[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"distal-radius-fractures\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:distal-radius-fractures":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,18,0,[8,47,76,101,125,151,177,199,234,255,275,292,310,334,354,380,424,449],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100545634","phase-4-topical-tranexamic-acid-vs-placebo-on-acute-postoperative-pain-following-drf-fixation-100545634",false,"NCT06384456","Topical TRanexamic Acid vs. Placebo on Acute Postoperative Pain Following DRF Fixation","The Effect of Topical TRanexamic Acid vs. Placebo on Acute Postoperative Pain Following Distal Radius Fracture Fixation: a Randomized Controlled Trial - The TRADR Study","TRADR","Inclusion Criteria:\n\n* Patients undergoing open reduction internal fixation (Volar approach) for operative management of a distal radius fracture;\n* Aged 18 or older;\n* Provision of informed consent;\n* Cognitive ability and English-language skills required to complete outcome measures.\n\nExclusion Criteria:\n\n* Revision surgery or any additional operative management of ipsilateral wrist injury\n* Distal radius fracture treated with a dorsal approach\n* Known history of lymphedema or lymph node dissection in the operative extremity\n* Known chronic pain conditions, fibromyalgia, or polymyalgia rheumatic\n* Current user of opioids and\u002For on chronic opioids use\n* Known allergic reaction to TXA\n* Anticoagulant use not stopped in time for surgery as per thrombosis Canada guidelines (i.e. warfarin, acetylsalicylic acid, direct oral anticoagulants, etc.)\n* Previous thrombotic stroke or thromboembolic disorders (i.e. known previous DVT, PE, or clotting disorders)\n* Current pregnancy or breastfeeding\n* Previous neurologic injury causing paralysis of affected shoulder\u002Farm\n* Severe cardio-respiratory disease (i.e. ASA Grade IV or higher).","ALL","18 Years",{"count":20,"type":21},90,"ESTIMATED","INTERVENTIONAL",[24],"PHASE4","The goal of this study is to find out whether the use of topical tranexamic acid (TXA) into the surgical wound will result in less post-operative pain, less pain killer use, and better post-operative use of the wrist in people undergoing surgery for a wrist fracture compared to not using topical TXA (placebo).",[27],"Distal Radius Fractures",[27,29,30,31,32,33],"acute pain","Topical tranexamic acid","Open Reduction and Internal FIxation","Placebo","Randomized Control Trial","RECRUITING","2026-04-28",{"date":37,"type":38},"2026-05-04","ACTUAL",{"date":40,"type":38},"2025-08-13",{"date":42,"type":21},"2027-12",{"name":44,"class":45},"University Health Network, Toronto","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":54,"sex":17,"minAge":55,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":22,"phases":58,"briefSummary":60,"conditions":61,"keywords":63,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":46},"100550927","prednisone-for-crps-in-distal-radius-fracture-100550927","NCT06453447","Prednisone for CRPS in Distal Radius Fracture","Prednisone for the Early Treatment of Complex Regional Pain Syndrome After Distal Radius Fracture - a Pilot Randomized Trial","Inclusion Criteria:\n\n1. Patient is aged 19 years or older;\n2. Patient has a unilateral, closed, distal radius fracture confirmed by radiographs;\n3. The fracture is acute, within 21 days of injury;\n4. Patient undergoes open reduction internal fixation with volar locking plate;\n5. Patient is identified as at risk of developing CRPS with 2 or more of the following:\n\n   1. Pain score on visual analogue scale (VAS) greater than or equal to 5\u002F10 within 1 week of injury and beyond;\n   2. Centre of Epidemiologic Studies Depression (CES-D) score on presentation is greater than or equal to 16;\n   3. Patient identifies as female;\n6. Patient is identified as developing signs of CRPS based on the Budapest CRPS Criteria;\n7. Patient provides informed consent.\n\nExclusion Criteria:\n\n1. Patient has previously fractured ipsilateral wrist;\n2. Patient has neurovascular injury associated with distal radius fracture;\n3. Patient has associated extremity or polytrauma injuries that would interfere with rehabilitation and outcome measurements, in the opinion of the investigator;\n4. Patient has allergy to prednisone or placebo ingredients;\n5. Patient has contraindication to prednisone or placebo ingredients;\n6. Patient already takes a glucocorticoid medication;\n7. Patient has active bacterial, viral, or fungal infection;\n8. Patient is diagnosed with diabetes;\n9. Patient is pregnant, planning on becoming pregnant, or breastfeeding;\n10. Patient is anticipated to have difficulty completing study follow up, in the opinion of the investigator.",true,"19 Years",{"count":57,"type":21},40,[59],"NA","Wrist fractures are the most prevalent adult fracture. Complex regional pain syndrome (CRPS) is a common complication that can occur, leading to permanent disability and is costly to the patient and healthcare system. In addition, amidst the opioid epidemic, the risk of increased opioid use in patients with CRPS prompts the need to find viable treatment strategies. This study aims to evaluate an anti-inflammatory medication, prednisone, in the early treatment of CRPS. Patients with wrist fractures who undergo surgical treatment will be randomized to receiving placebo vs prednisone for 2 weeks. Clinical assessments in the follow up period will be compared.",[62,27],"Complex Regional Pain Syndromes",[64,65,66],"wrist fracture","pain","orthopaedic surgery","2026-04-27",{"date":69,"type":38},"2026-05-01",{"date":71,"type":38},"2024-10-10",{"date":73,"type":21},"2027-07",{"name":75,"class":45},"University of British Columbia",{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":4,"eligibilityCriteria":82,"healthyVolunteers":54,"sex":17,"minAge":18,"maxAge":83,"enrollmentInfo":84,"targetDuration":4,"studyType":22,"phases":86,"briefSummary":87,"conditions":88,"keywords":89,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":46},"100633184","comparative-study-between-cannulated-screws-and-k-wires-in-the-fixation-of-distal-radius-fractures-100633184","NCT07523386","Comparative Study Between Cannulated Screws and K-wires in the Fixation of Distal Radius Fractures","A Comparative Study Between Cannulated Screws and K-wires in the Treatment of Distal Radius Fractures","Inclusion Criteria:\n\n* Patients aged between 18\\_60years.\n* Patients with displaced or unstable Distal Radius Fractures requiring surgical Fixation.\n* Type A Extra articular Fractures.\n* Patients fit for surgery and willing to participate in the study.\n\nExclusion Criteria:\n\n* open distal Radius Fractures.\n* Pathological Fractures.\n* Previous Fractures or surgeries affecting the wrist.\n* Associated neurovascular injury.\n* polytrauma patient.\n* Patients with severe osteoporotic or systemic condition affecting bone healing.","60 Years",{"count":85,"type":21},34,[59],"This comparative study aims to evaluate the clinical and radiological outcomes of cannulated screw fixation versus K-wire fixation in the treatment of distal radius fractures. Adult patients with distal radius fractures will be allocated to either cannulated screw fixation or K-wire fixation. The primary outcome measure will be functional outcome assessed using the DASH score, with secondary outcomes including radiographic parameters and complication rates.",[27],[27,90,91],"Cannulated screws","Colles'","2026-04-15",{"date":94,"type":38},"2026-04-20",{"date":96,"type":21},"2026-04-22",{"date":98,"type":21},"2027-01-23",{"name":100,"class":45},"Sohag University",{"id":102,"slug":103,"hasResults":11,"nctId":104,"briefTitle":105,"officialTitle":106,"acronym":107,"eligibilityCriteria":108,"healthyVolunteers":54,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":109,"targetDuration":4,"studyType":22,"phases":111,"briefSummary":113,"conditions":114,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":116,"lastUpdatePostDateStruct":117,"startDateStruct":119,"completionDateStruct":121,"leadSponsor":123,"locationsCount":46},"100529840","phase-3-supraclavicular-bupivacaine-vs-supraclavicular-liposomal-bupivacaine-for-orthopedic-wrist-surgery-100529840","NCT06179004","Supraclavicular Bupivacaine Vs. Supraclavicular Liposomal Bupivacaine for Orthopedic Wrist Surgery","Randomized Controlled Trial of Supraclavicular Bupivacaine Vs. Supraclavicular Liposomal Bupivacaine for Orthopedic Wrist Surgery","Vs","Inclusion Criteria:\n\n* Age greater than or equal to 18\n* Scheduled for orthopedic wrist surgery at University of North Carolina at Chapel Hill.\n\nExclusion Criteria:\n\n* Contraindications to regional anesthesia\n* Emergent surgery Open fractures will be treated emergently and will not allow adequate lead time for enrollment in this study. Also, open fractures are usually accompanied by other traumatic injuries that would confound the pain related outcomes in this study.\n* Significant peripheral neuropathy or neurological disorder affecting the upper extremity\n* Pregnancy Pregnant women have physiologic changes that make them more sensitive to local anesthetics. That would introduce a confounding element in interpreting the effectiveness of the peripheral nerve blocks being studied.\n* Cognitive or psychiatric condition that might affect patient assessment and\u002For inability to provide informed consent.",{"count":110,"type":21},100,[112],"PHASE3","Orthopedic wrist procedures often cause significant postoperative pain. A supraclavicular nerve block is an effective and proven method to help reduce postoperative pain and decrease opioid use around the time of upper extremity surgery. Liposomal bupivacaine (Exparel) has been approved for use around the brachial plexus, but its analgesic efficacy has limited data. The investigators' goal is to evaluate the effectiveness of Exparel as compared to plain bupivacaine. The investigators hope to ensure the quality of pain control around the time of distal radius fracture repair and reduce the variability of care at the investigators institution by prospectively and rigorously collecting perioperative data during this study.",[27,115],"Wrist Fractures","2025-10-23",{"date":118,"type":38},"2025-10-24",{"date":120,"type":38},"2024-04-10",{"date":122,"type":21},"2026-10",{"name":124,"class":45},"University of North Carolina, Chapel Hill",{"id":126,"slug":127,"hasResults":11,"nctId":128,"briefTitle":129,"officialTitle":130,"acronym":4,"eligibilityCriteria":131,"healthyVolunteers":54,"sex":17,"minAge":18,"maxAge":132,"enrollmentInfo":133,"targetDuration":4,"studyType":22,"phases":135,"briefSummary":137,"conditions":138,"keywords":139,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":142,"lastUpdatePostDateStruct":143,"startDateStruct":145,"completionDateStruct":147,"leadSponsor":149,"locationsCount":46},"100535390","phase-1-impact-of-early-adl-education-on-outcomes-post-drf-orif-100535390","NCT06251206","Impact of Early ADL Education on Outcomes Post DRF ORIF","Impact of Early Multimodal ADL Education on Outcomes Post Distal Radius Fracture Open Reduction Internal Fixation Surgery","Inclusion Criteria:\n\nEnglish Speaking DRF treated with ORIF Individuals 18 years of age or older 2 weeks or less post ORIF for DRF\n\nExclusion Criteria:\n\nIndividuals with pre-existing neurological coniditons affecting the upper limb Individuals with congnitive deficits that would limit the ability to correctly report information on outcome measures Individuals with psychological deficits which would limit the ability to correctly report information on outcome measures Individuals with multiple injuries to the affected upper limb Individuals with multiple injuries to both upper limbs Prior distal radius fracture involving the same wrist Individuals receiving hand therapy for another injury at enrollment into study","110 Years",{"count":134,"type":21},64,[136],"PHASE1","This study is a randomized controlled trial (RCT). This RCT which will study the effect of performing daily activities early after a distal radius fracture being treated with surgical intervention of open reduction and internal fixation. This study will have two groups. The experimental group will watch a video and be given a handout on how to perform daily activities with the hand of the injured wrist while recovering from surgery and postoperative instructions. The control group will watch a video on wound care and be given a handout on postoperative instructions. Outcome measures will be taken at initial evaluation between 1-2 weeks post surgery, at 5-7 weeks post surgery, at 8-10 weeks, and at 12-14 weeks. Outcome measures will include the Michigan Wrist Evaluation, Visual Analog Pain Scale, Tampa Scale of Kinesiophobia-11 Scale, finger mobility testing, grip and pinch strength, and the 9 hole peg test to test fine motor coordination. Outcome measure scores will be compared between groups using a t-test statistical test. Outcome measure scores will also be tested within groups using a paired t-test.",[27],[140,141],"Activities of Daily Living","Postsurgical Patient Education","2025-08-22",{"date":144,"type":38},"2025-08-28",{"date":146,"type":38},"2024-08-01",{"date":148,"type":21},"2026-09",{"name":150,"class":45},"George Washington University",{"id":152,"slug":153,"hasResults":11,"nctId":154,"briefTitle":155,"officialTitle":156,"acronym":4,"eligibilityCriteria":157,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":158,"enrollmentInfo":159,"targetDuration":4,"studyType":22,"phases":161,"briefSummary":162,"conditions":163,"keywords":164,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":168,"lastUpdatePostDateStruct":169,"startDateStruct":171,"completionDateStruct":173,"leadSponsor":175,"locationsCount":46},"100597128","clinical-study-on-the-healing-of-distal-radius-fractures-with-conservative-treatment-assisted-by-fus-subcutaneous-needling-100597128","NCT07054463","Clinical Study on the Healing of Distal Radius Fractures With Conservative Treatment Assisted by Fu's Subcutaneous Needling","Fu's Subcutaneous Needling-assisted Conservative Treatment for Distal Radius Fracture Healing: Protocol for a Randomized Controlled Trial","Inclusion Criteria:\n\nParticipants meeting the diagnostic criteria for distal radius fractures as outlined in both the Evidence-Based Guidelines for Diagnosis and Treatment of Adult Distal Radius Fractures (2024) (10) and the clinical practice guidelines (CPG) jointly issued by the American Academy of Orthopaedic Surgeons (AAOS) and the American Society for Surgery of the Hand (ASSH) (11), while also satisfying the following conditions, will be eligible for enrollment:\n\n1. Within 1 week post closed reduction and small splint immobilization treatment.\n2. Aged between 18 and 85 years (inclusive).\n3. Fracture caused by trauma.\n4. Acute fracture (≤2 weeks) or first-time fracture.\n5. No prior history of receiving Fu's subcutaneous needling therapy.\n6. Signed informed consent form obtained.\n\nExclusion Criteria:\n\n1. Pathological, open, or nonacute fractures (\\>2 weeks since injury).\n2. Patients with thrombocytopenia, bleeding tendency, or coagulation disorders (INR \\>1.5 or platelet count \\\u003C50×10⁹\u002FL).\n3. Cognitive impairment or psychiatric disorders affecting treatment compliance and follow-up.\n4. Local skin lesions, pregnancy, or lactation.\n5. History of syncope during Fu's subcutaneous needling therapy or intolerance to the procedure.\n6. Participation in other interventional clinical trials within the past 3 months.","85 Years",{"count":160,"type":21},84,[59],"The goal of this clinical trial is to evaluate the efficacy and safety of Fu's subcutaneous needling (FSN) therapy combined with rehabilitation exercises in promoting fracture healing after conservative treatment of distal radius fractures (DRFs) in adult patients (aged 18-85 years) with acute DRFs. The main questions it aims to answer are:\n\n* Does FSN therapy accelerate radiographic union compared to Sham FSN therapy?\n* Does FSN therapy improve functional outcomes (e.g., pain, swelling, joint mobility) and anatomical stability (e.g., volar tilt, radial height) in DRF patients?\n\nResearchers will compare the FSN therapy plus rehabilitation training group to the Sham FSN therapy plus rehabilitation training group to see if FSN provides superior clinical benefits in fracture healing and functional recovery.\n\nParticipants will:\n\n1. Receive either FSN or Sham FSN therapy (12 sessions over 8 weeks) alongside standardized rehabilitation exercises.\n2. Undergo periodic assessments (weeks 2, 4, 6, 8, 10, and 12) for radiographic union, pain (VAS), swelling, wrist mobility, and functional status (DASH questionnaire).\n3. Follow a phased rehabilitation protocol, including finger\u002Fshoulder exercises (weeks 1-3), gentle wrist movements (weeks 4-5), and resistance training (week 6 onward).",[27],[165,166,167],"Fu's subcutaneous needle therapy","distal radius fractures","conservative treatment","2025-08-18",{"date":170,"type":38},"2025-08-19",{"date":172,"type":38},"2025-04-15",{"date":174,"type":21},"2027-05",{"name":176,"class":45},"Guangzhou University of Chinese Medicine",{"id":178,"slug":179,"hasResults":11,"nctId":180,"briefTitle":181,"officialTitle":182,"acronym":4,"eligibilityCriteria":183,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":184,"enrollmentInfo":185,"targetDuration":4,"studyType":22,"phases":187,"briefSummary":188,"conditions":189,"keywords":4,"overallStatus":190,"whyStopped":4,"lastUpdateSubmitDate":191,"lastUpdatePostDateStruct":192,"startDateStruct":194,"completionDateStruct":196,"leadSponsor":198,"locationsCount":4},"100601288","antegrade-versus-retrograde-cross-k-wire-in-distal-radius-fracture-100601288","NCT07108543","Antegrade Versus Retrograde Cross K-Wire In Distal Radius Fracture","Antegrade Versus Retrograde Cross K-Wire In Distal Radius Fracture; A Comparative Study","Inclusion Criteria:\n\nPatients with extra-articular distal radius fractures. Fractures classified as Frykmann type 1 and type 2. Patients aged 18 years and above.\n\nExclusion Criteria:\n\n* Skeletally immature patient.\n* Intra-articular distal radius fractures.\n* Communited fractures.\n* Open fractures or fractures with neurovascular compromise.\n* Patients with fractures requiring surgical interventions other than K-wire fixation.\n* Patients with a history of infection or other conditions impair wound healing.","65 Years",{"count":186,"type":21},30,[59],"This study aims to compare the clinical and radiological outcomes of distal radius fractures treated with cross K-wire fixation using the antegrade versus retrograde technique. Adult patients with extra-articular distal radius fractures will be randomly assigned to one of the two surgical approaches. The primary outcomes include fracture stability, functional recovery, and complication rates. The study is designed as a prospective, randomized controlled trial conducted at sohag university",[27],"NOT_YET_RECRUITING","2025-08-06",{"date":193,"type":38},"2025-08-07",{"date":195,"type":21},"2025-08",{"date":197,"type":21},"2026-02",{"name":100,"class":45},{"id":200,"slug":201,"hasResults":11,"nctId":202,"briefTitle":203,"officialTitle":203,"acronym":4,"eligibilityCriteria":204,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":205,"targetDuration":4,"studyType":22,"phases":207,"briefSummary":208,"conditions":209,"keywords":214,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":225,"lastUpdatePostDateStruct":226,"startDateStruct":228,"completionDateStruct":230,"leadSponsor":232,"locationsCount":46},"100568224","phase-4-brachial-plexus-nerve-block-versus-haematoma-block-for-closed-reduction-of-distal-radius-fracture-in-adults---the-block-trial-a-multicentre-randomised-controlled-trial-100568224","NCT06678438","Brachial Plexus Nerve Block Versus Haematoma Block for Closed Reduction of Distal Radius Fracture in Adults - The BLOCK Trial. A Multicentre Randomised Controlled Trial.","Inclusion Criteria:\n\n* Adults (age ≥ 18 years) with a distal radius fracture in need of closed reduction\n\nExclusion Criteria:\n\n* Patients who would never qualify for surgery according to local guidelines\n* Lack of informed consent\n* No Danish Central Person Register (CPR) number\n* Allergies to the trial medication\n* Distal radius fracture initially deemed to require surgery regardless of the outcome of the closed reduction\n* Open fractures (fracture-related wound requiring sutures)\n* Other fractures on the same extremity ((NOT including distal ulna fracture(s))\n* Bilateral distal radius fractures both requiring closed reduction\n* Concomitant medical or surgical condition taking priority over the closed reduction of the distal radius fracture.",{"count":206,"type":21},1716,[24],"The aim of the project is to evaluate the beneficial and harmful effects of an ultrasound-guided brachial plexus nerve block for patients with a distal radius (wrist) fracture in the need of realignment of fractured bone endings without cutting the skin (closed reduction), in comparison to a haematoma block, which is standard care in Denmark.\n\nEvery participant will receive one of the following types of anaesthesia for the realignment of the wrist fracture:\n\n1. A nerve block of the arm (plexus brachialis block)\n2. A haematoma block, which is the current standard anaesthesia in the emergency departments.",[27,210,211,212,213],"Fracture Dislocation","Fracture Dislocation of Upper Limb Joint","Colles' Fracture","Closed Reduction of Fracture and Application of Plaster Cast",[215,216,217,218,219,220,221,222,223,224],"Lidocaine","Local anaesthesia","Regional anaesthesia","Peripheral nerve block","Brachial plexus block","Lateral infraclavicular block","Axillary plexus block","Distal radius fracture","Colles' fracture","Wrist fracture","2025-06-12",{"date":227,"type":38},"2025-06-17",{"date":229,"type":38},"2024-12-10",{"date":231,"type":21},"2027-04",{"name":233,"class":45},"Nordsjaellands Hospital",{"id":235,"slug":236,"hasResults":11,"nctId":237,"briefTitle":238,"officialTitle":239,"acronym":4,"eligibilityCriteria":240,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":241,"targetDuration":4,"studyType":242,"phases":4,"briefSummary":243,"conditions":244,"keywords":4,"overallStatus":190,"whyStopped":4,"lastUpdateSubmitDate":172,"lastUpdatePostDateStruct":247,"startDateStruct":249,"completionDateStruct":251,"leadSponsor":253,"locationsCount":46},"100582671","evaluation-of-limb-function-and-perception-in-rehabilitation-after-traumatic-wrist-fracture-surgery-100582671","NCT06866340","Evaluation of Limb Function and Perception in Rehabilitation After Traumatic Wrist Fracture Surgery","Evaluation of the Functionality and Perception of the Injured Limb in the Rehabilitation Process of Orthopedic Patients Undergoing Surgical Treatment for Traumatic Wrist Fracture","Inclusion Criteria:\n\n* Adults (≥18 years old)\n* Patients who have undergone surgical treatment with a volar approach for a traumatic distal radius fracture at IRCCS Ospedale Galeazzi - Sant'Ambrogio.\n* Willingness and ability to provide written informed consent.\n\nExclusion Criteria:\n\n* Pre-existing neurological, psychiatric, or cognitive disorders that could affect motor function or body perception.\n* Previous fractures of the same limb.\n* Pregnancy or breastfeeding (self-reported).",{"count":110,"type":21},"OBSERVATIONAL","The goal of this observational study is to assess the functional and perceptual alterations of the affected limb during rehabilitation in adult orthopedic patients who underwent surgical treatment for distal radius fractures. The main questions it aims to answer are:\n\nWhat is the correlation between functional and perceptual alterations of the affected limb at the beginning and end of rehabilitation? How do these alterations influence rehabilitation duration and effectiveness?\n\nParticipants will:\n\nComplete the patient questionnaires ((QuickDASH and ALPQ). Undergo handgrip strength tests and digital dynamometer tests to assess forearm muscle strength.\n\nHave their range of motion evaluated by a physiotherapist during outpatient visits.\n\nNo additional diagnostic or instrumental examinations are required beyond routine clinical practice. The study will recruit 100 adult patients, last 24 months, and provide insights into the role of body perception in rehabilitation after wrist fractures.",[27,245,246],"Rehabilitation","Body Perception",{"date":248,"type":38},"2025-04-18",{"date":250,"type":21},"2025-05-01",{"date":252,"type":21},"2027-02",{"name":254,"class":45},"I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio",{"id":256,"slug":257,"hasResults":11,"nctId":258,"briefTitle":259,"officialTitle":260,"acronym":4,"eligibilityCriteria":261,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":184,"enrollmentInfo":262,"targetDuration":4,"studyType":22,"phases":264,"briefSummary":265,"conditions":266,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":267,"lastUpdatePostDateStruct":268,"startDateStruct":270,"completionDateStruct":271,"leadSponsor":273,"locationsCount":46},"100586326","mechanical-modalities-vs-standard-care-for-edema-and-pain-management-after-drf-fixation-100586326","NCT06913920","Mechanical Modalities vs. Standard Care for Edema and Pain Management After DRF Fixation","A Two-Arm, Single-Blinded Randomized Controlled Trial Evaluating the Effectiveness of Mechanical Modalities Combined With Standard Therapy Versus Standard Therapy Alone for Edema and Pain Management After Distal Radius Fracture Fixation","Inclusion Criteria:\n\nAdults aged 18 years or older. Undergoing surgical treatment for distal radius fracture with stable internal fixation.\n\nAble to initiate formal rehabilitation approximately 2 weeks postoperatively. Willing and able to attend in-clinic therapy sessions at the outpatient hand therapy center.\n\nExclusion Criteria:\n\nUnstable fixation or need for further surgical intervention. Pre-existing conditions that would significantly affect upper limb function (e.g., severe arthritis, neurological disorders).\n\nHistory of skin conditions or allergies that contraindicate the use of mechanical devices.\n\nAny contraindication to mechanical modalities (for example, severe peripheral vascular disease).\n\nInability to comply with study procedures or follow-up visits. Pregnant or breastfeeding individuals.",{"count":263,"type":21},50,[59],"This single-blinded, randomized controlled trial (RCT) will evaluate the added benefit of mechanical modalities (continuous passive motion (CPM) and intermittent pneumatic compression (IPC)) when integrated into standard therapy for managing postoperative edema and pain in patients undergoing distal radius fracture (DRF) fixation. The primary outcomes are edema volume (measured via volumeter) and pain intensity (Numeric Pain Rating Scale, NPRS) at 6 weeks post-operation. Secondary outcomes include wrist\u002Fforearm range of motion (ROM), grip strength, Patient-Rated Wrist Evaluation (PRWE), and adverse events.",[27],"2025-03-31",{"date":269,"type":38},"2025-04-06",{"date":172,"type":21},{"date":272,"type":21},"2026-01-15",{"name":274,"class":45},"Al Hayah University In Cairo",{"id":276,"slug":277,"hasResults":11,"nctId":278,"briefTitle":279,"officialTitle":280,"acronym":4,"eligibilityCriteria":281,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":184,"enrollmentInfo":282,"targetDuration":4,"studyType":22,"phases":283,"briefSummary":284,"conditions":285,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":267,"lastUpdatePostDateStruct":286,"startDateStruct":287,"completionDateStruct":289,"leadSponsor":291,"locationsCount":46},"100586327","static-vs-dynamic-progressive-splinting-for-persistent-wrist-stiffness-after-drf-100586327","NCT06913933","Static vs. Dynamic Progressive Splinting for Persistent Wrist Stiffness After DRF","A Two-Arm, Parallel-Group Randomized Controlled Trial Comparing Static Progressive Splinting Versus Dynamic Splinting for Improving Wrist PROM\u002FAROM in Patients With Persistent Post-DRF Stiffness","Inclusion Criteria:\n\nAdults aged 18 years or older. At least 8 weeks post distal radius fracture (operative or nonoperative) who have completed standard rehabilitation.\n\nDemonstrated persistent wrist stiffness with ≤50% of contralateral wrist extension or flexion.\n\nCapable of providing written informed consent and complying with study procedures\n\nExclusion Criteria:\n\nPresence of complex regional pain syndrome (CRPS) or active fracture healing issues.\n\nHistory of significant wrist pathology unrelated to the DRF. Uncontrolled medical conditions that would interfere with splint application or therapy.\n\nKnown skin conditions or allergies that preclude orthosis use. Inability or unwillingness to adhere to the intervention protocol or follow-up schedule.\n\nPregnant or breastfeeding individuals.",{"count":263,"type":21},[59],"This randomized controlled trial will compare the effectiveness of static progressive splinting versus dynamic splinting for treating persistent wrist stiffness in adults ≥18 years old at least 8 weeks post distal radius fracture (DRF) injury. Both splinting modalities are provided as an adjunct to one weekly supervised therapy session over a 6-week period. The primary outcomes are wrist active and passive range of motion (AROM\u002FPROM) measured using goniometry, with secondary outcomes including patient-reported wrist function (PRWE), overall satisfaction, and adverse events.",[27],{"date":269,"type":38},{"date":288,"type":21},"2025-04-17",{"date":290,"type":21},"2026-04-17",{"name":274,"class":45},{"id":293,"slug":294,"hasResults":11,"nctId":295,"briefTitle":296,"officialTitle":297,"acronym":4,"eligibilityCriteria":298,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":184,"enrollmentInfo":299,"targetDuration":4,"studyType":22,"phases":301,"briefSummary":302,"conditions":303,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":267,"lastUpdatePostDateStruct":304,"startDateStruct":305,"completionDateStruct":307,"leadSponsor":309,"locationsCount":46},"100586324","supervised-vs-home-based-vs-no-therapy-for-uncomplicated-distal-radius-fracture-in-younger-adults-100586324","NCT06913894","Supervised vs. Home-Based vs. No Therapy for Uncomplicated Distal Radius Fracture in Younger Adults","Supervised Therapy Versus a Standardized Home-Based Program Versus No Formal Therapy for Uncomplicated, Nonoperatively Treated Distal Radius Fracture in Adults Under 50: A Three-Arm, Parallel-Group Randomized Controlled Trial","Inclusion Criteria:\n\nAdults aged 18-50 years. Diagnosed with an extra-articular, stable distal radius fracture treated nonoperatively with a short-arm cast for approximately 4-6 weeks.\n\nThe fracture is uncomplicated (no significant soft-tissue injury, no evidence of CRPS, and no other major complications).\n\nWilling to provide written informed consent and comply with follow-up assessments.\n\nExclusion Criteria:\n\nIntra-articular or unstable fracture patterns. Surgical intervention planned or performed for the distal radius fracture. Presence of significant comorbidities (e.g., chronic inflammatory arthritis or severe neurological impairment affecting the injured limb).\n\nFracture complications such as CRPS or major soft-tissue injury. Inability to comply with study procedures or follow-up assessments. Pregnant or breastfeeding individuals.",{"count":300,"type":21},96,[59],"This three-arm, parallel-group RCT will compare the effectiveness of three rehabilitation strategies following conservative treatment of an uncomplicated distal radius fracture in adults under 50 years old. The study will compare:\n\nSupervised Therapy: Outpatient physical therapy sessions plus a daily home exercise program Home-Based Program: A structured, detailed home exercise program with weekly telephone follow-up No Therapy (minimal intervention): Standard minimal instruction via an educational brochure The primary outcome is the Patient-Rated Wrist Evaluation (PRWE) measured at 6 weeks and 6 months.",[27],{"date":269,"type":38},{"date":306,"type":21},"2025-04-21",{"date":308,"type":21},"2026-04-21",{"name":274,"class":45},{"id":311,"slug":312,"hasResults":11,"nctId":313,"briefTitle":314,"officialTitle":315,"acronym":4,"eligibilityCriteria":316,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":184,"enrollmentInfo":317,"targetDuration":4,"studyType":22,"phases":319,"briefSummary":320,"conditions":321,"keywords":322,"overallStatus":190,"whyStopped":4,"lastUpdateSubmitDate":325,"lastUpdatePostDateStruct":326,"startDateStruct":328,"completionDateStruct":330,"leadSponsor":332,"locationsCount":46},"100584832","sensory-training-in-distal-radius-fractures-100584832","NCT06894485","Sensory Training in Distal Radius Fractures","Effectiveness of Sensory Training in Distal Radius Fractures: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Aged 18-65 years\n* Diagnosed with distal radius fracture\n* In the rehabilitation phase after fracture healing\n* No prior upper extremity injuries\n* No neurological or psychiatric disorders affecting hand function\n* Able to comply with the rehabilitation program\n\nExclusion Criteria:\n\n* Any other musculoskeletal injury affecting the upper limb\n* Previous upper extremity surgeries\n* Severe neuropathy or sensory disorders\n* Uncontrolled chronic pain conditions",{"count":318,"type":21},44,[59],"This randomized controlled trial examines the effectiveness of sensory training in patients undergoing rehabilitation for distal radius fractures. Forty-four participants (aged 18-65, with no prior upper extremity injuries) will be randomly assigned to a control group (conventional physiotherapy) or an experimental group (conventional physiotherapy plus sensory training, including desensitization and proprioception exercises). Assessments will be conducted at baseline, 4 weeks, and 8 weeks using grip strength, sensory function, fine motor skills, pain level, and functional capacity measures. The study aims to compare the impact of sensory training versus conventional physiotherapy on pain reduction, sensory recovery, grip strength, and functional hand use.",[27],[27,323,324,245],"Sensory","Physiotherapy","2025-03-19",{"date":327,"type":38},"2025-03-25",{"date":329,"type":21},"2025-04-01",{"date":331,"type":21},"2026-04-01",{"name":333,"class":45},"Istanbul University",{"id":335,"slug":336,"hasResults":11,"nctId":337,"briefTitle":338,"officialTitle":338,"acronym":4,"eligibilityCriteria":339,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":184,"enrollmentInfo":340,"targetDuration":4,"studyType":242,"phases":4,"briefSummary":342,"conditions":343,"keywords":344,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":346,"lastUpdatePostDateStruct":347,"startDateStruct":349,"completionDateStruct":351,"leadSponsor":352,"locationsCount":46},"100563562","radiological-criteria-for-instability-in-distal-radius-fractures-100563562","NCT06617780","Radiological Criteria for Instability in Distal Radius Fractures","Inclusion criterias:\n\n* 18-65 years old, living in Oslo\u002Fsurroundings (available for follow-up)\n* AO class A2\u002F3 or C1\u002FC2 fractures\n* Dorsally displaced fracture of the distal radius (minimum VLDV more than100 or ulnar variance more than 2 mm compared to healthy side before reduction) with or without PSU fracture\n* Reduced to an acceptable position (VLDV 75-95 degrees, RIV more than 15 degrees, ulnar variance more than 2 mm, step\u002Fdiastasis in the joint surface less than 2 mm)\n\nExclution criterias:\n\n* Volar comminution (AO A3.3), step\u002Fdiastasis more than 2 mm before reduction\n* Ad latus more than 2 cortex widths after reduction\n* Bilateral fractures\n* Open fractures\n* Previous wrist fracture in adulthood\n* Still open growth disc on X-ray\n* Antebrachium or carpal fracture\n* Ligament damage in the root of the hand or DRUJ\n* Lack of compliance (dementia, psychiatry\u002Fdrug abuse, etc.)\n* Language problems\n* Rheumatoid arthritis or other systemic disease that can affect the result",{"count":341,"type":21},212,"The study examines whether there are radiological criteria that can give an indication if a dorsally displaced distal radius fracture remains stable without the needs for surgery after closed reduction in patients between 18 and 65 years of age.",[27],[115,345],"Distal Forearm Fractures","2025-03-17",{"date":348,"type":38},"2025-03-20",{"date":350,"type":38},"2024-10-07",{"date":231,"type":21},{"name":353,"class":45},"Oslo University Hospital",{"id":355,"slug":356,"hasResults":11,"nctId":357,"briefTitle":358,"officialTitle":359,"acronym":4,"eligibilityCriteria":360,"healthyVolunteers":11,"sex":17,"minAge":361,"maxAge":362,"enrollmentInfo":363,"targetDuration":4,"studyType":22,"phases":365,"briefSummary":366,"conditions":367,"keywords":368,"overallStatus":190,"whyStopped":4,"lastUpdateSubmitDate":371,"lastUpdatePostDateStruct":372,"startDateStruct":374,"completionDateStruct":376,"leadSponsor":378,"locationsCount":46},"100569755","unilateral-training-of-the-uninjured-limb-on-clinical-outcomes-in-patients-with-surgically-treated-radius-fracture-100569755","NCT06698367","Unilateral Training of the Uninjured Limb on Clinical Outcomes in Patients with Surgically Treated Radius Fracture","Addition of Unilateral Training of the Uninjured Limb to Standard Rehabilitation on Grip Strength and Manual Dexterity of Patients with Surgically Treated Distal Radius Fracture.","Inclusion Criteria:\n\n* Age between 30-50 years\n* Radiological diagnosis of unilateral distal radius fracture without concomitant fractures.\n* Fracture treated surgically.\n\nExclusion Criteria:\n\n* Patients with lesion of the triangular fibrocartilage.\n* Patients with distal radius fracture with consolidation disorders.\n* Patients with health conditions that cause pain or affect the motor skills of the upper limb (radiocarpal osteoarthritis, carpal tunnel syndrome, Quervain's tenosynovitis, neurodegenerative diseases, sequelae of stroke)\n* Patients with multi-site pain or chronic polyarticular diseases such as osteoarthritis or rheumatoid arthritis.\n* Unstable cardiovascular, respiratory, systemic or metabolic conditions that do not allow high-intensity physical exercise.\n* Patients who are taking nutritional supplements that interfere with the regulation of skeletal muscle strength and mass (example: whey protein, creatine, etc.)\n* Inability to understand, read and\u002For speak the Spanish language.","30 Years","50 Years",{"count":364,"type":21},52,[59],"The objective will be to determine the effectiveness of adding unilateral upper limb postoperative training to standard rehabilitation compared to standard rehabilitation on maximum grip strength and manual dexterity in patients aged 30-50 years with surgically treated distal radius fracture. It is presumed that the addition of unilateral upper limb training will significantly improve maximum grip strength and manual dexterity at the end of the intervention period compared to the group receiving only standard rehabilitation.\n\nPatients who agree to participate in this research will be randomly assigned to a control group (standard rehabilitation with unilateral training with mobility exercises) or an experimental group (standard rehabilitation with unilateral high-intensity strength training). The duration of the postoperative intervention will be 12 weeks. The primary variables are maximum grip strength and manual dexterity. Secondary variables are wrist mobility, forearm circumference, maximum voluntary isometric strength, functionality and health-related quality of life. Results will be measured at 0, 6 and 12 weeks postoperative.",[115,27],[222,369,245,370],"Cross-education","Exercise","2024-11-27",{"date":373,"type":38},"2024-12-03",{"date":375,"type":21},"2025-01",{"date":377,"type":21},"2027-08",{"name":379,"class":45},"Universidad Catolica de Temuco",{"id":381,"slug":382,"hasResults":11,"nctId":383,"briefTitle":384,"officialTitle":385,"acronym":4,"eligibilityCriteria":386,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":387,"targetDuration":4,"studyType":22,"phases":389,"briefSummary":390,"conditions":391,"keywords":413,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":416,"lastUpdatePostDateStruct":417,"startDateStruct":419,"completionDateStruct":421,"leadSponsor":422,"locationsCount":46},"100522111","opioid-free-pain-treatment-in-trauma-patients-100522111","NCT06078371","Opioid-Free Pain Treatment in Trauma Patients","Peri-operative Opioid-free Analgesic Protocol for Orthopedic Trauma Patients","Inclusion Criteria:\n\n* Patient is over the age of 18 years old\n* Underwent surgical treatment for the injuries of interest (stated elsewhere) by an Orthopedic Traumatology Attending Physician at the University of Kansas Hospital\n\nExclusion Criteria:\n\n* Patients that are unable to provide informed consent due to sustaining a head injury or incoherence from narcotics given to them post-injury\n* Chronic opioid use\n* Under the age of 18 years old\n* Undergoing revision surgery\n* Did not undergo surgical fixation\n* Pregnant\u002Fnursing women\n* Vulnerable populations as defined by the University of Kansas Medical Center IRB\n* Did not experience one of the following fractures listed in D.1. above.\n* Patients with CKD and\u002For cirrhosis will be excluded from the opioid-free pain block (block 2) and will only qualify for the standard of care opioid group (Block 1)",{"count":388,"type":21},250,[59],"Analgesic drug study that will compare pain outcomes of opioid analgesia and opioid-free analgesia in post-operative orthopedic patients.",[392,393,394,395,396,397,398,399,400,401,402,403,404,405,406,407,408,409,410,411,412,27],"Femoral Neck Fractures","Intertrochanteric Fractures","Femoral Shaft Fracture","Distal Femur Fracture","Patella Fracture","Tibial Shaft Fracture with or Without Associated Fibula Fracture","Ankle Fracture (bimalleolar Equivalent, Bimalleolar, or Trimalleolar)","Tibial Pilon Fracture","Talar Head, Neck, Body, or Process Fractures","Calcaneus Fractures","Lisfranc Injuries","Isolated or Multiple Metatarsal Fractures","Phalanx Fractures of the Foot, Single or Multiple","Clavicle Fractures","Proximal Humerus Fractures","Humeral Shaft Fractures","Distal Humerus Fractures (intra or Extra-articular)","Olecranon Fractures","Radial Head or Neck Fractures","Elbow Fractures Involving a Combination of Fractures of the Radius and Uln","Forearm Fractures (both Bone Forearm Fractures, Isolated Ulnar Shaft, Isolated Radial Shaft)",[414,415],"Surgical Intervention","Trauma","2024-10-22",{"date":418,"type":38},"2024-10-26",{"date":420,"type":38},"2023-11-01",{"date":122,"type":21},{"name":423,"class":45},"University of Kansas Medical Center",{"id":425,"slug":426,"hasResults":11,"nctId":427,"briefTitle":428,"officialTitle":429,"acronym":430,"eligibilityCriteria":431,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":432,"targetDuration":4,"studyType":22,"phases":434,"briefSummary":436,"conditions":437,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":439,"lastUpdatePostDateStruct":440,"startDateStruct":442,"completionDateStruct":444,"leadSponsor":446,"locationsCount":46},"100556987","phase-1-long-term-safety-trial-with-nvdx3-100556987","NCT06532253","Long-term Safety Trial with NVDX3","Long-term Safety Bucket Trial with NVDX3, an Osteogenic Implant of Human Allogenic Origin.","X3LTFU","Inclusion Criteria:\n\n1. Patient being implanted with NVDX3.\n2. Previously participated to one of the NVDX3 core clinical trials.\n3. Patient accepts to comply to a yearly follow-up safety visit for 10 additional years\n4. Patient has understood and accepted to participate in the long-term follow-up study by signing the informed consent.\n\nExclusion Criteria:\n\nNo exclusion criteria are applicable.",{"count":433,"type":21},15,[136,435],"PHASE2","An study evaluating the long-term safety of all patients previously treated with NVDX3.",[27,438],"Degenerative Lumbar Spondylolisthesis","2024-09-01",{"date":441,"type":38},"2024-09-05",{"date":443,"type":38},"2024-08-22",{"date":445,"type":21},"2036-03",{"name":447,"class":448},"Novadip Biosciences","INDUSTRY",{"id":450,"slug":451,"hasResults":11,"nctId":452,"briefTitle":453,"officialTitle":454,"acronym":4,"eligibilityCriteria":455,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":456,"enrollmentInfo":457,"targetDuration":4,"studyType":22,"phases":459,"briefSummary":460,"conditions":461,"keywords":463,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":467,"lastUpdatePostDateStruct":468,"startDateStruct":470,"completionDateStruct":472,"leadSponsor":474,"locationsCount":476},"100517595","inmobilization-with-compression-bandage-vs-antebraquial-splint-in-distal-radius-fractures-100517595","NCT06019585","Inmobilization With Compression Bandage vs Antebraquial Splint in Distal Radius Fractures","Inmobilization With Compression Bandage vs Antebraquial Splint in Distal Radius Fractures Operated by Internal Fixation With Volar Locking Plate: A Pilot Study","Inclusion Criteria:\n\n* Patients with type A, B, C fractures of AO classification of distal radius fractures\n* Patents aged between 18 and 75 years,\n* Patients operated on in the first 3 weeks after the trauma, and independent for the basic activities of daily living\n\nExclusion Criteria:\n\n* Patients with open fractures\n* Patients with mental disorders (dementia, alcoholism, etc.),\n* Patient dependent for basic activities of daily living\n* Patients with fractures with severe articular and metaphyseal comminution and\u002For severe soft tissue injuries (type 2R3C3 AO),\n* Patients with previous diseases or anatomical alterations in the injured wrist (previous fractures, rheumatoid arthritis, etc.).","75 Years",{"count":458,"type":21},120,[59],"The aim of this study is to compare functional and radiological results in two groups of distal radius fractures treated with internal fixation with locking plate, and immobilized with antebrachial splint or compression bandage for 3 weeks.",[27,462],"Internal Fixation; Complications, Mechanical",[166,464,465,466],"volar plate","internal fixation","Inmobilization","2023-08-25",{"date":469,"type":38},"2023-08-31",{"date":471,"type":38},"2021-06-01",{"date":473,"type":21},"2026-12-30",{"name":475,"class":45},"Hospital Costa del Sol",2]