[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"distal-ureteral-stone\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:distal-ureteral-stone":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,49],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100640931","phase-2-intravesical-aminophylline-to-facilitate-ureteroscopic-access-in-children-with-distal-ureteral-stones-100640931",false,"NCT07617896","Intravesical Aminophylline to Facilitate Ureteroscopic Access in Children With Distal Ureteral Stones.","Intravesical Aminophylline to Facilitate Semi-Rigid Ureteroscopic Access in Children With Lower Ureteral Stones: A Prospective Randomized Double-Blind Placebo-Controlled Trial","Inclusion Criteria:\n\n* Children older than 2 years and younger than 18 years.\n* Single unilateral lower\u002Fdistal ureteral stone confirmed by low-dose non-contrast computed tomography according to local policy.\n* Stone size 5 to 15 mm.\n* Candidate for definitive treatment by semi-rigid ureteroscopy.\n* Sterile urine culture before surgery, or previously positive urine culture that has been properly treated before intervention.\n* Intraoperative failed initial gentle negotiation of the ureteric orifice\u002Fintramural ureter according to the study definition.\n* Written informed consent from the parent or legal guardian, with child assent when appropriate.\n\nExclusion Criteria:\n\n* Known hypersensitivity to aminophylline, theophylline, or ethylenediamine.\n* Use of oral or intravenous aminophylline or theophylline within the previous 24 hours.\n* Pre-existing ipsilateral JJ ureteral stent.\n* Stone peeping at the ureteric orifice.\n* Congenital or acquired abnormality that may affect distal ureteric access, such as ureterocele, obstructive megaureter, distal ureteric stricture, previous ureteric reimplantation, or previous ipsilateral ureteral reconstruction.\n* Known bladder dysfunction or conditions likely to affect normal bladder capacity.\n* Multiple ipsilateral ureteral stones or associated renal stones requiring flexible ureteroscopy or a ureteral access sheath strategy.\n* Febrile urinary tract infection, pyonephrosis, sepsis, or any case requiring urgent decompression instead of definitive ureteroscopy.\n* Cardiac disease, arrhythmia, uncontrolled hypertension, hyperthyroidism, epilepsy or seizure disorder, or significant hepatic impairment.\n* Inability to complete follow-up.","ALL","2 Years","18 Years",{"count":20,"type":21},60,"ESTIMATED","INTERVENTIONAL",[24],"PHASE2","This study will evaluate whether intravesical aminophylline can facilitate semi-rigid ureteroscopic access in children with distal ureteral stones when the first gentle attempt to enter the ureter is unsuccessful.\n\nChildren scheduled for semi-rigid ureteroscopy for distal ureteral stones will first undergo the standard gentle attempt to pass the ureteroscope through the ureteric orifice and intramural ureter. If access is achieved, the child will continue standard treatment and will not be randomized. If access is not achieved, the child will be randomized during the operation to receive either intravesical aminophylline or intravesical normal saline placebo.\n\nThe study solution will be instilled into the bladder for approximately 5 minutes, then drained, and a second gentle ureteroscopic access attempt will be made. The main outcome is successful same-session passage of the intended semi-rigid ureteroscope without balloon dilation. The study will also assess the need for JJ stenting and deferred ureteroscopy, same-session stone treatment, operative outcomes, complications, and early aminophylline-related safety.",[27,28,29],"Pediatric Urolithiasis","Distal Ureteral Stone","Ureteral Calculi",[31,32,33,34,35],"Intravesical Aminophylline","Semi-Rigid Ureteroscopy","Pediatric Ureteroscopy","Ureteroscopic Access","Distal Ureteral Stones","RECRUITING","2026-05-25",{"date":39,"type":40},"2026-06-01","ACTUAL",{"date":42,"type":40},"2026-05-09",{"date":44,"type":21},"2027-05",{"name":46,"class":47},"Beni-Suef University","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":16,"minAge":18,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":22,"phases":59,"briefSummary":60,"conditions":61,"keywords":63,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":68,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":48},"100637394","phase-2-l-citrulline-versus-tamsulosin-for-medical-expulsive-therapy-of-distal-ureteral-stones-100637394","NCT07617909","L-Citrulline Versus Tamsulosin for Medical Expulsive Therapy of Distal Ureteral Stones","L-Citrulline Versus Tamsulosin for Medical Expulsive Therapy of Distal Ureteral Stones: A Prospective Randomized Study","Inclusion Criteria:\n\n* Adults aged 18 to 60 years.\n* Single distal ureteral stone.\n* Stone size 5 to 10 mm.\n* Normal renal function.\n* Controlled pain.\n* Willingness to comply with follow-up for 4 weeks.\n* Written informed consent.\n\nExclusion Criteria:\n\n* Fever or active urinary tract infection.\n* Severe hydronephrosis.\n* Solitary kidney.\n* Pregnancy.\n* Previous ureteric surgery.\n* Multiple ureteral stones.\n* Indication for urgent surgical intervention.\n* Known hypersensitivity or contraindication to L-citrulline or tamsulosin.\n* Inability to complete follow-up.","60 Years",{"count":58,"type":21},120,[24],"This study will compare L-citrulline and tamsulosin as medical expulsive therapy for adults with single distal ureteral stones.\n\nEligible participants with a single distal ureteral stone measuring 5 to 10 mm will be randomly assigned to receive either oral L-citrulline 750 mg twice daily or oral tamsulosin 0.4 mg once daily. Treatment will continue until documented stone passage or completion of 4 weeks of therapy, whichever occurs first.\n\nParticipants will be followed weekly for up to 4 weeks. The main outcome is stone expulsion within 4 weeks. The study will also assess time to stone expulsion, pain episodes, analgesic use, need for additional intervention, and adverse events.",[28,62,29],"Urolithiasis",[64,65,66,67],"L-Citrulline","Medical Expulsive Therapy","Ureteral Stone Passage","Tamsulosin",{"date":39,"type":40},{"date":70,"type":40},"2026-05-06",{"date":72,"type":21},"2026-11",{"name":46,"class":47}]