[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"driving-pressure\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:driving-pressure":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,47,71,97,130],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":30,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100643495","intraoperative-driving-pressure-and-postoperative-lung-ultrasound-score-in-robot-assisted-radical-prostatectomy-100643495",false,"NCT07610824","Intraoperative Driving Pressure and Postoperative Lung Ultrasound Score in Robot-Assisted Radical Prostatectomy","Evaluation of the Relationship Between Intraoperative Driving Pressure and Postoperative Lung Ultrasound Score in Patients Undergoing Robot-Assisted Laparoscopic Radical Prostatectomy","Inclusion Criteria:\n\n* Male patients aged between 18 and 80 years.\n\nScheduled for elective robot-assisted laparoscopic radical prostatectomy.\n\nAmerican Society of Anesthesiologists (ASA) physical status I, II, or III.\n\nWillingness to provide written informed consent.\n\nExclusion Criteria:\n\n* Patient refusal to participate.\n\nSevere obstructive or restrictive pulmonary disease (e.g., severe COPD, uncontrolled asthma).\n\nBody Mass Index (BMI) \\> 35 kg\u002Fm\\^2.\n\nPre-existing severe lung pathology or active pulmonary infection.\n\nHemodynamic instability or severe cardiovascular disease (e.g., severe heart failure, recent myocardial infarction).\n\nRequirement for postoperative mechanical ventilation.\n\nEmergency surgery.","MALE","18 Years","80 Years",{"count":20,"type":21},76,"ESTIMATED","OBSERVATIONAL","The primary objective of this study is to evaluate the relationship between intraoperative driving pressure and postoperative lung ultrasound scores in patients undergoing robot-assisted laparoscopic radical prostatectomy. During this specific surgery, factors such as pneumoperitoneum and patient positioning can significantly affect respiratory mechanics. Postoperative lung condition will be objectively assessed using the lung ultrasound score (LUS). The findings may provide valuable insights for optimizing intraoperative mechanical ventilation strategies.",[25,26,27,28,29],"Mechanical Ventilation","Postoperative Pulmonary Complications (PPCs)","Prostatic Neoplams","Driving Pressure","Lung Ultrasonography Score",[31,32,33],"driving pressure","lung ultrasonography score","postoperative pulmonary comlications","RECRUITING","2026-06-09",{"date":37,"type":38},"2026-06-11","ACTUAL",{"date":40,"type":21},"2026-05-30",{"date":42,"type":21},"2026-09-15",{"name":44,"class":45},"Ankara Etlik City Hospital","OTHER_GOV",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":54,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":56,"conditions":57,"keywords":4,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":46},"100637220","intraoperative-lung-mechanics-changes-during-holep-surgery-100637220","NCT07607704","Intraoperative Lung Mechanics Changes During HoLEP Surgery","Evaluation of Intraoperative Driving Pressure and Static Lung Compliance Changes in Holmium Laser Enucleation of Prostate (HoLEP) Surgery","Inclusion Criteria:\n\n* Male patients over 18 years of age\n* Patients scheduled for elective HoLEP surgery\n* Patients who provide written informed consent\n\nExclusion Criteria:\n\n* Preoperative severe lung disease\n* Thoracic pathology that may affect mechanical ventilation\n* Conditions where spontaneous breathing cannot be suppressed\n* Missing data severe lung disease\n* Thoracic pathology that may affect mechanical ventilation\n* Conditions where spontaneous breathing cannot be suppressed\n* Missing data",{"count":55,"type":21},45,"This study aims to evaluate changes in driving pressure and static lung compliance during HoLEP surgery and to investigate their relationship with surgical and perioperative factors. This study is observational, and no changes will be made to the patients' current treatment processes.",[58,59,28],"Holmium Laser Enucleation of the Prostate","Lung Protective Ventilation","NOT_YET_RECRUITING","2026-05-21",{"date":63,"type":38},"2026-05-26",{"date":65,"type":21},"2026-05-15",{"date":67,"type":21},"2026-08-31",{"name":69,"class":70},"Ankara City Hospital Bilkent","OTHER",{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":4,"eligibilityCriteria":77,"healthyVolunteers":78,"sex":79,"minAge":17,"maxAge":4,"enrollmentInfo":80,"targetDuration":4,"studyType":82,"phases":83,"briefSummary":85,"conditions":86,"keywords":4,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":46},"100628641","effect-of-neuromuscular-block-depth-on-driving-pressure-and-postoperative-respiratory-events-in-abdominal-surgeries-100628641","NCT07464288","Effect of Neuromuscular Block Depth on Driving Pressure and Postoperative Respiratory Events in Abdominal Surgeries","The Effect of Different Depths of Neuromuscular Blockade, Assessed by Train of Four (TOF) Monitoring, On Driving Pressure and the Development of Postoperative Critical Respiratory Events in Abdominal Surgeries","Inclusion Criteria:\n\n* Elective abdominal surgery under general anesthesia that is expected to last longer than one hour\n* ASA I-II-III\n* Age ≥18 years\n* Written informed consent\n\nExclusion Criteria:\n\n* Refusal to participate in the study\n* ASA ≥ IV\n* Age \\\u003C18\n* Obesity (BMI\\>30) and cachexia (BMI \\\u003C18)\n* Laparoscopic surgery\n* Emergency procedure\n* Allergy to drugs used during induction and maintenance of general anesthesia\n* Presence of psychiatric\u002Fneurologic\u002Fneuromuscular disease\n* Risk of malignant hyperthermia or having any relative with history of malignant hyperthermia\n* Use of medications that may affect neuromuscular function (anticonvulsants, aminoglycosides, magnesium salts, etc.)\n* Pregnancy\n* Presence of advanced chronic lung disease (asthma, COPD, etc.)\n* Presence of advanced liver and renal disease (creatinine\\>1.6, liver function tests above twice the normal range)",true,"ALL",{"count":81,"type":21},128,"INTERVENTIONAL",[84],"NA","This randomized controlled study aims to evaluate the effects of deep versus moderate neuromuscular blockade on intraoperative driving pressure and the development of postoperative critical respiratory events in patients undergoing abdominal surgery under general anesthesia.",[28,87,88],"Neuromuscular Blockade Monitoring","Postoperative Respiratory Complications","2026-03-15",{"date":91,"type":38},"2026-03-17",{"date":93,"type":21},"2026-03-23",{"date":95,"type":21},"2026-04-24",{"name":69,"class":70},{"id":98,"slug":99,"hasResults":11,"nctId":100,"briefTitle":101,"officialTitle":101,"acronym":4,"eligibilityCriteria":102,"healthyVolunteers":78,"sex":79,"minAge":17,"maxAge":4,"enrollmentInfo":103,"targetDuration":4,"studyType":82,"phases":105,"briefSummary":106,"conditions":107,"keywords":117,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":121,"lastUpdatePostDateStruct":122,"startDateStruct":124,"completionDateStruct":126,"leadSponsor":128,"locationsCount":46},"100607313","driving-pressure-during-surgeries-with-high-risk-for-postoperative-pulmonary-complications-100607313","NCT07186933","Driving Pressure During Surgeries With High Risk for Postoperative Pulmonary Complications","Inclusion Criteria\n\n* \\>17 years old\n* Surgery with general anesthesia \\& invasive mechanical ventilation\n* Preoperative ARISCAT score estimation \\>25\n\nExclusion Criteria:\n\n* \\\u003C18 years old\n* Preoperative ARISCAT score estimation \\\u003C26\n* Women during pregnancy or just given birth\n* Other type of anesthesia (Not general)\n* Contraindication of administration of neuromuscular blockade agents.\n* Contraindication of cease of spontaneous ventilation.\n* Mechanical ventilation without endotracheal intubation.\n* Severe heart failure \u002F Severe cardiac arrhythmia.\n* Severe emphysematous lung disease.\n* Patient denial of participation in the trial.",{"count":104,"type":21},200,[84],"The goal of this clinical trial is to compare two different types of perioperative mechanical ventilation (MV), specifically Protective Mechanical Ventilation (PMV) and MV with the lowest possible Driving Pressure (ΔP), in relation to the appearance of postoperative pulmonary complications (PPCs) in adult patients who are operated and have higher risk of PPCs.\n\nThe main questions it aims to answer are:\n\n* Is MV with lower ΔP better than conventional PMV in preventing PPCs in patients with higher risk for PPCs?\n* Does MV with lower ΔP decrease hospital stay, Intensive Care Unit (ICU) need and mortality?\n* Does MV with lower ΔP suit better than PMV to lung characteristics and needs intraoperatively?\n\nResearchers will compare MV with the lowest possible Driving Pressure (ΔP) to Protective Mechanical Ventilation (PMV) to see if any of this is more protective than the other concerning PPCs.\n\nAll participants will receive perioperative MV.\n\nHalf of them will receive conventional Protective Mechanical Ventilation (PMV). This will include well known generally protective settings for mechanical ventilation of patients, concerning volumes, pressures, respiratory rate, inspiratory gases and ventilation maneuvers.\n\nThe rest of participants will be ventilated with the lowest possible Driving Pressure (ΔP). This will be similar to PMV in the chosen volumes, respiratory rate, inspiratory gases and ventilation maneuvers. However, the pressure inside lung at the end of expiration, eg Positive End Expiratory Pressure (PEEP), will be not be preset for every patient. Initially, the investigators will perform a maneuver that will quantify each individual's lung characteristics and mechanics. According to this, the investigators will find the exact PEEP that seems to suit each patients lungs most, and use this perioperatively, trying to provide lungs the best conditions every time.\n\nAfter the completion of the operation, all the patients will be screened for PPCs, via arterial blood testing and chest X ray, and the results will be statistically analyzed trying to find if any of the forementioned strategies of mechanical ventilation surpasses the other concerning PPCs appearance. PPCs include atelectasis, respiratory failure, bronchospasm, pleural effusion, pneumonia, aspiration and pneumothorax.\n\nFurthermore hospital stay, ICU need and mortality will be noted. Finally, measurements of perioperative lung pressures, volumes and derived variables will be noted and compared statistically as well.",[108,109,110,111,112,113,114,115,116,28],"Postoperative Pulmonary Atelectasis","Postoperative Pulmonary Complications","Postoperative Respiratory Failure","Postoperative Bronchospasm","Postoperative Pleural Effusion","Postoperative Pneumothorax","Postoperative Pneumonia","Postoperative Aspiration Pneumonitis","Mechanical Power",[28,116,118,119,109,110,120],"Atelectasis","Pulmonary Complications","Elastic Power","2026-02-08",{"date":123,"type":38},"2026-02-11",{"date":125,"type":38},"2025-11-03",{"date":127,"type":21},"2027-11-30",{"name":129,"class":70},"University General Hospital of Patras",{"id":131,"slug":132,"hasResults":11,"nctId":133,"briefTitle":134,"officialTitle":135,"acronym":4,"eligibilityCriteria":136,"healthyVolunteers":78,"sex":79,"minAge":137,"maxAge":18,"enrollmentInfo":138,"targetDuration":4,"studyType":82,"phases":140,"briefSummary":141,"conditions":142,"keywords":143,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":146,"lastUpdatePostDateStruct":147,"startDateStruct":149,"completionDateStruct":151,"leadSponsor":153,"locationsCount":46},"100600088","driving-pressure-guided-mechanical-ventilation-versus-lung-protective-ventilation-among-patients-undergoing-elective-surgeries-100600088","NCT07092943","Driving Pressure Guided Mechanical Ventilation Versus Lung Protective Ventilation Among Patients Undergoing Elective Surgeries","A Comparison of Driving Pressure Guided Mechanical Ventilation With Lung Protective Ventilation Among Patients Presenting for Elective Surgeries at a Tertiary Care Hospital; A Randomized Control Trial","Inclusion Criteria:\n\n* American Society of Anesthesiologists (ASA) class: I and II.\n* Elective laparoscopic surgeries requiring General Anesthesia and Mechanical ventilation\n* Patients receiving neuromuscular blockade during surgery.\n* Receiving Mechanical ventilation for at least 1h.\n\nExclusion Criteria:\n\n* Pregnancy\n* Patients who had received mechanical ventilation of more than 1h in the previous 2 weeks.\n* Body mass index \\>35 kg\u002Fm2\n* Smokers and ASA class III and above.\n* Thoracic and Cardiac surgery","16 Years",{"count":139,"type":21},70,[84],"Patient undergoing surgeries in general anesthesia require support of their breathing by ventilator. Different strategies can be used to manage breathing of the patient. Lung protective ventilation provides breathing at a set volume determined by patient ideal body weight, along with a set rate to maintain adequate breathing. The pressures in the lower airway are kept less than 30 cm of H20 while a pressure of 5cm of H20 is applied to prevent lung collapse. Recently to above mentioned regimen a driving pressure is added which is a difference between lower airway pressure and pressure applied to prevent lung collapse. Ventilatory settings are adjusted to keep this driving pressure less than 15 cm of H2O.",[25,59,28],[144,145],"General Anesthesia","Mechanical ventilation","2025-07-28",{"date":148,"type":38},"2025-07-30",{"date":150,"type":38},"2025-07-20",{"date":152,"type":21},"2025-10-20",{"name":154,"class":70},"Rawalpindi Medical College"]