[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"dopamine\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:dopamine":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":32,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":5},"100420079","phase-3-management-of-shock-in-children-with-sam-or-severe-underweight-and-diarrhea-100420079",false,"NCT04750070","Management of Shock in Children With SAM or Severe Underweight and Diarrhea","Randomized Controlled Trial of Dopamine, Adrenaline, and Blood Transfusion for Treatment of Fluid Refractory Shock in Children With Severe Acute Malnutrition or Severe Underweight and Cholera or Other Dehydrating Diarrheas","Inclusion Criteria:\n\n1. Children of either sex with acute malnutrition and diarrhea\n2. Age: 1-59 months\n3. Children with cerebral palsy (CP) and\u002For developmental delay, Down Syndrome with or without heart diseases\n4. Fluid refractory shock\n5. Consent from the caregivers\u002Fparents\n\nExclusion Criteria:\n\n1. Having a rare blood group (Rh negative blood groups provided that donor is not available)\n2. A child requiring cardio-pulmonary resuscitation during screening or having gasping respiration","ALL","1 Month","59 Months",{"count":20,"type":21},135,"ESTIMATED","INTERVENTIONAL",[24],"PHASE3","Diarrhea is one of the leading causes of under-five childhood mortality and accounts for 8% of 5.4 million global under-5 deaths. The coexistence of sepsis and hypovolemic shock in children with severe acute malnutrition (SAM) having diarrhea is common. At Dhaka hospital of icddr,b, the death rate is as high as 40% and 69% in children with severe sepsis and septic shock respectively with co-morbidities such as severe malnutrition.\n\nThe conventional management of SAM children with features of severe sepsis recommended by WHO includes administration of boluses of isotonic saline followed by blood transfusion in unresponsive cases with septic shock; whereas the Surviving Sepsis Campaign (SSC) guideline recommends vasoactive support. To date, no study has evaluated systematically the effects of inotrope(s) and vasopressor or blood transfusion in children with dehydrating diarrhea (for example, in cholera) and SAM having shock and unresponsive to WHO standard fluid therapy.\n\nThis randomized trial will generate evidence whether inotrope and vasopressor or blood transfusion should be selected for severely malnourished children having hypotensive shock and who failed to respond to WHO standard fluid bolus.",[27,28,29,30,31],"Shock Hypovolemic","Shock, Septic","Blood Transfusion","Adrenaline","Dopamine",[33,34,35,36,37,38,39],"Severe acute malnutrition","Children","Shock","Cholera","Dehydrating diarrhea","Severe underweight","Acute malnutrition","RECRUITING","2025-04-13",{"date":43,"type":44},"2025-04-16","ACTUAL",{"date":46,"type":44},"2021-08-17",{"date":48,"type":21},"2025-11-30",{"name":50,"class":51},"International Centre for Diarrhoeal Disease Research, Bangladesh","OTHER"]