[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"disorders-of-consciousness\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:disorders-of-consciousness":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,17,0,[8,45,74,107,133,165,193,214,239,252,279,301,325,346,369,389,416],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100054300","spontaneous-eye-blinking-in-disorders-of-consciousness-100054300",false,"NCT06323031","Spontaneous Eye Blinking in Disorders of Consciousness","Spontaneous Eye Blinking as a Diagnostic and Prognostic Marker in Patients With Disorders of Consciousness After Severe Acquired Brain Injury","Blink-DoC","Inclusion Criteria:\n\n* clinical diagnosis of DoC (UWS, MCS minus, MCS plus) following repeated clinical evaluation (at least four CRS-R in a week)\n* age ≥ 18 years\n* time post-onset ≤6 months\n* Previous sABI of any etiology (traumatic, vascular, anoxic, mixed, etc.)\n* Negative anamnesis for neurological or psychiatric disorders.\n\nExclusion Criteria:\n\n* unstable clinical conditions (e.g. respiratory failure, fever, status epilepticus, etc.);\n* ophthalmic diseases, or clinically detected peripheral damage in eyelid motility (e.g. orbital fracture);\n* intake of sedative drugs in the preceding 24 hours;\n* additional brain event following admission (e.g., stroke).",true,"ALL","18 Years",{"count":21,"type":22},70,"ESTIMATED","OBSERVATIONAL","Differential diagnosis between Unresponsive Wakefulness Syndrome (UWS) and Minimally Conscious State (MCS) is complicated due to severe cognitive and\u002For sensorimotor deficits in these patients. In this study the investigators aimed at exploring the diagnostic and prognostic validity of spontaneous eye blinking parameters (rate, amplitude, duration, variability) in a sample of patients with Disorders of Consciousness (DoC).\n\nThis is a multi-center prospective observational study conducted in patients with Severe Acquired Brain Injury (sABI) and DoC admitted to 8 European participating centers, with clinical data collection not deviating from routine practice. The study is non-commercial and will have a maximum total duration of 24 months.",[26],"Disorders of Consciousness",[26,28,29,30,31],"blinking","diagnosis","prognosis","rehabilitation","RECRUITING","2026-07-10",{"date":35,"type":36},"2026-07-13","ACTUAL",{"date":38,"type":36},"2025-05-08",{"date":40,"type":22},"2026-12-31",{"name":42,"class":43},"Fondazione Don Carlo Gnocchi ETS","OTHER",8,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":54,"phases":55,"briefSummary":57,"conditions":58,"keywords":59,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":73},"100610492","early-phase-1-restoring-consciousness-with-neurostimulation-of-the-central-thalamus-the-reconnect-study-100610492","NCT07228286","REstoring CONsciousness With NEurostimulation of the Central Thalamus: The RECONNECT Study","Inclusion Criteria:\n\n* Central nervous system injury of any etiology (e.g., cardiac arrest, traumatic brain injury, ischemic stroke, cerebral hemorrhage, encephalitis) that occurred at least 3 months prior to the eligibility phone call\n* The participant does not exhibit either of the following behaviors every day: meaningful interaction (defined as intelligible speech and ability to follow verbal commands) or functional object use\n* A CRS-R based diagnosis of DoC; either Unresponsive Wakefulness Syndrome (UWS) or Minimally Conscious State (MCS- or +).\n* The participant must have a documented health care proxy or court-appointed guardian\n* Neurologist and neurosurgeon consensus review of most recent clinical MRI (if no MRI, then most recent CT) determines there is no bilateral subcortical injury preventing precise placement of electrodes (e.g., major injuries to the bilateral thalami or severe and bilateral subcortical anatomical distortions).\n\nExclusion Criteria:\n\n* \\- Pregnant\n* Contraindication to brain MRI\n* Due to transportation requirements, participants whose primary residence (Skilled Nursing Facility, Long Term Acute Care, or home) is outside the Greater Boston metropolitan area\n* Pre-existing psychiatric, neurological or medical condition that makes the patient, in the opinion of the study team, a poor surgical candidate (e.g., neurodegenerative disorder, significant cardiopulmonary disorder, need for chronic anticoagulation)\n* Structural abnormality of the chest wall, neck, brain, or skull that makes safe placement of the electrodes, in the opinion of the study team, infeasible or prone to complication\n* Neurologist and neurosurgeon consensus review of most recent clinical MRI (if no MRI, then most recent CT) determines there is no bilateral diffuse injury to the basal ganglia\n* Medical contraindications to surgery including:\n\n  * Chronic infection\n  * Coagulopathy (INR \\> 1.5, aPTT 45 sec, platelet count \\\u003C 100 x 103 \u002F uL)\n  * Poorly controlled blood pressure (\\> 2 episodes during screening phase of blood pressure \\> 180\u002F110 sustained on repeated measurements) and evidence of cardiovascular disease\n  * Participation in another drug, device or biological trial within 90 days\n  * Current implanted stimulation device (e.g., pacemaker, defibrillator, spinal cord stimulator, deep brain stimulator)\n  * Anticoagulant or anti-platelet medication that cannot be safely stopped for \\> 2.5 weeks in the peri-operative period","55 Years",{"count":53,"type":22},2,"INTERVENTIONAL",[56],"EARLY_PHASE1","The RE-CONNECT study is an early feasibility study to establish the safety, feasibility, and efficacy of two central thalamic deep brain stimulation targets in patients with chronic disorders of consciousness.",[26],[60,61,62,63],"deep brain stimulation","disorders of consciousness","brain injury","thalamus","2026-06-18",{"date":66,"type":36},"2026-06-23",{"date":68,"type":36},"2025-11-01",{"date":70,"type":22},"2029-02-10",{"name":72,"class":43},"Samuel Snider, MD",1,{"id":75,"slug":76,"hasResults":11,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":4,"eligibilityCriteria":80,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":81,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":83,"conditions":84,"keywords":91,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":73},"100630260","fnirs-for-disorders-of-consciousness-100630260","NCT07485361","fNIRS for Disorders of Consciousness","Functional Near-infrared Spectroscopy in Disorders of Consciousness: Protocol Testing and Pilot in Neuro-ICU Setting","Inclusion Criteria:\n\nHealthy Control Participants:\n\n* Age 18 years or older\n* Proficient in English language\n* Intact cognition\n* Montreal Cognitive Assessment (MoCA) score \\> 26\n\nDoC Patients:\n\n* Age 18 years or older\n* Proficient in English language\n* Surrogate decision maker available\n* Admission to the intensive care unit within 28 days\n* Documented Glasgow Coma Scale (GCS) score\n* Auditory Function subscale score ≥1 on the Coma Recovery Scale-Revised (CRS-R)\n\nExclusion Criteria:\n\nHealthy Control Participants:\n\n* Known baseline hearing impairment without available hearing aids\n* Neurological or psychiatric history\n\nDoC Patients:\n\n* Known baseline hearing impairment without available hearing aids\n* Inability to obtain informed consent\n* Extensive bilateral frontal injury on available imaging (CT\u002FMRI)\n* Patients who have undergone craniectomy surgery\n* IV sedation in the past 24 hours\n* Absent auditory startle response (\\\u003C1 from Auditory Function subscale score of CRS-R)",{"count":82,"type":22},55,"The goal of this observational study is to learn whether functional near-infrared spectroscopy (fNIRS) can measure brain activity in healthy adults and in people with disorders of consciousness (DoC) in the neuro-intensive care unit (Neuro-ICU). DoC include conditions such as coma and minimally conscious state that occur after severe brain injury. These conditions make it difficult to assess a person's level of awareness because many clinical tests rely on observable behaviors such as speaking or moving, which are commonly impaired after brain injury.\n\nThe main questions the study aims to answer are:\n\n* Can fNIRS detect changes in brain activity in healthy adults when they receive sensory stimulation or perform mental tasks?\n* Can the same fNIRS protocol be used in patients with disorders of consciousness in the Neuro-ICU to measure brain responses and determine whether the method is feasible in this clinical setting?\n\nThe investigators will first study healthy adult volunteers to establish baseline brain responses and determine which tasks produce the most reliable signals. The protocol will then be applied to patients with disorders of consciousness admitted to the Neuro-ICU.\n\nParticipants will take part in a single research session lasting about 30 to 45 minutes while wearing the lightweight fNIRS headband that measures brain oxygen levels using near-infrared light. During the session, participants will:\n\n* Wear a non-invasive fNIRS headband placed on the forehead\n* Receive gentle sensory stimulation (for example, compression devices on the legs or hands)\n* Listen to sounds or spoken sentences\n* Perform guided mental tasks such as imagining walking through their home or imagining moving a limb\n\nThe study does not test a treatment and will not change medical care. The goal is to determine whether fNIRS can safely and reliably measure brain activity at the bedside and provide preliminary information that may help guide future research on improving the assessment of consciousness after brain injury.",[85,26,86,87,88,89,90],"Disorders of Consciousness Due to Severe Brain Injury","Coma","Minimally Conscious State","Unresponsive Wakefulness Syndrome","Brain Injury","TBI Traumatic Brain Injury",[92,93,94,95,96,97],"Functional Near-Infrared Spectroscopy","Neurocritical Care","Functional Neuroimaging","Neuro Intensive Care Unit","Neurovascular Coupling","Consciousness Assessment","2026-06-04",{"date":100,"type":36},"2026-06-08",{"date":102,"type":36},"2026-05-01",{"date":104,"type":22},"2026-12",{"name":106,"class":43},"University of California, Los Angeles",{"id":108,"slug":109,"hasResults":11,"nctId":110,"briefTitle":111,"officialTitle":111,"acronym":112,"eligibilityCriteria":113,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":114,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":116,"conditions":117,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":127,"completionDateStruct":129,"leadSponsor":131,"locationsCount":73},"100639950","recovery-trajectory-for-coma-and-disorders-of-consciousness-100639950","NCT07614074","Recovery Trajectory for Coma and Disorders of Consciousness","Coma Cohort","Inclusion Criteria:\n\n* Age greater than or equal to 18 years on the day of hospital admission\n* Coma duration of at least 24 hours from presentation to the receiving hospital, or died prior to the 24 hour timepoint without return of consciousness. Coma defined as: GCS score of less than or equal to 10 AND GCS score of less than 6 on the motor component of the GCS(not following commands) AND GCS score less than 3 on the verbal component AND alteration of consciousness not explained by sedation only\n* Coma due to a neurological process (Including but not limited to: trauma, stroke, hypoxic- ischemic brain injury (HIBI), CNS infection, seizure, other processes at the discretion of the investigator)\n* Admission to the intensive care unit, or deceased prior to admission.\n\nExclusion Criteria:\n\n* Pre-existing score of 5 or less on the motor component of the Glasgow Coma Scale prior to hospital admission.\n* Transfer from another acute care hospital in which the motor component of the Glasgow Coma Scale on the day after initial hospital arrival is not known or cannot be reconstructed from medical records or history.\n* Coma due to sepsis, systemic metabolic processes (ex: organ failure or sedation).\n* GCS score of greater than 2 for eye opening with lack of command following due to a focal brain lesion causing receptive aphasia.\n* Prisoner",{"count":115,"type":22},2000,"This study aims to better understand recovery after coma caused by serious neurologic illness or injury. Patients who are unconscious (in a coma or disorder of consciousness) due to conditions such as stroke, cardiac arrest, traumatic brain injury, seizures, brain infection, or other neurologic emergencies may be enrolled during their hospitalization.\n\nThe purpose of this observational research study is to learn which medical, neurologic, psychological, and social factors are associated with recovery over time. Researchers will collect information from the medical record during hospitalization, including details about the patient's illness, treatments received, brain imaging, and neurologic examinations.\n\nFor patients who survive hospitalization, the study team will contact participants or their caregivers after discharge to assess recovery at scheduled time points using questionnaires and structured interviews about physical function, quality of life, emotional well-being, and daily activities.\n\nThis study does not assign participants to any experimental treatment. Participation will not change the medical care patients receive. Information learned from this study may help improve future care for patients with coma and disorders of consciousness.",[86,26,118,119,120,121,122,123],"Cardiac Arrest (CA)","Traumatic Brain Injuries","Ischemic Stroke","Hemorrhagic Stroke, Intracerebral","Meningitis\u002FEncephalitis","Status Epilepticus","2026-05-28",{"date":126,"type":36},"2026-06-02",{"date":128,"type":36},"2023-09-26",{"date":130,"type":22},"2033-09",{"name":132,"class":43},"University of California, San Francisco",{"id":134,"slug":135,"hasResults":11,"nctId":136,"briefTitle":137,"officialTitle":138,"acronym":4,"eligibilityCriteria":139,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":140,"enrollmentInfo":141,"targetDuration":4,"studyType":54,"phases":143,"briefSummary":145,"conditions":146,"keywords":148,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":156,"lastUpdatePostDateStruct":157,"startDateStruct":159,"completionDateStruct":161,"leadSponsor":163,"locationsCount":73},"100634442","effectiveness-of-ttis-for-improving-consciousness-in-patients-with-doc-100634442","NCT07539740","Effectiveness of tTIs for Improving Consciousness in Patients With DoC","Effectiveness of Theta-Burst Patterned Temporal Interference Stimulation for Improving Awareness in Patients With Disorders of Consciousness: A Multicenter Randomized Double-Blind Controlled Trial","Inclusion Criteria:\n\n* Age: 18 to 70 years old.\n* Condition: Patients diagnosed with Disorders of Consciousness (DoC), including Vegetative State (VS)\u002FUnresponsive Wakefulness Syndrome (UWS) or Minimally Conscious State (MCS) according to international guidelines.\n* Duration: Disease course ≤ 1 year.Medical History: No history of neuro-psychiatric disorders prior to the brain injury.\n* Handedness: Right-handed.Safety: No contraindications for tTIs, EEG, or MRI.\n* Medication: Not currently using sedative drugs or medications that interfere with brain stimulation, such as Na2+ or Ca2+ channel blockers, or NMDA receptor antagonists.\n\nExclusion Criteria:\n\n* Concurrent Trials: Participation in other non-invasive or invasive neuromodulation trials.\n* Epilepsy: Uncontrolled epilepsy, defined as a seizure within 4 weeks prior to enrollment.\n* Implants: Presence of metal implants in the skull, brain pacemakers, or implanted brain devices (e.g., spinal cord stimulator).\n* Structural Issues: Skull defects at the site of stimulation that prevent the implementation of tTIs.\n* Systemic Implants: Presence of systemic metal implants, such as cardiac pacemakers.","70 Years",{"count":142,"type":22},136,[144],"NA","The goal of this clinical trial is to learn if a new type of brain stimulation called theta-burst patterned temporal interference stimulation (tTIs) works to improve awareness in people with disorders of consciousness (DoC). The main questions it aims to answer are:\n\n1. Does tTIs help people with disorders of consciousness show more signs of awareness?\n2. Does tTIs improve the brain's ability to process information and connect different brain areas? Is tTIs safe and easy for people with disorders of consciousness to tolerate? Researchers will compare a group receiving active tTIs to a group receiving a \"sham\" stimulation (a look-alike stimulation that delivers no real current) to see if the real stimulation works better.\n\nParticipants will:Receive either active tTIs or sham stimulation twice a day for 5 consecutive days (total of 10 sessions). Undergo brain activity tests (EEG) and physical exams to check their level of awareness before and after the 5 days of treatment. Have their progress followed by researchers through phone calls at 1, 3, and 6 months after the treatment ends.",[26,147,87],"Vegetative State",[149,150,151,152,153,154,155],"Temporal Interference Stimulation (tTIs)","Theta-burst Patterned Stimulation","Deep Brain Stimulation (Non-invasive)","Thalamic Stimulation","Centromedian-parafascicular Nuclei (CM-pf)","Perturbational Complexity Index (PCI)","Coma Recovery Scale-Revised (CRS-R)","2026-04-13",{"date":158,"type":36},"2026-04-20",{"date":160,"type":36},"2026-03-08",{"date":162,"type":22},"2028-05-31",{"name":164,"class":43},"Zhujiang Hospital",{"id":166,"slug":167,"hasResults":11,"nctId":168,"briefTitle":169,"officialTitle":170,"acronym":171,"eligibilityCriteria":172,"healthyVolunteers":11,"sex":18,"minAge":173,"maxAge":4,"enrollmentInfo":174,"targetDuration":4,"studyType":54,"phases":176,"briefSummary":177,"conditions":178,"keywords":179,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":185,"lastUpdatePostDateStruct":186,"startDateStruct":187,"completionDateStruct":189,"leadSponsor":191,"locationsCount":53},"100589807","investigation-of-mnesic-capacities-in-patients-with-a-disorder-of-consciousness-100589807","NCT06959212","Investigation of Mnesic Capacities in Patients With a Disorder of Consciousness","Investigation of Mnesic Capacities in Patients With a Disorder of Consciousness - MemoDoC","MemoDoC","Inclusion criteria\n\nPatients suffering from a Disorder of Consciousness:\n\n* Patient not conscious according to the CRS-R scale (Kalmar \\& Giacino, 2005)\n* Age over 15 years and 3 months\n* Free and informed consent signed by a third party (parental authority, trusted support person)\n\nConscious patients (controls) :\n\n* Age over 15 years and 3 months\n* Cared for in an Intensive Care Unit\n* Free and informed consent signature\n\nPatients who have regained consciousness after having suffered from a Disorder of Consciousness (if not included during their disorder):\n\n* Age over 15 years and 3 months\n* Free and informed consent signature if able, otherwise signature of relative (holders of parental authority for minors)\n* Patient who has been unconscious for at least 3 days according to the CRS-R scale Exclusion criteria: - Deep sedation (Intracranial hypertension, refractory status epilepticus)\n* Previous severe neurodegenerative disease (e.g. Alzheimer's disease, Lewy body dementia)\n* Deafness\n* Patients under guardianship or trusteeship\n* Pregnant and breast-feeding women","15 Years",{"count":175,"type":22},175,[144],"Following severe brain damage, some individuals lose partial or total awareness of themselves and their environment, falling into a coma that can evolve towards a Disorder of Consciousness (DoC). Accurately diagnosing the depth of consciousness alteration, and thus characterizing the patient's residual state of consciousness, is a real medical challenge, yet crucial for establishing a neurological prognosis, predicting cognitive outcome, and guiding medical decisions. Clinicians attempt to classify DoC patients into different global states (e.g. coma, Unresponsive Wakefulness Syndrome (UWS), Minimally Conscious State (MCS)) depending on their residual level of arousal and awareness.\n\nIn recent years, the improvement of diagnostic tools and the use of a multimodal approach combining clinical, neurophysiological and neuroimaging examinations, have greatly refined this assessment and revealed the existence of possible discrepancies between clinical observation (e.g. poor consciousness state like UWS) and brain activity (richer, MCS+ type, or even conscious) so-called Cognitive-Motor Dissociation, making it essential to search for any 'hidden cognition' not revealed by the clinical behavioral examination. It is therefore essential to have tools that can not only probe consciousness level, but also provide a detailed profile of patients' residual cognitive abilities - such as language, attention or memory - which are essential dimmensions of conscious experience and shape waking cognitive life. This could crucially improve the neurological diagnostic and prognostic' accuracy of these disorders, as well as allowing to infer the eventual subjective experience of these patients. Indeed, The investigator still know very little about the possible conscious 'contents' involved in these states. What does the possible 'mental life' of DoC patients look like? A multidimensional exploration of their cognition is needed, requiring the development of innovative methods capable of probing cognitive functions in the absence of any communication with the patient.\n\nThus, the general aim of this study lies in the development of tools for the cognitive exploration of DoC patients and their application at patients' bedside in the Intensive Care Unit (ICU). We're particularly interested in assessing memory capacities in these patients, as exploration of memory has immediate clinical implications, since memory encoding during DoC could impact patients' quality of life and be implicated in the occurrence of post-traumatic stress disorder (PTSD) in case of consciousness recovery. More specifically, the investigator want to tackle the following questions: Are patients suffering from a DoC able to form, consolidate and retrieve new memories (anterograde memory)? Are they able to recall memories from their 'past life' (retrograde memory)? Previous research suggests that some DoC patients retain the ability to reactivate old autobiographical memory traces, and to present automatic short-term sensory memory processes, or residual working memory. Nevertheless, DoC patients' memory abilities have been little studied to date, despite their clinical relevance.\n\nThe investigator postulate that memory could be differentially preserved between different clinical states of DoC such as UWS and MCS. At the group level, we expect MCS patients to have better learning and memory retrieval abilities than UWS patients. The investigator therefore expect memory functions to be affected by brain lesions and, consequently, by consciousness alteration, although the invenvisage the preservation of unconscious memory processes (e.g. in non-declarative memory subtypes such as perceptual memory) in UWS patients. We hypothesize that the presence of robust markers of memory processes will vary, at the single-patient level, according to the types and stages of memory tested, informing the cognitive profile of the patient suffering from a DoC.\n\nBy providing information on the potential presence of memory capacities that cannot be revealed by clinical examination, the physiological tools we are developing in this study will open a crucial window onto non-communicating patients' cognition. Defining DoC patients' memory profile could not only improve their care during and after the disorder (reflection on the quality of life in ICU; better understanding of cognitive and psychological symptoms occurring after a DoC (e.g. amnesia, PTSD); orientation of rehabilitation strategies), but also improve the diagnostic accuracy of these troubles if memory proves to be differentially preserved between different DoC states such as UWS and MCS. Ultimately, we aim to refine the neurological prognosis of these non-responsive patients, by predicting their cognitive outcome thanks to these innovative physiological tools. On a more fundamental level, this project questions the interplay of memory and consciousness, exploring which forms of memory do and do not require a conscious state.",[26],[180,181,182,183,184],"DoC","hidden cognition","subjective experience","memory","neurophysiology","2026-04-08",{"date":156,"type":36},{"date":188,"type":36},"2025-09-30",{"date":190,"type":22},"2030-08-30",{"name":192,"class":43},"Assistance Publique - Hôpitaux de Paris",{"id":194,"slug":195,"hasResults":11,"nctId":196,"briefTitle":197,"officialTitle":198,"acronym":199,"eligibilityCriteria":200,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":140,"enrollmentInfo":201,"targetDuration":4,"studyType":54,"phases":203,"briefSummary":204,"conditions":205,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":206,"lastUpdatePostDateStruct":207,"startDateStruct":209,"completionDateStruct":211,"leadSponsor":213,"locationsCount":73},"100614833","effect-of-transcutaneous-auricular-vagus-nerve-stimulation-on-patients-with-disorders-of-consciousness-100614833","NCT07284732","Effect of Transcutaneous Auricular Vagus Nerve Stimulation on Patients With Disorders of Consciousness","Effects of Pairing Transcutaneous Auricular Vagus Nerve Stimulation on Patients With Disorders of Consciousness: An Exploratory Single-Center Randomized Controlled Trial","taVNS","Inclusion Criteria:\n\n* Aged 18-70 years, with a disease duration exceeding 28 days but not longer than 1 year.\n* Patients diagnosed with disorders of consciousness (DoC), specifically classified as either vegetative state (VS) or minimally conscious state (MCS) according to the Coma Recovery Scale-Revised (CRS-R) based on international guidelines.\n* No prior history of neuropsychiatric disorders.\n* Absence of contraindications to transcutaneous auricular vagus nerve stimulation (taVNS) or electroencephalography (EEG), and no concurrent use of sedatives or medications that may interfere with cerebral stimulation-including Na⁺ or Ca²⁺ channel blockers or NMDA receptor antagonists.\n* Intact skin at the auricular site.\n\nExclusion Criteria:\n\n* Participation in other trials involving non-invasive or invasive neuromodulation.\n* Uncontrolled epilepsy, defined as seizures occurring within 4 weeks prior to enrollment.\n* Presence of cranial metal implants, pacemakers, craniotomy at the stimulation site, implanted brain devices, or similar conditions.\n* Cardiac arrhythmia or other significant cardiovascular abnormalities;\n* History of respiratory disorders, including dyspnea, asthma, or hyperventilation.\n* History of vasovagal syncope.",{"count":202,"type":22},20,[144],"Consciousness disorders following severe brain injury refer to a series of disturbances in arousal and cognition secondary to organic brain diseases, including Unresponsive Wakefulness Syndrome (UWS) (also termed Vegetative State, VS) and Minimally Conscious State (MCS). Disorders of consciousness(DoC) is listed in the International Statistical Classification of Diseases and Related Health Problems, though it is not currently recognized as an independent and consistent diagnostic category. According to epidemiological surveys, conservative estimates suggest that 70,000 to 100,000 new cases of DoC are reported annually in China, posing significant challenges for clinical diagnosis and treatment. Accurately assessing DoC, understanding its neurobiological underpinnings, and developing effective rehabilitation strategies remain subjects requiring further investigation through both clinical and basic neuroscience research.\n\nTranscutaneous Auricular Vagus Nerve Stimulation (taVNS) is a non-invasive brain stimulation technique that delivers electrical impulses to the auricular branch of the vagus nerve. Substantial evidence indicates that taVNS serves as a therapeutic intervention for various neurological and psychiatric disorders, such as epilepsy, treatment-resistant depression, migraines, and cognitive impairments. As an emerging neurostimulation technique, taVNS has been investigated for its potential to promote the recovery of awareness in patients with DoC. However, clinical evidence remains limited, underscoring the need for further trials to substantiate its efficacy. Developed from traditional implanted Vagus Nerve Stimulation(VNS), taVNS offers high safety and minimal to negligible side effects, presenting a promising therapeutic avenue for patients with severe traumatic brain injury and disorders of consciousness.\n\nMethods: This study is a single-arm trial. A total of 20 patients are planned to be enrolled. Each patient will receive taVNS twice daily over a period of 10 consecutive days, totaling 20 sessions. Primary and secondary outcome measures will be assessed at baseline and after the completion of taVNS treatment. The primary efficacy endpoint will be the change in behavioral responses as evaluated by the Coma Recovery Scale-Revised (CRS-R). Additionally, resting-state high-density electroencephalography (EEG) and combined transcranial magnetic stimulation with EEG (TMS-EEG) recordings will be utilized to investigate the neurophysiological correlates of taVNS intervention.\n\nDiscussion: This study will provide valuable insights to inform the selection of treatment approaches for patients with disorders of consciousness. By employing a pre-post within-subject comparison design, it aims to validate the therapeutic role of Closed-Loop Transcutaneous Auricular Vagus Nerve Stimulation (CL-taVNS) in this patient population.",[26],"2026-03-25",{"date":208,"type":36},"2026-03-31",{"date":210,"type":36},"2024-05-01",{"date":212,"type":22},"2027-05-31",{"name":164,"class":43},{"id":215,"slug":216,"hasResults":11,"nctId":217,"briefTitle":218,"officialTitle":219,"acronym":4,"eligibilityCriteria":220,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":221,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":223,"conditions":224,"keywords":225,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":230,"lastUpdatePostDateStruct":231,"startDateStruct":233,"completionDateStruct":235,"leadSponsor":237,"locationsCount":53},"100609006","diagnosis-value-of-interoceptive-eeg-indicators-by-rectal-stimulation-in-doc-100609006","NCT07208942","Diagnosis Value of Interoceptive EEG Indicators by Rectal Stimulation in DoC","Diagnosis Value of Interoceptive EEG Indicators by Rectal Stimulation in Patients With Disorders of Consciousness","Inclusion Criteria:\n\n* Patients with non-acute Disorders of Consciousness (DoC) (disease course ≥ 28 days).\n* Aged 18 years or older.\n* No symptoms of fever, infection, or other similar conditions within 15 days.\n* No use of sedatives within 15 days.\n* No use of any drugs that may alter gastrointestinal motility within 7 days prior to testing.\n* Family members of participating patients have provided consent and signed the informed consent form.\n\nExclusion Criteria:\n\n* Patients with functional impairments caused by developmental psychiatric disorders or neurological diseases.\n* Patients with untreated epilepsy.\n* Untreated cerebral edema.\n* Patients with unstable vital signs.\n* A history of intestinal diseases.\n* A history of abdominal surgery other than simple appendectomy or simple cholecystectomy.\n* Organic diseases such as spinal cord injury, traumatic brain injury, and thyroid dysfunction.",{"count":222,"type":22},45,"Study on the Significance and Value of Interoception-Related Indicators in the Classification of Patients with Disorders of Consciousness (DoC) via Rectal Stimulation",[26],[226,227,228,229],"Interoceptive","EEG","Rectal Stimulation","Diagnosis","2025-09-29",{"date":232,"type":36},"2025-10-06",{"date":234,"type":36},"2024-12-01",{"date":236,"type":22},"2025-12",{"name":238,"class":43},"YiLin Zhao",{"id":240,"slug":4,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":241,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":242,"keywords":243,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":244,"lastUpdatePostDateStruct":245,"startDateStruct":246,"completionDateStruct":248,"leadSponsor":250,"locationsCount":44},"100540913",{"count":21,"type":22},[26],[26,28,29,30,31],"2025-09-24",{"date":230,"type":36},{"date":247,"type":36},"2025-03-31",{"date":249,"type":22},"2026-06",{"name":251,"class":43},"Fondazione Don Carlo Gnocchi Onlus",{"id":253,"slug":254,"hasResults":11,"nctId":255,"briefTitle":256,"officialTitle":257,"acronym":258,"eligibilityCriteria":259,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":260,"enrollmentInfo":261,"targetDuration":263,"studyType":23,"phases":4,"briefSummary":264,"conditions":265,"keywords":266,"overallStatus":269,"whyStopped":4,"lastUpdateSubmitDate":270,"lastUpdatePostDateStruct":271,"startDateStruct":273,"completionDateStruct":275,"leadSponsor":277,"locationsCount":73},"100606825","advancing-assessment-for-disorders-of-consciousness-100606825","NCT07180589","Advancing Assessment for Disorders of Consciousness","Advancing Assessment for Disorders of Consciousness (AADOC): Innovative Standards and Intelligent Diagnostic System Based on Multi-source Heterogeneous Information","AADOC","Inclusion Criteria:\n\n* age range: 18-80 years old; brain injury caused by various reasons, confirmed by clinical physical and chemical, neuroimaging (head MRI or CT) examination; Glasgow Coma Score (GCS)\\\u003C12 points; modified Rankin Scale (mRS) score before the onset of the disease was less than 2 points; obtain informed consent from the patient's legal representative.\n\nExclusion Criteria:\n\n* patients with significant skull defects; contraindications for electromagnetic related examinations and treatments, including the presence of metal materials in the body (such as pacemakers, dentures, steel nails, cochlear implants, etc.); patients with a history of epilepsy and clinical indications of epileptic seizures or epileptic discharges on electroencephalogram (EEG); women who are pregnant, breastfeeding, or have a positive pregnancy test upon admission; patients with an estimated survival period of less than 3 months due to various serious illnesses.","80 Years",{"count":262,"type":22},200,"1 Year","Over the past two decades, major progress has been made in detecting, predicting and promoting recovery of consciousness in patients with disorders of consciousness (DOC) caused by severe brain injuries. This study will aim to establish innovative standards and intelligent diagnostic system based on multi-source heterogeneous information including clinical signs, advanced neuroimaging and electrophysiological techniques, thus raising hope for more accurate diagnosis and prognosis.",[26],[267,268],"Disorders of consciousness","Prognostication","NOT_YET_RECRUITING","2025-09-16",{"date":272,"type":36},"2025-09-18",{"date":274,"type":22},"2025-09-25",{"date":276,"type":22},"2028-04-30",{"name":278,"class":43},"Xuanwu Hospital, Beijing",{"id":280,"slug":281,"hasResults":11,"nctId":282,"briefTitle":283,"officialTitle":284,"acronym":4,"eligibilityCriteria":285,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":286,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":288,"conditions":289,"keywords":290,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":292,"lastUpdatePostDateStruct":293,"startDateStruct":295,"completionDateStruct":297,"leadSponsor":299,"locationsCount":53},"100565842","what-is-the-perceived-role-of-risk-in-doc-healthcare-100565842","NCT06647433","What is the Perceived Role of Risk in DOC Healthcare.","What is the Perceived Role of Risk in the Healthcare Received by People in Disorders of Consciousness (DOC)?","Inclusion Criteria:\n\n* People in a DOC:\n* Working diagnosis of being in a DOC.\n* Have an appropriate family member able to act as a consultee.\n* Over 18 years of age.\n\nFamily members and healthcare workers:\n\n* conversational English.\n* able to give consent.\n* over 18 years of age.\n* Involved in decision making on behalf of a person in a DOC\n\nExclusion Criteria:\n\nPerson in a Disorder of Consciousness\n\n* Not in a DOC, diagnosis uncertain, or appears to be emerging.\n* Clinically unstable or approaching the end of their life.",{"count":287,"type":22},40,"Critical ethnography exploring how decisions are made on behalf of people in disorder of consciousness (DOC).\n\nProspective longitudinal case study design including observation, field interview and video reflexive ethnography.",[26],[26,291],"Decision making","2025-07-04",{"date":294,"type":36},"2025-07-10",{"date":296,"type":36},"2025-05-01",{"date":298,"type":22},"2027-01",{"name":300,"class":43},"University of Nottingham",{"id":302,"slug":303,"hasResults":11,"nctId":304,"briefTitle":305,"officialTitle":306,"acronym":307,"eligibilityCriteria":308,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":309,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":310,"conditions":311,"keywords":312,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":316,"lastUpdatePostDateStruct":317,"startDateStruct":319,"completionDateStruct":321,"leadSponsor":323,"locationsCount":53},"100586959","tickle-stimulation-in-disorders-of-consciousness-doc-100586959","NCT06922162","Tickle Stimulation in Disorders of Consciousness (DoC)","Behavioural and Physiological Responses to Tickling in Patients With Disorders of Consciousness","TICKLING-DOC","Inclusion Criteria:\n\n* Diagnosis of disorders of consciousness (DoC) based on the CRS-R scale;\n* Age ≥18 years;\n* Time since the event ≥ 28 days\n\nExclusion Criteria:\n\n* Large craniectomy that may interfere with fNIRS recording; Unstable clinical conditions (e.g., respiratory failure, fever, status epilepticus, etc.);\n* Fractures, paralysis, injuries, or muscular dystrophy that prevent proper stimulation of the aforementioned body parts;\n* Lack of informed consent from the legal representative.",{"count":222,"type":22},"The aim of this project is to investigate whether tickling stimulations can have a short-term effect on the responsiveness of patients with Disorders of Consciousness due to Severe Acquired Brain Injury and to compare this effect with that of neutral tactile stimulations that do not induce tickling.",[26],[313,314,315,26],"Tickle stimulation","Behavioural evaluation","Neurophysiological evaluation","2025-04-17",{"date":318,"type":36},"2025-04-23",{"date":320,"type":36},"2023-06-30",{"date":322,"type":22},"2025-10-31",{"name":324,"class":43},"Anna Estraneo",{"id":326,"slug":327,"hasResults":11,"nctId":328,"briefTitle":329,"officialTitle":330,"acronym":331,"eligibilityCriteria":332,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":333,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":335,"conditions":336,"keywords":337,"overallStatus":269,"whyStopped":4,"lastUpdateSubmitDate":316,"lastUpdatePostDateStruct":340,"startDateStruct":341,"completionDateStruct":343,"leadSponsor":345,"locationsCount":4},"100586956","tactile-stimulation-in-disorders-of-consciousness-doc-100586956","NCT06922123","Tactile Stimulation in Disorders of Consciousness (DoC)","Behavioural and Neurophysiological Reactions During Tactile Stimulation in Patients Suffering From Disorders of Consciousness (DoC)","TACTILE-DOC","Inclusion Criteria:\n\n* Clinical diagnosis of a disorder of consciousness (DoC), as determined by repeated Coma Recovery Scale-Revised (CRS-R) assessments;\n* Age ≥ 18 years;\n* Time since acute event ≥ 28 days.\n* Written informed consent obtained from the legal representative\n\nExclusion Criteria:\n\n* Presence of large craniectomy that may interfere with fNIRS signal acquisition;\n* Unstable clinical conditions (e.g., respiratory insufficiency, fever, status epilepticus);\n* Fractures, paralysis, lesions, or muscular atrophy that prevent proper tactile stimulation of the specified body areas;\n* Absence of informed consent from the legal representative.",{"count":334,"type":22},30,"The aim of this project is to evaluate the behavioural and neurophysiological responses to pleasant touch in patients with disorders of consciousness (DoC) and to determine whether these responses are related to the level of consciousness. Specifically, the study aims to:\n\n1. explore the relationship between pleasant tactile stimulation and behavioural and neurophysiological responses in patients with DoC;\n2. determine whether behavioural responses to pleasant touch stimulation correlate with the level of consciousness;\n3. assess whether behavioural responses vary depending on the valence of the stimulus (pleasant, neutral, or unpleasant);\n4. examine neurophysiological responses to tactile stimulation using functional near-infrared spectroscopy (fNIRS), and evaluate whether brain activation patterns are associated with behavioural responses;\n5. improve diagnostic accuracy in patients with DoC by exploring the value of somatosensory responses in distinguishing unresponsive wakefulness syndrome (UWS) from minimally conscious state (MCS) or conscious patients;\n6. explore the potential usefulness of implementing this type of stimulation within rehabilitation programs to support better recovery of consciousness.",[26],[338,26,314,315,339],"Tactile stimulation","Pleasant touch stimulation",{"date":318,"type":36},{"date":342,"type":22},"2025-04",{"date":344,"type":22},"2025-10",{"name":324,"class":43},{"id":347,"slug":348,"hasResults":11,"nctId":349,"briefTitle":350,"officialTitle":351,"acronym":4,"eligibilityCriteria":352,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":353,"enrollmentInfo":354,"targetDuration":4,"studyType":54,"phases":356,"briefSummary":357,"conditions":358,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":360,"lastUpdatePostDateStruct":361,"startDateStruct":363,"completionDateStruct":365,"leadSponsor":367,"locationsCount":53},"100581503","transcranial-temporal-interference-stimulation-in-severely-brain-injured-patients-with-disorders-of-consciousness-100581503","NCT06851156","Transcranial Temporal Interference Stimulation In Severely Brain Injured Patients With Disorders of Consciousness","An Exploratory Trial Evaluating Temporal Interference Stimulation of CM-pf In Patients With Disorders of Consciousness","Inclusion Criteria:\n\n* traumatic and nontraumatic etiology of VS\u002FUWS or MCS according to published diagnostic criteria.\n\nExclusion Criteria:\n\n* patients in coma, with less than 1 week after acute brain insult, with fluctuating diagnosis on baseline assessment, and with a metallic cerebral implant or pacemaker, and with epilepsy.","65 Years",{"count":355,"type":22},10,[144],"The purpose of this academic lead study is to explore the effect of noninvasive neuromodulation of the CM-pf via tTIS for patients with disorders of consciousness.",[26,359,88,87],"Severe Brain Injury","2025-04-06",{"date":362,"type":36},"2025-04-09",{"date":364,"type":36},"2025-04-07",{"date":366,"type":22},"2025-12-31",{"name":368,"class":43},"Xijing Hospital",{"id":370,"slug":371,"hasResults":11,"nctId":372,"briefTitle":373,"officialTitle":374,"acronym":4,"eligibilityCriteria":375,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":376,"enrollmentInfo":377,"targetDuration":4,"studyType":54,"phases":378,"briefSummary":379,"conditions":380,"keywords":4,"overallStatus":269,"whyStopped":4,"lastUpdateSubmitDate":381,"lastUpdatePostDateStruct":382,"startDateStruct":384,"completionDateStruct":386,"leadSponsor":387,"locationsCount":4},"100579276","the-temporally-interfering-in-patients-with-disorders-of-consciousness-100579276","NCT06822192","The Temporally Interfering in Patients with Disorders of Consciousness","The Efficacy and Safety of Temporally Interfering in Patients with Disorders of Consciousness","Inclusion Criteria:\n\nIn accordance with the international diagnostic criteria for MCS formulated by Giacino in 2002 or the diagnostic criteria for UWS proposed by Laureys in 2010; Patients with disease duration ≥28 days and unconscious improvement tendency in the past one month; No use of any sedative drugs or antiepileptic drugs (sodium or calcium channel blockers) in the past 1 month; stable vital signs; No obvious brain edema, hydrocephalus, and severe brain atrophy; Age from 18 to 70 years old; Informed consent was obtained from the patients' family members.\n\nExclusion Criteria:\n\nPrevious history of neurological or psychiatric disorders; Previous history of traumatic brain injury; History of cancer; Taking sedative drugs or antiepileptic drugs in the past 1 month; Unstable vital signs; Skull defect; The patients' family members did not sign the informed consent.","75 Years",{"count":287,"type":22},[144],"This project will help the patient recover consciousness by giving TI (temporally interfering) treatment",[26],"2025-02-06",{"date":383,"type":36},"2025-02-12",{"date":385,"type":22},"2025-02-20",{"date":40,"type":22},{"name":388,"class":43},"Zhejiang Provincial People's Hospital",{"id":390,"slug":391,"hasResults":11,"nctId":392,"briefTitle":393,"officialTitle":393,"acronym":4,"eligibilityCriteria":394,"healthyVolunteers":17,"sex":18,"minAge":395,"maxAge":4,"enrollmentInfo":396,"targetDuration":4,"studyType":54,"phases":397,"briefSummary":398,"conditions":399,"keywords":401,"overallStatus":269,"whyStopped":4,"lastUpdateSubmitDate":407,"lastUpdatePostDateStruct":408,"startDateStruct":410,"completionDateStruct":412,"leadSponsor":414,"locationsCount":4},"100556809","the-effects-of-psilocybin-on-shared-experience-in-film-processing-100556809","NCT06529939","The Effects of Psilocybin on Shared Experience in Film Processing","Inclusion Criteria:\n\nParticipants must:\n\n* Have access to an internet connection\n* Be in good general health\n* Be 19 years of age, or older\n* Be willing to follow the study protocol\n\nExclusion Criteria:\n\nThe following people will be excluded from the study. Those who:\n\n* Are unable to read English\n* Have high blood pressure\n* Are pregnant (determined by a urine pregnancy test at in-person screening)\n* Are not using effective methods of contraception with their partner(s) (e.g. oral contraceptive pill, injection, implant, patch, vaginal ring, intrauterine coil, intrauterine device, tubal ligation, or barrier method)\n* Are taking chronic administration of tricyclic antidepressants and\u002For lithium\n* Are taking acute administration of serotonin reuptake inhibitors\n* Are currently using the antipsychotic medication haloperidol\n* Are currently using monoamine oxidase inhibitors\n* Have any current or past history of meeting the Diagnostic and Statistical Manual of Mental Illnesses (DSM-V) criteria for schizophrenia, bipolar I, bipolar II, or psychotic symptoms\n* Have any first or second-degree relatives with history of above disorders\u002Fsymptoms\n* Have any other diagnosed and\u002For extreme psychiatric disorders, such as anxiety, depression, post-traumatic stress disorder (PTSD), addiction, obsessive-compulsive disorder (OCD), etc.\n* Have any history of suicidal behaviour or current\u002Frecent suicidal ideation (determined by the Columbia-Suicide Severity Rating Scale \\[C-SSRS\\] at in-person screening)","19 Years",{"count":334,"type":22},[144],"The goal of this clinical trial is to learn whether certain methods of detecting awareness in vegetative or minimally conscious patients (using neuroimaging) are sensitive to the effects of psilocybin (a psychedelic drug). One of these methods includes scanning peoples\\' brains while they watch a film. When different individuals watch a film, their brains become synchronized with each other as they watch the plot unfold. Most importantly, if a seemingly unconscious patient also shows the same brain-synchronization, it means they might actually be conscious and aware.\n\nTo approach this goal, the investigators will be carrying out this trial in healthy volunteers. This will help better understand whether psilocybin may be a potential treatment for restoring awareness in these patients. The main questions it aims to answer are:\n\n* Does psilocybin enhance or diminish brain synchrony during a film?\n* Do changes in brain synchrony reflect differences in each individual\\'s conscious experience?\n\nParticipants will be asked to:\n\n* Attend two brain scanning sessions and watch a series of film clips, perform a brief mental imagery task, and listen to music - once under a placebo, and once under psilocybin.\n* Play a series of games that assess their cognition (memory, reasoning, planning, etc.).\n* Perform a series of visual illusions tasks.",[26,400],"Psychedelic Experiences",[402,403,404,26,405,406],"Psilocybin","Functional Magnetic Resonance Imaging (fMRI)","Cognition","Film Processing","Healthy Volunteers","2024-09-24",{"date":409,"type":36},"2024-09-27",{"date":411,"type":22},"2024-11",{"date":413,"type":22},"2025-09",{"name":415,"class":43},"Western University, Canada",{"id":417,"slug":418,"hasResults":11,"nctId":419,"briefTitle":420,"officialTitle":421,"acronym":4,"eligibilityCriteria":422,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":353,"enrollmentInfo":423,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":425,"conditions":426,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":427,"lastUpdatePostDateStruct":428,"startDateStruct":430,"completionDateStruct":432,"leadSponsor":434,"locationsCount":73},"100528149","brain-network-analysis-of-anesthesia-characteristics-in-patients-with-pdoc-based-on-psg-100528149","NCT06157008","Brain Network Analysis of Anesthesia Characteristics in Patients With pDoC Based on PSG","Brain Network Analysis of Anesthesia Characteristics in Patients With Prolonged Disorders of Consciousness Based on Polysomnography","Inclusion Criteria:\n\n* Inclusion criteria of health volunteer group:\n\n  1. Aged 18-65, native Chinese\n  2. No history of sleep apnea\n  3. No history of insomnia\n  4. Volunteer to participate in this study and obtain informed consent.\n* Inclusion criteria of pDoC group:\n\n  1. Aged 18-65, native Chinese\n  2. pDoC after acquired brain injury\n  3. The spinal electric stimulator was implanted under general anesthesia\n  4. Obtain informed consent.\n* Exclusion Criteria:\n\n  1. Healthy volunteers took hypnotic drugs 72 hours before the study\n  2. Continuous sedation treatment was carried out within 72 hours before the study\n  3. The integrity of brain structures such as open head injury and brain parenchyma resection\n  4. Intracranial compliance decreased due to hydrocephalus\n  5. Airway stenosis and severe ventilation or ventilation dysfunction caused by various reasons\n  6. Known or suspected to have serious heart, lung and kidney dysfunction\n  7. Allergic history of sedative drugs\n  8. Combined with other mental or nervous system diseases\n  9. Other reasons are not suitable for this study.",{"count":424,"type":22},60,"The goal of this prospective, exploratory and observational study is to learn about in healthy volunteers and patients with prolonged disorders of consciousness(pDoC). The main questions it aims to answer are:\n\n1. Observe the similarities and differences of polysomnography between pDoC patients and healthy volunteers, and analyze the characteristic brain network changes based on polysomnography\n2. To observe the similarities and differences of polysomnography in pDoC patients before and after Insertion of spinal cord electric stimulator under general anesthesia,and analyze the changes of anesthesia characteristic brain network in patients with consciousness disorders based on polysomnography.\n3. To observe the similarities and differences of polysomnography in pDoC patients before and after spinal cord stimulation,and analyze the characteristic changes of brain network after spinal cord stimulation.\n\nWe will record the 8h polysomnography of healthy volunteers,record the polysomnography of DOC patients before and 24 hours after operation;and record the 24h polysomnography of patients with spinal cord electric stimulator.",[26],"2024-07-30",{"date":429,"type":36},"2024-08-01",{"date":431,"type":36},"2023-01-11",{"date":433,"type":22},"2025-06-01",{"name":435,"class":43},"Beijing Tiantan Hospital"]