[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"discogenic-pain\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:discogenic-pain":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,43],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":27,"conditions":28,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":5},"100513739","phase-2-evaluation-of-efficacy-and-safety-of-intradiscal-gelified-ethanol-in-refractory-cervical-discogenic-pain-100513739",false,"NCT05969392","Evaluation of Efficacy and Safety of Intradiscal Gelified Ethanol in Refractory Cervical Discogenic Pain","Intradiscal Gelified Ethanol in Refractory Cervical Discogenic Pain : a Interventional, Prospective, Multi-center, Open-label Study.","DISCOCERV","Inclusion Criteria:\n\n* Patient 18 years or older;\n* Pain refractory to conservative treatments for more than 2 months, non-surgical patients\n* Cervicobrachialgia due to disc herniation\n* Chronic discogenic pain (1 or 2 cervical discs) with concordant MRI;\n* Patient agreeing to participate in the study and having given written consent;\n* Patient enrolled in a health insurance plan.\n\nExclusion Criteria:\n\n* Prior surgical treatment of the disc(s) studied;\n* Sick leave of more than 12 months secondary to painful symptoms;\n* Patient with Modic 1 score or more\n* History of cognitive-behavioral disorders that could affect the completion of self-questionnaires;\n* Local or systemic infection, or suspicion of infection;\n* Severe coagulation disorders;\n* Other inflammatory rheumatic disease;\n* Severe underlying pathology with life expectancy \\\u003C1 year;\n* Women of childbearing age who are pregnant at the inclusion visit or who wish to become pregnant before the administration of the treatment (V0);\n* Known allergy to contrast material and\u002For local anesthetic substances;\n* Patients who cannot read or write Italian;\n* Major person benefiting from a legal protection regime (guardianship, curatorship, safeguard of justice);","ALL","18 Years","120 Years",{"count":21,"type":22},60,"ESTIMATED","INTERVENTIONAL",[25,26],"PHASE2","PHASE3","The purpose of this study is to assesse safety and efficacy of the Intradiscal Gelified Ethanol for treatment in refractory cervical discogenic pain.",[29,30],"Pain, Cervical","Discogenic Pain","NOT_YET_RECRUITING","2025-03-07",{"date":34,"type":35},"2025-03-11","ACTUAL",{"date":37,"type":22},"2025-04",{"date":39,"type":22},"2026-04",{"name":41,"class":42},"Gelscom SAS","INDUSTRY",{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":17,"minAge":50,"maxAge":51,"enrollmentInfo":52,"targetDuration":54,"studyType":55,"phases":4,"briefSummary":56,"conditions":57,"keywords":66,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":82},"100544681","tornado-omics-techniques-and-neural-networks-for-the-development-of-predictive-risk-models-100544681","NCT06372054","TORNADO-Omics Techniques and Neural Networks for the Development of Predictive Risk Models","Integration of Omics-based Technologies and Artificial Intelligence to Identify Predictive Risk Models in a Air Force's Pilot Cohort for the Maintenance of Safety, Well-being, Health, and Performance to be Translated to Civil Population","Inclusion Criteria:\n\n* Being part of the Italian Air Force, as in active flight service or ground staff\n* Age between 26 and 38 years\n* Consent to collect biological samples and use the wearable device to monitor exposure parameters\n\nExclusion Criteria:\n\n* Age \\\u003C 25 years and \\> 39 years\n* no signature on informed consent","26 Years","38 Years",{"count":53,"type":22},200,"3 Years","OBSERVATIONAL","The goal of this observational study is to define a personalized risk model in the super healthy and homogeneous population of Italian Air Force high-performance pilots. This peculiar cohort conducts dynamic activities in an extreme environment, compared to a population of military people not involved in flight activity. The study integrates the analyses of biological samples (urine, blood, and saliva), clinical records, and occupational data collected at different time points and analyzed by omic-based approaches supported by Artificial Intelligence. Data resulting from the study will clarify many etiopathological mechanisms of diseases, allowing the creation of a model of analyses that can be extended to the civilian population and patient cohorts for the potentiation of precision and preventive medicine.",[58,59,30,60,61,62,63,64,65],"Oxidative Injury","Stress Physiological","Cardiovascular Risk Factor","Space Maintenance","Epigenetic Changes","LONGEVITY 1","Neuroplasticity","NGS",[67,68,69,70],"pilots","air force","epigenetic change","environmental exposure","RECRUITING","2024-04-16",{"date":74,"type":35},"2024-04-17",{"date":76,"type":35},"2024-02-05",{"date":78,"type":22},"2027-02-05",{"name":80,"class":81},"Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico","OTHER",1]