[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"donor-site-complication\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:donor-site-complication":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,50,80,106],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100627845","blue-light-for-donor-site-healing-in-burn-patients-100627845",false,"NCT07453927","Blue Light for Donor Site Healing in Burn Patients","Blue Light in the Treatment of Donor Site in Burn Patient: a Controlled Clinical Trial","CGU01_BL","Inclusion Criteria:\n\n* Patients with intermediate-deep burns with Total Body Surface Area (TBSA) \\> 10% requiring surgical treatment with escharectomy, presenting at least two Donor Site.\n* Patients over 18 years of age;\n* Patients who have signed the informed Consent Form (ICF) and understood the purpose of the study, or, if unable to give consent personally due to their condition, their legal guardian.\n\nExclusion Criteria:\n\n* Intermediate-deep burns TBSA \\\u003C 10% or superficial burns;\n* Patients under the age of 18;\n* Patients who are participating in other clinical trials with drugs or medical devices;\n* Patients with neoplasms or other conditions requiring the use of cytostatic or immunosuppressive drugs;\n* Patients with conditions that induce skin photosensitivity;\n* Pregnant or breastfeeding women;\n* Patients or relatives who are unable to understand the purposes of the trial;","ALL","18 Years",{"count":20,"type":21},25,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this clinical trial is to learn whether blue light (BL) photobiomodulation can improve the healing of donor site (DS) wounds in patients with burn injuries who are treated surgically. This study will investigate whether adding BL therapy to the usual treatment can improve healing and patient outcomes in adult patients with intermediate and deep burns.\n\nThe main questions it aims to answer are:\n\n* Does the use of BL therapy combined with standard treatment reduce the healing time of DS compared with standard treatment alone?\n* Does BL therapy improve wound conditions, reduce pain, and decrease signs of infection during the healing process?\n* Is BL therapy safe and well tolerated when applied to DS?\n* Does the treatment improve the long-term quality of the scar after healing?\n\nResearchers will compare DS areas treated with standard care alone to DS areas treated with standard care plus BL therapy to see whether BL improves healing outcomes. Each participant will serve as their own comparison: two different DS areas on the same patient will receive the two different treatments.\n\nParticipants will:\n\n* Receive the standard treatment for DS, which includes routine wound care and dressing\n* Receive BL therapy on one DS area in addition to the standard treatment, while another DS area will receive standard treatment alone\n* Attend regular clinical evaluations where clinicians will assess wound healing and the condition of the wound bed\n* Report their pain levels using a simple numeric scale during the healing period\n* Undergo skin swabs to detect possible signs of infection\n* Be monitored for any local side effects, such as redness, burning sensation, warmth, itching, or skin irritation related to the light treatment\n\nAfter the DS have completely healed, participants will return for follow-up visits at 1 month and 3 months. During these visits, researchers will evaluate the quality of the scars and monitor for any late side effects.",[27,28,29,30],"Donor Site Complication","Burn","Photobiomodulation Therapy","Blue Light",[32,33,34,35,36],"donor site","burns","photobiomodulation","blue light","healing","RECRUITING","2026-03-31",{"date":40,"type":41},"2026-04-06","ACTUAL",{"date":43,"type":41},"2025-09-29",{"date":45,"type":21},"2026-09-28",{"name":47,"class":48},"AUSL Romagna Rimini","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":57,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":58,"targetDuration":4,"studyType":22,"phases":60,"briefSummary":61,"conditions":62,"keywords":66,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":49},"100618325","the-effectiveness-of-nano-bio-fusion-gingival-gel-nbf-on-wound-healing-at-the-palate-donor-site-after-soft-tissue-graft-surgery-compared-to-placebo-gel-100618325","NCT07330154","The Effectiveness of Nano Bio Fusion Gingival Gel (NBF) on Wound Healing at the Palate (Donor Site) After Soft Tissue Graft Surgery Compared to Placebo Gel.","The Effectiveness of Nano Bio Fusion Gel (NBF) on Early Wound Healing at the Palate (Donor Site) After Soft Tissue Graft Surgery Compared to Placebo Gel: a Double Blinded Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n1. Patients with gingival recession that is indicated for root coverage or need for phenotype modification.\n2. 18 years or older.\n3. absence of systemic disease\n4. Non-smoker\n5. No use of antibiotics, corticosteroids, anti-inflammatory medication or hormones in the past 3 months\n\nExclusion Criteria:\n\n1. Pregnant or lactating woman.\n2. patients with immune or systemic diseases.\n3. Patients with an allergy to any ingredient in the gel.",true,{"count":59,"type":21},36,[24],"The goal of this clinical trial is to assess the effect of Nano-biofusion gingival gel (NBF) on wound healing at the palatal donor site following soft tissue graft surgery and compare it to placebo gel. The main questions it aims to answer are:\n\n* Does NBF gel enhance wound healing after graft harvesting from the palate?\n* Does NBF gel reduce the number of inflammatory mediators after surgery?\n* Does NBF gel reduce pain and discomfort at the palatal donor site? Researchers will compare NBF gel to a placebo (a look-alike gel that does not contain the active ingredients) to see if NBF gel enhances wound healing.\n\nStudy steps include:\n\n* Participants will apply the assigned gel on the surgical wound 4 times a day for 4 weeks.\n* Clinical photographs and measurements will be obtained on days (0, 1, 2, 4, 7, 15, 21, 30).\n* Wound fluid samples will be collected on days (0, 1, 2, 4, 7).\n* Participants will be asked about the level of pain and analgesic consumption on each follow-up visit.",[63,64,27,65],"Wound Healing","Palatal Wound","Inflammatory Cytokines",[67,68,69,70],"NBF gel","wound healing","palatal donor site","soft tissue graft","2026-01-21",{"date":73,"type":41},"2026-01-23",{"date":75,"type":41},"2025-10-29",{"date":77,"type":21},"2026-12",{"name":79,"class":48},"King Abdullah University Hospital",{"id":81,"slug":82,"hasResults":11,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":86,"eligibilityCriteria":87,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":88,"enrollmentInfo":89,"targetDuration":4,"studyType":22,"phases":91,"briefSummary":92,"conditions":93,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":49},"100597366","aloe-vera-vs-paraffin-tulle-dressings-for-pain-management-in-split-thickness-skin-graft-donor-sites-100597366","NCT07057557","Aloe Vera vs Paraffin Tulle Dressings for Pain Management in Split Thickness Skin Graft Donor Sites","Comparison of Postoperative Pain After Application of Aloe Vera Gel Dressings With Conventional Paraffin-Based Tulle Dressings at Split-Thickness Skin Graft Donor Site","AloePaTu","Inclusion Criteria:\n\n* • Patients aged 18-60 years of age of either gender needing Split thickness skin graft\n\nExclusion Criteria:\n\n* • Patients known to have exaggerated\u002Fdiminished pain response due to certain medical conditions (e.g. diabetes, neuropathy, chemotherapy, opioids etc.)\n\n  * Patients allergic to either dressings","60 Years",{"count":90,"type":21},72,[24],"The goal of this clinical trial is to learn if Aloe Vera gel dressing helps reduce pain better than traditional paraffin-based tulle dressing at the donor site of split-thickness skin grafts in adult patients aged 18 to 60. The main questions it aims to answer are:\n\nDoes Aloe Vera gel dressing reduce postoperative pain more effectively than paraffin-based tulle dressing on the 7th day after surgery?\n\nIs there a difference in the need for additional pain medication between the two groups?\n\nResearchers will compare Aloe Vera gel dressing to paraffin-based tulle dressing to see if Aloe Vera leads to better pain control.\n\nParticipants will:\n\nUndergo split-thickness skin graft surgery\n\nReceive either Aloe Vera gel dressing or paraffin-based tulle dressing at the donor site\n\nHave pain measured using a visual analogue scale (VAS) on the 7th day after surgery\n\nBe given pain medication if their pain score is 4 or higher, and the amount used will be recorded",[94,27,95,96],"Skin Graft Wounds","Pain, Postoperative","Skin Transplantation","2025-09-21",{"date":99,"type":41},"2025-09-25",{"date":101,"type":41},"2025-08-05",{"date":103,"type":21},"2026-04-14",{"name":105,"class":48},"King Edward Medical University",{"id":107,"slug":108,"hasResults":11,"nctId":109,"briefTitle":110,"officialTitle":111,"acronym":4,"eligibilityCriteria":112,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":113,"targetDuration":4,"studyType":22,"phases":115,"briefSummary":116,"conditions":117,"keywords":120,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":127,"completionDateStruct":129,"leadSponsor":131,"locationsCount":49},"100496116","radial-forearm-donor-site-closure-100496116","NCT05740033","Radial Forearm Donor Site Closure","Functional and Aesthetic Outcomes of Radial Forearm Free Flap Closure Using Split-Thickness Skin Graft vs Primary Closure; a Randomized Control Trial","Inclusion Criteria:\n\n* Adults aged 18 or older\n* Oral cavity disease (malignant or benign) requiring radial forearm free flap reconstruction\n\nExclusion Criteria:\n\n* Serious medical comorbidities including metastatic disease or other contraindications to surgery\n* Any pre-existing condition affecting the use of both hands, including previous major scars\n* Unable or unwilling to complete post-operative questionnaires in English\n* Pregnant or lactating women",{"count":114,"type":21},120,[24],"The radial forearm free flap (RFFF) is widely used in head and neck reconstruction. Its thinness, pliability, pedicle length, and vessel size are particularly suited for oropharyngeal and oral cavity reconstruction. Concerns about aesthetic and functional morbidity at the donor site have given rise to various techniques of closing the donor site, two of which are the split-thickness skin graft (STSG), taken from the thigh, and the hatchet flap, which uses a local flap within the radial forearm. This RCT will determine whether retrospectively reported improvements to aesthetic and functional outcomes for STSG patients are greater compared to hatchet flap patients.",[118,119,27],"Oral Cancer","Oral Cavity Cancer",[118,119,121,122,123],"Radial Forearm","Donor Site","Surgical Complications","2025-06-09",{"date":126,"type":41},"2025-06-12",{"date":128,"type":41},"2023-02-01",{"date":130,"type":21},"2025-12",{"name":132,"class":48},"University of British Columbia"]