[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"dynapenia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:dynapenia":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,46,76],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100634012","blood-flow-restriction-parameters-and-lower-limb-function-in-older-adults-with-dynapenia-100634012",false,"NCT07534150","Blood Flow Restriction Parameters and Lower Limb Function in Older Adults With Dynapenia","The Effects of Blood Flow Restriction Training Parameters on Lower Limb Muscle Function in Elderly Adults With Dynapenia: Mechanism and Intervention Outcomes","Inclusion Criteria\n\n* Aged 55 years and older.\n* No regular physical activity within the past three months, defined as exercising no more than twice per week.\n* No cognitive impairment and able to follow exercise and assessment instructions.\n\nExclusion Criteria\n\n* Have contraindications to exercise, such as severe musculoskeletal problems, osteoporosis, deep vein thrombosis, or coagulation disorders.\n* Have comorbid conditions that are severe or end-stage, such as stroke diagnosed by a neurologist, diabetes with severe complications (e.g., retinopathy), or cardiovascular disease including heart failure, coronary ischemia, or arrhythmia.\n* Have high-risk factors for exercise, such as uncontrolled hypertension (systolic blood pressure \\>160 mmHg or diastolic blood pressure \\>100 mmHg), angina or chest tightness during exercise, or deep vein thrombosis.\n* Have a history of hematologic disorders or are currently taking blood-related medications, such as hormones or anticoagulants.\n* Are expected to move out of the local community within three months.",true,"ALL","55 Years","85 Years",{"count":21,"type":22},720,"ESTIMATED","INTERVENTIONAL",[25],"NA","The objective of the first year is to collect limb occlusion pressure (LOP) measurements in older adults with varying levels of muscle health, which will serve as foundational data for subsequent investigations on blood flow restriction (BFR) combined with resistance training in individuals with dynapenia. This phase aims to examine LOP values and their potential influencing factors, including demographic and physiological characteristics such as age, height, body weight, blood pressure, waist circumference, body fat percentage, medical history of chronic diseases, and habitual physical activity. Muscle-related assessments will include skeletal muscle mass, thigh and calf circumference, handgrip strength, and lower limb muscle strength. Functional performance will be evaluated using the five-times sit-to-stand test and the SARC-F questionnaire for sarcopenia risk screening. LOP of the lower limbs will be measured using a BFR cuff system combined with a laboratory-developed blood flow detection device. The study will further investigate whether LOP values are associated with the aforementioned factors.\n\nThe objective of the second year is to utilize high-density surface electromyography (dEMG) to analyze the electrophysiological characteristics of muscle contraction in individuals with sarcopenia under varying BFR pressures and resistance intensities. This includes examining motor unit recruitment patterns and recruitment thresholds, with the goal of identifying effective and appropriate BFR exercise parameters for this population.\n\nThe objective of the third year is to investigate the effects of lower limb BFR combined with resistance training on functional performance in individuals with dynapenia. Building upon the findings from the first year, this phase will implement BFR resistance training interventions and evaluate both short-term and long-term effects. Through an experimental design, the study will assess changes in body composition, muscle strength, and functional performance following a four-month intervention, along with a three-month follow-up period, to determine whether participants can improve to a healthy status and maintain these improvements over time.",[28],"Dynapenia",[30,31,28,32],"Blood Flow Restriction Training","Elderly","Occlusion Pressure","NOT_YET_RECRUITING","2026-04-15",{"date":36,"type":37},"2026-04-16","ACTUAL",{"date":39,"type":22},"2026-04",{"date":41,"type":22},"2028-12",{"name":43,"class":44},"Kaohsiung Medical University","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":17,"minAge":53,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":23,"phases":57,"briefSummary":58,"conditions":59,"keywords":61,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":4},"100606817","effectiveness-of-whole-body-vibration-on-health-outcomes-in-older-adults-with-dynapenic-abdominal-obesity-100606817","NCT07180485","Effectiveness of Whole Body Vibration on Health Outcomes in Older Adults With Dynapenic Abdominal Obesity","The Effectiveness of Whole Body Vibration Training in Improving Brain Activity, Bone Mineral Density, Quality of Life, and Biomarkers for the Older People With Dynapenic Abdominal Obesity","Inclusion Criteria:\n\nOutpatients aged 65 years or older\n\nDiagnosed with dynapenic abdominal obesity\n\nAble to understand and follow simple instructions\n\nAble to communicate clearly and express their own will\n\nWilling to sign the informed consent form\n\nExclusion Criteria:\n\nInability to communicate in Mandarin or Taiwanese, resulting in inability to participate in research activities\n\nSevere visual or hearing impairment that hinders study participation\n\nPresence of cognitive impairment, musculoskeletal or severe osteoporosis-related conditions\n\nRefusal to sign the informed consent form","65 Years","100 Years",{"count":56,"type":22},120,[25],"This study focuses on whole body vibration training (WBVT), a form of neuromuscular training that uses mechanical vibrations. WBVT has been shown to improve muscle function, bone mineral density, and quality of life. While some benefits have been observed in the elderly population, there remains a research gap concerning its effectiveness in older adults with dynapenic abdominal obesity. Therefore, the findings of this study will provide new evidence for health interventions targeting this specific group.\n\nThis research targets outpatients aged 65 and above who meet the criteria for dynapenic abdominal obesity. It aims to evaluate the effects of WBVT on brain activity, osteoporosis, quality of life, and biological markers. The study period is from February 1, 2025, to January 31, 2027, with a planned sample size of 120 participants, equally divided into an experimental group and a control group (60 participants each).",[28,60],"Abdominal Obesity",[62,63,64,65,66],"whole-body vibration training","brain activity","bone mineral density","quality of life","biomarkers","2025-09-16",{"date":69,"type":37},"2025-09-18",{"date":71,"type":22},"2025-10-01",{"date":73,"type":22},"2027-10-01",{"name":75,"class":44},"Dalin Tzu Chi General Hospital",{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":80,"acronym":4,"eligibilityCriteria":81,"healthyVolunteers":16,"sex":17,"minAge":82,"maxAge":83,"enrollmentInfo":84,"targetDuration":4,"studyType":86,"phases":4,"briefSummary":87,"conditions":88,"keywords":91,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":103,"locationsCount":4},"100563877","effect-of-the-presence-of-dynapenia-on-posture-spine-muscle-elasticity-strength-and-endurance-in-young-adults-100563877","NCT06621875","Effect Of The Presence Of Dynapenia On Posture, Spine Muscle Elasticity, Strength And Endurance In Young Adults","Inclusion Criteria:\n\n* Being between the ages of 18-25\n* Filling out all the survey questions\n\nExclusion Criteria:\n\n* Presence of chronic diseases that may affect the musculoskeletal system (diabetes, heart disease, neurological disorders)\n* Use of medications that may affect muscle functions (corticosteroids, muscle relaxants)\n* Presence of serious musculoskeletal injury within the last six months\n* Presence of surgery and\u002For pain related to the musculoskeletal system\n* History of eating disorders such as anorexia nervosa, bulimia nervosa were defined as exclusion criteria","18 Years","25 Years",{"count":85,"type":22},40,"OBSERVATIONAL","The aim of the present study was to determine the effect of dynapenia on posture, spinal muscle elasticity, strength and endurance in young adults.",[28,89,90],"Muscle Weakness","Sarcopenia",[92,90,93,94,95,28,96],"Muscle strength","Posture","Muscle elasticity","Muscle endurance","Hand Grip","2024-10-13",{"date":99,"type":37},"2024-10-16",{"date":101,"type":22},"2024-11-01",{"date":71,"type":22},{"name":104,"class":44},"Aynur Ayazzade"]