[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"drug-use-disorders\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:drug-use-disorders":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,49,86,125],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":30,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":4},"100614575","reducing-co-occurring-substance-use-and-hiv-risk-among-stimulant-using-men-at-high-risk-for-hiv-in-the-united-states-of-america-100614575",false,"NCT07281378","Reducing Co-occurring Substance Use and HIV Risk Among Stimulant-using Men at High Risk for HIV in the United States of America.","Inclusion Criteria:\n\n1. be 18 years of age or older;\n2. be sexually active cisgender men at high risk for HIV (foreign and US-born, residing in the US)-reporting any condomless anal sex (CAS) in the past three months with a man;\n3. report use of stimulant (i.e., methamphetamine, powder cocaine, or crack-cocaine) at least one day in the past three or six month;\n4. have HIV-negative serostatus;\n5. be bilingual (Spanish and English), or Spanish or English monolingual;\n6. meet CDC criteria for PrEP eligibility.\n\nExclusion Criteria:\n\n1. display diminished capacity to consent (e.g., cognitive impairment); or\n2. severe psychiatric symptoms (e.g., psychosis) that require more intensive treatment;\n3. if they are HIV positive or living with HIV;\n4. if they are already taking PrEP; and\n5. if the participant can't consent to participate in English or Spanish.",true,"MALE","18 Years",{"count":19,"type":20},84,"ESTIMATED","INTERVENTIONAL",[23],"NA","This intervention will focus on stimulant-using men at high risk for HIV who are in need of tailored behavioral interventions to mitigate co-occurring stimulant use and HIV risk in the era of pre-exposure prophylaxis (PrEP). The study is a pilot randomized controlled trial to evaluate the adaptation, feasibility, acceptability, and preliminary efficacy of a behavioral intervention.",[26,27,28,29],"Drug Use Disorders","PrEP Uptake","PrEP Adherence","HIV Risk Behavior",[31,32,33,34,35,36],"PrEP","PrEP uptake","HIV","substance use","stimulant use","men at high risk for HIV","NOT_YET_RECRUITING","2026-06-29",{"date":40,"type":41},"2026-06-30","ACTUAL",{"date":43,"type":20},"2026-07-20",{"date":45,"type":20},"2027-12-31",{"name":47,"class":48},"University of Florida","OTHER",{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":55,"minAge":17,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":21,"phases":58,"briefSummary":59,"conditions":60,"keywords":66,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":85},"100643749","pilot-study-of-an-adapted-partner-navigation-intervention-booster-session-for-sustained-healthcare-engagement-among-people-who-inject-drugs-100643749","NCT07631559","Pilot Study of an Adapted Partner Navigation Intervention Booster Session for Sustained Healthcare Engagement Among People Who Inject Drugs","Inclusion criteria:\n\nFor index participants:\n\n* 18 years of age or older at enrollment\n* History of injecting drug use\n* Completed HCV treatment within the past 3 months\n* Report a primary injecting partner willing to participate\n* Willing and able to provide informed consent\n* English or Spanish speaking\n\nFor primary injecting partners:\n\n* Primary injecting partner of an enrolled index participant:\n* 18 years of age or older at enrollment\n* Willing and able to provide informed consent\n* English or Spanish speaking\n* has context menu\n\nExclusion criteria:\n\nFor both index participants and injecting partners:\n\n* Unable to provide informed consent due to cognitive impairment or acute intoxication at the time of enrollment\n* Previously participated in this study in any capacity","ALL",{"count":57,"type":20},50,[23],"This study builds upon an ongoing NIH-funded randomized controlled trial (R01DA053325) evaluating a Partner Navigation Intervention to increase hepatitis C virus (HCV) treatment initiation among young adult people who inject drugs (PWID) and their injecting partners in San Francisco. The proposed research includes secondary analyses of existing trial data, additional survey measures, qualitative interviews, and a pilot intervention adaptation.\n\nThe study has two primary objectives. First, it examines how racialized discrimination (structural, interpersonal, and internalized) affects HCV treatment initiation and dyadic partner support processes within injecting partnerships. Second, it evaluates whether a brief, adapted \"booster\" partner navigation session delivered at HCV treatment completion can improve engagement in ongoing healthcare.\n\nParticipants include adults (≥18 years) who inject drugs and have been diagnosed with HCV, along with their primary injecting partners. Study activities include longitudinal surveys, qualitative interviews with a subset of participants, and a pilot intervention session with follow-up evaluation.\n\nThis research addresses critical gaps in understanding how social relationships and structural inequities influence healthcare engagement among PWID. Findings will inform culturally responsive adaptations to dyadic interventions and improve continuity of care in a population disproportionately affected by HCV and systemic barriers to healthcare.",[61,62,63,26,64,65],"HEPATITIS C (HCV)","Opioid Use Disorder","Substance Use Disorder (SUD)","Healthcare Access","Harm Reduction",[67,68,69,70,71,72,73,74,75],"People who inject drugs (PWID)","Partner navigation","Dyadic intervention","Post-treatment healthcare engagement","Behavioral intervention","HCV treatment","Injecting partnerships","Feasibility pilot","Substance use","2026-06-01",{"date":78,"type":41},"2026-06-08",{"date":80,"type":20},"2026-09-01",{"date":82,"type":20},"2027-06-30",{"name":84,"class":48},"University of California, San Francisco",1,{"id":87,"slug":88,"hasResults":11,"nctId":89,"briefTitle":90,"officialTitle":91,"acronym":92,"eligibilityCriteria":93,"healthyVolunteers":11,"sex":55,"minAge":17,"maxAge":4,"enrollmentInfo":94,"targetDuration":4,"studyType":21,"phases":96,"briefSummary":97,"conditions":98,"keywords":103,"overallStatus":114,"whyStopped":4,"lastUpdateSubmitDate":115,"lastUpdatePostDateStruct":116,"startDateStruct":118,"completionDateStruct":120,"leadSponsor":122,"locationsCount":124},"100528659","evaluating-a-one-year-version-of-the-parent-child-assistance-program-100528659","NCT06163651","Evaluating a One-Year Version of the Parent-Child Assistance Program","Promoting Parent and Child Well-Being and Reducing the Need for Foster Care: An Evaluation of a One-Year, Home-Visiting and Case Management Program for People Using Substances","PCAP-1","Inclusion Criteria:\n\n* People over the age of 18\n* Parents with children under the age of 6 living with them\n* Resides within a 50-mile radius of Enid, OK or Oklahoma City, OK (for treatment group)\n\nExclusion Criteria:\n\n\\- Incarcerated at the time of enrollment",{"count":95,"type":20},80,[23],"The proposed project seeks to achieve three objectives that will, collectively, evaluate the effectiveness of a one-year version of the Parent-Child Assistance Program (PCAP-1) -a model for a home visitation and case management program for parents who used substances. First, the proposed project aims to estimate the causal impact of PCAP-1 on preventing the need for foster care and promoting reunification. Second, the project will estimate PCAP-1's effectiveness in achieving other program goals: parent recovery, parent's connection with needed comprehensive community resources, and preventing future children from being exposed to drugs and alcohol. Finally, causal evidence of program effectiveness across the prior two objectives would enable PCAP-1 to be rated according to strength of evidence on relevant federal registries (i.e., FFPSA and HOMEVEE). All objectives will be pursued with substantial backing from public and private partners, including the Oklahoma Department of Human Services (OK's Title IV-E agency). This quasi-experimental project will recruit 40 new participants to receive one year of PCAP-1 services. It will use administrative data on participants from the Oklahoma Department of Human Services for the control group. Given that the population PCAP serves are disproportionately poor and low-income and PCAP is designed to be culturally competent and relevant, PCAP-1 harbors the potential to address inequities in child welfare outcomes, substance use disorder treatment services, and child and family well- being by improving outcomes for these families. With a strong backing by state agencies and community partners, the evaluation of PCAP-1 will contribute to a knowledge gap in the field for in-home program models serving a highly vulnerable population with high rates of child welfare involvement and use of foster care.",[99,100,101,26,102],"Alcohol Use Disorder","Substance Use Disorders","Alcohol Use Complicating Pregnancy, Unspecified Trimester","Drug Use Complicating Pregnancy, Unspecified Trimester",[104,105,106,107,108,109,110,111,112,113],"Parent-Child Assistance","Substance Use Disorder","Addictions","Drug Dependence","Drug Abuse","Alcohol Dependence","Alcohol Abuse","Alcoholism","Recovery Services","PCAP","RECRUITING","2025-06-30",{"date":117,"type":41},"2025-07-03",{"date":119,"type":41},"2025-06-23",{"date":121,"type":20},"2026-09-30",{"name":123,"class":48},"University of Oklahoma",2,{"id":126,"slug":127,"hasResults":11,"nctId":128,"briefTitle":129,"officialTitle":130,"acronym":4,"eligibilityCriteria":131,"healthyVolunteers":11,"sex":132,"minAge":17,"maxAge":4,"enrollmentInfo":133,"targetDuration":4,"studyType":21,"phases":135,"briefSummary":136,"conditions":137,"keywords":151,"overallStatus":114,"whyStopped":4,"lastUpdateSubmitDate":161,"lastUpdatePostDateStruct":162,"startDateStruct":164,"completionDateStruct":166,"leadSponsor":168,"locationsCount":124},"100480329","the-oklahoma-parent-child-assistance-program-100480329","NCT05534568","The Oklahoma Parent-Child Assistance Program","A Randomized Controlled Trial of the Parent-Child Assistance Program in Oklahoma","Inclusion Criteria:\n\n* 18 years or older\n* Women who have used alcohol, opioids, or other drugs during pregnancy\n* Women who are (1) pregnant or have a child under 24 months old who was exposed to substances and are not well connected to community services or (2) have a child with fetal Alcohol Spectrum Disorder and are currently with at-risk alcohol use and in childbearing years\n* Resides in Oklahoma City, Oklahoma or Tulsa, Oklahoma\n\nExclusion Criteria:\n\n* Not meeting eligible criteria above\n* Incarcerated at the time of enrollment\n* Enrollment in similar services (i.e., ReMerge, Systems of Care (SOC) and\u002For Family Treatment Courts (FTC) and heading to Termination of Parental Rights (TPR))\n* If the participant is receiving services from the Substance use Treatment and Recovery (STAR) Prenatal Clinic and is part of the research, their enrollment in PCAP will be delayed until STAR Prenatal Clinic graduation","FEMALE",{"count":134,"type":20},200,[23],"The Parent-Child Assistance Program (PCAP) helps mothers who have used alcohol, opioids, or other drugs during pregnancy and their children through the work of highly trained, closely supervised case managers. Case managers work closely with mothers over the course of three years, meeting the mothers in their own homes when possible, to help them to set goals and take advantage of available resources. The primary aims of PCAP include: (1) assisting mothers in obtaining substance use disorder (SUD) treatment and staying in recovery, (2) linking mothers to community resources that will help them build and maintain healthy, independent family lives for themselves and their children, and (3) preventing future drug and alcohol use during pregnancy.\n\nThis study brings PCAP to Oklahoma (the state with the highest incarceration rate for women, where most enter the criminal justice system for drug charges) for the first time. This five-year project includes 200 women who will enroll in the study and be randomly assigned to the treatment (100 women) or control group (100 women). The intervention (i.e., PCAP services) will take place over a three-year period at two sites: Oklahoma City, Oklahoma and Tulsa, Oklahoma.\n\nThis evaluation will measure participants' substance use, substance use disorder (SUD) treatment outcomes, and a host of other well-being outcomes-including but not limited to subsequent substance-exposed births, use of public assistance, education, use of family planning methods, and employment-to evaluate the effects of PCAP services. Among these, the investigators have identified four key outcomes: (1) the mother is on a reliable method of birth control, (2) abstinence for six months, (3) child custody (i.e., placement of children in foster care and\u002For with kinship providers), and (4) criminal justice involvement.",[100,138,139,140,141,142,101,143,144,145,26,146,147,148,102,149,150],"Pregnancy Related","Alcohol Use Disorder (AUD)","Alcohol Use Complicating Pregnancy, First Trimester","Alcohol Use Complicating Pregnancy, Second Trimester","Alcohol Use Complicating Pregnancy, Third Trimester","Alcohol Use Complicating Pregnancy, Childbirth, and the Puerperium","Fetal Alcohol Spectrum Disorders","Fetal Alcohol Syndrome","Drug Use Complicating Pregnancy, First Trimester","Drug Use Complicating Pregnancy, Second Trimester","Drug Use Complicating Pregnancy, Third Trimester","Drug Use Complicating Pregnancy, Childbirth, and the Puerperium","Maternal Drugs Affecting Fetus",[152,153,154,155,156,157,158,159,160,113],"Parent-child assistance","Substance use disorder","addictions","drug dependence","drug abuse","alcohol dependence","alcohol abuse","alcoholism","recovery services","2024-06-05",{"date":163,"type":41},"2024-06-07",{"date":165,"type":41},"2022-11-15",{"date":167,"type":20},"2026-11-15",{"name":123,"class":48}]