[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"dynamic-arterial-elastance\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:dynamic-arterial-elastance":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100588171","effect-of-dynamic-arterial-elastance-and-assisted-fluid-management-software-guided-resuscitation-in-septic-shock-pilot-study-100588171",false,"NCT06937918","Effect of Dynamic Arterial Elastance and Assisted Fluid Management Software Guided Resuscitation in Septic Shock: Pilot Study","Effect of Dynamic Arterial Elastance and Assisted Fluid Management Software Guided Adjustment of Vasopressor and Fluid Therapy in Septic Shock Resuscitation; A Pilot Study","DAFM shock","Inclusion Criteria:\n\n* All Thai consecutive patients older than 18 years with a diagnosis of sepsis or septic shock in medical ICU, defined by clinically suspected or confirmed infection and MAP \\\u003C65 mmHg according to the criteria of the Surviving Sepsis Campaign 2021(11)with onset of shock in less than 24 hours.\n* Already receiving or planning for mechanical ventilation\n* Already receiving or planning for arterial catheter placement for invasive arterial pressure monitoring\n* All patients will receive an echocardiogram with a cut point of LVEF \\> 30% to be included in the study\n\nExclusion Criteria:\n\n* Active, immediate, life-threatening cardiac arrhythmia, defined as ventricular tachycardia and ventricular fibrillation\n* Acute cerebral vascular event, including both acute ischemic stroke or intracranial hemorrhage\n* Acute coronary syndrome\n* cardiogenic shock, acute heart failure\n* Severe asthma exacerbation\n* Fluid intolerance: hypoxemia (P:F ratio \\\u003C 150)\n* Life-threatening gastrointestinal hemorrhage\n* Pregnancy\n* Requirement for immediate surgery within 2 hours of randomization\n* Advanced-stage cancer with predicted survival of less than 6 months\n* Oliguric AKI with signs of volume overload\n\nWithdrawal or termination criteria\n\n* The patient and legal representative request for withdrawal\n* The attending physician requested a withdrawal","ALL","18 Years",{"count":20,"type":21},60,"ESTIMATED","INTERVENTIONAL",[24],"NA","To investigate the benefit of using the AFM and Eadyn-guided fluid and vasopressor therapy in septic shock resuscitation for mechanically ventilated patients compared with the standard of care. The investigators hypothesize that using the AFM and Eadyn-guided fluid\u002Fvasopressor titration in septic shock patients who underwent mechanical ventilation might reduce the time to shock reversal.",[27,28,29,30],"Critical Illness","Fluid Over-load","Dynamic Arterial Elastance","Septic Shock",[32,33,34,35,36,37],"critical illness","dynamic arterial elastance","stroke volume change prediction","fluid overload","ischemic complication","septic shock","RECRUITING","2025-04-22",{"date":41,"type":42},"2025-04-27","ACTUAL",{"date":44,"type":21},"2025-04-23",{"date":46,"type":21},"2028-04-08",{"name":48,"class":49},"Mahidol University","OTHER",3]