[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"disc-herniation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:disc-herniation":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,8,0,[8,47,76,101,125,152,186,206],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":23,"studyType":24,"phases":4,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100644701","fear-avoidance-beliefs-and-physical-function-in-patients-with-lumbar-disc-herniation-100644701",false,"NCT07674407","Fear-Avoidance Beliefs and Physical Function in Patients With Lumbar Disc Herniation","The Relationship Between Fear-Avoidance Beliefs and Trunk Muscle Endurance, Balance, and Functional Impairment in Patients With Lumbar Disc Herniation","FAB-LDH","Inclusion Criteria:\n\n* Aged between 18 and 65 years\n* Clinically and\u002For radiologically diagnosed with lumbar disc herniation\n* Presence of low back pain for at least 3 months\n* Sufficient cognitive capacity to understand and perform the assessment procedures\n* Ability to walk independently\n* Willingness to participate voluntarily and provide written informed consent\n\nExclusion Criteria:\n\n* History of lumbar spine surgery\n* History of neurological disorders, such as stroke or Parkinson's disease\n* Vestibular disorders or severe balance impairment\n* History of orthopedic injury or surgery affecting the lower extremities\n* Presence of rheumatological disease\n* Pregnancy\n* Severe pain or an acute inflammatory condition that prevents completion of the assessment procedures","ALL","18 Years","65 Years",{"count":21,"type":22},65,"ESTIMATED","1 Day","OBSERVATIONAL","Lumbar disc herniation is one of the most common causes of low back pain and is associated with substantial functional limitations and reduced quality of life, particularly among working-age individuals. Displacement of disc material toward the spinal canal may result in mechanical compression and inflammation of the nerve roots, leading to pain, restricted movement, and reduced functional performance.\n\nThe course of low back pain cannot be explained solely by biomechanical and anatomical factors. Psychosocial factors also play an important role in symptom persistence and functional outcomes. Within this context, the fear-avoidance model provides an important theoretical framework, suggesting that individuals may develop fear of movement and avoid physical activities because they believe these activities may increase pain or cause further injury. Over time, avoidance behaviors may contribute to physical deconditioning, reduced muscle function, and increased functional impairment.\n\nThe Fear-Avoidance Beliefs Questionnaire is commonly used to assess individuals' beliefs regarding the relationship between pain, physical activity, and work-related activities. Higher levels of fear-avoidance beliefs have been associated with greater pain severity, increased disability, and poorer physical performance in individuals with low back pain.\n\nTrunk muscle endurance plays a key role in maintaining spinal stability. Adequate endurance of the paraspinal and abdominal muscles supports mechanical stability of the spine and contributes to the safe performance of functional movements. The Biering-Sørensen Test and plank test are commonly used to assess trunk muscle endurance in clinical and research settings. The Biering-Sørensen Test evaluates the endurance of the trunk extensor muscles, whereas plank-based tests assess the endurance of the anterior and lateral trunk musculature.\n\nFunctional impairment in individuals with low back pain can be evaluated using the Oswestry Disability Index, a self-reported questionnaire that assesses limitations experienced during activities of daily living. Functional mobility and performance may also be evaluated using the Timed Up and Go test, which involves standing up from a chair, walking a short distance, turning, returning to the chair, and sitting down. This test reflects mobility, dynamic balance, and functional performance during daily activities.\n\nPostural control and balance may also be affected in individuals with low back pain. Reduced static balance performance can negatively influence functional activities and mobility. The Single-Leg Stance Test is a practical clinical measure used to assess postural stability and static balance.\n\nAlthough previous studies have examined associations between psychosocial factors and functional status in individuals with low back pain, studies evaluating the relationship between fear-avoidance beliefs, trunk muscle endurance, balance, and functional performance together remain limited. Identifying these relationships may contribute to the development of more comprehensive rehabilitation programs for individuals with lumbar disc herniation.",[27],"Disc Herniation",[29,30,31,32,33],"fear-avoidance beliefs","trunk muscle endurance","balance","functional impairment","low back pain","RECRUITING","2026-06-23",{"date":37,"type":38},"2026-06-29","ACTUAL",{"date":40,"type":22},"2026-06-30",{"date":42,"type":22},"2026-10-30",{"name":44,"class":45},"Istinye University","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":54,"targetDuration":4,"studyType":56,"phases":57,"briefSummary":59,"conditions":60,"keywords":62,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":71,"leadSponsor":73,"locationsCount":46},"100644064","phase-4-return-to-activity-after-surgery-for-lumbar-disc-herniation-100644064","NCT07667348","Return to Activity After Surgery for Lumbar Disc Herniation","Return to Activity After Surgery for Lumbar Disc Herniation: An Exploratory, Post-Market, Prospective, Randomized, Controlled Trial of an Annular Closure Device","Inclusion Criteria:\n\n* Skeletally mature (male or female).\n* Patients with posterior or posterolateral disc herniations at one level between L4 and S1 with radiographic confirmation of neural compression using MRI. \\[Note: Intraoperatively, only patients with an annular defect (post discectomy) between 4mm and 6mm tall and 6mm and 10mm wide shall qualify.\\]\n* Minimum posterior disc height of 5mm at the index level.\n* Radiculopathy (with or without back pain) with a positive Straight Leg Raise (0 - 60 degrees)22 (L45, L5S1)\n* VAS leg pain (one or both legs) of at least 40\u002F100 at baseline\n* Psychosocially, mentally and physically able to fully comply with the clinical protocol and willing to adhere to follow-up schedule and requirements.\n* Implanted with annular closure device.\n\nExclusion Criteria:\n\n* Spondylolisthesis Grade II or higher (25% slip or greater).\n* Subject requires spinal surgery other than a discectomy (with or without laminotomy) to treat leg\u002Fback pain (scar tissue and osteophyte removal is allowed).\n* Subject has been diagnosed with active hepatitis, AIDS, or HIV.\n* Subject has been diagnosed with rheumatoid arthritis or other autoimmune disease.\n* Subject has a known allergy to titanium, polyethylene or polyester materials.\n* Any subject that cannot have a baseline MRI taken.\n* Subject is pregnant or interested in becoming pregnant in the next year.\n* Subject has active tuberculosis or has had tuberculosis in the past three (3) years.\n* Subject has a history of active malignancy: A patient with a history of any invasive malignancy (except non-melanoma skin cancer), unless he\u002Fshe has been treated with curative intent and there have been no signs or symptoms of the malignancy for at least two (2) years.\n* Subject is immunologically suppressed, received steroids \\>1 month over the past year.\n* Currently taking anticoagulants, other than aspirin, unless the patient can be taken off the anticoagulant for surgery.\n* Subject has a current chemical\u002Falcohol dependency or significant psychosocial disturbance.\n* Subject has a life expectancy of less than three (3) years.\n* Subject is currently involved in active spinal litigation (Workers' compensation patients may be included.\n* Subject is currently involved in another investigational study.\n* Subject is incarcerated.\n* Subject has back or non-radicular leg pain of unknown etiology.\n* Prior surgery at the index lumbar vertebral level.\n* Subject requiring a spine DEXA (i.e., patients with SCORE of ≥ 6) with a T Score less than -2.0 at the index level. For patients with a herniation at L5\u002FS1, the average T score of L1-L4 shall be used.\n* Subject has clinically compromised vertebral bodies in the lumbosacral region due to any traumatic, neoplastic, metabolic, or infectious pathology.\n* Subject has sustained pathologic fractures of the vertebra or multiple fractures of the vertebra or hip.\n* Subject has scoliosis of greater than ten (10) degrees (both angular and rotational).\n* Any metabolic bone disease.\n* Subject has an active infection either systemic or local.\n* Subject has cauda equina syndrome or neurogenic bowel\u002Fbladder dysfunction.\n* Subject has severe arterial insufficiency of the legs or other peripheral vascular disease. (Screening on physical examination for patients with diminution or absence of dorsalis pedis or posterior tibialis pulses. If diminished or absent by palpation, then an arterial ultrasound is required with vascular plethysmography. If the absolute arterial pressure is below 50mm of Hg at the calf or ankle level, then the patient is to be excluded.)\n* Subject has significant peripheral neuropathy, patient defined as a patient with Type I or Type II diabetes or similar systemic metabolic condition causing decreased sensation in a stocking-like or non-radicular and non-dermatomal distribution in the lower extremities.\n* Subject has insulin-dependent diabetes mellitus.\n* Subject is morbidly obese (defined as a body mass index \\>40 or weighs more than 100 lbs. over ideal body weight).",{"count":55,"type":22},120,"INTERVENTIONAL",[58],"PHASE4","RCT investigating postoperative activity restriction after lumbar discectomy in patients treated with annular closure.",[61,27],"Lumbar Disc Herniation Surgery",[63,64,65],"Lumbar discectomy","postoperative instructions","lumbar disc herniation","NOT_YET_RECRUITING","2026-06-18",{"date":69,"type":38},"2026-06-25",{"date":40,"type":22},{"date":72,"type":22},"2027-10-31",{"name":74,"class":75},"Intrinsic Therapeutics","INDUSTRY",{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":4,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":17,"minAge":83,"maxAge":84,"enrollmentInfo":85,"targetDuration":4,"studyType":56,"phases":87,"briefSummary":89,"conditions":90,"keywords":91,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":46},"100563071","discogen-for-low-back-pain-100563071","NCT06611397","Discogen for Low Back Pain","Double-Blinded Pilot Feasibility Study of the Discogen Device to Alleviate Discogenic Back\u002FRadicular Leg Pain","Inclusion Criteria\n\nThe subject may be included in the study if the following conditions are met:\n\n1. Adult (\\> 21 y.o.) males and females legally able and willing to participate and provide consent in the study and attend follow-up visits\n2. Able and willing to complete study forms and communicate with the investigator\n3. Presenting with unilateral radicular leg pain with or without axial back pain of \\>1 month duration\n4. No epidural injections at treatment site within the last three months\n5. Leg NPS pain score of 4 - 9 in the last month (on a scale of 0 to 10)\n6. Clinical presentation of sensory radiculopathy referable to single-level disc disease\u002Fherniation at L3-4, L4-5 or L5-S1\n7. MRI lumbar spine negative for extruded disc herniation, tumor, or bleeding, but positive for disc disease\u002Fherniation at L3-4, L4-5 or L5-S1 with mild to moderate foraminal or spinal stenosis (less than 50%).\n\nExclusion Criteria:\n\n1. Pregnant or breastfeeding patient\n2. Younger than 21 or older than 75 years\n3. Presenting with motor deficits\n4. Presenting with a baseline Oswestry Disability Index ≥ 41% (severe disability or worse)\n5. Presence of metal hardware within the lumbosacral spine\n6. History of spine surgery at the level of treatment.\n7. Lumbar spine pathology that may increase procedural risk and\u002For influence symptoms and\u002For generate unrelated adverse events (per the discretion of the study PI)\n8. Severe lumbar central canal stenosis (greater than 50%)\n9. Severe lumbar foraminal stenosis (greater than 50%)\n10. Severe herniated lumbar disc 4(Grade 2 and above)\n11. Lumbar instability on flexion\u002Fextension plain films, greater the Grade 1 spondylolisthesis\n12. Unable to understand and complete research questionnaires\n13. Any severe medical condition preventing the patient from safely and effectively being treated in the study or reporting study outcomes.\n14. BMI greater than 30\n15. Implanted spinal stimulators\n16. Epidural injections at treatment site within the last three months","21 Years","75 Years",{"count":86,"type":22},5,[88],"NA","This study will be a double-blinded, two-arm, prospective, randomized controlled pilot feasibility study in 40 evaluable subjects (20 in each arm) at one study site within the United States. Subjects in Arm 1 will receive unilateral Discogen treatment; subjects in Arm 2 will receive unilateral sham treatment (control). Treatment in both arms can include medications, e.g. NSAIDs or muscle relaxants for axial or radicular pain.",[27],[27],"2026-04-06",{"date":94,"type":38},"2026-04-09",{"date":96,"type":38},"2025-03-15",{"date":98,"type":22},"2027-08",{"name":100,"class":45},"Columbia University",{"id":102,"slug":103,"hasResults":11,"nctId":104,"briefTitle":105,"officialTitle":106,"acronym":107,"eligibilityCriteria":108,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":84,"enrollmentInfo":109,"targetDuration":4,"studyType":56,"phases":111,"briefSummary":112,"conditions":113,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":115,"lastUpdatePostDateStruct":116,"startDateStruct":118,"completionDateStruct":120,"leadSponsor":122,"locationsCount":124},"100517913","safety-and-performance-of-disc-care-to-prevent-lumbar-disc-herniation-recurrence-100517913","NCT06023719","Safety And Performance Of Disc Care To Prevent Lumbar Disc Herniation Recurrence","Multicentric Clinical Investigation To Assess The Safety And Performance Of Disc Care To Prevent Lumbar Disc Herniation Recurrence","ACE-2","Inclusion Criteria:\n\n* Subject is between 18 and 75 years old.\n* Posterolateral disc hernia between levels L4 and S1 with radiological (CT scan or MRI) confirmation of neural compression.\n* At least six weeks of failed conservative treatment prior to surgery, including physical therapy, use of anti-inflammatory medications at maximum specified dosage and\u002For administration of epidural\u002Ffacet injections.\n* Minimum posterior disc height of 5 mm at the index level.\n* Radiculopathy with positive straight leg raise test.\n* ODI score of at least 30\u002F100.\n* Subjects who are able to give voluntary informed consent to participate in the clinical investigation and from whom consent has been obtained.\n* Subject is able and willing to comply with the protocol requirements.\n\nExclusion Criteria:\n\n* Spondylolisthesis and\u002For instability at the index level that, in the judgement of the surgeon, could affect the device implantation.\n* Central, foraminal or extraforaminal disc hernia.\n* Subject has vertebral bodies of the index level affected by any traumatic, neoplastic, metabolic, or infectious pathology.\n* Subject has scoliosis of greater than 20 degrees (both angular and rotational).\n* Grossly distorted anatomy due to congenital abnormalities.\n* Deformation that affects the posterior corners of the vertebra at the index level (e.g., osteophytes) that, in the judgment of the surgeon, could affect the device implantation.\n* Endplate irregularities that, in the judgment of the surgeon, could affect the device implantation.\n* Prior surgery at the index lumbar vertebral level that, in the judgment of the surgeon, could affect the device implantation.\n* Radiological confirmation of severe facet joint disease or degeneration.\n* Patients diagnosed or at a high risk of osteoporosis (such as postmenopausal women and patients receiving long-term treatment with corticosteroids) who present a bone densitometry DXA (dual energy x-ray absorptiometry) T-score of less than -2.0 at the index level.\n* Cauda equina syndrome.\n* Fever, leucocytosis and\u002For systemic or localized active infection.\n* Systemic inflammation and\u002For inflammation at the implantation site.\n* Any uncontrolled metabolic bone disease that affects the spine.\n* Uncontrolled insulin-dependent diabetes mellitus.\n* Peripheral neuropathy.\n* Active hepatitis, AIDS or HIV.\n* Rheumatoid arthritis or other autoimmune disease that affects the spine joints.\n* Active or history of any invasive malignancy; patients with curatively-treated malignancies who have been disease-free for at least 5 years are eligible.\n* Uncontrolled active tuberculosis or history of uncontrolled tuberculosis in the past 3 years.\n* Immunologically suppressed patients.\n* Current anticoagulation therapy, unless anticoagulation therapy can be suspended for surgery.\n* Patients who have received medication (e.g., methotrexate, alendronate) that interferes with bone mineral metabolism within 4 weeks of the planned date of the index surgery.\n* Suspected or known allergies or intolerance to the device materials: titanium, nitinol, stainless steel, polyetheretherketone and polyethylene terephthalate.\n* Any condition that precludes the use of general anaesthesia.\n* Any condition that precludes the surgical procedure.\n* Any contraindication for MRI or CT scan.\n* Class III obesity: Body mass index ≥ 40.\n* Current alcohol or recreational drug dependency.\n* Pregnant or interested in becoming pregnant in the following 24 months.\n* Breastfeeding.\n* Life expectancy less than 2 years.\n* Subject is currently participating or has participated in the previous 4 weeks in any other interventional clinical study.",{"count":110,"type":22},30,[88],"The goal of this clinical investigation is to learn about DISC Care, an Hernia Blocking System, in patients who have undergone lumbar disc hernia surgery. The main questions it aims to answer are:\n\n* if the implant (DISC Care) prevents disc herniation recurrence\n* if DISC Care is a safe device\n\nParticipants will be implanted with DISC Care and followed up for two years (7 visits).",[27,114],"Disk Herniated Lumbar","2026-01-09",{"date":117,"type":38},"2026-01-12",{"date":119,"type":38},"2023-11-30",{"date":121,"type":22},"2028-06",{"name":123,"class":75},"NEOS Surgery",7,{"id":126,"slug":127,"hasResults":11,"nctId":128,"briefTitle":129,"officialTitle":130,"acronym":4,"eligibilityCriteria":131,"healthyVolunteers":132,"sex":17,"minAge":133,"maxAge":134,"enrollmentInfo":135,"targetDuration":4,"studyType":56,"phases":137,"briefSummary":138,"conditions":139,"keywords":140,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":143,"lastUpdatePostDateStruct":144,"startDateStruct":146,"completionDateStruct":148,"leadSponsor":150,"locationsCount":4},"100570759","caudal-neuroplasty-using-epidural-catheter-combined-with-pulsed-radiofrequency-versus-pulsed-radiofrequency-alone-100570759","NCT06711419","Caudal Neuroplasty Using Epidural Catheter Combined with Pulsed Radiofrequency (versus Pulsed Radiofrequency Alone","Safety and Efficacy of Caudal Neuroplasty Using Epidural Catheter Combined with (PRF) Versus (PRF) Alone Both Targeting the Dorsal Root Ganglion in Patients with Lumbosacral Radicular Pain","Inclusion Criteria:\n\n* Adult patients aged 20-80 years old complaining with lumbosacral radicular pain.\n* pain intensity ≥4 out of 10 on the numerical rating scale (NRS).\n* dominant leg pain with less intense back pain.\n* previous failure of conservative management such as physiotherapy, exercise therapy, or analgesic medications.\n* Epidural injections administered ≥12 weeks prior to recruitment were permitted because most of the patients visiting our clinic had a history of interlaminar or transforaminal epidural injections.\n* Magnetic resonance imaging (MRI) was obtained in all patients and the diagnosis of lumbar disc prolapse was confirmed.\n\nExclusion Criteria:\n\n* patient refusal to participate in the study,\n* age \\\u003C20 years,\n* unbearable pain \\>9-points on NRS, pain \\\u003C4-points on NRS.\n* signs of progressive motor weakness or neurologic deficits.\n* Instability of the spine\n* allergies to steroids or contrast dyes.5\n* coagulopathy.\n* steroid injection within the previous 12 weeks.\n* systemic infection, injection site infection.\n* malignancy.\n* unstable medical or psychiatric condition",true,"20 Years","80 Years",{"count":136,"type":22},70,[88],"Evaluating the superiority of caudal neuroplasty using epidural catheter (Perifix® Complete Set 16 G) combined with Pulsed Radiofrequency (PRF) versus Pulsed Radiofrequency (PRF) alone targeting the dorsal root ganglion In patients with lumbar radicular pain on pain reduction and quality of life within six months follow up.",[27],[141,142],"Pulsed radio freqency","caudal neuroplasty","2024-11-27",{"date":145,"type":38},"2024-12-02",{"date":147,"type":22},"2024-12-10",{"date":149,"type":22},"2028-03-10",{"name":151,"class":45},"Assiut University",{"id":153,"slug":154,"hasResults":11,"nctId":155,"briefTitle":156,"officialTitle":157,"acronym":158,"eligibilityCriteria":159,"healthyVolunteers":11,"sex":17,"minAge":160,"maxAge":4,"enrollmentInfo":161,"targetDuration":4,"studyType":56,"phases":163,"briefSummary":164,"conditions":165,"keywords":171,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":177,"lastUpdatePostDateStruct":178,"startDateStruct":180,"completionDateStruct":182,"leadSponsor":184,"locationsCount":46},"100462821","preventing-pain-after-surgery-100462821","NCT05306665","PREventing Pain After Surgery","PREventing Pain After Surgery: a Feasibility and Acceptability Study of Acceptance and Commitment Therapy for the Prevention of Chronic Post-surgical Pain (PREPS)","PREPS","Inclusion Criteria:\n\n* scheduled to undergo fusion, discectomy, vertebroplasty, kyphoplasty, or foraminotomy\n* age 22 and older\n* able to communicate fluently in English\n\nExclusion Criteria:\n\n* inability to complete study procedures due to delirium, dementia, psychosis, or other cognitive impairment\n* have a history of severe neurologic movement disorder\n* are pregnant or intent to become pregnant during study\n* have undergone previous spinal surgery\n* have spinal deformity, pseudarthrosis, trauma, infection, or tumor as primary indication for surgery\n* have undergone Acceptance and Commitment Therapy in last 2 years","22 Years",{"count":162,"type":22},140,[88],"The present study aims to adapt and modify a brief presurgical Acceptance and Commitment Therapy (ACT) intervention aimed at preventing the transition to Chronic Post-Surgical Pain (CPSP) and reducing long-term opioid use. Investigators will then assess the acceptability, feasibility, and preliminary efficacy of the finalized intervention to prevent the transition to CPSP and reduce post-surgical opioid use six months following lumbar spine surgery. Finally, investigators will identify psychosocial and psychophysical phenotypes associated with response to this intervention.",[166,167,27,168,169,170],"Pain, Back","Spinal Stenosis","Spondylosis","Spondylolisthesis","Back Injuries",[172,173,174,175,176],"Chronic pain","Surgery","opioid","acceptance and commitment therapy","Prevention","2024-10-25",{"date":179,"type":38},"2024-10-28",{"date":181,"type":38},"2023-01-13",{"date":183,"type":22},"2026-08-01",{"name":185,"class":45},"Brigham and Women's Hospital",{"id":187,"slug":188,"hasResults":11,"nctId":189,"briefTitle":190,"officialTitle":190,"acronym":4,"eligibilityCriteria":191,"healthyVolunteers":132,"sex":17,"minAge":133,"maxAge":192,"enrollmentInfo":193,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":195,"conditions":196,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":197,"lastUpdatePostDateStruct":198,"startDateStruct":200,"completionDateStruct":202,"leadSponsor":204,"locationsCount":46},"100550931","silent-lumbar-disc-herniation-syndrome-100550931","NCT06453499","Silent Lumbar Disc Herniation Syndrome","Inclusion Criteria:\n\n* Inclusion criteria patients with LDH and root compression with no back or lower extremity symptoms.\n\nExclusion Criteria:\n\n* Any previous history that would affect the alignment or the motion to lower extremity joints as fractures or surgery.\n\nAny fixed deformity True leg length discrepancy (\\>5mm). Any medical condition affecting peripheral nerves as diabetes mellitus. Any neuromuscular dysfunction and vestibular disorder.Sacroiliac pain or dysfunction low back pain.\n\nRadicular or referred or radiating pain Previous lower extremity injury","40 Years",{"count":194,"type":22},180,"LDH is a common phenomenon that is often described in association with various pathological processes affecting the neuromuscular and locomotor systems. It is not only associated with pathology but it can also be observed in healthy individuals with no evidence of any dysfunction. Since LDH is observed in such a large percentage of healthy subjects, it is probably more appropriate to perceive it as a physiological phenomenon with silent clinical biomechanical changes",[27],"2024-06-09",{"date":199,"type":38},"2024-06-11",{"date":201,"type":38},"2023-02-01",{"date":203,"type":22},"2024-09",{"name":205,"class":45},"Noha Khaled Shoukry",{"id":207,"slug":208,"hasResults":11,"nctId":209,"briefTitle":210,"officialTitle":211,"acronym":4,"eligibilityCriteria":212,"healthyVolunteers":11,"sex":17,"minAge":19,"maxAge":4,"enrollmentInfo":213,"targetDuration":4,"studyType":56,"phases":215,"briefSummary":216,"conditions":217,"keywords":4,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":220,"lastUpdatePostDateStruct":221,"startDateStruct":223,"completionDateStruct":225,"leadSponsor":227,"locationsCount":46},"100529835","effects-of-cognitive-intervention-therapy-on-postoperative-delirium-100529835","NCT06178939","Effects of Cognitive Intervention Therapy on Postoperative Delirium","Effects of Cognitive Intervention Therapy on Postoperative Delirium in Elderly Non-cardiac Surgical Patients","Inclusion Criteria:\n\n* Elderly patients aged 65 and above.\n* Patients undergoing orthopedic, thoracic, or hepatopancreatobiliary surgery under general anesthesia with an expected surgery duration of 2 hours or more.\n* Patients scheduled for arterial catheterization.\n\nExclusion Criteria:\n\n* Patients with uncontrolled systemic conditions such as diabetes and hypertension.\n* Those with visual impairment.\n* Patients with cognitive impairment based on the MMSE-DS criteria.\n* Individuals experiencing difficulty in communication.\n* Those diagnosed with neurological disorders (such as brain hemorrhage, stroke, brain tumor, dementia, Parkinson's disease, cognitive impairment, depression, etc.).\n* Patients diagnosed with alcohol or substance addiction.",{"count":214,"type":22},60,[88],"This study is a prospective, single-center, randomized controlled trial to compare whether applying cognitive intervention therapy before and after surgery in elderly patients aged 65 years or older undergoing non-cardiac surgery can reduce the incidence of postoperative delirium compared to conservative treatment.",[167,27,218,219],"Lung Neoplasms","Carcinoma, Hepatocellular","2023-12-15",{"date":222,"type":38},"2023-12-21",{"date":224,"type":22},"2023-12",{"date":226,"type":22},"2027-10",{"name":228,"class":45},"Yonsei University"]