[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"dizziness\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:dizziness":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,21,0,[8,40,72,105,138,164,187,215,253,289,315,336,362,385,413,439,466,497,525,558,583],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":4},"100639763","motion-sickness-severity-and-sensorimotor-performance-100639763",false,"NCT07619469","Motion Sickness Severity and Sensorimotor Performance","The Relationship of Balance, Proprioception, Coordination, and Reaction Time Measurements With Motion Sickness Severity in Individuals With Motion Sickness: A Cross-Sectional Study","Inclusion Criteria:\n\n* Individuals aged between 18 and 40 years.\n* Diagnosed with motion sickness according to the Motion Sickness -Susceptibility Questionnaire Short Form (MSSQ-SF).\n* Normal hearing acuity.\n* No history of acute or chronic vestibular disease, other than motion sickness.\n* Normal or corrected-to-normal vision.\n* Adequate physical capability to fully perform the measurement protocols, including balance, proprioception, coordination, and reaction time tests.\n\nExclusion Criteria:\n\n* Presence of any physical or orthopedic problem that could interfere with testing.\n* History of acute or chronic instability, unsteadiness, or vertigo.\n* Severe visual impairment.\n* History of prior ear surgery.\n* Presence of any neurological condition or disorder.\n* History of migraines.\n* Current use of medications that could affect balance or vestibular function (e.g., vestibular suppressants, sedatives).\n* Use of alcohol or psychoactive substances within the last 48 hours prior to testing.","ALL","18 Years","40 Years",{"count":20,"type":21},41,"ESTIMATED","OBSERVATIONAL","Background: Motion sickness (MS) is a common syndrome characterized by autonomic and behavioral symptoms, such as nausea and dizziness, resulting from exposure to motion stimuli. Its pathophysiology is closely linked to sensory conflict and postural instability theories. While previous studies suggest that postural control, proprioception, and reaction times are affected in individuals susceptible to MS, there is a lack of comprehensive, comparative research evaluating all these parameters concurrently within the same cohort using standardized methods. Objective: This study aims to systematically measure balance, proprioceptive sensitivity, coordination, and reaction time parameters, and quantitatively analyze their relationship with motion sickness severity. Methodology: In this prospective, cross-sectional study, at least 41 participants aged 18-40 with motion sickness will be recruited. Participants will undergo motion sickness susceptibility and severity grading using the Motion Sickness Susceptibility Questionnaire Short Form (MSSQ-SF) and the Graybiel Scale. Objective assessments will include static and dynamic balance testing (ProKin®), knee joint position sense (Clinometer app), manual dexterity and dynamic balance coordination (Nine-Hole Peg Test, Tandem Walk, Romberg Test), and upper\u002Flower extremity reaction time measurements (BlazePod system).",[25,26,27],"Motion Sickness","Somatosensory Disorders","Dizziness","NOT_YET_RECRUITING","2026-06-23",{"date":31,"type":32},"2026-06-26","ACTUAL",{"date":34,"type":21},"2026-06-01",{"date":36,"type":21},"2026-08-05",{"name":38,"class":39},"Istinye University","OTHER",{"id":41,"slug":42,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":46,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":48,"minAge":17,"maxAge":49,"enrollmentInfo":50,"targetDuration":4,"studyType":52,"phases":53,"briefSummary":55,"conditions":56,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":4},"100635936","ai-chi-based-rehabilitation-for-peripheral-unilateral-vestibular-dysfunction-100635936","NCT07559162","Ai Chi-Based Rehabilitation for Peripheral Unilateral Vestibular Dysfunction","Contribution of an Ai Chi-Based Rehabilitation Program in Patients With Peripheral Unilateral Vestibular Dysfunction: A Randomized Prospective Single-Blind Study","AICHI-VR","Inclusion Criteria:\n\n* Age between 18 and 70 years\n* Diagnosis of unilateral peripheral vestibular hypofunction\n* Presence of dizziness symptoms for at least 3 months\n* Ability to participate in Ai Chi and aquatic exercise program\n* Berg Balance Scale score ≥21\n* Willingness to participate in the study\n\nExclusion Criteria:\n\n* Inability to complete assessment tests and questionnaires\n* Severe systemic disease that may interfere with exercise participation\n* Central vestibular disorders\n* Berg Balance Scale score ≤20\n* Severe visual or hearing impairment\n* Initiation or change of psychiatric medication within the last 3 weeks\n* Severe cardiopulmonary disease\n* Contraindications to hydrotherapy, including water phobia, behavioral disorders, dyspnea at rest, incontinence, known chlorine allergy, open wounds, acute systemic illness, epilepsy, tracheostomy, permanent drainage devices, immunodeficiency, or known neurological disorders","FEMALE","70 Years",{"count":51,"type":21},38,"INTERVENTIONAL",[54],"NA","This study aims to evaluate the effects of an Ai Chi-based rehabilitation program on balance, dizziness severity, and quality of life in patients with unilateral peripheral vestibular hypofunction. Participants will be randomly assigned to either a control group receiving standard home-based vestibular rehabilitation exercises or an intervention group receiving additional Ai Chi sessions. The intervention will be conducted over a 4-week period with a total of 10 sessions under the supervision of a certified therapist.",[57,58,27,59,60,61],"Unilateral Peripheral Vestibular Hypofunction","Vestibular Disorders","Vertigo Benign Positional","Dizziness and Vertigo","Vestibular Function Disorder","2026-05-04",{"date":64,"type":32},"2026-05-07",{"date":66,"type":21},"2026-04-27",{"date":68,"type":21},"2026-07-27",{"name":70,"class":71},"Gaziosmanpasa Research and Education Hospital","OTHER_GOV",{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":76,"acronym":4,"eligibilityCriteria":77,"healthyVolunteers":78,"sex":16,"minAge":79,"maxAge":4,"enrollmentInfo":80,"targetDuration":4,"studyType":52,"phases":82,"briefSummary":83,"conditions":84,"keywords":91,"overallStatus":94,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":104},"100467352","fall-risk-assessment-and-speech-intelligibility-enhancement-using-in-ear-device-100467352","NCT05365646","Fall Risk Assessment and Speech Intelligibility Enhancement Using In-ear Device","Inclusion Criteria:\n\n* Age 55 years or older\n* Bilateral hearing aid user\n* Able to consent in English\n* Having access to a phone capable of running the mobile app required for the study\n* Screen for fall risk (\"Yes\" to any question: Feels unsteady when standing or walking? Worries about falling? Has fallen in past year? If the participant has fallen: how many times? were they injured\u002Fhurt?)\n* Ambulatory without need for a wheelchair\n\nExclusion Criteria:\n\n* People with mobility restrictions (e.g., wheelchair bound) that would prevent the performance of the functional assessments.\n* People with severe movement (e.g., Advanced Parkinson's disease) or cognitive (e.g., advanced dementia) disorders that would prevent the individual from either performing the functional assessments, or would lead to restricted activities that would prevent motion data from being collected according to the goal of the study.\n* Inability to understand, consent, and complete requirements including verbal instructions and non-ambulatory\u002Fwheelchair-dependent.",true,"55 Years",{"count":81,"type":21},350,[54],"The purpose of this study is to develop and validate methods to use hearing aids equipped with embedded sensors and artificial intelligence to assist in the assessment of fall risk and in the implementation of interventions aimed at reducing the risk of falling, as well as to improve speech intelligibility in quiet and in background noise, track physical activity, and social engagement. The investigators hope is that the knowledge that is generated through this study will ultimately translate to the clinical setting and will help reduce the likelihood that individuals experience a fall, and improve the quality of hearing in individuals who wear hearing aids.",[85,27,86,87,88,89,90],"Hearing Loss","Vertigo","Fall Related Injury Risk","Fall Prevention","Imbalance","Speech Intelligibility",[92,93],"Fall risk","Hearing loss","RECRUITING","2026-04-25",{"date":97,"type":32},"2026-04-28",{"date":99,"type":32},"2022-05-23",{"date":101,"type":21},"2026-10",{"name":103,"class":39},"Stanford University",1,{"id":106,"slug":107,"hasResults":11,"nctId":108,"briefTitle":109,"officialTitle":110,"acronym":111,"eligibilityCriteria":112,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":113,"enrollmentInfo":114,"targetDuration":4,"studyType":52,"phases":116,"briefSummary":117,"conditions":118,"keywords":122,"overallStatus":94,"whyStopped":4,"lastUpdateSubmitDate":129,"lastUpdatePostDateStruct":130,"startDateStruct":132,"completionDateStruct":134,"leadSponsor":136,"locationsCount":104},"100635683","osteopathic-manipulative-treatment-vs-physiotherapy-in-cervicocranial-dysfunction-100635683","NCT07555873","Osteopathic Manipulative Treatment vs Physiotherapy in Cervicocranial Dysfunction","Comparative Effects of Osteopathic Manipulative Treatment and Standard Physiotherapy on Dizziness, Headache Impact, Neck Disability, and Psychological Stress in Patients With Cervicocranial Dysfunction: A Randomized Controlled Trial","OMT-CCD","Inclusion Criteria:\n\n* Participants will be eligible for inclusion in the study if they meet the following criteria:\n\n  * Age between 18 and 65 years.\n  * Presence of cervicocranial symptoms for at least three months, indicating a chronic condition.\n  * Neck pain with or without associated headache.\n  * Dizziness associated with neck movement or cervical position.\n  * Clinical findings consistent with cervicocranial dysfunction, based on clinical examination.\n  * Ability to understand and complete standardized clinical questionnaires used in the study.\n  * Willingness to participate in the study and provision of written informed consent.\n\nExclusion Criteria:\n\n* Participants will be excluded from the study if they present with any of the following conditions:\n\n  * Clinically confirmed vestibular disorders.\n  * Central neurological disorders that may influence dizziness or balance.\n  * Recent severe trauma to the cervical spine.\n  * History of cervical spine surgery.\n  * Systemic inflammatory diseases or serious spinal pathologies.\n  * Presence of red flags related to the cervical spine identified during clinical screening.\n  * Participation in concurrent intensive physiotherapy or rehabilitation treatment during the study period.","65 Years",{"count":115,"type":21},50,[54],"This study aims to compare the effects of osteopathic manipulative treatment and standard physiotherapy in patients with cervicocranial dysfunction. The study will evaluate outcomes including dizziness, headache impact, neck disability, and psychological stress.\n\nParticipants will be randomly assigned to one of two groups: osteopathic treatment or standard physiotherapy. The interventions will be applied over a defined treatment period, and outcomes will be measured before and after the intervention.\n\nThe purpose of this study is to determine which approach is more effective in improving symptoms and functional outcomes in patients with cervicocranial dysfunction.",[119,27,120,121],"Cervicogenic Headache","Neck Pain Musculoskeletal","Cervicocranial Dysfunction",[123,124,125,126,127,128],"osteopathic manipulation treatmant","manual therapy","physiotherapy","RCT","cervicogenic headache","dizziness rehabilitation","2026-04-21",{"date":131,"type":32},"2026-04-29",{"date":133,"type":21},"2026-05-01",{"date":135,"type":21},"2026-09-30",{"name":137,"class":39},"Burim Peli",{"id":139,"slug":140,"hasResults":11,"nctId":141,"briefTitle":142,"officialTitle":142,"acronym":143,"eligibilityCriteria":144,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":145,"targetDuration":4,"studyType":52,"phases":147,"briefSummary":148,"conditions":149,"keywords":150,"overallStatus":94,"whyStopped":4,"lastUpdateSubmitDate":155,"lastUpdatePostDateStruct":156,"startDateStruct":158,"completionDateStruct":159,"leadSponsor":161,"locationsCount":163},"100610241","a-multi-site-feasibility-trial-of-embedded-emergency-department-physical-therapy-for-dizziness-100610241","NCT07225023","A Multi-Site Feasibility Trial of Embedded Emergency Department Physical Therapy for Dizziness","FEED-PT","Inclusion Criteria:\n\n* Emergency Department (ED) visit with primary diagnosis related to dizziness\n* ED visit occurring at an ED site participating in randomization (Northwestern Memorial Hospital, University of Utah Hospital)\n* ED visit check-in time during the hours of 8am-8pm\n* Age greater than or equal to 18 years; there is no age maximum\n* English or Spanish-speaking\n\nExclusion Criteria:\n\n* Severe neurologic deficit concerning for ischemic or hemorrhagic stroke (i.e., that would necessitate activating a stroke code)\n* Currently in police custody\n* Unable to consent\n* Known pregnancy",{"count":146,"type":21},100,[54],"This is a multi-site feasibility trial of an embedded emergency department (ED) physical therapy care model for dizziness at two EDs in the Northwestern Medicine and University of Utah Health systems. The study intervention (embedded ED physical therapy) is a reconceptualization of the traditional outpatient physical therapy care model in which we place a physical therapist directly in the ED to initiate timely care for patients with dizziness; we previously evaluated this intervention in a single center randomized trial for low back pain. This multi-site feasibility trial will be comprised of 9 months of active intervention and 12 months of longitudinal data collection. The two sites will be parallel randomized 1:1 to receive either the embedded ED physical therapy condition (intervention, n=1) or usual care (control, n=1) via simple randomization. This trial focuses on feasibility outcomes - such as our ability to enroll participants, deliver the intervention with fidelity, and collect longitudinal patient-reported outcome data and electronic health record data.",[27],[151,152,143,153,154],"dizziness","Physical therapy","Feasibility","Emergency Department","2026-04-01",{"date":157,"type":32},"2026-04-07",{"date":155,"type":32},{"date":160,"type":21},"2028-04-01",{"name":162,"class":39},"Northwestern University",2,{"id":165,"slug":166,"hasResults":11,"nctId":167,"briefTitle":168,"officialTitle":169,"acronym":4,"eligibilityCriteria":170,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":113,"enrollmentInfo":171,"targetDuration":4,"studyType":52,"phases":173,"briefSummary":176,"conditions":177,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":178,"lastUpdatePostDateStruct":179,"startDateStruct":181,"completionDateStruct":183,"leadSponsor":185,"locationsCount":4},"100626396","phase-2-efficacy-and-safety-of-rimegepant-for-acute-dizziness-100626396","NCT07435090","Efficacy and Safety of Rimegepant for Acute Dizziness","A Multicenter Randomized Controlled Trial on the Efficacy and Safety of Rimegepant in the Treatment of Acute Dizziness","Inclusion Criteria:\n\n1. Age between 18 and 65 years;\n2. Spontaneous dizziness without cochlear symptoms, with moderate or severe symptom intensity. The severity of dizziness is assessed based on the Vertigo or Dizziness Visual Analog Scale (VAS) score, and this study included patients with dizziness exceeding 4 points on the VAS score;\n3. The patient has experienced at least 3 similar dizziness attacks in the past, with each attack lasting more than 2 hours;\n4. The accompanying symptoms or related medical history during the attack period meet any of the following criteria: 1) Migraine-like headache (unilateral, pulsatile, moderate to severe, aggravated by activity; at least 2 items); 2) Photophobia and phonophobia; 3) Nausea or vomiting; 4) Visual aura; 5) Nystagmus; 6) The patient has a personal history of migraine; 7) Severe kinetosis; 8) Family history of migraine; 9) Typical triggering factors for migraine (menstrual period, alcohol consumption, sleep disturbances);\n5. The patient has completed emergency laboratory examination and imaging evaluation to preliminarily rule out dizziness attacks caused by other reasons;\n6. The patient can sign an informed consent form.\n\nExclusion Criteria:\n\n1. New focal neurological signs;\n2. History of previous stroke or transient ischemic attack;\n3. ABCD2 score ≥ 4 points;\n4. Presence of other vestibular peripheral vertigo disorders, such as benign paroxysmal positional vertigo, Meniere's disease, vestibular neuritis, sudden deafness, etc.;\n5. Unexplained hearing abnormalities;\n6. History of serious internal medical or mental illnesses, such as coronary heart disease (acute coronary syndrome), severe heart failure (New York Heart Association Functional Classification class II or above), severe arrhythmia (such as severe bradycardia, third-degree atrioventricular block, ventricular tachycardia, etc.), severe liver dysfunction (alanine aminotransferase or aspartate aminotransferase exceeding three times the upper limit of normal), severe renal dysfunction (serum creatinine level exceeding twice the upper limit of normal), uncontrolled severe hypertension (blood pressure above 180\u002F120 mmHg), active malignant tumors, and uncontrolled mental illness;\n7. Pregnant or breastfeeding women;\n8. Self-administered vestibular inhibitors or CGRP drugs after the dizziness attack;\n9. History of intolerance or allergy to rimegepant use;\n10. Anticipated inability to comply with research requirements.",{"count":172,"type":21},370,[174,175],"PHASE2","PHASE3","This study aims to explore the efficacy and safety of rimegepant for acute dizziness, including vestibular migraine (VM) and benign recurrent vertigo (BRV), through a multicenter, randomized controlled clinical trial. This study addresses the urgent clinical need for effective therapies for acute dizziness. Additionally, we will dynamically observe the changes in calcitonin gene-related peptide (CGRP) levels before and after treatment and explore the predictive value of CGRP levels for treatment efficacy and the prognosis of recurrence in patients. This study aims to provide a scientific basis to improve clinical management strategies for acute dizziness.",[27],"2026-02-25",{"date":180,"type":32},"2026-02-27",{"date":182,"type":21},"2026-03-20",{"date":184,"type":21},"2028-06-30",{"name":186,"class":39},"Shi Tianming",{"id":188,"slug":189,"hasResults":11,"nctId":190,"briefTitle":191,"officialTitle":192,"acronym":193,"eligibilityCriteria":194,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":195,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":197,"conditions":198,"keywords":201,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":208,"lastUpdatePostDateStruct":209,"startDateStruct":210,"completionDateStruct":211,"leadSponsor":213,"locationsCount":104},"100625387","prospective-registry-of-vertigo-due-to-vertebrobasilar-transient-attacks-100625387","NCT07421973","Prospective Registry of Vertigo Due to Vertebrobasilar Transient Attacks.","The UTRAVERA: a Multicenter Prospective Observational Investigation on Vertigo and Dizziness Due to Vertebrobasilar Transient Neurological Attacks - Diagnoses, Clinical Features, Treatment Responses, and Prognostic Factors.","UTRAVERA","Inclusion Criteria:\n\n* Episodic acute vertigo, dizziness or unsteadiness transient or in evolution, therefore, lasting \\\u003C24 h\n* Such an episode may be isolated or associated with one or more of the following:\n\n  1. focal central neurological symptoms or severe postural instability;\n  2. new-onset, moderate-to-severe craniocervical pain; or\n  3. symptoms that are not better accounted for by another disease or disorder.\n\nExclusion Criteria:\n\n* Patients who present with findings of acute hemorrhage or ischemia on the cranial magnetic resonance imaging (MRI), including diffusion-weighted MRI (DWI-MRI) at recruitment;\n* Patients who also fulfill the diagnostic criteria for other neurotological diseases that may present acute or recurrent transient dizziness\u002FVertigo (Unilateral Vestibulopathy; benign paroxysmal positional vertigo; Meniére's disease; Vestibular Migraine; Vestibular Paroxysmia; Persistente Postural-Perceptual Dizziness; and Postural Hypotension;\n* Patients whose symptoms last more than 24 hours or who have evidence of sequelae during follow-up;\n* Patients with contraindications to any of the therapeutic options proposed by this study method;\n* Patients who have other symptoms during the follow-up that suggest another etiology of dizziness or vertigo;\n* Patients who do not complete the entire evaluation;\n* Patients who refuse to sign the informed consent form.",{"count":196,"type":21},400,"Vertigo and dizziness are common neurological complaints in the emergency department and may represent a wide spectrum of etiologies, including vertebrobasilar transient neurological attacks (VB-TNAs). Distinguishing VB-TNAs, particularly vertebrobasilar transient ischemic attacks (VB-TIAs), from migraine-like and other non-vascular conditions is often challenging at first presentation due to the absence of specific biomarkers and overlapping clinical features. The UTRAVERA study is a multicenter, prospective, observational investigation designed to characterize the clinical features of patients presenting with acute transient vertigo or dizziness suspected to be VB-TNAs. The study will also evaluate diagnostic evolution over time, treatment responses, and prognostic factors associated with clinical outcomes.",[86,27,199,200],"TIA (Transient Ischemic Attack)","Transient Neurologic Symptoms",[202,203,204,205,206,207,154],"vertigo and dizziness","Vertebrobasilar Transient Neurological Attack","TIA","Vestibular Symptom","Diagnostic Accuracy","Prognostic Factors","2026-02-24",{"date":180,"type":32},{"date":133,"type":21},{"date":212,"type":21},"2028-10",{"name":214,"class":39},"University of Sao Paulo General Hospital",{"id":216,"slug":217,"hasResults":11,"nctId":218,"briefTitle":219,"officialTitle":220,"acronym":4,"eligibilityCriteria":221,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":113,"enrollmentInfo":222,"targetDuration":4,"studyType":52,"phases":224,"briefSummary":225,"conditions":226,"keywords":238,"overallStatus":94,"whyStopped":4,"lastUpdateSubmitDate":245,"lastUpdatePostDateStruct":246,"startDateStruct":247,"completionDateStruct":249,"leadSponsor":251,"locationsCount":104},"100521768","phase-2-personalized-brain-stimulation-to-treat-chronic-concussive-symptoms-100521768","NCT06073886","Personalized Brain Stimulation to Treat Chronic Concussive Symptoms","Personalized Circuit-Based Frontoamygdala Neuromodulation for Persistent Post-Concussive Symptoms","Inclusion Criteria:\n\n* Mild traumatic brain injury (mTBI) defined in accord with the World Health Organization criteria in the last 12 months\n* age 18-65 at the time of the mTBI\n* high burden of post-concussive symptoms defined as a score \\>=20 on the Rivermead Post-Concussion Symptoms Questionnaire\n\nExclusion Criteria:\n\n* objective neurologic deficits\n* ongoing or prolonged (\\>3 months) post-concussive symptoms from a prior mTBI within 2 years of the index injury\n* history of transcranial magnetic stimulation (TMS) therapy\n* contraindications for TMS or magnetic resonance imaging (MRI) (e.g., metallic implant other than dental, pacemaker)\n* severe mental, physical, or medical problems that would impede participation or pose a risk for the planned intervention (e.g., liver, kidney, or heart disease, uncontrolled diabetes or hypertension, malignancy, psychosis, previous seizure, pregnancy)\n* active alcohol or illicit drug abuse\n* inability to speak and read English",{"count":223,"type":21},75,[174],"The goal of this study is to investigate a new treatment for chronic symptoms after concussion or mild traumatic brain injury in people aged 18-65 years old. Chronic symptoms could include dizziness, headache, fatigue, brain fog, memory difficulty, sleep disruption, irritability, or anxiety that occurred or worsened after the injury. These symptoms can interfere with daily functioning, causing difficulty returning to physical activity, work, or school. Previous concussion therapies have not been personalized nor involved direct treatments to the brain itself. The treatment being tested in the present study is a noninvasive, personalized form of brain stimulation, called transcranial magnetic stimulation (TMS).\n\nThe investigators intend to answer the questions:\n\n1. Does personalized TMS improve brain connectivity after concussion?\n2. Does personalized TMS improve avoidance behaviors and chronic concussive symptoms?\n3. Do the improvements last up to 2 months post-treatment?\n4. Are there predictors of treatment response, or who might respond the best?\n\nParticipants will undergo 14 total visits to University of California Los Angeles (UCLA):\n\n1. One for the baseline symptom assessments and magnetic resonance imaging (MRI)\n2. Ten for TMS administration\n3. Three for post-treatment symptom assessments and MRIs\n\nParticipants will have a 66% chance of being assigned to an active TMS group and 33% chance of being assigned to a sham, or inactive, TMS group. The difference is that the active TMS is more likely to cause functional changes in the brain than the inactive TMS.",[227,228,229,230,231,27,232,233,234,235,236,237],"Post-Concussion Syndrome","Concussion, Brain","Mild Traumatic Brain Injury","Head Injury","Headache","Cognitive Symptom","Dysautonomia","Anxiety","Irritability; Syndrome","Depression","Post-traumatic Stress Disorder",[239,240,241,242,243,244],"Transcranial Magnetic Stimulation","Magnetic Resonance Imaging","Functional MRI","Personalized neuromodulation","Amygdala","Prefrontal Cortex","2026-02-21",{"date":208,"type":32},{"date":248,"type":32},"2024-03-06",{"date":250,"type":21},"2027-01",{"name":252,"class":39},"University of California, Los Angeles",{"id":254,"slug":255,"hasResults":11,"nctId":256,"briefTitle":257,"officialTitle":258,"acronym":4,"eligibilityCriteria":259,"healthyVolunteers":78,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":260,"targetDuration":4,"studyType":52,"phases":261,"briefSummary":262,"conditions":263,"keywords":275,"overallStatus":94,"whyStopped":4,"lastUpdateSubmitDate":280,"lastUpdatePostDateStruct":281,"startDateStruct":283,"completionDateStruct":285,"leadSponsor":287,"locationsCount":104},"100624078","the-effect-of-surgical-mask-and-n95-mask-use-on-surgical-smoke-in-operating-room-nurses-100624078","NCT07404956","THE EFFECT OF SURGICAL MASK AND N95 MASK USE ON SURGICAL SMOKE IN OPERATING ROOM NURSES","COMPARISON OF THE EFFECTS OF SURGICAL MASK AND N95 MASK USE ON PHYSICAL SYMPTOMS OF SURGICAL SMOKE IN OPERATING ROOM","Inclusion Criteria:\n\n* Willingness to participate in the study\n* Aged 18 years or older\n* Working as a sterile operating room nurse at least 4 hours per day, 5 days per week\n* Compliance with the protocol requiring continuous use of both surgical mask and N95 mask for at least 4 hours per day\n* Ability to communicate verbally and provide informed consent\n\nExclusion Criteria:\n\n* Diagnosed psychiatric disorders\n* Presence of chronic respiratory, musculoskeletal, or neurological diseases\n* Presence of chronic dermatological conditions or allergies affecting the facial or respiratory area\n* Speech or communication impairments\n* Pregnancy\n* Holding a supervisory role (e.g., charge nurse) or non-sterile nursing role\n* Planned unit change or rotation during the study period",{"count":51,"type":21},[54],"This study was conducted to compare the effect of surgical mask and N95 mask use on physical symptoms due to surgical smoke in operating theatre nurses. The study, which was conducted in a single-group prospective quasi-experimental design, was completed with 38 nurses in the operating theatre unit of a state hospital in the Western Black Sea Region. Data were collected for four weeks using the Descriptive Information Form, Numerical Rating Scale and Symptom Follow-up Form. According to the findings, muscle weakness, myalgia in the upper extremities and muscle cramps were statistically significantly less in nurses using N95 masks. Respiratory parameters, watery eyes and redness were significantly lower in nurses using surgical masks. As a result, it was determined that the type of mask was effective on the incidence of physical symptoms related to surgical smoke.",[264,265,231,27,266,267,268,269,270,271,272,273,274],"Surgical Smoke Exposure","Occupational Exposure to Surgical Smoke","Nause and Vomiting","Fatigue Symptom","Eye Allergies","Abdominal Pain (AP)","Heart Rate Determination","SpO2","Muscle Weakness | Patient","Muscle Aches","Dispnea",[276,277,278,279],"Surgical Smoke","Masks","Operating Room Nurses","Occupational Exposure","2026-02-09",{"date":282,"type":32},"2026-02-12",{"date":284,"type":32},"2024-09-15",{"date":286,"type":21},"2026-02-28",{"name":288,"class":39},"Bartın Unıversity",{"id":290,"slug":291,"hasResults":11,"nctId":292,"briefTitle":293,"officialTitle":294,"acronym":4,"eligibilityCriteria":295,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":296,"targetDuration":4,"studyType":52,"phases":298,"briefSummary":299,"conditions":300,"keywords":301,"overallStatus":94,"whyStopped":4,"lastUpdateSubmitDate":305,"lastUpdatePostDateStruct":306,"startDateStruct":308,"completionDateStruct":310,"leadSponsor":312,"locationsCount":314},"100533179","vestibular-rehabilitation-app-for-adults-with-dizziness-related-to-mtbi-100533179","NCT06222450","Vestibular Rehabilitation App for Adults With Dizziness Related to mTBI","Rock Steady: A Mobile, Gamified Vestibular Rehabilitation Therapy App for Adults With Dizziness Related to Mild Traumatic Brain Injury","Inclusion Criteria:\n\n* at least 18 years of age,\n* diagnosis of mTBI,\n* documented dizziness (total DHI score ≥ 16) and\u002For imbalance (total functional gait assessment score \\\u003C 23\u002F30 or \\\u003C age-referenced norms)\n\nExclusion Criteria:\n\n* severe neurological disease (e.g., Parkinson's disease, neuropathy),\n* moderate to severe cognitive impairment (\\\u003C 23\u002F30 on the Montreal Cognitive Assessment),\n* significant orthopedic issues that would impact mobility or ability to perform gaze stabilization exercises (e.g., significant cervical dysfunction or pain),\n* vision impairment (best-corrected visual acuity worse than 20\u002F40 in the better eye), and\n* severe depression\u002Fanxiety (≥ 9 on the 4-item Patient health Questionnaire)",{"count":297,"type":21},68,[54],"The goal of this clinical trial is to compare outcomes for standard vestibular rehabilitation home program to a digital vestibular rehabilitation home program in adults with dizziness related to mild traumatic brain injury (mTBI). The main question is whether participants who use the digital format of vestibular rehabilitation improve to a greater extent at discharge than those who use the standard format. Participants will undergo a customized vestibular rehabilitation home exercise program per standard of care, consisting of gaze stabilization, habituation, balance and gait exercises, and endurance training under the supervision of a physical therapist. Participants will complete the gaze stabilization and habituation exercises 2-3 times per day and the balance and gait exercises 1 time per day for 4 weeks.\n\nParticipants will be tested before and after the 4-week intervention. At the initial session, the researcher will perform standard clinical tests of the inner ear balance system. Also at the initial session, the researcher will perform standard clinical tests of balance and walking and questionnaires about the impact of dizziness on daily activities. At the final session, the researcher will repeat the tests of balance and walking and questionnaires. Three months after completing the intervention participants will complete an online questionnaire about the impact of dizziness on daily activities.",[229,27],[302,303,304],"vestibular rehabilitation","digital health","remote therapeutic monitoring","2025-12-09",{"date":307,"type":32},"2025-12-17",{"date":309,"type":32},"2024-12-01",{"date":311,"type":21},"2026-09-15",{"name":313,"class":39},"Mountain Home Research & Education Corporation",3,{"id":316,"slug":317,"hasResults":11,"nctId":318,"briefTitle":319,"officialTitle":319,"acronym":320,"eligibilityCriteria":321,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":322,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":324,"conditions":325,"keywords":4,"overallStatus":94,"whyStopped":4,"lastUpdateSubmitDate":328,"lastUpdatePostDateStruct":329,"startDateStruct":330,"completionDateStruct":332,"leadSponsor":334,"locationsCount":104},"100615075","lost-in-the-labyrinth-predicting-central-neurological-causes-of-vertigo-dizziness-and-unsteadiness-in-the-emergency-department-a-multicentre-cross-sectional-observational-study-100615075","NCT07287891","Lost in the Labyrinth: Predicting Central Neurological Causes of Vertigo Dizziness and Unsteadiness in the Emergency Department. A Multicentre Cross-sectional Observational Study","VERTIGO","Inclusion Criteria:\n\n* Patients presenting at the ED with vertigo, dizziness or unsteadiness\n* \\>= 18 years of age\n* Patients able to give their consent\n\nExclusion Criteria:\n\n* Patients with dementia\n* Bedridden patients (for causes other than the current symptoms)\n* Patients with obvious neurological findings presenting with vertigo but with suspected stroke at triage",{"count":323,"type":21},825,"This study will assess the sensitivity and specificity of the bedside examination algorithm performed by ED physicians. Finally, it aims to identify predictors of a central cause of the symptoms. This will consequently reduce the rate of misdiagnosis as well as the costs and length of stay due to inappropriate neuroimaging.",[326,27,327],"ED With Vertigo","Unsteadiness","2025-12-04",{"date":307,"type":32},{"date":331,"type":32},"2024-01-26",{"date":333,"type":21},"2027-02-26",{"name":335,"class":39},"Fondazione IRCCS Policlinico San Matteo di Pavia",{"id":337,"slug":338,"hasResults":11,"nctId":339,"briefTitle":340,"officialTitle":340,"acronym":4,"eligibilityCriteria":341,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":342,"enrollmentInfo":343,"targetDuration":4,"studyType":52,"phases":345,"briefSummary":346,"conditions":347,"keywords":350,"overallStatus":94,"whyStopped":4,"lastUpdateSubmitDate":353,"lastUpdatePostDateStruct":354,"startDateStruct":356,"completionDateStruct":358,"leadSponsor":360,"locationsCount":104},"100613545","additional-effects-of-brandt-daroff-exercises-with-gans-maneuver-on-dizziness-and-quality-of-life-in-patients-with-bppv-100613545","NCT07267988","Additional Effects Of Brandt-Daroff Exercises With GANS Maneuver On Dizziness And Quality Of Life In Patients With BPPV","Inclusion Criteria:\n\n* Diagnosed Patients of Benign Paroxysmal Vertigo (BPPV)\n* Age between 18-60\n* Acute and Chronic BPPV Patients\n* Positive Dix-Hallpike Test\n* DHI Scale: Mild-Severe (0-100)\n\nExclusion Criteria:\n\n* Patients with a history of vestibular surgery or cochlear\n* Patients with a history of seizures or epilepsy\n* Patients with a pacemaker or implantable cardioverter-defibrillator (ICD)\n* Patients with a history of severe head injury or concussion within the past year\n* No other vestibular disorders or conditions that may affect balance (e.g., Meniere's disease, labyrinthitis\n* No musculoskeletal or neurological conditions that may affect balance (e.g., stroke, Parkinson's disease)","60 Years",{"count":344,"type":21},30,[54],"Benign Paroxysmal Positional Vertigo (BPPV) is the most common cause of recurrent vertigo, with a lifetime prevalence of about 2.4% and a yearly incidence of roughly 0.6%. It results from displaced otoconia within the semicircular canals and is especially common in older adults. BPPV leads to brief, position-provoked episodes of vertigo, dizziness, and imbalance, and reduced quality of life. Although canalith-repositioning maneuvers are highly effective, recurrence is common, emphasizing the need for supportive and adjunctive management strategies.This randomized controlled trial will evaluate the Additional Effects OF Brandt-Daroff Exercise With GANS Maneuver On dizziness And Quality of Life In Patients with BPPV. Thirty patients with BPPV will be recruited at Fauji Foundation Hospital and screened using the Dizziness Handicap Inverntory Scale(DHI) and Vestibular Activities and Participation measure(VAP). Participants will be randomized into two groups: (1) Reciving GANS Manuever Alone (2) GANS Manuever with Brandt-Daroff Exercises(3 sessions per week\u002F40minutes). Dizziness will be assessed using the Dizziness Handicap Inverntory Scale(DHI) , quality of life using the Activities and Participation Measure(VAP) Scale. Outcome measures will be recorded at baseline and post-intervention. Ethical approval will be obtained from FUMC ERC, and data will be analyzed using SPSS v.22.",[348,27,349],"BPPV","Quality of Life",[27,348,351,352],"Postural pain","Quality of life","2025-11-25",{"date":355,"type":32},"2025-12-05",{"date":357,"type":32},"2024-09-13",{"date":359,"type":21},"2026-01-10",{"name":361,"class":39},"Foundation University Islamabad",{"id":363,"slug":364,"hasResults":11,"nctId":365,"briefTitle":366,"officialTitle":366,"acronym":4,"eligibilityCriteria":367,"healthyVolunteers":78,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":368,"targetDuration":4,"studyType":52,"phases":369,"briefSummary":370,"conditions":371,"keywords":372,"overallStatus":94,"whyStopped":4,"lastUpdateSubmitDate":376,"lastUpdatePostDateStruct":377,"startDateStruct":379,"completionDateStruct":381,"leadSponsor":383,"locationsCount":104},"100520884","reducing-vertigo-associated-with-mri-machines-100520884","NCT06062368","Reducing Vertigo Associated With MRI Machines","Inclusion Criteria:\n\n* Participants who will be undergoing an MRI scan at a 7 Tesla MRI.\n\nExclusion Criteria:\n\n* Exclusion criteria include pacemaker, defibrillator wires, metal implants, cochlear implants, or ferromagnetic surgical clips in the brain.\n* Pregnancy\n* Claustrophobia occurs in perhaps 5% of patients, and they will not proceed with the test. All subjects will fill out the routine pretesting MRI questionnaire.",{"count":146,"type":21},[54],"Vertigo, dizziness, and imbalance are commonly reported by patients and technologists when near high-field strength magnets (\\>4 Tesla, T) used for magnetic resonance imaging (MRI) (1-5) Prior research from the investigators has established that the mechanism is likely a Lorentz force occurring in the inner ear, as a result of interactions with normal electrical currents in the inner ear and the strong static magnetic field of the MRI machine. The investigators have recently developed preliminary data to suggest that slower rates of entry into the magnetic field can greatly attenuate the sensations of vertigo. The explanation for this is that the rates of vestibular adaptation exceed that of the stimulus, allowed a reduction or elimination of the symptoms of vertigo. The aim of this study is to recruit individuals who are already getting an MRI scan as part of other research studies to randomize the rate of entry into and exit from the static magnetic field (i.e., before and after imaging is performed). The usual rate of entry is 20 seconds. This will be increased to one, two or three minutes. The investigators will record subjective sensations of dizziness and vertigo associated with the entry into the MRI.",[86,27],[373,374,375],"MRI","7 Tesla","Magnetic Vestibular Stimulation","2025-11-10",{"date":378,"type":32},"2025-11-12",{"date":380,"type":32},"2024-01-15",{"date":382,"type":21},"2028-01-01",{"name":384,"class":39},"Johns Hopkins University",{"id":386,"slug":387,"hasResults":11,"nctId":388,"briefTitle":389,"officialTitle":390,"acronym":4,"eligibilityCriteria":391,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":392,"enrollmentInfo":393,"targetDuration":395,"studyType":22,"phases":4,"briefSummary":396,"conditions":397,"keywords":399,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":404,"lastUpdatePostDateStruct":405,"startDateStruct":407,"completionDateStruct":409,"leadSponsor":411,"locationsCount":4},"100608568","chinese-real-world-study-of-treatment-of-vestibular-migraine-100608568","NCT07203248","Chinese Real-world Study of Treatment of Vestibular Migraine","A Real-world Study on the Use of CGRP-targeted Medications for the Treatment of Vestibular Migraine in Chinese Patients","Inclusion Criteria:\n\n1. Male or female, aged between 18 and 75 years.\n2. Meet the following criteria established by the Barany Society for the diagnosis of vestibular migraine or probable vestibular migraine:\n\n   Vestibular Migraine A: At least five episodes with moderate or severe vestibular symptoms lasting from 5 minutes to 72 hours.\n\n   B: Current or past history of migraine, with or without aura, according to the International Classification of Headache Disorders (ICHD-3).\n\n   C: One or more migraine features during at least 50% of vestibular episodes:\n\n   Headache with at least two of the following characteristics: unilateral, pulsating, moderate or severe pain, worsening with routine physical activity.\n\n   Photophobia and phonophobia. Visual aura. D: Not better accounted for by another vestibular or ICHD diagnosis. Probable Vestibular Migraine A. At least five episodes with moderate or severe vestibular symptoms lasting from 5 minutes to 72 hours.\n\n   B. Meets only one of the criteria B or C for vestibular migraine (history of migraine or migraine features during episodes).\n\n   C. Not better accounted for by another vestibular or ICHD diagnosis.\n3. More than or equal to 4 days per month with confirmed vestibular symptom in the three months prior to enrollment (only required for group B).\n4. Able to complete at least 80% of the electronic diary during the treatment period.\n5. The investigator believes that the participant is able to read, understand, and complete the study questionnaires and headache diary.\n\nUnderstanding and compliance with the study procedures and methods, voluntary participation in this trial, and written informed consent.\n\nExclusion Criteria:\n\n1. Pregnant women, breastfeeding women, or those unwilling to use approved contraceptive methods during study participation.\n2. Presence of a condition or abnormality that the investigator believes would affect the safety of the patient or the quality of the data.\n3. History of ear surgery (excluding ear tube surgery).\n4. Other vestibular diagnoses (excluding treated benign paroxysmal positional vertigo, BPPV). This includes Ménière's disease, superior semicircular canal dehiscence syndrome, vestibular neuritis, persistent postural-perceptual dizziness, unilateral or bilateral vestibular hypofunction, cerebellar or brainstem disorders, multiple sclerosis, or seasickness.\n5. More than two preventive migraine medications have failed.\n6. Previous or current treatment with CGRP class drugs.\n7. History of serious medical or psychiatric conditions, as judged by the treating physician (including significant coronary artery disease, peripheral vascular disease, cerebrovascular disease, renal disease, liver disease, Raynaud's disease, uncontrolled psychiatric illness, or past psychiatric hospitalization).\n8. History of mania, psychosis, or suicidal ideation.\n9. Acceptable if using no more than two migraine preventive medications (prescribed specifically for this purpose), with stable dosing for at least 2 months prior to study start.\n10. History of drug or alcohol abuse within the 12 months prior to screening, based on the participant's medical records or self-report.\n11. Those who have received or plan to receive botulinum toxin (e.g., Dysport®, Botox®, Xeomin®, Myobloc®, Jeuveau™) for therapeutic or cosmetic purposes in the head, face, or neck within 4 months prior to screening or during the study period.","75 Years",{"count":394,"type":21},2000,"12 Weeks","Vestibular migraine is a phenotype of migraine, characterized by more prominent vertigo symptoms compared to headache. Treatments for VM are mainly divided into two categories: acute treatment and preventive treatment. Acute treatment aims to reduce the severity and duration of a single episode, while preventive treatment aims to decrease the frequency, severity, and duration of attacks. Current acute treatments are primarily divided into pain relief and anti-dizziness, with specific drugs such as triptans and ergots being applicable for pain relief, but only betahistine has weak evidence for anti-dizziness, and relevant clinical evidence is very scarce. Preventive treatment mainly refers to migraine preventive treatments, with recommended medications including traditional drugs like topiramate, flunarizine, propranolol, etc., but the efficacy and safety of these drugs are limited. CGRP-targeted drugs are believed to play a role in the preventive treatment of VM, and there are related literature reports, but most are small-sample studies or retrospective studies. This study aims to explore the real-world efficacy of CGRP-targeted drugs in the acute and preventive treatment of VM through a prospective real-world study.",[398,27,86],"Vestibular Migraine",[398,400,401,402,403],"CGRP","acute treatment","preventive treatment","real-world","2025-09-24",{"date":406,"type":32},"2025-10-02",{"date":408,"type":21},"2025-12",{"date":410,"type":21},"2028-12",{"name":412,"class":39},"Second Affiliated Hospital, School of Medicine, Zhejiang University",{"id":414,"slug":415,"hasResults":11,"nctId":416,"briefTitle":417,"officialTitle":418,"acronym":4,"eligibilityCriteria":419,"healthyVolunteers":78,"sex":16,"minAge":17,"maxAge":342,"enrollmentInfo":420,"targetDuration":4,"studyType":52,"phases":422,"briefSummary":423,"conditions":424,"keywords":428,"overallStatus":94,"whyStopped":4,"lastUpdateSubmitDate":430,"lastUpdatePostDateStruct":431,"startDateStruct":433,"completionDateStruct":435,"leadSponsor":437,"locationsCount":163},"100584721","dizziness-due-to-visual-stimuli-in-patients-with-concussion-and-other-causes-of-dizziness-examination-of-balance-behaviour-100584721","NCT06893029","Dizziness Due to Visual Stimuli in Patients With Concussion and Other Causes of Dizziness: Examination of Balance Behaviour","Visually Induced Dizziness in Concussed and Non-Concussed Dizzy Patients: Identifying the Pathophysiology of Postural Control Upon Optokinetic Stimuli","Inclusion Criteria:\n\n* Age between 18 and 60 years\n* Binocular vision\n* Recent concussion\u002FmTBI within 4 weeks to 18 months post-injury for concussed patients\n* Diagnosis related to dizziness or VID within 4 weeks to 18 months for non-concussed dizzy patients (including vestibular migraine)\n* Signed ICF for included participants or signed general consent for retrospectively included patients if an ICF cannot be obtained.\n\nExclusion Criteria:\n\n* BMI greater than 30\n* Acute vestibular syndrome lasting at least 24 hours\n* Severe non-correctable visual impairment\n* Balance issues not dizziness-related, including:\n\n  1. Neurological conditions (e.g., migraine)\n  2. Orthopaedic conditions (e.g., lower extremity injury)\n  3. Infectious diseases\n  4. Other medical contexts\n* Dizziness attributed to prescribed drugs, substance abuse, or mental disorders\n* Cognitive impairments compromising task comprehension\n* Preceding history of traumatic brain injury in the last 12 months\n* History of severe traumatic brain injury with persisting impairments\n* Other potentially confounding problems (e.g., psychiatric disease)\n* Frequent episodes of rotatory vertigo",{"count":421,"type":21},240,[54],"This research project aims to measure how balance is affected by special visual stimulation. Dizziness caused by complex moving visual patterns, known as optokinetic stimulation, is usually called visually induced dizziness (VID).\n\nThe study includes patients with persistent symptoms after a concussion and those with non-traumatic dizziness. Healthy participants serve as a control group for the comparison of balance and symptom responses.\n\nThe optokinetic stimulation is done using either a physical rotating disk or a virtual reality (VR) headset. The visual effects are created by bright moving dots. During the stimulation, these patterns move in a specific manner and directions while the subject's balance is recorded. Symptoms such as dizziness, headache, and nausea are also documented.\n\nThe goal of this project is to improve objective diagnosis of VID. By comparing patients and healthy subjects, the study aim to assess the severity of the disorder. It is also assumed that using different visual stimuli during the balance assessment will offer more sensitive and accurate results.\n\nIn the long term, this innovative assessment method shall support clinicians to establish the diagnosis of VID, and improve the treatment and management of patients with VID.",[27,425,426,427],"Concussion (Diagnosis)","Traumatic Brain Injury","Balance Assessment",[429],"Visually induced dizziness","2025-09-15",{"date":432,"type":32},"2025-09-19",{"date":434,"type":32},"2025-05-14",{"date":436,"type":21},"2027-10-31",{"name":438,"class":39},"Dominik Straumann",{"id":440,"slug":441,"hasResults":11,"nctId":442,"briefTitle":443,"officialTitle":444,"acronym":4,"eligibilityCriteria":445,"healthyVolunteers":11,"sex":16,"minAge":446,"maxAge":447,"enrollmentInfo":448,"targetDuration":4,"studyType":52,"phases":450,"briefSummary":451,"conditions":452,"keywords":453,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":457,"lastUpdatePostDateStruct":458,"startDateStruct":460,"completionDateStruct":462,"leadSponsor":464,"locationsCount":104},"100597770","comparing-the-effects-of-sub-occipital-myofascial-release-with-and-without-snag-on-people-with-cervicogenic-dizziness-100597770","NCT07062809","Comparing the Effects of Sub-Occipital Myofascial Release With and Without SNAG on People With Cervicogenic Dizziness.","Comparative Effects of Sub-Occipital Myofascial Release With and Without Sustained Natural Apophyseal Glide Among Patients With Cervicogenic Dizziness.","Inclusion Criteria:\n\n* Cervicogenic dizziness patients both male and female.\n* Age group between 22 to 54 Years old.\n* Passive Accessory Assessment of the UCS (C0-1, C1-2, C2-3).\n* Dizziness related to either movements or positions of the cervical spine, or occurring with a stiff or painful neck.\n* Symptoms \\> 3 months.\n* Moderate disability score on the Dizziness Handicap Inventory (DHI) \\[31-60 points\\] .\n\nExclusion Criteria:\n\n* Conditions for which manual therapy is contraindicated\n* Traumatic brain injury\n* Previous surgery to the upper cervical spine and marked cervical spine disc protrusion\n* By neurologist .Vestibular disorders (e.g. Benign Paroxysmal Positional Vertigo, Meniere's disease, peripheral vestibulopathy)\n\n  * CNS disorder (e.g.cerebellar ataxia, stroke, demyelination)\n  * Migraine associated vertigo\n  * Psychogenic dizziness\n  * Cardiovascular disorders","22 Years","54 Years",{"count":449,"type":21},42,[54],"Cervicogenic dizziness is defined as a sensation of rotation, resulting from an alteration of the neck proprioceptive afferents of the upper cervical spine.Sub-occipital Release, a type of Myofascial Release (MFR) is a form of manual therapy technique which can be used for the treatment of cervicogenic dizziness. Sub-occipital muscles, dura matter and C2 vertebrae are connected to each other through the fascia. Sustained natural apophyseal glides (SNAGs) are also an effective treatment for cervicogenic dizziness. This study aim to determine Comparative Effect of Sub-Occipital Myofascial release with and without Sustained Natural Apophyseal Glide among patients with Cervicogenic Dizziness.",[27,119],[454,455,456],"Cervicogenic Dizziness","Pain","Suboccipital Myofascial Release","2025-07-03",{"date":459,"type":32},"2025-07-14",{"date":461,"type":21},"2025-07-24",{"date":463,"type":21},"2025-10-20",{"name":465,"class":39},"Riphah International University",{"id":467,"slug":468,"hasResults":11,"nctId":469,"briefTitle":470,"officialTitle":471,"acronym":4,"eligibilityCriteria":472,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":473,"targetDuration":4,"studyType":52,"phases":475,"briefSummary":476,"conditions":477,"keywords":483,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":488,"lastUpdatePostDateStruct":489,"startDateStruct":491,"completionDateStruct":493,"leadSponsor":495,"locationsCount":4},"100505635","clinical-trial-of-vit-d-and-calcium-for-recurrent-bppv-100505635","NCT05863949","Clinical Trial of Vit D and Calcium for Recurrent BPPV","STOP Vertigo: Supplementation of Vitamin D for Termination of Recurrences From Benign Paroxysmal Positional Vertigo","Inclusion Criteria:\n\n* Age 18 years or older\n* 2 or more distinct episodes of benign paroxysmal positional vertigo within a 12-month period on history\n* At least 1 episode diagnosed based on physical examination by trained study personnel, meeting the diagnostic criteria of the Bárány Society\n* Episodes separated in time, with a minimum of 1 week symptom-free between episodes\n* Serum evidence of Vitamin D deficiency, as evidenced by 25-hydroxy vitamin D level of \\\u003C75 nmol\u002FL (\\\u003C30 ng\u002FmL)48\n* Subject able to provide informed consent to participate in the study\n\nExclusion Criteria:\n\nPotential subjects will be excluded if they\n\n* have another identifiable cause of vertigo identified on history or physical examination\n* have a history of allergy or medically significant adverse reaction to vitamin D or calcium carbonate\n* have a chronic medical disorder which is a contraindication to vitamin D or calcium carbonate supplementation, including uncontrolled hyperparathyroidism, nephrolithiasis, or GI malabsorption disorders\n* are on loop diuretic agents or thiazides\n* have a contraindication to routine bloodwork for study purposes, including being hospitalized with a critical illness, cellulitis at blood draw sites, or presence of vascular grafts.",{"count":474,"type":21},860,[54],"Randomized double blind placebo controlled trial of vitamin D supplements, with or without calcium supplementation, versus placebo in reduction of recurrences in BPPV.",[348,478,86,479,27,480,481,482],"Benign Paroxysmal Positional Vertigo","Vertigo, Peripheral","Dizziness; Epidemic","Vitamin D Deficiency","Calcium Deficiency",[484,485,486,151,487],"bppv","benign paroxysmal positional vertigo","vertigo","vitamin D","2025-06-20",{"date":490,"type":32},"2025-06-25",{"date":492,"type":21},"2025-08",{"date":494,"type":21},"2026-09",{"name":496,"class":39},"Ottawa Hospital Research Institute",{"id":498,"slug":499,"hasResults":11,"nctId":500,"briefTitle":501,"officialTitle":502,"acronym":4,"eligibilityCriteria":503,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":504,"enrollmentInfo":505,"targetDuration":4,"studyType":52,"phases":507,"briefSummary":508,"conditions":509,"keywords":4,"overallStatus":94,"whyStopped":4,"lastUpdateSubmitDate":516,"lastUpdatePostDateStruct":517,"startDateStruct":519,"completionDateStruct":521,"leadSponsor":523,"locationsCount":104},"100570242","postoperative-analgesia-between-paravertebral-block-and-epidural-block-in-esophageal-surgery-100570242","NCT06704698","Postoperative Analgesia Between Paravertebral Block and Epidural Block in Esophageal Surgery","Paravertebral Block With Liposomal Bupivacaine and Epidural Block With Plane Bupivacaine for Postoperative Analgesia in Esophageal Surgery: A Randomized, Non-inferiority Study","Inclusion Criteria:\n\n* American Society of Anesthesiologist physical status I-III;\n* Scheduled elective thoracoscopic esophagectomy(three-incision approach);\n* Approved participation before study.\n\nExclusion Criteria:\n\n* Patients with contraindications for local nerve block such as spinal anatomic structure abnormality or local infection of puncture area;\n* Anergic to medications used in this study;\n* Patient have chronic pain;\n* Patient receiving anticoagulants, opioids or have a history of narcotic abuse or alcohol abuse;\n* Inability to complete postoperative pain assessments or questionnaires due to communication barriers or mental disorders;","80 Years",{"count":506,"type":21},132,[54],"Prevention of postoperative pain is essential for the recovery of esophageal surgery. Epidural analgesia is a traditional and standard perioperative pain management for these patients. Beneficials of epidural analgesia have been widely established. However, there are still several potential disadvantages such as perioperative hypotension, failure of administration, rare but serious neurological complications. Ultrasound-guided regional nerve block has become a widely used technique due to its low degree of trauma and precise target of action. In combined with liposome bupivacaine (LB), a new long-acting local anesthetic, was proven to have a maximum duration of 72 hours, thus improving postoperative analgesia, reducing opioid consumption, and enhancing patient satisfaction. The aim of this study was to evaluate the efficacy of TPVB liposomal bupivacaine (LB) or plane bupivacaine (SB) for Overall Benefit of Analgesic Score (OBAS) after esophageal surgery.",[510,27,511,512,513,514,515],"Pain Syndrome","Vomiting","Itching","Sweet Syndrome","Cold","Satisfaction, Patient","2024-12-23",{"date":518,"type":32},"2024-12-30",{"date":520,"type":32},"2024-12-03",{"date":522,"type":21},"2025-12-30",{"name":524,"class":39},"Zhejiang Cancer Hospital",{"id":526,"slug":527,"hasResults":11,"nctId":528,"briefTitle":529,"officialTitle":530,"acronym":4,"eligibilityCriteria":531,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":342,"enrollmentInfo":532,"targetDuration":4,"studyType":52,"phases":534,"briefSummary":535,"conditions":536,"keywords":540,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":549,"lastUpdatePostDateStruct":550,"startDateStruct":552,"completionDateStruct":554,"leadSponsor":555,"locationsCount":104},"100568606","effectiveness-of-vestaid-app-100568606","NCT06683417","Effectiveness of VestAid App","Vestibular Rehabilitation Aid (VestAid)","Inclusion:\n\n* Snellen visual acuity (corrected) greater than 20\u002F40\n* No more than 25dB hearing loss at 500,1000, 2000, and 4000 Hz\n* Ability to detect 4.31 using Semmes-Weinstein monofilament at the lower extremity\n* At least 40 degrees of neck yaw motion with only mild to moderate pain (6 or under on 0-10 numeric pain scale)\n* Internet access at home\n* No significant residual from past musculoskeletal or neuromuscular conditions\n* Ability ambulates unassisted\n* Diagnosed with a concussion or inner ear problem the last 30 days\n* Between 18-60 years of age\n* Can read and understand English\n* Has complaints of dizziness\n\nExclusion criteria:\n\n* Greater then 30 days since diagnosis of concussion\u002FmTBI or inner ear problem\n* No access to internet at home\n* Younger than 18 years of age or older than 60 years of age\n* Cannot read or understand English\n* No complaints of dizziness and\u002For balance deficits\n* Have significant neuropathy\n* Cannot see tablet clearly at 1 meter\n* Neck pain \\>5 on a 10-point pain scale.",{"count":533,"type":21},80,[54],"This multi-center randomized trial (MCRT) will investigate the effectiveness of the VestAid application to provide equivalent or faster recovery from dizziness compared to standard-of-care delivery of vestibular rehabilitation exercises.",[537,538,539,58,27],"MTBI - Mild Traumatic Brain Injury","Vestibular Disease","Balance Deficits",[541,302,542,543,544,151,545,546,547,548],"mTBI","vestibular disorder","technology","application","balance disorder","image processing","eye gaze compliance","VOR","2024-11-08",{"date":551,"type":32},"2024-11-12",{"date":553,"type":21},"2025-01-15",{"date":522,"type":21},{"name":556,"class":557},"BlueHalo","INDUSTRY",{"id":559,"slug":560,"hasResults":11,"nctId":561,"briefTitle":562,"officialTitle":563,"acronym":4,"eligibilityCriteria":564,"healthyVolunteers":11,"sex":16,"minAge":565,"maxAge":113,"enrollmentInfo":566,"targetDuration":4,"studyType":52,"phases":568,"briefSummary":569,"conditions":570,"keywords":572,"overallStatus":94,"whyStopped":4,"lastUpdateSubmitDate":575,"lastUpdatePostDateStruct":576,"startDateStruct":578,"completionDateStruct":580,"leadSponsor":582,"locationsCount":104},"100564139","effects-of-epleys-maneuver-versus-semont-plus-maneuver-combined-with-brandt-daroff-exercises-on-dizziness-and-quality-of-life-in-benign-paroxysmal-positional-vertigo-100564139","NCT06625281","Effects of Epleys Maneuver Versus Semont-Plus Maneuver Combined with Brandt-Daroff Exercises on Dizziness and Quality of Life in Benign Paroxysmal Positional Vertigo","Effects of Epleys Maneuver Versus Semont-Plus Maneuver Combined with Brandt-Daroff Exercises on Dizziness and Quality of Life in Benign Paroxysmal Positional Vertigo;","Inclusion Criteria:\n\n* Both genders\n* Positive Dix Hallpike test.\n* Patients diagnosed with Posterior canal Benign Paroxysmal Positional Vertigo.\n* Patients with recurrent episodes of dizziness.\n* Age group 20-65.\n* Positive Dix Hallpike Test\n\nExclusion Criteria:\n\n* Dix Hallpike test negative.\n* DHI Scale: 54+ Severe\n* Trauma\n* Ankylosing spondylitis\n* Cervical pathology-related dizziness\n* Spinal cord injury\n* Carotid stenosis\n* Other Vestibular pathologies (Meniere's disease, Vestibular hypofunction, Labyrinthitis","20 Years",{"count":567,"type":21},40,[54],"Vestibular hypofunction can result in symptoms consisting of dizziness, imbalance, and\u002For oscillopsia, gaze and gait instability, and impaired navigation and spatial orientation; thus, may negatively impact an individual\\'s quality of life, and ability to perform activities of daily living.\n\nBenign paroxysmal positional vertigo (BPPV) is the most common peripheral vestibular disorder which occurs with changing of the positions lying down, rolling over, climbing stairs, or looking up and down. The typical symptoms include dizziness, loss of balance, nystagmus, and nausea, limiting the daily activities of life and functional capacity.\n\nMuch research has been done to rule out the prime treatment for posterior canal-BPPV using vestibular rehabilitation therapy (VRT), Canalith repositioning maneuvers (CRM), and habituation exercises, but scarce literature renders the combination of maneuvers and exercises.\n\nThe current study will be used to determine and compare the effects of Epley\\'s maneuver Versus the Semont-Plus maneuver combined with Brandt-Daroff exercises on Dizziness and Quality of life in participants with pc-Benign paroxysmal positional vertigo. The participants having clinically diagnosed Posterior canal Benign paroxysmal positional vertigo (BPPV) will be selected in this study.\n\nThe outcome measure will be the Dizziness Handicap Inventory (DHI) to assess the Dizziness in participants and Vestibular activities and the participation measure (VAP) will assess the Quality of life. For such a randomized control trial a sample of 40 participants will be taken with 20 participants in each group will be included in the study. One group will undergo Epley's Maneuver and Brandt-daroff exercises and the second group will receive Semont-plus maneuver and Brandt-daroff exercises. Scores will be taken again after intervention. The study will be conducted over 1 year at Fauji Foundation Hospital and Foundation University Islamabad. Participants of interest would be approached and explained about the research. Informed written consent will be taken first. Recruited participants will be allocated to either of the groups through a convenient sampling method.\n\nAll outcome measurements would be performed first at baseline and then after the 6 weeks intervention period..",[27,571],"Benign Paroxysmal Positional Vertigo (BPPV)",[573,574,478],"PhysicalTherapy","Vestibular Rehabilitation Therapy","2024-10-01",{"date":577,"type":32},"2024-10-03",{"date":579,"type":32},"2024-07-20",{"date":581,"type":21},"2024-12-20",{"name":361,"class":39},{"id":584,"slug":585,"hasResults":11,"nctId":586,"briefTitle":587,"officialTitle":588,"acronym":4,"eligibilityCriteria":589,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":342,"enrollmentInfo":590,"targetDuration":4,"studyType":52,"phases":591,"briefSummary":592,"conditions":593,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":597,"lastUpdatePostDateStruct":598,"startDateStruct":600,"completionDateStruct":602,"leadSponsor":604,"locationsCount":4},"100503158","new-rehabilitation-protocol-for-patients-with-pppd-100503158","NCT05831618","New Rehabilitation Protocol for Patients With PPPD","New Rehabilitation Protocol for Patients With Persistent Postural Perceptual Dizziness","Inclusion Criteria:\n\n* Diagnostic criteria established for PPPD by the Barany Society (Staab et al., 2017) will be adopted\n\nExclusion Criteria:\n\n* Patients with neurological, otological or psychiatric disorders other than PPPD will be excluded.",{"count":567,"type":21},[54],"The investigators will test a new rehabilitation protocol on patients with persistent postural perceptual dizziness (PPPD). The investigators hypothesize that patients with PPPD, in the absence of vestibular deficits, do not benefit from standard vestibular rehabilitation but instead need a rehabilitation that acts on visual and postural stability, through training of saccadic movements in dynamic contexts of cognitive-motor dual-task and rehabilitation of postural stability.",[594,595,596,27],"Rehabilitation","Balance","Vestibular Disorder","2023-07-12",{"date":599,"type":32},"2023-07-13",{"date":601,"type":21},"2023-07-30",{"date":603,"type":21},"2026-12-31",{"name":605,"class":39},"I.R.C.C.S. Fondazione Santa Lucia"]