[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"drm-gene-mutation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:drm-gene-mutation":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":5},"100566910","primary-and-secondary-drug-resistance-mutations-drms-in-hiv-as-a-risk-factor-of-failure-of-art-including-two-drugs-based-regimens-100566910",false,"NCT06661317","Primary and Secondary Drug Resistance Mutations (DRMs) in HIV As a Risk Factor of Failure of ART, Including Two Drugs Based Regimens.","Presence of HIV-1 DRMs As a Risk Factor of Failure of Two Drugs Based ART Regimens, Including LAI ART, in Cohorts of Primary and Secondary DRMs.","Inclusion Criteria:\n\nInclusion criteria were: diagnosis with HIV-1 infection, age 18 years or older.\n\nExclusion Criteria:\n\nLack of HIV genotyping before ART treatment or change of ART","ALL","18 Years","100 Years",{"count":20,"type":21},200,"ESTIMATED","OBSERVATIONAL","The presence of drug resistance mutations (DRMs) in HIV plays an important role in ART effectiveness. Despite very good results of ART, there is constant concern about the emergence of HIV strains with DRMs, what may lead to virological suppression failure. The concerns grow especially among patients treated with two drugs based regimens, including long acting therapies in injections (LAI ART) or regimens used in preexposure prophylaxis (PreP).",[25,26,27,28],"HIV-1-infection","DRM","DRM Gene Mutation","ART",[30,31,26,32,28,33],"HIV","drug resistance mutations","LAI","integrase inhibitors","NOT_YET_RECRUITING","2024-10-24",{"date":37,"type":38},"2024-10-28","ACTUAL",{"date":40,"type":21},"2024-11-01",{"date":42,"type":21},"2024-12-30",{"name":44,"class":45},"Medical University of Warsaw","OTHER"]