitive stimulation","immersive virtual reality","multicomponent physical exercise","2025-01-10",{"date":737,"type":38},"2025-01-13",{"date":739,"type":38},"2024-04-01",{"date":741,"type":22},"2025-04-01",{"name":743,"class":45},"Fundacion Miguel Servet",{"id":745,"slug":746,"hasResults":12,"nctId":747,"briefTitle":748,"officialTitle":749,"acronym":750,"eligibilityCriteria":751,"healthyVolunteers":12,"sex":18,"minAge":752,"maxAge":4,"enrollmentInfo":753,"targetDuration":4,"studyType":23,"phases":755,"briefSummary":756,"conditions":757,"keywords":764,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":776,"lastUpdatePostDateStruct":777,"startDateStruct":779,"completionDateStruct":781,"leadSponsor":783,"locationsCount":46},"100505942","effects-of-physical-activity-on-prescription-pap-as-a-health-enhancing-intervention-in-people-with-disabilities-100505942","NCT05867940","Effects of Physical Activity on Prescription (PAP) as a Health-enhancing Intervention in People With Disabilities","Effects of Physical Activity on Prescription (PAP) as an Individualised and Health-enhancing Intervention for Children, Adolescents and Adults With Different Disabilities Including Health Economic Analysis","PAP","Inclusion Criteria:\n\n* Physical inactivity\n* Not meeting the physical activity recommendations\n* Much sedentary time\n* Physical disability\n* Intellectual disability\n* Autism\n* Living in the Skåne Region in Sweden\n* Receiving treatment from the habilitation Services in the Skåne Region, Sweden\n\nExclusion Criteria:\n\n* Meeting the physical activity recommendations","8 Years",{"count":754,"type":22},80,[25],"Physical inactivity is an increasing problem in the general population in society. However, in people with disabilities, inactivity is even more frequently reported. Physical activity on prescription (PAP) is a well-established method to enhance physical activity. The prescribed physical activity can be activities such as walking, cycling, swimming, or gardening, and should be performed over a longer period. In children with cerebral palsy, PAP has shown to be feasible to increase participation in physical activity and to reduce sedentary behaviour, and the habilitation services in the Region of Skåne have decided to offer PAP to all children and youth with disabilities. It is of great importance to study these interventions when applied on a broader group of patients than previously studied.\n\nThe aim is to study the effects of an individualised and health-enhancing intervention in physically inactive people with autism, intellectual and physical disabilities. Also, the cost-effectiveness of PAP will be studied.\n\n60 physically inactive children, aged 8- 17 years, and 20 adults, with autism, intellectual or physical disability will be included. The participants are recruited by their clinical physiotherapists, who also will be carrying out the PAP-intervention. The self-selected physical activity\u002Factivities may either be a physical activity organized by a club and\u002For an everyday activity such as walking a dog or riding a bicycle to school. Each participant fills in an activity logbook. Motivational interviewing will be used to support the participants. The Canadian Occupational Performance Measure can be used to identify what activities the participants are motivated to do, and to detect changes in the participants' perception of their performance of the activity. Quality of life will be monitored. Physical activity will be measured through the International Physical Activity Questionnaire (IPAQ) and a movement monitor (accelerometer). Study specific questionnaires will be filled in regarding costs and background information. Data on health care use of the participants will retrospectively be collected and studied using the health care database in Region Skåne. Data will be collected at 3 months prior to the intervention, just before the intervention starts, when the intervention is finished, and at 6, 12 and 24 months after the intervention. The study has been approved by the Swedish Ethical Review Authority.",[758,759,760,761,762,28,763],"Physical Inactivity","Cerebral Palsy","Autism","Autism Spectrum Disorder","Intellectual Disability","Sedentary Behavior",[765,766,767,768,769,770,771,772,773,774,760,775],"Physical activity on prescription","Children","Adolescents","Adults","Individualised intervention","Participation","Health-enhancing physical activity","Disabilities","Physical disability","Intellectual disability","Cerebral palsy","2024-11-14",{"date":778,"type":38},"2024-11-15",{"date":780,"type":38},"2023-06-05",{"date":782,"type":22},"2027-12",{"name":784,"class":45},"Region Skane"]