[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"dissociation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:dissociation":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,48,82,109,137,168],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100413980","mechanistic-interventions-and-neuroscience-of-dissociation-100413980",false,"NCT04670640","Mechanistic Interventions and Neuroscience of Dissociation","MIND","Inclusion Criteria:\n\n* experience of at least one Diagnostic and Statistical Manual of Mental Disorders (DSM-5) Criterion A trauma (assessed using the Life Events Checklist)\n* a score of 7 or higher on the Multiscale Dissociation Inventory (MDI) depersonalization subscale\n* willingness to participate in the study\n\nExclusion Criteria:\n\n* actively psychotic and cognitively compromised individuals (assessed using the Moderate-severe cognitive impairment screening tool (MoCA) will be excluded\n* moderate or more severe substance dependence (assessed with the MINI)\n* persons with imminent risk of physical violence to self or others","ALL","18 Years","65 Years",{"count":20,"type":21},350,"ESTIMATED","INTERVENTIONAL",[24],"NA","The purpose of this study is to test the neurophysiological mechanisms of an intervention to reduce symptoms of dissociation in traumatized people. The intervention will be tested in dissociative traumatized people at two sites: Emory University and University of Pittsburgh. The researchers are interested in whether neural networks associated with attentional control and interoceptive awareness can be enhanced in this population. The researchers propose to evaluate whether different body-focused and non-body focused interventions can change these mechanisms.",[27],"Dissociation",[29,30,31,32,33,34],"Trauma","PTSD","Mindfulness","Meditation","Neuroimaging","MRI","RECRUITING","2026-04-15",{"date":38,"type":39},"2026-04-20","ACTUAL",{"date":41,"type":39},"2021-09-18",{"date":43,"type":21},"2027-03",{"name":45,"class":46},"Emory University","OTHER",2,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":56,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":57,"targetDuration":4,"studyType":59,"phases":4,"briefSummary":60,"conditions":61,"keywords":65,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":81},"100595537","predictors-and-process-moderators-of-emdr-therapy-for-depressive-symptoms-100595537","NCT07033741","Predictors and Process Moderators of EMDR Therapy for Depressive Symptoms","Predictors and Process Moderators of EMDR Therapy for Depressive Symptoms: Protocol for a Real-world Prospective Observational Study","PROCESS-EMDR","Participants:\n\nTherapist\n\n* Inclusion Criteria:\n* certified members of the Italian Eye Movement Desensitization and Reprocessing (EMDR) Association\n* Exclusion Criteria:\n* inability or unwillingness to comply with study protocols or schedules Patient\n* Inclusion Criteria:\n* age 18 years or older\n* capacity of providing informed consent\n* presenting with clinically significant symptoms in at least one of the following domains: anxiety, depression, post-traumatic stress symptoms, or dissociative symptoms.\n* Exclusion Criteria:\n* history of psychotic symptoms or schizophrenia\n* dementia\n* severe personality disorders\n* a serious, unstable medical condition\n* acute suicidality that needs hospitalization.",true,{"count":58,"type":21},40,"OBSERVATIONAL","The goal of this clinical trial is to evaluate which factors influence the effectiveness of Eye Movement Desensitization and Reprocessing (EMDR) therapy for depressive symptoms in real-world settings in Italy.\n\nThe main questions the study seeks to answer are:\n\n* Which key factors influence EMDR outcomes in terms of mediators, moderators, and predictors of its effectiveness for depressive symptoms?\n* Do lower levels of individual psychological functioning at baseline, including high co-occurrence of personality domains and pathogenic personal beliefs, predict the effects of EMDR in treating depressive symptoms?\n* Are baseline psychological comorbidities (anxiety, dissociation, post-traumatic symptoms, emotional dysregulation, and sleep difficulties) and the quality of the therapeutic alliance related to the effectiveness of EMDR therapy for depressive symptoms? Participants will be both therapists and patients.\n* Eligible therapists must be certified members of the EMDR Italian National Association to ensure adherence to established standards in the practice of EMDR therapy and consistency in therapeutic delivery. Therapists will identify patients from their routine clinical practice who meet the study inclusion criteria and facilitate their enrollment.\n* Eligible patients must meet the following criteria:\n\n  1. Being 18 years of age or older.\n  2. being able to give informed consent.\n  3. presenting clinically significant symptoms in at least one of the following domains: anxiety, depression, dissociative, or post-traumatic stress symptoms.\n\nIndividuals presenting with severe neurological impairment or other severe psychiatric conditions were excluded.\n\nResearchers will combine data from multiple N-of-1 trials (N-of-1 or single-subject clinical trials studies) using a Bayesian multilevel random-effects meta-analysis and meta-regression to generate robust estimates of treatment efficacy.",[62,63,27,64],"Depression, Anxiety","Post-traumatic Stress Symptoms","Psychotherapy Research and Outcome Measures",[66,67,68,69,70,71],"Eye Movement Desensitization and Reprocessing","depressive symptoms","predictors","moderators","psychotherapy","study protocol","2025-11-24",{"date":74,"type":39},"2025-11-25",{"date":76,"type":39},"2025-01-08",{"date":78,"type":21},"2027-12",{"name":80,"class":46},"University of Turin, Italy",1,{"id":83,"slug":84,"hasResults":11,"nctId":85,"briefTitle":86,"officialTitle":87,"acronym":4,"eligibilityCriteria":88,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":89,"enrollmentInfo":90,"targetDuration":4,"studyType":22,"phases":92,"briefSummary":93,"conditions":94,"keywords":4,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":4},"100609695","neurofeedback-and-well-being-among-people-with-co-occurring-obsessive-compulsive-disorder-and-post-traumatic-stress-symptoms-100609695","NCT07217925","Neurofeedback and Well-Being Among People With Co-Occurring Obsessive Compulsive Disorder and Post-traumatic Stress Symptoms","Exploring the Influence of Neurofeedback on the Well-Being of People With Symptoms of Obsessive Compulsive Disorder and Post-traumatic Stress Symptoms","Inclusion Criteria:\n\n1. being a client placed on the clinic waitlist to receive exposure-response prevention for OCD symptoms at the Anxiety and OCD Treatment Center of Ann Arbor, in Ann Arbor, MI.\n2. having self-reported symptoms of OCD;\n3. having post-traumatic stress symptoms as indicated by a score of 3 or higher on the Primary Care PTSD Screen for DSM-5 (PC-PTSD-5) screening measure;\n4. being age 18+.\n5. being a citizen of the United States of America -\n\nExclusion Criteria:\n\n1. a lifetime history of significant untreated mental illness (not currently treated schizophrenia, schizoaffective disorder, bipolar disorder, or substance use disorder) or neurological or pervasive developmental disorder;\n2. a documented history of epilepsy;\n3. lifetime history of any head injury with loss of consciousness;\n4. current exposure domestic or intimate partner violence or otherwise state that their current living conditions are unsafe;\n5. current experiences of psychosis or suicidality within the last six months;\n6. currently taking, or in the past month has taken benzodiazepines, narcotic drugs, or cannabis;\n7. currently pregnant\n8. engagement in self-harming behaviors in the last 3 months that required medical attention;\n9. lack of competence to understand or consent to the study procedures;\n10. lack of fluency in written and spoken English. -","90 Years",{"count":91,"type":21},20,[24],"The proposed study will collect novel data evaluating the feasibility of a neurofeedback training program delivered to prospective clients with a history of clinically concerning trauma-related mental health symptoms who are on a wait list to receive obsessive compulsive disorder-specific psychotherapy at an outpatient mental health clinic. This study will evaluate the influence of neurofeedback training on participant's overall sense of well-being, and additionally, whether any enhanced well-being is subsequently associated with positive changes in symptoms of obsessive compulsive disorder, post-traumatic stress, dissociation and other trauma-related mental health symptoms, emotional regulation, etc.",[95,96,97,27,98],"Well-Being, Psychological","Mood Disturbance","Emotional Regulation","Post Traumatic Stress Symptoms","NOT_YET_RECRUITING","2025-11-10",{"date":102,"type":39},"2025-11-12",{"date":104,"type":21},"2025-11",{"date":106,"type":21},"2029-01",{"name":108,"class":46},"Wayne State University",{"id":110,"slug":111,"hasResults":11,"nctId":112,"briefTitle":113,"officialTitle":114,"acronym":115,"eligibilityCriteria":116,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":117,"targetDuration":4,"studyType":22,"phases":119,"briefSummary":120,"conditions":121,"keywords":125,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":129,"lastUpdatePostDateStruct":130,"startDateStruct":132,"completionDateStruct":134,"leadSponsor":135,"locationsCount":81},"100597711","empowering-narratives-100597711","NCT07062042","Empowering Narratives","Styrkende Narrativ: Hjelp Til Selvhjelp for Ukrainske Flyktninger \u002F Empowering Narratives: Help to Self-help to Ukrainian Refugees","EN","Inclusion Criteria:\n\n* Ukrainian refugee residing in Norway.\n* Arrival in Norway after 24 February 2022.\n* Minimum 18 years old\n* Provided informed consent for participation.\n* Classified as having PTSD symptoms (ITQ) OR reported traumatic experience (LEC-5) OR present PTSD comorbidities (PHQ-9, Shut-D).\n\nExclusion Criteria:\n\n* Diagnosis, history, or scores compatible with the psychotic spectrum\n* Diagnostic of neurodevelopmental disorders\n* Current participation in ongoing trauma-focused psychological treatment (e.g., therapy for PTSD).\n* Declining consent for mandatory elements of the study (e.g., participation in screening or treatment delivery).",{"count":118,"type":21},50,[24],"Background: The Russian invasion of Ukraine has resulted in forced displacement, with over 80,000 Ukrainian refugees now residing in Norway. This displacement has led to increased vulnerability to trauma and mental health challenges. Narrative Exposure Therapy (NET), a short-term trauma-focused intervention, has demonstrated efficacy in reducing PTSD symptoms among individuals exposed to organized violence and war.\n\nAim: The protocol aims to assess the clinical effects of Narrative Exposure Therapy (NET) on PTSD and depression symptoms among Ukrainian refugees in Norway and to facilitate training and supervised practice for Ukrainian health professionals and workers in using NET.\n\nMethods: This study employs a pretest-posttest randomized controlled experimental design. Ukrainian health professionals and workers in Norway will receive standardized NET training through a digital course. Subsequently, they will treat Ukrainian refugees using NET under supervision. Participants will be screened and assessed at three time points: baseline, immediately after treatment, and at 6-month follow-up. Validated questionnaires in Ukrainian and Russian will be used: PHQ-9, ITQ, LEC-5, SHUT-D, and demographic questionnaire. Exclusion criteria include active psychotic spectrum disorders, neurodevelopmental disorders and concurrent trauma therapy.",[122,123,27,124],"PTSD - Post Traumatic Stress Disorder","Depression Disorders","Refugee",[30,123,27,126,127,128],"Ukrainian Refugees","Norway","Narrative Exposure Therapy","2025-08-12",{"date":131,"type":39},"2025-08-17",{"date":133,"type":39},"2025-03-01",{"date":38,"type":21},{"name":136,"class":46},"Kristiania University College",{"id":138,"slug":139,"hasResults":11,"nctId":140,"briefTitle":141,"officialTitle":142,"acronym":143,"eligibilityCriteria":144,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":145,"targetDuration":4,"studyType":22,"phases":147,"briefSummary":149,"conditions":150,"keywords":154,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":159,"lastUpdatePostDateStruct":160,"startDateStruct":162,"completionDateStruct":164,"leadSponsor":166,"locationsCount":81},"100555013","phase-4-low-dose-ketamine-infusion-during-burn-wound-care-100555013","NCT06506565","Low-Dose Ketamine Infusion During Burn Wound Care","A Randomized, Placebo-Controlled, Double-Blind Evaluation of Low-Dose Ketamine Infusion During Burn Wound Care Procedures to Improve Pain Intensity and Reduce Opioid Consumption","IMPROVE","Inclusion Criteria:\n\n* Admitted to burn service with thermal injury\n\nExclusion Criteria:\n\n* unable\u002Funwilling to consent within 72 hours\n* unable to report NRS\n* known contraindication to ketamine\n* \\\u003C than 18 years of age\n* pregnant\n* incarcerated\n* TBSA over 50 %",{"count":146,"type":21},140,[148],"PHASE4","The current standard of care (SOC) (i.e. fentanyl and midazolam) offers limited efficacy for preventing or relieving pain. Ketamine infusions may provide the benefits of analgesia, minimize adverse events, and reduce opioid use. The purpose of this study is to determine if adding a low dose ketamine infusion during wound care will safely provide pain relief for patients with burn injury.",[151,152,27,153],"Burn","Pain","Opioid",[155,156,157,158],"ketamine","burn","opioid","analgesia","2024-12-09",{"date":161,"type":39},"2024-12-13",{"date":163,"type":39},"2024-07-08",{"date":165,"type":21},"2025-12",{"name":167,"class":46},"University of Tennessee",{"id":169,"slug":170,"hasResults":11,"nctId":171,"briefTitle":172,"officialTitle":173,"acronym":174,"eligibilityCriteria":175,"healthyVolunteers":56,"sex":16,"minAge":176,"maxAge":177,"enrollmentInfo":178,"targetDuration":4,"studyType":22,"phases":179,"briefSummary":180,"conditions":181,"keywords":183,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":190,"lastUpdatePostDateStruct":191,"startDateStruct":193,"completionDateStruct":195,"leadSponsor":197,"locationsCount":81},"100558570","caveat-an-open-trial-feasibility-study-100558570","NCT06552832","CAVEAT: An Open-Trial Feasibility Study","Clinician-Assisted Video Feedback Exposure-Approach Therapy (CAVEAT): An Open-Trial of a Brief Psychotherapy for Traumatized Mothers and Their Young Children","CAVEAT-OT","Inclusion Criteria:\n\n* French-speaking, biological child living with mother\n\nExclusion Criteria:\n\n* Physical and\u002For mental handicap that can interfere with participation in play and measures, active psychotic illness or substance abuse","12 Months","50 Years",{"count":91,"type":21},[24],"This is an open-clinical trial to study the feasibility of a brief manualized psychotherapy for mothers interpersonal violence-related posttraumatic stress disorder (PTSD) and their very young children ages 1-3 years, entitled: Clinician-Assisted Videofeedback Exposure Approach Therapy (CAVEAT). This project, to be conducted with referred mothers and children to an academic medical center ambulatory care setting, intends to pilot along with the manualized intervention, pre- and post-intervention measures for up to 10 dyads over 2 years.",[182,30,27],"Parent-Child Relations",[184,185,186,187,188,189],"Brief Psychotherapy","Videofeedback","Mentalization","Infant Mental Health","Parenting","Interpersonal Violence","2024-08-09",{"date":192,"type":39},"2024-08-14",{"date":194,"type":39},"2024-07-01",{"date":196,"type":21},"2026-07-31",{"name":198,"class":46},"University of Lausanne Hospitals"]