[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"dissection-of-aortic-arch\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:dissection-of-aortic-arch":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,43],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":4},"100606037","zipper-stent-graft-trial-for-aortic-arch-dissection-100606037",false,"NCT07170332","ZIPPER™ Stent-Graft Trial for Aortic Arch Dissection","Clinical Study on the Safety and Efficacy of the ZIPPER™ Aortic Arch Stent-Graft System in the Treatment of Aortic Arch Dissection","Inclusion Criteria:\n\n* Age: 18-80 years of age.\n\nDiagnosis and Anatomical Suitability:\n\nSubacute or chronic aortic arch dissection requiring intervention, where the proximal end of the stent graft requires anchoring in Zone 0, and meets the following vascular anatomical criteria:\n\nAscending aorta (may include graft segments) ≥ 40 mm in length (measured from the sinotubular junction to the proximal edge of the IA along the centerline).\n\nProximal landing zone diameter ≥ 24 mm and ≤ 47 mm. Proximal landing zone length ≥ 20 mm. Diameters of the IA, LCCA, and LSA ≤ 24 mm and ≥ 6 mm, with lengths ≥ 20 mm. Suitable arterial access for endovascular intervention. Informed Consent: Capable of understanding the study purpose, voluntarily agreeing to participate, and providing written informed consent (by the subject or their legal representative). Willing to comply with follow-up requirements per the protocol.\n\nSurgical Risk Assessment: Deemed high surgical risk (evaluated by at least two independent vascular or cardiac surgeons) or confirmed to have significant contraindications to open surgery.\n\nExclusion Criteria:\n\n* Prior aortic intervention: History of open or endovascular repair of the descending or abdominal aorta.\n\nConcurrent AAA requiring intervention: Coexisting abdominal aortic aneurysm requiring surgical intervention within 30 days.\n\nSpecific aortic pathologies: infectious aortitis, Takayasu arteritis, Marfan syndrome, or other connective tissue disorders.\n\nActive systemic infection: Ongoing systemic infection or high risk of systemic infection.\n\nSevere arch vessel disease: Severe stenosis, calcification, thrombosis, or tortuosity of the IA, LCCA, or LSA.\n\nAcute ischemia: Bowel necrosis or lower limb ischemic necrosis. Pre-existing paraplegia. Post-cardiac transplant status. Recent cardiovascular events: Myocardial infarction or stroke within the past 3 months.\n\nAdvanced heart failure: NYHA Class IV or left ventricular ejection fraction (LVEF) \\\u003C30%.\n\nActive gastrointestinal bleeding: Active peptic ulcer or upper gastrointestinal bleeding within the past 3 months.\n\nHematologic abnormalities: Leukopenia (WBC \\\u003C 3×10⁹\u002FL), Anemia (Hb \\\u003C 90 g\u002FL), Coagulopathy, Thrombocytopenia (platelets \\\u003C 50×10⁹\u002FL).\n\nRenal insufficiency: Serum creatinine \\> 221 μmol\u002FL (2.5 mg\u002FdL) or end-stage renal disease requiring dialysis (investigator discretion).\n\nSevere hepatic dysfunction: ALT\u002FAST \\> 5× upper limit of normal (ULN), Serum total bilirubin (STB) \\> 2× ULN.\n\nHigh-risk intracranial lesions (any of the following):\n\n1. Unruptured aneurysm ≥7 mm (anterior circulation) or ≥5 mm (posterior circulation)\n2. Prior rupture or high-risk morphology (daughter sac, aspect ratio \\>1.6)\n3. Intracranial arterial stenosis ≥50% with poor collateral flow. Contrast allergy. Pregnancy or lactation. Anesthesia\u002Fsurgery contraindications: Severe comorbidities precluding tolerance to anesthesia or surgery.\n\nLife expectancy \\\u003C 12 months. Current participation in other drug or device clinical trials. Other exclusions: Any conditions deemed unsuitable for participation by the investigator.","ALL","18 Years","80 Years",{"count":20,"type":21},127,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study is the feasible study on a new technique of ZIPPER aortic arch stentgraft system",[27],"Dissection of Aortic Arch",[29,30],"Aortic Arch","Dissection","NOT_YET_RECRUITING","2025-09-11",{"date":34,"type":35},"2025-09-15","ACTUAL",{"date":37,"type":21},"2025-09-30",{"date":39,"type":21},"2032-09-30",{"name":41,"class":42},"Hangzhou Endonom Medtech Co., Ltd.","INDUSTRY",{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":50,"targetDuration":52,"studyType":53,"phases":4,"briefSummary":54,"conditions":55,"keywords":58,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":77},"100480001","outcome-of-a-triple-inner-branched-aortic-arch-stentgraft-a-prospective-multicenter-registry-100480001","NCT05530304","Outcome of a Triple Inner Branched Aortic Arch Stentgraft. A Prospective, Multicenter Registry.","triple_branch","Inclusion Criteria:\n\n* 18 years or older\n* Presence of Aortic arch pathology\n* Treatment planned with triple inner branch from Terumo Aortic\n* Availability of the patients during the follow up period\n* Informing patients about the study and providing written informed consent\n\nExclusion Criteria:\n\n* Women of childbearing age\n* Patients under 18 years",{"count":51,"type":21},30,"1 Year","OBSERVATIONAL","Outcome of a triple inner branched aortic arch stentgraft. A prospective, mulitcenter registry.",[29,56,27,57],"Aortic Arch Aneurysm","Triple Branch",[59,60,61,62,63,64,65],"Aortic arch pathologies","Aortic arch aneruysm","Aortic arch dissection","triple branch","stentgraft","Double branch","Inner branch","RECRUITING","2023-09-11",{"date":69,"type":35},"2023-09-13",{"date":71,"type":35},"2023-02-09",{"date":73,"type":21},"2027-03-31",{"name":75,"class":76},"University Hospital Muenster","OTHER",1]