[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"drug-abuse\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:drug-abuse":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,10,0,[8,47,80,103,135,161,186,208,241,273],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100135709","advanced-functional-and-structural-mri-techniques-for-neuropharmacological-imaging-100135709",false,"NCT01036581","Advanced Functional and Structural MRI Techniques for Neuropharmacological Imaging","* Subjects must be between the ages of 18-80, be generally healthy and male or non-pregnant female. Smokers, non-smokers, drug using and non-drug using populations will participate in this study.\n\nINCLUSION CRITERIA:\n\nGeneral:\n\n* Male and non-pregnant female adults between the ages of 18-80.\n* All subjects must be able to provide informed consent.\n\nEXCLUSION CRITERIA:\n\nSubjects will be excluded if they:\n\n* Are pregnant. Urine pregnancy tests will be performed on all female volunteers of child-bearing potential before each experimental session.\n* Are unable to undergo MRI scanning due to implanted metallic devices (cardiac pacemaker or neurostimulator, some artificial joints, metal pins, surgical clips or other implanted metal parts including Copper 7 IUD) or claustrophobia.\n* Have major medical illnesses severe enough to impact data being gathered. Potential exclusions may include a history of chronic uncontrolled hypertension, diabetes, HIV, or other clinically significant medical conditions that may alter the signal being measured.\n* Have current major psychiatric disorders to include, but not limited to, mood, anxiety, psychotic disorders.\n* Have neurological illnesses severe enough to impact data being gathered. Potential exclusions may include seizure disorders, migraine, multiple sclerosis, movement disorders, or history of significant head trauma, CVA, or CNS tumor. The MAI will assess the severity in relation to the potential impact on data.\n* Are non-English speaking. Justification: There is no direct benefit to participants in this study, and some of the study procedures involve more than minimal risk. To include non-English speakers, we would have to translate the consent and other study documents and hire and train bilingual staff, which would require resources that we do not have and could not justify given the small sample size for each experiment. Additionally, the data integrity of some of the cognitive tasks and standardized questionnaires used in this study would be compromised as they have only been validated in English. Most importantly, ongoing communication regarding safety procedures is necessary when participants are undergoing MRI and TMS\u002FTRPMS procedures. The inability to effectively communicate MRI and TMS\u002FTRPMS safety procedures could compromise the safety of non-English speaking participants.\n* Are cognitively impaired, as assessed by medical history. A validated IQ test such as the WASI or Shipley-2 may also be considered. Justification: Cognitive impairment and learning disabilities are associated with alterations in brain regions used to accomplish tasks, and, therefore, may introduce significant variably into the data. Cognitive impairment may affect one s ability to give informed consent.\n\nSubjects to be considered for Non-Invasive Brain Stimulation (NIBS) will also be excluded if they:\n\n-Are unable to safely undergo a NIBS procedure as assessed by a TMS safety screening form.\n\nAdditional information will be gathered during screening for some experiments. As the purpose of this protocol is to develop imaging techniques, this information will be gathered as needed, depending on the phase of development and specific technique requirements. Based on the scientific and medical requirements of the particular experiment, participants may also be assessed for:\n\n* Age (some experiments may want to target a particular age range. For example, cognitive tasks generally exclude participants over 60, an age when cognitive issues tend to become more commonplace)\n* Left-handedness (if desired for a particular task)\n* Color-blindness (if using a task requiring color discrimination)\n* Drug use diagnosis\n* Use of psychoactive or vascularly active medications (if a functional fMRI technique that is sensitive to hemodynamic changes is being used). MAI discretion regarding timeframe of allowed use will be based on clinically relevant factors including drug half-life, pharmacology of the drug in question and pattern of use by the participant.",true,"ALL","18 Years","80 Years",{"count":20,"type":21},1000,"ESTIMATED","INTERVENTIONAL",[24],"NA","Background:\n\n\\- Functional and structural magnetic resonance imaging (MRI) techniques have allowed researchers to map and study how the brain works when at rest and when engaged in specific tasks. MRI scans have provided more information about how drugs affect the brain, and about how drug addiction changes the brain and influences behavior, mood, and thinking processes. To better understand the underlying mechanism of drug addiction and to develop strategies for more effective treatment, researchers are interested in developing new MRI techniques to study the effects of addiction on the brain.\n\nObjectives:\n\n\\- To develop new functional and structural MRI techniques, and to evaluate their potential use in brain imaging studies related to addiction.\n\nEligibility:\n\n* Individuals between 18 and 80 years of age.\n* Participants may be smokers or nonsmokers, and may use drugs or not use drugs.\n\nDesign:\n\n* During the initial screening, participants will complete questionnaires about family and personal history, drug use, and other information as required by the researchers. Participants who will be asked to complete tasks during the MRI scan will be shown how to perform these tasks before the scanning session.\n* Before each study session, participants may be asked to complete some or all of the following: questions about their drug use during the last week, a breathalyzer test, a urine drug-use assessment, a urine pregnancy test, or a measure of carbon monoxide. Participants will also provide blood samples before the start of the scan.\n* For each scanning session, participants will have an MRI scan that will last approximately 2 hours.\n* MRI scans may include specific tasks to be performed during the scan, or an experiment that studies the brain's response to carbon dioxide.",[27,28],"Drug Abuse","Nicotine Dependence",[30,31,32,33,27],"Magnetic Resonance Imaging (MRI)","Functional Brain Imaging","Magnetic Resonance Spectroscopy","Diffusion Tensor Imaging","RECRUITING","2026-06-23",{"date":37,"type":38},"2026-06-24","ACTUAL",{"date":40,"type":38},"2003-10-24",{"date":42,"type":21},"2029-12-31",{"name":44,"class":45},"National Institute on Drug Abuse (NIDA)","NIH",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":15,"sex":16,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":22,"phases":59,"briefSummary":61,"conditions":62,"keywords":65,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":46},"100444435","phase-1-evaluation-of-oral-thc-and-cbd-in-men-and-women-100444435","NCT05067387","Evaluation of Oral THC and CBD in Men and Women","Evaluation of Oral THC and CBD in Oral Fluid, Pharmacokinetics, and Subjective and Neurocognitive Effects in Men and Women","O-TACOFS","Inclusion Criteria:\n\n* Male or non-pregnant and non-lactating females aged 21-55 years\n* Report weekly-monthly use of cannabis (≤1 day per week) over the past month prior to screening,\n* Not currently seeking treatment for their cannabis use\n* Have a Body Mass Index from 18.5 - 34kg\u002Fm2.\n* Able to perform all study procedures\n* Must be using a contraceptive (hormonal or barrier methods)\n\nExclusion Criteria:\n\n* Meeting DSM-V criteria for moderate to severe Cannabis Use disorder (CUD) or any substance use disorder other than nicotine, caffeine\n* Any other Axis I disorder\n* Report using other illicit drugs in the prior 4 weeks, other than cannabis.\n* Current use of any medications that may affect study outcomes\n* If medical history, physical and psychiatric examination, or laboratory tests performed during the screening process are not within the normal range and \u002F or reveal any significant illness (e.g., hypertension) as judged by the study physician and to put the participant at greater risk of experiencing adverse events due to completion of study procedures.\n* Pregnancy is exclusionary due to the possible effects of the study medication on fetal development.\n* History of an allergic reaction or adverse reaction to cannabis is exclusionary.\n* History of respiratory illness or current respiratory illness\n* Currently enrolled in another research protocol\n* Not using a contraceptive method (hormonal or barrier methods)\n* The evaluating physician reviews all medical assessments along with medical history. Any disorders that might make cannabis administration hazardous are exclusionary.","21 Years","55 Years",{"count":58,"type":21},22,[60],"PHASE1","The purpose of this study is to determine the pharmacokinetics and pharmacodynamics of oral delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) and to evaluate detection of recently smoked THC in oral fluid.",[27,63,64],"Intoxication by Drug","Impairment",[66,67,68,64],"THC","CBD","Intoxication","NOT_YET_RECRUITING","2026-06-09",{"date":72,"type":38},"2026-06-11",{"date":74,"type":21},"2026-07-15",{"date":76,"type":21},"2028-06-15",{"name":78,"class":79},"University of California, Los Angeles","OTHER",{"id":81,"slug":82,"hasResults":11,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":4,"eligibilityCriteria":86,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":87,"enrollmentInfo":88,"targetDuration":4,"studyType":90,"phases":4,"briefSummary":91,"conditions":92,"keywords":93,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":4},"100643277","general-well-being-after-quitting-drug-use-100643277","NCT07641712","General Well-being After Quitting Drug Use","Physical and Physicosocial Well-being After Quitting Drug Use","Inclusion Criteria:\n\n\\- Individuals aged 18-65 who used drugs and asymptomatic individuals in the same age group.\n\nExclusion Criteria:\n\n* Active drug users and those using psychotic drugs","65 Years",{"count":89,"type":21},120,"OBSERVATIONAL","The aim of this study is to investigate physical and physicosocial well-being after quitting drug use.",[27],[94],"well-being","2026-06-08",{"date":72,"type":38},{"date":98,"type":21},"2026-07-01",{"date":100,"type":21},"2027-02-28",{"name":102,"class":79},"Alanya Alaaddin Keykubat University",{"id":104,"slug":105,"hasResults":11,"nctId":106,"briefTitle":107,"officialTitle":107,"acronym":108,"eligibilityCriteria":109,"healthyVolunteers":15,"sex":16,"minAge":110,"maxAge":4,"enrollmentInfo":111,"targetDuration":4,"studyType":22,"phases":113,"briefSummary":114,"conditions":115,"keywords":120,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":127,"lastUpdatePostDateStruct":128,"startDateStruct":130,"completionDateStruct":131,"leadSponsor":133,"locationsCount":46},"100595983","harm-reduction-intervention-for-anabolic-androgenic-steroids-users-a-randomized-controlled-trial-100595983","NCT07039539","Harm Reduction Intervention for Anabolic-androgenic Steroids Users: a Randomized Controlled Trial","SOS-RCT-HR","Inclusion Criteria:\n\n* Anyone over 15 years of age;\n* Planning to use\u002Fincrease the dose of AAS for aesthetic and\u002For physical performance purposes;\n* Plan to use\u002Fincrease the dose of AAS during eight to twelve weeks.\n\nExclusion Criteria:\n\n* Medical prescription for AAS use;\n* Use for sexual reassignment.","15 Years",{"count":112,"type":21},32,[24],"This clinical trial aims to investigate the short and long-term efficacy of a harm reduction intervention in reducing the use of non-clinical anabolic-androgenic steroids (AAS) in abusive users of AAS. As secondary objectives, the study will investigate the intervention's effect on health parameters (i.e., blood), quality of life, sleep quality, body image, eating behavior, depression, anxiety, fatigue, aggressiveness, cardiovascular parameters, muscle strength, body composition and muscle cross-sectional area outcomes.",[27,116,117,118,119],"Harm Reduction","Minimization, Harm","Anabolic Steroids Adverse Events","Brief Intervention",[121,122,123,124,125,126,119],"human enhancement drug","performance and image enhancement drug","anabolic androgenic steroids","drug consumption","doping","harm reduction","2026-05-12",{"date":129,"type":38},"2026-05-18",{"date":98,"type":21},{"date":132,"type":21},"2027-12-30",{"name":134,"class":79},"University of Sao Paulo",{"id":136,"slug":137,"hasResults":11,"nctId":138,"briefTitle":139,"officialTitle":140,"acronym":4,"eligibilityCriteria":141,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":142,"enrollmentInfo":143,"targetDuration":4,"studyType":22,"phases":145,"briefSummary":146,"conditions":147,"keywords":150,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":152,"lastUpdatePostDateStruct":153,"startDateStruct":155,"completionDateStruct":157,"leadSponsor":159,"locationsCount":46},"100255457","suicidal-behavior-in-patients-diagnosed-with-bipolar-disorder-100255457","NCT02604277","Suicidal Behavior in Patients Diagnosed With Bipolar Disorder","Suicidal Behavior in Patients Diagnosed With Bipolar Disorder: The Roles of Biological and Childhood and Adult Environmental Risk Factors","Inclusion Criteria:\n\n* English speaking\n* Diagnosis of Bipolar Disorder (BD)\n* Able to provide written informed consent\n\nExclusion Criteria:\n\n* Cognitive impairments\n* Acutely psychotic\n* Medically unstable\n* History of schizophrenia spectrum disorder\n* History of mood incongruent psychotic symptoms\n* History of primary substance disorder\n* History of primary organic disease and\u002For dementia","64 Years",{"count":144,"type":21},130,[24],"The purpose of this study is to learn the environmental and psychological factors that impact suicidality in patients diagnosed with Bipolar Disorder. Additionally, the study aims to identify treatments to reduce the suicidal behavior and improve quality of life through a 6-week group-based intervention program.",[148,149,27],"Depression","Alcoholism",[151],"Psychology","2026-01-05",{"date":154,"type":38},"2026-01-07",{"date":156,"type":38},"2016-01",{"date":158,"type":21},"2026-12",{"name":160,"class":79},"Emory University",{"id":162,"slug":163,"hasResults":11,"nctId":164,"briefTitle":165,"officialTitle":166,"acronym":4,"eligibilityCriteria":167,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":168,"targetDuration":4,"studyType":90,"phases":4,"briefSummary":170,"conditions":171,"keywords":174,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":177,"lastUpdatePostDateStruct":178,"startDateStruct":180,"completionDateStruct":182,"leadSponsor":184,"locationsCount":46},"100373344","structured-physical-exercise-in-short-term-inpatient-treatment-of-substance-use-disorder-100373344","NCT04141202","Structured Physical Exercise in Short-term Inpatient Treatment of Substance Use Disorder","Structured Physical Exercise in Short-term Inpatient Treatment of Substance Use Disorder: Implications for Abstinence, Quality of Life, Physical- and Mental Health","Inclusion Criteria:\n\n* Being an inpatient at the clinic\n\nExclusion Criteria:\n\n\\-",{"count":169,"type":21},200,"In 2017, structured physical exercise with high intensity was implemented as a part of the treatment program at St. Olav Hospital Clinic of Substance Use and Addiction Medicine.\n\nThe objective of this study is to examine whether implementing structured physical exercise in the treatment program has implications for patients' physical and mental health and quality of life after completing a 3 month residential treatment program.\n\nThe results of this study will benefit substance use disorder patients in the future, and may have an impact on further implementation of physical exercise in addiction treatment clinics both nationally and internationally.",[172,27,173],"Substance-Related Disorders","Drug Dependence",[175,176],"Exercise therapy","Exercise physiology","2025-06-04",{"date":179,"type":38},"2025-06-08",{"date":181,"type":38},"2020-02-25",{"date":183,"type":21},"2025-12-30",{"name":185,"class":79},"St. Olavs Hospital",{"id":187,"slug":188,"hasResults":11,"nctId":189,"briefTitle":190,"officialTitle":191,"acronym":4,"eligibilityCriteria":192,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":193,"targetDuration":4,"studyType":22,"phases":194,"briefSummary":195,"conditions":196,"keywords":198,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":199,"lastUpdatePostDateStruct":200,"startDateStruct":202,"completionDateStruct":204,"leadSponsor":206,"locationsCount":46},"100509835","peer-led-personalized-support-program-100509835","NCT05918601","Peer-led Personalized Support Program","Effectiveness of a Peer-led Personalized Support Program Using Instant Messaging Applications and a Self-determination Theory-based Intervention to Help Young Drug Abusers Quit Drugs: A Randomized Controlled Trial","The inclusion criteria of target service group (drug abusers) for this programme:\n\n* be aged 35 or below\n* be able to communicate in Cantonese\n* have an history of drug abuse within the past 12 months (including all types of drugs such as narcotics analgesics, hallucinogens, depressants, stimulants, tranquillizers and other recreational drugs)\n\nThe exclusion Criteria of target service group (drug abusers) for this programme:\n\n* psychologically or physically unable to communicate\n\nThe inclusion criteria of peer supporters:\n\n* be aged 18 - 35\n* be able to communicate in Cantonese\n* have a medical background\n* complete the training courses and pass the evaluation of peer supporter qualification\n\nThe exclusion Criteria of peer supporters:\n\n* psychologically or physically unable to communicate",{"count":169,"type":21},[24],"Aim: To test the effectiveness of a peer-led personalized support program using instant messaging applications and a self- determination theory-based intervention to help young drug abusers quit drugs.\n\nHypothesis to be tested: The investigators hypothesize that compared with those in the control group, the participants in the intervention group will experience greater success in reducing and quitting drugs and will have a better health-related quality of life at 12 months follow-up.",[197,27],"Health-risk Behaviours",[197,27],"2025-05-27",{"date":201,"type":38},"2025-05-31",{"date":203,"type":38},"2023-06-30",{"date":205,"type":21},"2026-12-31",{"name":207,"class":79},"Chinese University of Hong Kong",{"id":209,"slug":210,"hasResults":11,"nctId":211,"briefTitle":212,"officialTitle":213,"acronym":4,"eligibilityCriteria":214,"healthyVolunteers":15,"sex":16,"minAge":110,"maxAge":215,"enrollmentInfo":216,"targetDuration":4,"studyType":22,"phases":218,"briefSummary":219,"conditions":220,"keywords":227,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":232,"lastUpdatePostDateStruct":233,"startDateStruct":235,"completionDateStruct":237,"leadSponsor":239,"locationsCount":4},"100584805","team-based-learning-intervention-to-prevent-risk-factors-for-chronic-diseases---a-cluster-randomized-trial-100584805","NCT06894134","Team-based Learning Intervention to Prevent Risk Factors for Chronic Diseases - a Cluster Randomized Trial","Team-based Learning Intervention in Adolescents to Prevent Risk Factors for Chronic Diseasers - a Cluster Randomized Controlled Trial","Inclusion Criteria:\n\n* Adolescent students of high school\n* Age ranging from 15 to 19 years old.\n\nExclusion Criteria:\n\n* Cognitive limitations\n* Physical limitations\n* Communication limitations\n* Use of medications that interfere with eating, physical activity, or sleeping habits.","19 Years",{"count":217,"type":21},240,[24],"Background: Chronic diseases, such as cardiovascular diseases, diabetes, and cancer, are a major global health issue. Their modifiable risk factors, including poor diet, physical inactivity, irregular sleep, tobacco use, and excessive alcohol consumption, often emerge during adolescence and persist into adulthood. Early educational interventions can promote healthy habits and reduce their prevalence. Team-Based Learning (TBL), an active teaching method, has demonstrated effectiveness in improving knowledge and behaviors essential for a healthy lifestyle. Objective: evaluate whether a TBL-based educational intervention can improve adolescents' knowledge and habits related to chronic disease risk factors. Methods: A cluster randomized controlled trial (cRCT) will be conducted in public schools in Palmares, Brazil, targeting high school students aged 15-19 years. Fourteen schools will be randomly assigned to intervention and control groups. The intervention, consisting of four TBL modules, will cover healthy eating, physical activity, screen time, sleep, tobacco, and alcohol use, delivered by graduate nursing students under faculty supervision. Data collection will take place at three time points: pre-intervention, post-intervention, and three months later. The control group will continue receiving standard health education. Primary outcomes will assess behavioral changes, while secondary outcomes will analyze body mass index (BMI) and blood pressure. Analysis: Data will be analyzed using SPSS, with descriptive statistics, paired and unpaired t-tests, ANOVA, and chi-square tests. The analysis will account for clustering and be conducted using intention-to-treat analysis. Statistical significance will be set at p\\\u003C0.05. Conclusion: The study will provide evidence on TBL as a scalable tool for preventing risk factors in adolescents, contributing to long-term public health benefits.",[221,222,223,224,225,27,226],"Cardiovascular Diseases","Obesity Prevention","Sedentary Behaviors","Sleep Perception","Alcohol Abuse","Physical Inactivity",[228,229,230,231],"team-based learning","adolescents","prevention","chronic diseases","2025-03-25",{"date":234,"type":38},"2025-03-30",{"date":236,"type":21},"2025-09-01",{"date":238,"type":21},"2026-11-30",{"name":240,"class":79},"Professor Fernando Figueira Integral Medicine Institute",{"id":242,"slug":243,"hasResults":11,"nctId":244,"briefTitle":245,"officialTitle":245,"acronym":246,"eligibilityCriteria":247,"healthyVolunteers":15,"sex":16,"minAge":248,"maxAge":215,"enrollmentInfo":249,"targetDuration":4,"studyType":22,"phases":251,"briefSummary":252,"conditions":253,"keywords":257,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":263,"lastUpdatePostDateStruct":264,"startDateStruct":266,"completionDateStruct":268,"leadSponsor":270,"locationsCount":272},"100502140","wakaya-rising-up-for-choctaw-youth-health-100502140","NCT05818384","Wakaya: Rising Up for Choctaw Youth Health","Wakaya","Inclusion Criteria:\n\n* Be enrolled in Choctaw Nation of Oklahoma (CNO)\n* Live within CNO tribal region for 12 months\n\nYES to one of the following:\n\n* Consumed sweetened beverages or processed\u002Ffast food 2x or more per week; OR\n* Engaged in excessive sitting or lying around (\\>540 min\u002Fday) or engage in small screen recreation (\\>2 hours\u002Fday); OR\n* Physical activity - spend \\\u003C60 minutes\u002Fday outdoors or \\\u003C2.5 hrs per week in moderate or vigorous physical activity OR spend \\\u003C60 minutes a day in moderate or vigorous intensity aerobic activity; OR\n* Engage in any T.V., small screen\u002Fvideo game recreation (\\> 2 hours\u002Fday)\n\nExclusion Criteria:\n\n* opioid\u002Fmethamphetamine drug use (2 times or more in past month)\n* allergic reactions to food (e.g. peanuts), plant (poison oak or ivy) or insects (e.g. bees, fire ants) that caused difficulty in breathing or necessitated hospitalization or caused an anaphylactic reaction\n* disability that prevents student from walking or from engaging in exercise\n* aggressive, violent, combative or inappropriate behaviors\n* inability to follow directions\n* psychotic symptoms","12 Years",{"count":250,"type":21},176,[24],"Investigators will conduct a two-group randomized waitlist-control trial to assess the efficacy of the Wakaya: Rising Up for Choctaw Youth Health program on improving physical activity, reducing sedentary behaviors and improving healthful eating habits as well as delaying or reducing alcohol, tobacco and other drug use. Wakaya is an experiential, outdoor, nature-based program grounded in Choctaw values. It is a multi-level intervention that increases individual motivation and leadership skills to make healthy behavioral choices for behavior and exercise.",[254,255,256,27],"Obesity, Adolescent","Healthy Nutrition","Sedentary Behavior",[258,259,260,261,262],"Native Americans","Youth","Oklahoma","Adolescents","Obesity prevention","2025-02-18",{"date":265,"type":38},"2025-02-20",{"date":267,"type":38},"2023-04-28",{"date":269,"type":21},"2027-04-30",{"name":271,"class":79},"University of Washington",2,{"id":274,"slug":275,"hasResults":11,"nctId":276,"briefTitle":277,"officialTitle":278,"acronym":4,"eligibilityCriteria":279,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":87,"enrollmentInfo":280,"targetDuration":4,"studyType":22,"phases":282,"briefSummary":283,"conditions":284,"keywords":290,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":297,"lastUpdatePostDateStruct":298,"startDateStruct":300,"completionDateStruct":302,"leadSponsor":303,"locationsCount":4},"100431377","neurobiological-effects-of-transcranial-direct-current-stimulation-treatment-in-alcohol-use-disorder-100431377","NCT04897295","Neurobiological Effects of Transcranial Direct Current Stimulation Treatment in Alcohol Use Disorder","Neurobiological Effects of Transcranial Direct Current Stimulation Treatment in Alcohol Use Disorder: a Sham-controlled Trial.","Inclusion Criteria:\n\n* diagnosis of Alcohol Use Disorder (at least 12 months);\n* drug free\u002Fstable psychopharmacological therapy (one month), with the exception of guidelines treatments for alcoholic abstinence (treatment-as-usual);\n* any assumption of substances for at least 48 hours.\n\nExclusion Criteria:\n\n* presence of organic pathologies (capable of interfering with the safety of the procedure) in comorbidities;\n* presence of intellectual disability;\n* history of epileptic seizures (also in first degree relatives);\n* score\\> 12 on the Young Mania Rating Scale (Y-MRS).",{"count":281,"type":21},30,[24],"Background: Alcohol Use Disorder (AUD) is a complex psychiatric disorder, involving several brain areas and neurocircuits. Transcranial Direct Current Stimulation (tDCS) allows to stimulate superficial areas of brain using a weak electrical current. Preliminary data suggest that tDCS may reduce alcohol craving and consumption.\n\nObjectives: The main outcome is to test if tDCS can reduce alcohol craving and use and to assess the changes in BDNF and pro-BDNF levels. Secondary outcomes are the assessment of other psychiatric dimensions (mood, behavioral and cognitive alterations) associated with prolonged alcohol use.\n\nEligibility: Healthy, right-handed adults ages 18-65 who do have AUD (moderate to severe).\n\nDesign: This is a randomized, double-blind, sham-controlled study with three phases: 1) a tDCS intensive treatment phase; 2) follow-up with weekly tDCS stimulation; 3) follow-up without tDCS stimulation.\n\nParticipants will be screened with:\n\n* Psychometric Scales\n* Medical history\n* Physical exam\n* Urine tests and breathalyzer\n* After being enrolled, baseline behavioral and laboratory data will be collected. In particular, participants will undergo:\n* Psychometric Scales\n* Venous blood sample (BDNF\u002FproBDNF levels)\n\nParticipants will be randomized to real or sham tDCS arm. The stimulation will be delivered daily for five days during the first week (intensive treatment phase) and then weekly for 3 months (follow-up with stimulation). During this period patient will be tested with a behavioral and psychometric evaluation.Therefore, participants will receive 3 follow-up monthly visits without tDCS stimulation, in which behavioral and psychometric data will be collected.\n\nTreatment includes:\n\n* tDCS: The tDCS will be delivered with a stimulator connected to two sponge electrodes, soaked in a saline solution. The stimulation will be administered at a current intensity of approximately 1 mA, for the duration of 20 minutes. The anode will be placed on the right DLPFC, the cathode on the contralateral cortical area.\n* BDNF\u002FproBDNF levels: A venous blood sample will be collected before the first stimulation and after the last stimulation of the intensive-stimulation period (first week). The blood sample will be centrifuged within 20 minutes of sampling at 1000 × g for 15 minutes. Then, the serum will be aliquoted and stored at -80 ° C until analysis.\n* Repeat of screening tests and questionnaires\n* Urine toxicological screen and breathalyzer",[285,225,286,287,27,288,289],"Alcohol Use Disorder (AUD)","Alcohol Dependence","Alcohol-Related Disorders","Substance Use Disorders","Mental Disorder",[291,292,293,294,295,296],"Alcohol Use Disorder","transcranial Direct Current Stimulation","Non-Invasive Brain Stimulation","Craving","Brain Derived Neurotrophic Factor","Pro-Brain Derived Neurotrophic Factor","2021-10-25",{"date":299,"type":38},"2021-10-26",{"date":301,"type":21},"2021-12-01",{"date":238,"type":21},{"name":304,"class":79},"ITAB - Institute for Advanced Biomedical Technologies"]