[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"driving-under-the-influence\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:driving-under-the-influence":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,42],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100479685","combined-and-separate-effects-of-cannabis-and-tobacco-psychomotor-subjective-and-physiological-outcomes-100479685",false,"NCT05526196","Combined and Separate Effects of Cannabis and Tobacco: Psychomotor, Subjective and Physiological Outcomes","CASE-CT","Inclusion Criteria:\n\n* • Adults aged 19 years to 45 years (to control for the effects of age on cognition)\n\n  * Smoke or vape cannabis at least once a month but no more than 4 times a week (to avoid enrolling people with cannabis use disorder who may experience withdrawal when asked to abstain from cannabis)\n  * Experience with smoked cannabis in the past year\n  * Report use of at least 100 cigarettes in their lifetime to ensure familiarity with the tobacco used in the present study\n  * Use of any nicotine (smoked, vaped, etc) in the past year\n  * G2 or full G driver's licence for at least a year\n  * Willing to abstain from alcohol and other drugs (other than drugs required for treatment of a medical condition) for 48 hours prior to study session\n  * Normal heart rate and blood pressure as determined by the QI (because cannabis and tobacco increase heart rate)\n  * Normal ECG (because cannabis and tobacco increase heart rate)\n  * Willing to abstain from cannabis for 72 hours prior to the test session and from smoking tobacco for 12 hours\n  * Willing to use an accepted form of contraception during the study (both males and females)\n  * Past lifetime experience with co-use of cannabis or tobacco (either simultaneous or concurrent)\n  * Provides written and informed consent\n\nExclusion Criteria:\n\n* • Use of psychoactive medications or drugs\n\n  * Current alcohol or other substance use disorder, including cannabis (as assessed with the SCID)\n  * Current or past nicotine dependence (to avoid precipitating a relapse)\n  * Withdrawal symptoms as assessed with the Marijuana Withdrawal Checklist \\[57, 58\\]\n  * A score of less than 10 on the Clinical Institute Withdrawal Assessment for Alcohol (CIWA-Ar) \\[59\\]\n  * Family history of schizophrenia or psychosis (to avoid giving cannabis to anyone with a predisposition to psychosis)\n  * Respiratory illnesses (due to the smoked route of administration in this study)\n  * Any serious medical condition precluding participation as judged by the responsible study physician\n  * Pregnancy or breastfeeding\n  * Negative urine screen for cannabis at eligibility assessment (to ensure experience with cannabis)\n  * Neurological disorders that may affect cognitive function\n  * Treatment-seeking for tobacco or cannabis use\n  * Use of more than 5 cigarettes a day (to avoid confound of the effects of chronic smoking on measures)\n  * Concomitant therapy with sedative-hypnotics or other psychoactive drugs (counter-indicated with cannabis)",true,"ALL","19 Years","45 Years",{"count":21,"type":22},60,"ESTIMATED","INTERVENTIONAL",[25],"NA","Co-administration of cannabis and tobacco is a common practice, but there is little experimental evidence aimed at understanding the reasons for this prevalence. Some preliminary evidence suggests that tobacco may actually counteract the cognitive-impairing effects of cannabis, and may also increase the subjective ('liking') effects of cannabis, but results are inconclusive. Further, there are no studies into the effects of tobacco on other cannabis-related harms such as driving, or on the ability of tobacco to alter the blood levels of THC, the chemical responsible for the psychoactive properties of cannabis. The purpose of the present study will be to evaluate the effects of tobacco, cannabis or combinations of tobacco and cannabis on driving, cognition, subjective effects and blood THC. Driving will be assessed using a state-of-the-art driving simulator that allows for the safe and objective measurement of the effects of intoxicating substances on driving. Participants will be regular users of cannabis and will be invited to the lab for four counterbalanced test sessions. In these test sessions they will drive the simulator and undergo cognitive tests before and after smoking: 1) cannabis; 2) tobacco; 3) cannabis + tobacco; or 4) placebo. Outcomes will be measured at several time points after smoking the product. Participants will also give blood for determination of levels of THC, and will complete subjective effects questionnaires both before and after smoking the cigarette. This study will be one of the first experimental laboratory studies of the reasons behind co-administration of tobacco and cannabis.",[28],"Driving Under the Influence","RECRUITING","2026-03-16",{"date":32,"type":33},"2026-03-17","ACTUAL",{"date":35,"type":33},"2024-10-07",{"date":37,"type":22},"2027-03-01",{"name":39,"class":40},"Centre for Addiction and Mental Health","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":16,"sex":17,"minAge":50,"maxAge":4,"enrollmentInfo":51,"targetDuration":4,"studyType":23,"phases":53,"briefSummary":54,"conditions":55,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":57,"lastUpdatePostDateStruct":58,"startDateStruct":60,"completionDateStruct":62,"leadSponsor":64,"locationsCount":41},"100623822","in-vehicle-real-time-cannabis-influenced-driving-detection-100623822","NCT07401628","In-Vehicle Real-Time Cannabis Influenced Driving Detection","Randomised, Controlled, Interventional Single-center Study for the Design and Evaluation of an In-vehicle Real-time System for Detecting Cannabis-impaired Driving (CID)","REVELIO","Inclusion Criteria:\n\n* Informed consent as documented by signature\n* Recreational cannabis-consumption (more than once per month)\n* In possession of a definite Swiss or European Union (EU) driving license\n* At least 21 years old\n* Active, regular driving a car in the last 6 months\n* Must be in good health condition\n* No special equipment needed when driving (special seats, levers, etc.)\n* Fluent in (Swiss) German and no speech impairment\n\nExclusion Criteria:\n\n* Health concerns where cannabis consumption is contra-indicated (such as: high blood pressure, psychiatric problems (e.g. psychosis, depression, attention-deficit conditions, etc.)\n* Cannabis-abstinence or excessive consumption, , assessed using the Cannabis Use Disorders Identification Test-Revised (CUDIT-R)\n* For women: pregnancy or breastfeeding or if intention to become pregnant during study period (time between telephone screening and study day (visit 2)\n* Alcohol misuse or excessive alcohol consumption habits\u002Frisky drinking behaviour, assessed using the Alcohol Use Disorders Identification Test (AUDIT) and\u002For phosphatidylethanol (PEth) in capillary blood \\> 200 ng\u002FmL at first visit\n* If breath alcohol test is positive at Visit 1 or Visit 2 (study day)\n* Consumption of drugs of abuse (others than cannabis) within 4 weeks before the study\n* Consumption of medications \u002F pharmaceutical drugs which interfere with driving ability\n* Inability to follow the procedures of the study, e.g., due to language","21 Years",{"count":52,"type":22},45,[25],"The goal of this clinical trial is to evaluate whether in-vehicle sensor data can be used to detect cannabis-impaired driving in healthy adult recreational cannabis users.\n\nThe study aims to assess whether changes in vehicle, driver, and physiological sensor data can distinguish sober driving from cannabis-impaired driving, and how driving performance changes from baseline to approximately 1 to 6 hours after controlled cannabis consumption.\n\nResearchers will compare driving behavior and in-vehicle sensor data from participants who receive controlled cannabis administration with data from a randomized reference group without cannabis exposure, to determine whether cannabis-related impairment driving can be identified on the basis of machine learning.\n\nParticipants will complete screening and baseline assessments and drive an instrumented vehicle on a closed test track under sober conditions. Participants assigned to the experimental arm will receive controlled cannabis administration, while participants in the reference arm will receive no intervention. All participants will perform repeated standardized driving sessions over several hours and complete traffic-medical, traffic-psychological, and in-vehicle pre-driving tests. Biological samples and in-vehicle sensor data will be collected throughout the study.",[28,56],"Cannabis-impaired Driving","2026-02-03",{"date":59,"type":33},"2026-02-10",{"date":61,"type":33},"2026-01-05",{"date":63,"type":22},"2026-06-19",{"name":65,"class":40},"University of Bern"]