[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"dual-diagnosis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:dual-diagnosis":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,45,82],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100443464","crp-and-sa-for-inpatient-veterans-100443464",false,"NCT05054738","CRP and S&A for Inpatient Veterans","Impact of Combined Recovery Program and Home Telehealth Among Veterans With Substance Use Disorders in the VA Inpatient Setting","CRP and S&A","Inclusion Criteria:\n\n* Meeting DSM-V criteria for current SUD diagnosis of alcohol and\u002For illicit drug use disorder\n* Use of substances in past 30 days prior to date of index inpatient admission\n* Able to comprehend English\n* Able to provide informed consent\n* Functioning at an intellectual level sufficient to allow accurate completion of all assessments\n* Willing to commit to 6 group inpatient therapy sessions, telehealth S\\&A, as well as baseline, and 1-and 3-month follow-up assessments\n\nExclusion Criteria:\n\n* Auditory or visual impairment that would interfere with study procedures\n* Inability to speak or understand English\n* Acutely psychotic patients","ALL","18 Years",{"count":20,"type":21},195,"ESTIMATED","INTERVENTIONAL",[24],"NA","The purpose of this study is to evaluate how well three types of treatments work to improve the outcomes for people with substance use problems. Veterans admitted to the Charleston VA Psychiatric inpatient unit may be invited to participate. The three types of treatments that will be evaluated are:\n\n1. Combined Recovery Program (CRP), a six-session treatment group delivered on the inpatient unit.\n2. A Home Telehealth program, called Stable and Able (S\\&A), provided just prior to discharge and provides additional support for up to 3 months\n3. Treatment-as-usual (TAU), which is the treatment currently provided on the unit, consisting of various mental health topics and sessions designed to help with recovery.\n\nParticipation begins on the inpatient unit, beginning with CRP and\u002For TAU, and may continue with S\\&A post discharge. Participants will be followed up at 1 and 3- months post treatment.",[27,28,29],"Alcoholism","Substance-related Disorders","Dual Diagnosis",[27,31,29],"Substance-related disorders","RECRUITING","2026-04-27",{"date":35,"type":36},"2026-05-04","ACTUAL",{"date":38,"type":36},"2022-09-06",{"date":40,"type":21},"2026-12-31",{"name":42,"class":43},"VA Office of Research and Development","FED",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":55,"phases":4,"briefSummary":56,"conditions":57,"keywords":60,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":44},"100627007","psychosocial-factors-in-dual-diagnosis-in-a-general-hospital-100627007","NCT07443033","Psychosocial Factors in Dual Diagnosis in a General Hospital","Psychosocial Protective Factors and Clinical-Functional Outcomes in Hospitalized Patients With Dual Diagnosis: An Observational, Cross-Sectional, Single-Center Study","DUAL-HVP","Inclusion Criteria:\n\n* Adults (≥18 years).\n* Hospitalized patients with a clinical diagnosis of dual diagnosis.\n* Ability to provide informed consent.\n\nExclusion Criteria:\n\n* Severe cognitive impairment or acute clinical condition preventing assessment.\n* Refusal or inability to provide informed consent.",{"count":54,"type":21},125,"OBSERVATIONAL","Dual diagnosis, defined as the co-occurrence of a mental disorder and a substance use disorder, is frequently associated with increased clinical severity, functional impairment, and poorer health outcomes. Identifying psychosocial protective factors related to better clinical and functional outcomes is essential to improve patient care and treatment planning.\n\nThe aim of this observational, cross-sectional, single-center study is to analyze psychosocial protective factors and their association with clinical-functional outcomes in hospitalized patients with dual diagnosis. The study will be conducted in a general hospital setting and will include adult inpatients diagnosed with dual diagnosis according to clinical criteria.\n\nSociodemographic, clinical, and psychosocial variables will be collected using standardized assessment tools and clinical records. The results of this study are expected to contribute to a better understanding of psychosocial factors associated with clinical severity and functional outcomes in patients with dual diagnosis, supporting more comprehensive and patient-centered care approaches.",[29,58,59],"Substance Use Disorder","Mental Disorders",[61,62,63,64,65,66,67,68,69,70],"Addiction psychiatry","Mental health","Cross-sectional study","Observational study","Hospitalized patients","Functional outcomes","Clinical outcomes","Protective factors","Psychosocial factors","Dual diagnosis","NOT_YET_RECRUITING","2026-02-24",{"date":74,"type":36},"2026-03-02",{"date":76,"type":21},"2026-03-01",{"date":78,"type":21},"2027-04-30",{"name":80,"class":81},"Hospital Virgen del Puerto","OTHER_GOV",{"id":83,"slug":84,"hasResults":11,"nctId":85,"briefTitle":86,"officialTitle":87,"acronym":4,"eligibilityCriteria":88,"healthyVolunteers":11,"sex":17,"minAge":89,"maxAge":90,"enrollmentInfo":91,"targetDuration":4,"studyType":22,"phases":93,"briefSummary":94,"conditions":95,"keywords":101,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":107,"startDateStruct":109,"completionDateStruct":111,"leadSponsor":113,"locationsCount":116},"100540053","building-social-and-structural-connections-for-the-prevention-of-opioid-use-disorder-among-youth-experiencing-homelessness-100540053","NCT06311838","Building Social and Structural Connections for the Prevention of Opioid Use Disorder Among Youth Experiencing Homelessness","Building Social and Structural Connections for the Prevention of Opioid Use Disorder Among Youth Experiencing Homelessness: An RCT Examining Biopsychosocial Mechanisms","Inclusion Criteria:\n\n* Youth must meet the criteria for homelessness as defined by the McKinney-Vento Act: children and youth who lack a fixed, regular, and adequate nighttime residence; or live in a welfare hotel, or place without regular sleeping accommodations, or live in a shared residence with other persons due to the loss of one's housing or economic hardship\n* Must speak english adequately to complete measures\n\nExclusion Criteria:\n\n* Youth who have a stable housing situation.\n* Non-English speaker","14 Years","24 Years",{"count":92,"type":21},300,[24],"Homelessness severely affects health and well-being and is particularly negative for youth. Between 70-95% of youth experiencing homelessness (YEH) report problem substance use and 66-89% have a mental health disorder. Youth appear to be at greater risk for living on the streets or being homeless than adults and are more vulnerable to long term consequences of homelessness. Multiple social determinants of health (SDOH) are uniquely associated with homelessness, driving substance use and adverse mental health consequences. However, limited research has identified pragmatic interventions that have a long-term ameliorating impact on the complex, multi-symptomatic issues among these youth. This study overcomes prior gaps in research through testing a multi-component comprehensive prevention intervention targeting SDOH that may affect biopsychosocial health indicators and longer-term health outcomes. In partnership with a drop-in center for YEH, youth between the ages of 14 to 24 years, will be engaged and randomly assigned to conditions using a dismantling design so that essential intervention components can be efficiently identified. In particular, youth (N = 300) will be randomly assigned to a) Motivational Interviewing\u002FCommunity Reinforcement Approach + Services as Usual (MI\u002FCRA + SAU, n = 80), b) Strengths-Based Outreach and Advocacy + Services As Usual (SBOA + SAU, n = 80), c) MI\u002FCRA + SBOA + SAU (n = 80) or d) SAU (n=60) through the drop-in center. In order to assess the longer-term prevention effects on substance use, mental health and other outcomes, all youth will be assessed at baseline and at 3, 6, 12, 18 and 24-months post-baseline. The primary goal of this study is to establish the impact of a comprehensive intervention embedded within a system that serves YEH, a community drop-in center, on youth's opioid misuse and disorder, other substance misuse and disorders, mental health diagnoses, and other targeted outcomes. This study will offer unique information on the physiological and psychological stress pathways underlying change for specific subgroups of youth along with cost estimates to inform future implementation efforts in drop-in centers around the country.",[96,29,97,98,99,100],"Opioid Use Disorder","Housing Problems","Mental Disorder in Adolescence","Risk Behavior","Homelessness",[102,103,104,105],"youth experiencing homelessness","social determinants of health","opioid use disorder","substance use","2025-09-18",{"date":108,"type":36},"2025-09-22",{"date":110,"type":36},"2024-05-06",{"date":112,"type":21},"2029-12-01",{"name":114,"class":115},"Ohio State University","OTHER",2]