[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"diverticular-disease-of-colon\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:diverticular-disease-of-colon":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,41,66],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":21,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100645313","analysis-of-the-role-of-the-microbiota-in-diverticular-disease-100645313",false,"NCT07681505","Analysis of the Role of the Microbiota in Diverticular Disease","Analysis of the Role of the Microbiota in Diverticular Disease.","Inclusion Criteria:\n\n* Age 18 or older.\n* Signing of the informed consent form.\n* Assignment to one of the study groups mentioned above.\n\nExclusion Criteria:\n\n* An episode of acute diverticulitis located in the right colon or transverse colon.\n* Antibiotic treatment within the six weeks prior to the episode (except for antibiotics started in the emergency department or within 24 hours prior to sample collection).\n* Mechanical bowel preparation within the three weeks prior to sample collection.\n* Diagnosis of colorectal cancer.\n* Diagnosis of inflammatory bowel disease.\n* Failure to sign the informed consent form.","ALL","18 Years",{"count":19,"type":20},285,"ESTIMATED","24 Months","OBSERVATIONAL","A single-center, prospective observational cohort study conducted at the University Hospital of Navarra. The primary objective is to expand knowledge of diverticular disease and its pathological variants, as well as the influence of the microbiota in our environment, both clinically and molecularly; to describe the clinical and pathological characteristics of patients with diverticulosis and acute diverticulitis; to analyze any differences in the microbiota; and to identify the risk factors and groups associated with diverticular disease in order to establish the best strategies for prevention and treatment.",[25,26,27],"Diverticular Disease of Colon","Acute Diverticulitis","Gut Microbiota","NOT_YET_RECRUITING","2026-06-26",{"date":31,"type":32},"2026-07-02","ACTUAL",{"date":34,"type":20},"2027-06-01",{"date":36,"type":20},"2032-01-01",{"name":38,"class":39},"Hospital of Navarra","OTHER",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":4,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":48,"targetDuration":4,"studyType":50,"phases":51,"briefSummary":53,"conditions":54,"keywords":55,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":57,"lastUpdatePostDateStruct":58,"startDateStruct":60,"completionDateStruct":62,"leadSponsor":64,"locationsCount":4},"100620052","percutaneous-drainage-versus-antibiotic-therapy-for-acute-diverticulitis-with-abscess-100620052","NCT07352605","Percutaneous Drainage Versus Antibiotic Therapy for Acute Diverticulitis With Abscess.","Percutaneous Drainage Versus Antibiotic Therapy for Acute Diverticulitis With Abscess. The PANDA Randomized Controlled Trial Pilot Study","Inclusion criteria\n\n* Patients of both sexes, ≥ 18 years old.\n* Patients with abdominal CT scan diagnosis of colonic AD classifiable as WSES 2A with abscess ≥4 cm and \\\u003C 8 cm in size;\n* Patients with haemodynamic stability at hospital admission and no clinical or radiological evidence of diffuse peritonitis.\n* Patients who accept and sign the informed consent\n\nExclusion criteria\n\n* Patients with a final diagnosis other than diverticular abscess, including those diagnosed with colonic cancer.\n* Pregnancy or lactation.\n* Immunosuppressed patients.",{"count":49,"type":20},50,"INTERVENTIONAL",[52],"NA","the management of diverticular abscesses is guided by consensus-based recommendations from the WSES guidelines, the American College of Physicians, and the American Gastroenterological Association, all of which acknowledge the predominance of anecdotal and observational evidence and the urgent need for randomized controlled trials to inform clinical practice.The PANDA trial (Percutaneous drainage versus Antibiotic therapy for acute Diverticulitis with Abscess. Randomized controlled trial) is designed to address this evidence gap by directly comparing percutaneous drainage plus antibiotics versus antibiotics alone in patients with acute diverticulitis and large abscesses (WSES stage 2A). By employing strict inclusion criteria, standardized interventions, and predefined outcome measures, this study aims to clarify the relative efficacy, safety, and long-term impact of the two strategies, thereby guiding future clinical decision-making and informing guideline recommendations.\n\nHowever, before we can proceed with the launch of the PANDA trial, we need to start a pilot study that will allow us to understand both the methodological and practical feasibility of starting this pilot study.\n\nPrimary objective The PANDA trial pilot study want to evaluate the local feasibility of the individual centers under study. Specifically, the primary objective will be to assess a minimum adherence rate of 70% for each participating center out of all patients with acute diverticulitis WSES 2A being evaluated. Adherence refers to the ability to enroll patients, randomize them, and perform clinical follow-up.\n\nSecondary objectives The Panda trial pilot study want to compare the efficacy of antibiotic therapy alone versus percutaneous drainage plus antibiotic therapy in achieving complete clinical resolution at 30 days in patients with acute diverticulitis classified as WSES stage 2A, presenting with a pericolic or distant abscess ≥4 cm and \\\u003C 8 cm in size.\n\nIn addition the PANDA trial pilot study wants to compare the rate of treatment failure, defined as the need for urgent surgical intervention (e.g., colectomy, resection with or without stoma formation) within 30 days.\n\nMoreover the PANDA trial aimed to asses: the recurrence rate of diverticulitis after 90 days, defined as a new clinical episode confirmed radiologically and requiring hospital admission; to evaluate the length of hospital stay; to record and compare adverse events related to each treatment strategy, graded according to the Clavien-Dindo classification, with a focus on procedure-specific complications in the drainage arm.\n\nStudy Design\n\nThe PANDA trial pilot study is a prospective, multicentre, open-label, randomized controlled trial designed to compare two accepted non operative strategies for the management of large diverticular abscesses (WSES 2A Stage) to evaluate the methodological and structural feasibility of a national RCT. Participating centres will include high-volume emergency and general surgery units with access to both advanced interventional radiology and standardized medical management protocols. Two Intervention arms:\n\n* Arm 1 (Control Arm) - Percutaneous drainage plus antibiotics.\n* Arm 2 (Experimental Arm) - Antibiotics alone\n\nIn both arms the patients will be evaluated daily clinically and through laboratory tests.\n\nCollaborators at each participating center will prospectively collect data for all eligible patients for 6 months followed by 3 months of follow-up.",[25],[56],"Diverticulitis, Colonic diverticular abscess","2026-01-12",{"date":59,"type":32},"2026-01-20",{"date":61,"type":20},"2026-04",{"date":63,"type":20},"2027-01",{"name":65,"class":39},"Azienda Sanitaria di Firenze",{"id":67,"slug":68,"hasResults":11,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":72,"eligibilityCriteria":73,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":74,"targetDuration":4,"studyType":50,"phases":76,"briefSummary":77,"conditions":78,"keywords":87,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":40},"100601686","post-operative-hospital-at-home-after-colorectal-surgery-100601686","NCT07113717","Post Operative Hospital at Home After Colorectal Surgery","Early Post-operative Discharge of Colorectal Surgical Patients to a Virtual Hospital at Home Model (Post Operative Hospital at Home) - a Clinical Feasibility Study","POPHaH","Inclusion Criteria:\n\n* Planned minimally invasive (laparoscopic or robot-assisted) CRS\n* No epidural analgesia\n* No new stoma\n* Bleeding \\\u003C 500 ml\n* Actual condition assessed to be clinically stable\n* Meeting the Chung score discharge criteria for ambulatory surgery\n* Self-reliant or receives sufficient formal care to be care-independent of a primary informal caregiver\n* Home-based admission will be located within catchment area of the hospital (according to the official address of the individual)\n* Signed informed written and oral consent\n\nExclusion Criteria:\n\n* Patients who cannot comply with self-assessment\n* Improficiency in Danish\n* Pregnancy\n* Conversion to emergency surgery (uncontrolled perforation of bowel, ileus)\n* Complications during surgery warranting in-hospital admission (observation in intensive care unit or close observation from other specialities, e.g. cardiology)",{"count":75,"type":20},20,[52],"The goal of this feasibility study is to investigate whether a virtual Hospital at Home is safe and possible for patients undergoing planned minimally invasive colorectal surgery. The study aims to answer the following main questions:\n\nWhat are the patient- and next-of-kin-related effects, as well as the clinical and organizational effects, of home-based admission? What are the implementation barriers for a full-scale randomized controlled trial? Participants will follow a standardized protocol for their care befor, during and after surgery. However, the care after surgery will be conducted at home using telemedicine.",[79,80,81,82,25,83,84,85,86],"Colo-rectal Cancer","Colo-rectal Surgery","Colocolic and Ileocolic Anastomosis","Colon and\u002For Rectal Resection With Anastomosis for Cancer","Colon Benign Tumor","Crohn Disease and Ulcerative Colitis","Ileostomy Closure","Stoma Reversal Procedure",[88,89],"hospital at home for colorectal surgery","postoperative hospital at home","2025-08-02",{"date":92,"type":32},"2025-08-11",{"date":94,"type":20},"2025-12-15",{"date":96,"type":20},"2027-06",{"name":98,"class":39},"Nordsjaellands Hospital"]