[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"dynamic-cerebral-autoregulation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:dynamic-cerebral-autoregulation":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":5},"100606771","remote-ischaemic-conditioning-in-the-older-person-and-effects-on-dynamic-cerebral-autoregulation-100606771",false,"NCT07179887","Remote Ischaemic Conditioning in the Older Person and Effects on Dynamic Cerebral Autoregulation","RICE-DCA","Inclusion Criteria:\n\n* Participant is willing and able to give informed consent for participation in the study\n* Participant aged 65 - 85\n* Participant is able to perform RIC independently at home\n\nExclusion Criteria:\n\n* Active cardiovascular or cerebrovascular disease (acute event within the last 12 months)\n* Atrial fibrillation or other significant arrhythmias\n* Peripheral Vascular Disease\n* Haemostatic disorders\n* Soft tissue injury or fracture to the upper limb\n* Pregnant or breast feeding\n* History or current psychiatric illness\n* History or current neurological condition (e.g. epilepsy)\n* Inability to identify temporal window for transcranial doppler ultrasound at screening visit\n* Any condition or presentation under current investigation that is deemed by the study clinician to exclude the participant from the study.\n* Having taken part in a research study in the last 3 months involving invasive procedures or an inconvenience allowance",true,"ALL","65 Years","85 Years",{"count":21,"type":22},45,"ESTIMATED","INTERVENTIONAL",[25],"NA","Remote Ischaemic Conditioning (RIC) is the process of inducing short periods of ischaemia in a limb with the aim of improving vascular health systemically. Recent findings have demonsatrated efficacy in a variety of clinical settings. However, the ideal protocol of RIC \\[dose\\] is unknown. Dynamic Cerebral Autoregulation (dCA) has been shown to increase in response to RIC.\n\nThe goal of this trial is to study whether an increase in RIC protocol intensity results in a larger effect on biomarkers of vascular health such as dCA.\n\nParticipants shall:\n\nReceive RIC daily, RIC thrice weekly or sham RIC thrice weekly for 6 weeks Visit the School of Medicine at baseline and at 6 weeks for measurement of biomarkers of vascular health including blood pressure, indices od dCA and blood plasma samples",[28,29,30],"Cerebral Autoregulation","Blood Pressure","Dynamic Cerebral Autoregulation",[32,30,33,34],"Remote Ischaemic Conditioning","Vascular Health","Randomised Controlled Trial","RECRUITING","2025-09-15",{"date":38,"type":39},"2025-09-18","ACTUAL",{"date":41,"type":39},"2025-08-27",{"date":43,"type":22},"2027-09-30",{"name":45,"class":46},"University of Nottingham","OTHER"]