[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"drinking-alcohol\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:drinking-alcohol":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,58,91],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":35,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":46,"lastUpdatePostDateStruct":47,"startDateStruct":50,"completionDateStruct":52,"leadSponsor":54,"locationsCount":57},"100635054","carrii-native-intervention-optimization-trial-100635054",false,"NCT07547696","CARRII Native Intervention Optimization Trial","CARRII Native Intervention Optimization Trial 3-month Factorial Experiment With 512 Participants Randomized to 8 Conditions","Inclusion Criteria:\n\n* Native American\u002FAmerican Indian\u002FAlaska Native,\n* who are not surgically sterile,\n* who report alcohol consumption at risk levels and risk for pregnancy in the past 90 days due to having sex with a man with inconsistent, ineffective, or no contraception.\n* Participants must have access to the Internet via a mobile device they can access daily\n\nExclusion Criteria:\n\n* cognitive disorders including mental retardation, dementia, or psychotic disorders that could impair ability to understand the intervention material or give informed consent.",true,"FEMALE","18 Years","44 Years",{"count":21,"type":22},512,"ESTIMATED","INTERVENTIONAL",[25],"NA","The purpose of this study is to identify the best combination of new intervention components to use with CARRII, the first automated online intervention for alcohol-exposed pregnancies (AEP). This intervention is specifically designed for Native women and others who can become pregnant. Our goal is to maximize the effectiveness of the online intervention while keeping costs manageable for Native communities.",[28,29,30,31,32,33,34],"Fetal Alcohol Spectrum Disorders","Pregnancy","Alcohol-Related Disorders","Drinking, Alcohol","Contraception Behavior","Alcohol Exposed Pregnancy","Sexual Behavior",[36,37,38,39,40,41,42,43,44],"Native American","female","adult","contraception","alcohol","digital intervention","mobile health (mHealth)","optimization","risk reduction","RECRUITING","2026-06-18",{"date":48,"type":49},"2026-06-23","ACTUAL",{"date":51,"type":49},"2026-06-02",{"date":53,"type":22},"2028-07-30",{"name":55,"class":56},"University of Virginia","OTHER",1,{"id":59,"slug":60,"hasResults":11,"nctId":61,"briefTitle":62,"officialTitle":62,"acronym":4,"eligibilityCriteria":63,"healthyVolunteers":11,"sex":64,"minAge":65,"maxAge":66,"enrollmentInfo":67,"targetDuration":4,"studyType":23,"phases":69,"briefSummary":70,"conditions":71,"keywords":76,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":57},"100439178","mpfc-theta-burst-stimulation-as-a-treatment-tool-for-alcohol-use-disorder-effects-on-drinking-and-incentive-salience-100439178","NCT04998916","MPFC Theta Burst Stimulation as a Treatment Tool for Alcohol Use Disorder: Effects on Drinking and Incentive Salience","Inclusion Criteria:\n\n* Age 21-65 (to maximize participation; note: Scalp-to-Cortex distance will be included as a covariate to calculate adjusted TMS dose given expected cortical atrophy in heavy alcohol users and older adults and the demonstrated effect50 on TMS-fMRI responses in addiction)\n* Alcohol Use Disorder, determined by DSM-V criteria, using the Structured Clinical Interview for DSM-V\n* Consumption of more than 14 drinks (women) or 21 drinks (men) per week, with at least 4 heavy drinking days (defined as ≥ 4 drinks for women and ≥ 5 for men) per week during the 30-days prior to enrolling.\n* Able to read and understand questionnaires and informed consent.\n\nExclusion Criteria:\n\n* Has metal placed above the neck\n* Is at elevated risk of seizure (i.e., has a history of seizures, is currently prescribed medications known to lower seizure threshold)\n* Has a history of moderate to severe alcohol withdrawal or medicated alcohol withdrawal\n* Has a history of claustrophobia\n* Has a history of chronic migraines\n* Has a history of traumatic brain injury, including a head injury that resulted in hospitalization, loss of consciousness for more than 10 minutes, or having ever been informed that they have an epidural, subdural, or subarachnoid hemorrhage\n* Has an unstable medical illness requiring planned medical\u002Fsurgical intervention (e.g. chemotherapy, surgical procedure)\n* Medications: Is currently taking or initiates a new prescription for drugs known to improve alcohol drinking treatment outcomes (e.g. naltrexone, acamprosate, topiramate) or taking psychiatric\u002Fsleeping medications except for stable (1 month) antidepressants\u002FSSRI's. \\[Note: this criterion is for scientific rather than safety or patient comfort reasons\\].\n* Has a history of substance use disorder (other than nicotine) by DSM-V criteria in the past 6 months\n* Meets DSM V criteria for panic disorder, bipolar disorder, obsessive-compulsive disorder, schizophrenia, dissociative disorders, eating disorders, and any other psychotic disorder. \\[Note: The inclusion of participants with other affective and anxiety disorders is essential because of the marked frequency of the co-existence of mood and other anxiety disorders among patients with AUD at large\\]\n* Has current suicidal ideation or homicidal ideation\n* Females of childbearing potential who are pregnant (by urine HCG), nursing, or who are not using a reliable form of birth control.","ALL","21 Years","65 Years",{"count":68,"type":22},86,[25],"The purpose of this study is to develop transcranial magnetic stimulation (TMS), specifically TMS at a frequency known as theta burst stimulation (TBS), to see how it affects the brain and changes the brain's response to alcohol-related pictures. TMS and TBS are stimulation techniques that use magnetic pulses to temporarily excite specific brain areas in awake people (without the need for surgery, anesthetic, or other invasive procedures). TBS, which is a form of TMS, will be applied over the medial prefrontal cortex, (MPFC), which has been shown to be involved with drinking patterns and alcohol consumption. This study will test whether TBS can be used as an alternative tool to reduce the desire to use alcohol and reducing the brain's response to alcohol-related pictures.",[72,73,74,31,75],"Alcohol Use Disorder","Alcohol Drinking","Substance Use","Alcohol Use Disorder (AUD)",[77,78,79,80,81],"Transcranial Magnetic Stimulation","Medial Prefrontal Cortex","Brain Stimulation","Non-invasive","Adult","2026-03-27",{"date":84,"type":49},"2026-04-02",{"date":86,"type":49},"2021-07-06",{"date":88,"type":22},"2026-12-31",{"name":90,"class":56},"Medical University of South Carolina",{"id":92,"slug":93,"hasResults":11,"nctId":94,"briefTitle":95,"officialTitle":96,"acronym":97,"eligibilityCriteria":98,"healthyVolunteers":16,"sex":64,"minAge":18,"maxAge":4,"enrollmentInfo":99,"targetDuration":4,"studyType":23,"phases":101,"briefSummary":102,"conditions":103,"keywords":104,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":114,"lastUpdatePostDateStruct":115,"startDateStruct":117,"completionDateStruct":119,"leadSponsor":121,"locationsCount":57},"100486240","influence-of-tms-on-attention-modulation-100486240","NCT05611502","Influence of TMS on Attention Modulation","A Combined Neurofeedback- TMS Intervention for Alcohol Use Disorder - Aim 2","TAM","Inclusion Criteria:\n\n1\\. Age 18 or Older\n\n2A. (Drinker Group): Reports consuming 4 \\[if female\\]\u002F 5 \\[if male\\] or more standard drinks on one occasion at least 2 times a month AND\u002FOR reports consuming more than 7 \\[if female\\]\u002F 14 \\[if male\\] standard drinks per week on average\n\n2B. (Healthy Volunteer Group): Reports consuming 4 \\[if female\\]\u002F 5 \\[if male\\] or more standard drinks on one occasion less than once a month AND reports consuming less than 7 \\[if female\\]\u002F 14 \\[if male\\] standard drinks per week on average\n\nExclusion Criteria:\n\n1. MRI Contraindications\n\n   1. Presence of metal in the body that would make having a 7T MRI unsafe (including facial tattoos)\n   2. Claustrophobia, such that individual would be unable to stay in the MRI for up to 1 hr\n   3. Hearing loss, including tinnitus, that might be made worse by MRI or TMS\n2. TMS Contraindications\n\n   1. Has ever had a seizure, or has a family history of epilepsy\n   2. Taking medications or substances that lower the seizure threshold\\*\n   3. Implanted devices that are in the head or rely on physiological signals\n   4. History of neurological disease, such as stroke or brain tumor\n   5. Head injury with loss of consciousness greater than 30 minutes\n   6. Actively withdrawing from alcohol\n3. Family history of schizophrenia or presence of psychotic symptoms",{"count":100,"type":22},40,[25],"The purpose of this study is to help understand how attention processes influence brain engagement during emotion and social cognition. The investigators also want to know if these processes are associated with drinking alcohol.\n\nParticipation includes three study visits of about 2 hours each over approximately a month. The first visit involves a magnetic resonance imaging (MRI) scan and answering survey questions. Each of the next two visits will involve a session of transcranial magnetic stimulation (TMS, a non-invasive brain stimulation technique) followed by another MRI scan.\n\nPeople in the Auburn\u002FOpelika area 19 or older are eligible to participate. People who drink alcohol and people who do not drink or don't drink very much are invited to participate.",[31],[40,105,106,107,108,109,110,111,112,113],"attention","TMS","binge drinking","emotion","social cognition","moral","MRI","frontal eye fields","moral cognition","2025-10-02",{"date":116,"type":49},"2025-10-07",{"date":118,"type":49},"2022-08-11",{"date":120,"type":22},"2025-12-31",{"name":122,"class":56},"Auburn University"]