[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"dysequilibrium-syndrome\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:dysequilibrium-syndrome":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":5},"100544234","phase-1-adding-urea-to-the-final-dialysis-fluid-100544234",false,"NCT06366230","Adding Urea to the Final Dialysis Fluid","Adding Urea to the Final Dialysis Fluid in Order to Prevent Dialysis Disequilibrium in Patients Who Need Aggressive Dialysis for Electrolyte Abnormalities","Urea dialysate","Inclusion Criteria:\n\n* Serum Urea \\> 120\n* Serum Potassium \\> 5.5 or serum CO2 \\\u003C 15 or need for aggressive dialysis due to toxic ingestion\n* need for dialysis\n\nExclusion Criteria:\n\n* Pediatric\n* need for CRRT","ALL","18 Years",{"count":20,"type":21},20,"ESTIMATED","INTERVENTIONAL",[24,25],"PHASE1","PHASE2","At times patients with advanced renal failure present with severe hyperkalemia or acidosis and very high serum blood urea nitrogen (BUN) concentrations. These patients cannot be dialyzed aggressively as the lowering of serum BUN may results in disequilibrium syndrome but on the other hand they need aggressive dialysis in order to lower their serum potassium or fix their severe acidosis. If one is able to add urea to the dialysis fluid, one can prevent the rapid lowering of serum BUN and osmolality at the same time as doing aggressive dialysis to lower serum potassium and\u002For fix the metabolic acidosis.",[28,29,30,31],"Dysequilibrium Syndrome","ESRD","Hyperkalemia","Metabolic Acidosis",[29,33,34,35,36],"Urea","Disequilibrium","Potassium","Acid\u002Fbase","RECRUITING","2026-02-09",{"date":40,"type":41},"2026-02-12","ACTUAL",{"date":43,"type":41},"2025-09-16",{"date":45,"type":21},"2028-06-30",{"name":47,"class":48},"University of California, San Francisco","OTHER"]