[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"disseminated-intravascular-coagulation-dic\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:disseminated-intravascular-coagulation-dic":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,41],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100637629","early-diagnosis-of-septic-dic-100637629",false,"NCT07630415","EARLY DIAGNOSIS OF SEPTIC DIC","OPTIMIZATION AND CLINICAL VALIDATION OF AN INNOVATIVE TEST FOR THE EARLY DIAGNOSIS OF SEPTIC DIC VIA AN AUTOMATION INTEGRATING ARTIFICIAL INTELLIGENCE","EASY-DIC","Inclusion Criteria:\n\n* Male or female ≥ 18 years old\n* Patient admitted to intensive care for septic shock\n* Patient affiliated with a social security scheme or having rights\n* No objection from the patient or a relative in case the patient is not able to express consent, or inclusion under emergency procedure in case the patient is not able to express their opinion and no relative of the patient is reachable.\n\nExclusion Criteria:\n\n* Moribund patient on the day of inclusion\n* Child-Pugh C cirrhosis\n* Neutropenia (\\\u003C500 mm3)\n* Patient under legal protection\n* Patient under guardianship or curatorship\n* Pregnancy\u002F Breastfeeding","ALL","18 Years",{"count":20,"type":21},492,"ESTIMATED","OBSERVATIONAL","Disseminated Intravascular Coagulation is a severe complication of septic shock, associated with high mortality, whose diagnosis relies on complex scores that are rarely used in practice. Preliminary studies have shown that increased neutrophil fluorescence is associated with Disseminated Intravascular Coagulation and could reflect NETosis, a key mechanism of immunothrombosis. This study aims to validate neutrophil fluorescence measured on the SthemA 801 analyzer, alone or integrated into an artificial intelligence model, as an early, reliable, and routinely usable biomarker for the diagnosis of septic Disseminated Intravascular Coagulation.",[25,26,27],"Disseminated Intravascular Coagulation (DIC)","Reanimation","Septic Shock","NOT_YET_RECRUITING","2026-06-01",{"date":31,"type":32},"2026-06-05","ACTUAL",{"date":34,"type":21},"2026-06-15",{"date":36,"type":21},"2029-01-15",{"name":38,"class":39},"University Hospital, Strasbourg, France","OTHER",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":47,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":49,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":50,"conditions":51,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":53,"lastUpdatePostDateStruct":54,"startDateStruct":56,"completionDateStruct":58,"leadSponsor":60,"locationsCount":40},"100638787","fluorescent-leukocytes-as-a-marker-of-early-sepsisseverity-100638787","NCT07585942","Fluorescent Leukocytes as a Marker of Early Sepsis\u002FSeverity","NEUTROPHIL FLUORESCENCE AS AN EARLY BIOMARKER OF SEPSIS SEVERITY IN THE EMERGENCY DEPARTMENT","FLAMES","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Admission to the ED\n* Suspected or proven infection defined by the prescription of antibiotic therapy within 24 hours following admission to the ED\n* Collection of an EDTA blood sample as part of routine care\n* Patient informed and has not expressed opposition\n\nExclusion Criteria:\n\n* Pregnancy or breastfeeding\n* Legal protection measure (guardianship, curatorship, judicial protection)",{"count":20,"type":21},"Sepsis is a medical emergency whose prognosis depends on the early identification of patients at risk of septic shock, but the tools available in the Emergency Department remain insufficient. Neutrophils, key players in immunothrombosis, show alterations detectable via cell fluorescence (e.g., NE-SFL), which are strongly correlated with the severity of sepsis and septic DIC. The FLAMES study will evaluate, from the time of admission to the Emergency Department, the relevance of neutrophil fluorescence as an early biomarker of severity, either alone or integrated into an AI model based on the multiparametric data from the SthemA 801, with comparison to the Sysmex XN. It aims to address an unmet clinical need: the immediate stratification of the risk of severe forms of sepsis. Hypothesis: higher initial fluorescence will identify patients at risk of organ failure, septic shock, or DIC.",[52,25,27],"Sepsis","2026-05-06",{"date":55,"type":32},"2026-05-14",{"date":57,"type":21},"2026-05-12",{"date":59,"type":21},"2027-12-12",{"name":38,"class":39}]