[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"dna-damage\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:dna-damage":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,43,69],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100355499","phase-2-thinking-zinc-a-study-of-zinc-supplements-on-the-navajo-nation-100355499",false,"NCT03908736","Thinking Zinc: a Study of Zinc Supplements on the Navajo Nation","Thinking Zinc: A Study of Zinc Supplementation to Ameliorate Adverse Effects of Mine Waste Exposure on the Navajo Nation","Inclusion Criteria:\n\n* Men or women between the ages of 21 and 64 years of age\n* Lives in or near the participating communities of Blue Gap-Tachee Arizona or Red Water Pond Road Community New Mexico\n* Willing to provide blood and urine samples\n* Willing to attend study visits on scheduled dates\n* Willing to take a daily zinc supplement\n\nExclusion Criteria:\n\n* Women who are pregnant or nursing or women who plan to become pregnant during the course of the study.\n* Individuals who have self-reported diabetes, report that they are undergoing treatment for diabetes, or are currently taking medication for diabetes.\n* Known or suspected allergy to zinc.\n* Individuals previously diagnosed with syndromes of copper homeostasis (Menkes disease or Wilsons disease).\n* Individuals consuming zinc supplements or multivitamins and are unwilling to stop for the duration of the study.",true,"ALL","21 Years","64 Years",{"count":21,"type":22},100,"ESTIMATED","INTERVENTIONAL",[25],"PHASE2","This is a study to assess the effect of dietary zinc supplementation to mitigate biomarkers of metal toxicity in exposed tribal populations.",[28,29],"DNA Damage","Immune System Disorder","RECRUITING","2026-06-02",{"date":33,"type":34},"2026-06-04","ACTUAL",{"date":36,"type":34},"2019-05-19",{"date":38,"type":22},"2027-12",{"name":40,"class":41},"University of New Mexico","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":16,"sex":17,"minAge":50,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":23,"phases":54,"briefSummary":56,"conditions":57,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":42},"100592239","comparison-of-two-different-sperm-processing-methods-and-their-effects-on-sperm-dna-fragmentation-and-embryo-development-100592239","NCT06990841","Comparison of Two Different Sperm Processing Methods and Their Effects on Sperm DNA Fragmentation and Embryo Development","A Prospective Comparison of Two Different Sperm Preparation Techniques on the Prescence of DNA Fragmentation and Embryo Development","Inclusion Criteria:\n\n* Samples with ≥15 M\u002FmL spermatozoa concentration\n* Female partner between 18 and 34 years old.\n* Minimum of 4 fertilized eggs in gradient\u002Fswim prep group and 4 fertilized eggs in the Lenshooke prep group for each patient\n\nExclusion Criteria:\n\n* Samples with \\\u003C15 M\u002FmL spermatozoa concentration\n* female partner \\>35 years old\n* female patient with recurrent pregnancy loss\n* female patient with diminished ovarian reserve","18 Years","34 Years",{"count":53,"type":22},50,[55],"NA","The goal of this clinical trial is to learn if the LensHooke CA0 device lowers DNA fragmentation in sperm samples compared to a gradient\u002Fswim-up technique.\n\nThe main questions it aims to answer are:\n\n1. Does the LensHooke® CA0 device reduce DNA fragmentation compared to the gradient\u002Fswim-up technique?\n2. Does the LensHooke® CA0 device improve concentration, motility, and morphology compared to the gradient\u002Fswim-up technique?\n3. Is sibling embryo fertilization and development the same?\n4. Are pregnancy rates different between the 2 groups?\n\n1 semen sample will be split between the 2 treatment techniques. Half of the partner's egg cohort will be injected via intra-cytoplasmic sperm using sperm processed by one technique and the other half of the cohort will be injected by the sperm processed by the other technique. Both methods will look at DNA fragmentation, concentration, motility, and morphology of the sperm. Both methods will be compared in the resulting embryos looking at fertilization, embryo development and pregnancy rates.",[28,58,59],"DNA Strand Breaks","Sperm DNA Fragmentation","2025-09-10",{"date":62,"type":34},"2025-09-17",{"date":64,"type":34},"2025-08-11",{"date":66,"type":22},"2026-12",{"name":68,"class":41},"Richard Kordus, PhD, HCLD (ABB)",{"id":70,"slug":71,"hasResults":11,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":4,"eligibilityCriteria":75,"healthyVolunteers":11,"sex":76,"minAge":77,"maxAge":78,"enrollmentInfo":79,"targetDuration":4,"studyType":80,"phases":4,"briefSummary":81,"conditions":82,"keywords":4,"overallStatus":83,"whyStopped":4,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":4},"100604082","sperdna-fragmentation-a-a-predictor-for-outcome-after-varicocelectomym-100604082","NCT07144891","sperDNA Fragmentation a a Predictor for Outcome After Varicocelectomy,m","Sperm DNA Fragmentation Among Other Variableas a Predictor for Outcome After Varicocelectomy,","Inclusion Criteria:\n\n* Patients have been diagnosed with VC (GII and GIII) by physical examination and scrotal color Doppler ultrasonography.\n* Patients with stable relationships.\n* In the control group, those with high SDF.\n* Patients with documented infertility.\n* Normal female partners or having correctable cause of infertility.\n* Patients age from 20 to 45 years old.\n\nExclusion Criteria:\n\nPatients with a history of scrotal and spermatic cord injuries and congenital genitourinary abnormalities.\n\n* Patients with systemic or endocrine disease, cryptorchidism, hypogonadism, genital infection, hormonal treatment and azoospermic patients.\n* Recurrent varicocele.\n* Patients with any other disease that may cause VC (such as external kidney tumor, hydronephrosis, etc.)\n* Smoker patients and others risk factors (x ray, nuclear) workers\n* Abnormal or uncorrectable female factor. 7- Single patient.","MALE","20 Years","45 Years",{"count":42,"type":22},"OBSERVATIONAL","Varicocele is often associated with infertility and reduction in sperm quality, and it is one of the most common causes of reversible male infertility.\n\nThe exact mechanism of infertility caused due to varicocele formation remains unclear. One of the suggested theories is related to increased oxidative stress that causes sperm DNA damage, including DNA fragmentation, and is correlated with the decreased capacity of spermatozoa to fertilize oocytes during normal fertilization and assisted reproduction techniques. This is supported by the evidence that there is a higher prevalence of DNA fragmentation in varicocele patients and a correlation between the presence of varicocele and impaired sperm DNA integrity.\n\nSeveral tests have been developed to better assess the fertility potential of sperm, including those designed to measure sperm deoxyribonucleic acid (DNA) fragmentation (SDF). The sperm DNA fragmentation index (DFI) is a potential parameter for fertility investigation, reflecting sperm DNA integrity and damage.",[28],"NOT_YET_RECRUITING","2025-08-20",{"date":86,"type":34},"2025-08-28",{"date":88,"type":22},"2025-10-01",{"date":90,"type":22},"2026-10-01",{"name":92,"class":41},"Assiut University"]