[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"dysfunctional-voiding\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:dysfunctional-voiding":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,44,66,94],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100633191","local-injection-of-botulinium-toxin-a-in-children-with-dysfunctional-voiding-or-refractory-nocturnal-eneuresis-100633191",false,"NCT07523477","Local Injection of Botulinium Toxin-A in Children With Dysfunctional Voiding or Refractory Nocturnal Eneuresis","Evaluation of Local Injection of Botulinium Toxin-A in Children With Dysfunctional Voiding or Refractory Nocturnal Eneuresis","Inclusion Criteria:\n\n* Children \\\u003C 18 years.\n* Both sexes.\n* Patients with refractory nocturnal enuresis or dysfunctional voiding who are not responding to the traditional treatment.\n\nExclusion Criteria:\n\n* Bleeding disorders.\n* Neuromusclar disorder(e.g.,Myasthenia gravis).\n* Patients who are not fit for anaesthesia.\n* Active urinary tract infection (UTI).","ALL","18 Years",{"count":19,"type":20},64,"ESTIMATED","INTERVENTIONAL",[23],"NA","The aim of this study is to evaluate the outcome of botulinum toxin A (BTX-A) injection for management of children with :\n\nA-Dysfunctional voiding who are not responding to traditional treatment. B-Refractory nocturnal enuresis.",[26,27,28,29,30],"Local Injection","Botulinium Toxin-A","Children","Dysfunctional Voiding","Refractory Nocturnal Eneuresis","RECRUITING","2026-04-05",{"date":34,"type":35},"2026-04-13","ACTUAL",{"date":37,"type":35},"2025-06-01",{"date":39,"type":20},"2026-12-01",{"name":41,"class":42},"Tanta University","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":17,"enrollmentInfo":51,"targetDuration":4,"studyType":21,"phases":53,"briefSummary":54,"conditions":55,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":59,"startDateStruct":61,"completionDateStruct":63,"leadSponsor":65,"locationsCount":43},"100604439","standard-urotherapy-with-or-without-biofeedback-based-pelvic-floor-muscle-training-for-dysfunctional-voiding-in-children-100604439","NCT07149532","Standard Urotherapy With or Without Biofeedback-Based Pelvic Floor Muscle Training for Dysfunctional Voiding in Children","Standard Urotherapy With or Without Biofeedback-Based Pelvic Floor Muscle Training for Dysfunctional Voiding in Children: A Randomized Clinical Study","Inclusion Criteria:\n\n* Children less than 18 years old.\n* Both sexes.\n* Children with dysfunctional voiding.\n\nExclusion Criteria:\n\n* Patients with cognitive function impairment.\n* Patients who received any care for dysfunctional voiding.\n* Children with known anatomical anomalies of the urinary tract.\n* Children with known neurological anomalies (spinal dysraphism, multiple sclerosis, lumbar or spinal neuritis……… etc).\n* Children with a history of back or lower urinary tract trauma.",{"count":52,"type":20},124,[23],"This study aims to compare the efficiency of biofeedback therapy alone versus biofeedback therapy with medical treatment for dysfunctional voiding in children.",[56,57,29,28],"Biofeedback","Medical Treatment","2026-03-03",{"date":60,"type":35},"2026-03-05",{"date":62,"type":35},"2025-02-26",{"date":64,"type":20},"2026-04-01",{"name":41,"class":42},{"id":67,"slug":68,"hasResults":11,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":4,"eligibilityCriteria":72,"healthyVolunteers":11,"sex":16,"minAge":73,"maxAge":17,"enrollmentInfo":74,"targetDuration":4,"studyType":21,"phases":76,"briefSummary":77,"conditions":78,"keywords":79,"overallStatus":84,"whyStopped":4,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":43},"100585990","use-of-an-educational-video-to-improve-adherence-to-treatment-in-voiding-dysfunction-100585990","NCT06909552","Use of an Educational Video to Improve Adherence to Treatment in Voiding Dysfunction","Use of an Educational Video to Improve Caregiver Knowledge, Adherence to Recommendations, and Outcomes in Children With Dysfunctional Voiding","Inclusion Criteria:\n\n* Parents and Caregivers of pediatric urology patients with a diagnosis of Dysfunctional voiding (minimum 100 participants)\n* 5-18 years old, no younger than 5 and no older than 18 years old\n* Potty-trained - fully independent with toileting, can complete every step of the process and can do so satisfactorily by themselves.\n\nExclusion Criteria:\n\n* Children with Voiding dysfunctionDysfunctional voiders with medically complex conditions (neurogenic bladder, POTS, EDS, etc.)\n* Parent's child is notNot a first-time patient (i.e. has been seen in the past for dysfunctional voiding)\n* Child has severeSevere intellectual disability, developmental delay, or cognitive impairment.","5 Years",{"count":75,"type":20},100,[23],"This study aims to see whether an educational video on a common urinary dysfunction leads to improved parent and child perceived adherence to treatments recommendations.",[29],[80,81,82,83],"dysfunctional voiding","educational video","treatment adherence","behavioral modification","NOT_YET_RECRUITING","2025-07-21",{"date":87,"type":35},"2025-07-25",{"date":89,"type":20},"2025-08-01",{"date":91,"type":20},"2027-07-31",{"name":93,"class":42},"University of Colorado, Denver",{"id":95,"slug":96,"hasResults":11,"nctId":97,"briefTitle":98,"officialTitle":98,"acronym":4,"eligibilityCriteria":99,"healthyVolunteers":11,"sex":16,"minAge":100,"maxAge":101,"enrollmentInfo":102,"targetDuration":4,"studyType":104,"phases":4,"briefSummary":105,"conditions":106,"keywords":108,"overallStatus":84,"whyStopped":4,"lastUpdateSubmitDate":112,"lastUpdatePostDateStruct":113,"startDateStruct":115,"completionDateStruct":117,"leadSponsor":119,"locationsCount":43},"100373849","case-control-study-to-investigate-the-use-of-urethral-pressure-profile-measurement-in-children-100373849","NCT04147793","Case Control Study to Investigate the Use of Urethral Pressure Profile Measurement in Children","Inclusion Criteria All subjects • Age 7-16 years inclusive\n\nControls\n\n* Concurrent urological disease requiring surgery which includes cystoscopy\n* No significant urinary symptoms\n* No day-time urinary incontinence\n* Urinary frequency 4-7 per day\n* No history of recurrent urinary infections (more than two infections in previous year)\n* Has not passed a renal tract stone\n\nOveractive sphincter\n\n* Require VCMG as part of their clinical care\n* A prior diagnosis of dysfunctional voiding. This will have been made in a neurologically intact child following previous non-invasive bladder investigation including two representative urine flows that demonstrate the following (Austin et al., 2014):\n\n  * Intermittent and\u002For fluctuating flow rate\n  * Pelvic EMG activity during voiding\n* either perform intermittent catheterisation or have no contraindication to Entonox sedation (see below)\n\nUnderactive sphincter\n\n* Have either:\n\n  * Symptoms of stress urinary incontinence\n  * Or urinary incontinence with a neuropathic bladder\n* Require VCMG as part of their clinical care.\n* either perform intermittent catheterisation or have no contraindication to Entonox sedation (see below)\n* For the UPP data to be included for analysis their videocystometry should demonstrate o Stress urinary incontinence: defined as involuntary leakage of urine during increased abdominal pressure, in the absence of a detrusor contraction (Austin et al., 2014)\n\nExclusion Criteria:\n\n* Unaccompanied by adult with parental responsibility who can give consent\n* Previous bladder outlet or urethral surgery\n* Other urological disease not mentioned specifically in the treatment group inclusion criteria; including posterior urethral valves, cerebral palsy, inherited metabolic disease\n* Contraindication to Entonox if sedation required for catheter insertion:\n\n  * Conditions where gas may be trapped in a body cavity, eg middle ear occlusion, intestinal obstruction\n  * Unable to understand instruction for use of Entonox\n* Evidence urinary tract infection on day UPP measurement\n\n  * Symptoms of dysuria\n  * Abnormally cloudy or offensive urine\n  * Temperature of 38oc or more\n* Urine dipstick positive nitrates or leucocytes on the day of the study, in the absence of a renal tract stone or indwelling catheter","7 Years","16 Years",{"count":103,"type":20},36,"OBSERVATIONAL","The bladder has a muscle that acts like a tap called the sphincter. Just like a tap, when pee is stored the sphincter muscle is closed and during peeing the sphincter opens. Sometimes the sphincter tap does not work properly and can cause problems. If the sphincter is weak there can be urine leak (incontinence). If the sphincter is too strong bladder might not empty properly.\n\nChildren who require investigation of their urinary problems are usually assessed with non-invasive tests. Sometimes investigation is with a more invasive test videourodynamics or video cystometrogram (VCMG; this test requires the insertion of catheters into the bladder and rectum. This test provides only indirect information about sphincter function.\n\nIt would be helpful to have a more direct test of the sphincter. It will allow better targeted treatments of sphincter problems which are often therapeutically challenging. Urethral pressure profile is a test used in adults to assess the sphincter. Although it has been described in children normal values have not been described.\n\nThe research project is to define urethral pressure profile values in children and young people with normal, weak and overactive sphincters.\n\nUrethral pressure profile measurement is invasive as it requires the insertion of a special catheter. It will therefore be performed at the time of other invasive procedures eg VCMG or urology surgery under general anaesthetic.\n\nThe study will be conducted at single site, which is a children's hospital. The study will be an observational case controlled study with three arms: controls, those with overactive sphincters and those with underactive sphincters. The study is intended to run over three years.",[29,107],"Stress Incontinence, Urinary",[109,110,111],"child","Adolescent","urinary incontinence","2024-02-01",{"date":114,"type":35},"2024-02-02",{"date":116,"type":20},"2024-03-01",{"date":118,"type":20},"2028-03-01",{"name":120,"class":42},"King's College London"]