[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"dysmenorrhea-primary\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:dysmenorrhea-primary":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,11,0,[8,44,75,100,124,150,179,204,225,249,272],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":4},"100626505","effects-of-a-combined-home-based-exercise-program-on-menstrual-pain-dual-task-gait-performance-and-eeg-markers-of-cognitive-motor-control-in-females-with-primary-dysmenorrhea-100626505",false,"NCT07436507","Effects of a Combined Home-Based Exercise Program on Menstrual Pain, Dual-Task Gait Performance, and EEG Markers of Cognitive-Motor Control in Females With Primary Dysmenorrhea","Effects of a Combined Home-Based Exercise Program on Menstrual Pain, Dual-Task Gait Performance, and Neurophysiological Outcomes in Primary Dysmenorrhoea: A Randomised Controlled Trial Protocol","Inclusion Criteria:\n\n* single\n* 18-25 years\n* meet the diagnostic criteria for PD as outlined in the Primary Dysmenorrhea Consensus Guidelines - first onset of menstrual pain 6-24 months after menarche, pain lasting 8-72h in a cycle, and the most severe pain on the 1st or 2nd day of menstruation\n* having a regular menstrual cycle (28 ± 7 days)\n* menstrual pain intensity ≥4 cm on VAS in the previous 6 months\n* absence of any known medical condition\n\nExclusion Criteria:\n\n* history of pelvic surgery\n* history and\u002For findings of secondary dysmenorrhea\n* history of mental or physical diseases\n* history of joint, motion, muscle, or bone diseases which reduce the abilities to exercise\n* being a professional athlete\n* taking analgesic or non-pharmacological agents other than NSAID for menstrual pain\n* used an intrauterine device or oral contraceptive pill\n* metal implants, including pacemaker\n* history of non-normal brain activity, including seizures","FEMALE","18 Years","25 Years",{"count":20,"type":21},86,"ESTIMATED","INTERVENTIONAL",[24],"NA","What is this study about? Dysmenorrhea, commonly known as painful period, is a common gynecological symptom experienced by several women of reproductive age. This particular type of pain arises during the menstrual cycle, often negatively impacting the quality of life and ability to successfully carry out daily activities and academic or work performance. This is study will involve physiotherapy treatment in the form of a home-based exercise program for those experiencing dysmenorrhea. The purpose of this study is to determine how effective this exercise intervention is by assessing the pain score, menstrual symptoms, gait performance and cognitive-motor control.",[27],"Dysmenorrhea Primary",[27,29,30,31],"Home exercise program","Dual-Task Gait Performance","Cognitive Motor Control","NOT_YET_RECRUITING","2026-05-10",{"date":35,"type":36},"2026-05-13","ACTUAL",{"date":38,"type":21},"2026-07-06",{"date":40,"type":21},"2027-05-31",{"name":42,"class":43},"University of Sharjah","OTHER",{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":22,"phases":54,"briefSummary":55,"conditions":56,"keywords":59,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":74},"100623076","high-intensity-interval-training-and-menstrual-health-experience-in-primary-dysmenorrhea-100623076","NCT07391930","High-Intensity Interval Training and Menstrual Health Experience in Primary Dysmenorrhea.","Efficacy of a High-Intensity Interval Training Program and Analysis of Menstrual Health Experience in Women With Primary Dysmenorrhea: A Mixed-Methods Randomized Controlled Trial.","Inclusion Criteria:\n\n* nulliparous\n* primary dysmenorrhea\n* body mass index between 18 and 30\n* menstrual pain \\>5 according to the Numeric Pain Scale\n* exercise \\>45 minutes\u002Fweek\n* understand Spanish and can freely read and sign the informed consent form\n\nExclusion Criteria:\n\n* amenorrhea or cycles \\>35 days\n* secondary dysmenorrhea\n* pelvic or abdominal surgical intervention\n* use of hormonal drugs\n* diagnosed with fibromyalgia, muscoloskeletal injuries or medical comorbidities that prevent them from performing intense exercise\n* receiving physiotherapy for pelvic floor disorders\n* intense exercise \\>75 minutes\u002Fweek","40 Years",{"count":53,"type":21},60,[24],"The goal of this study is to evaluate whether a 12-week online supervised high-intensity interval training program can reduce menstrual pain and improve quality of life in women with primary dysmenorrhea. Participants will be divided into two groups: one receiving an educational workshop and the HIIT program, and a control group receiving only the workshop. Additionally, the study seeks to understand the personal experience of these women through weekly health diaries, exploring how the intervention affects their relationship with their bodies and their menstruation. The ultimate goal is to offer new, non-pharmacological evidence-based tools for managing menstrual pain.",[27,57,58],"Menstrual Pain","Pelvic Pain",[60,61,62,63],"High- Intensity Interval Training","Quality of Life","Menstrual Health","Therapeutic Exercise","RECRUITING","2026-04-19",{"date":67,"type":36},"2026-04-21",{"date":69,"type":36},"2026-02-18",{"date":71,"type":21},"2029-06",{"name":73,"class":43},"University of Alcala",1,{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":83,"enrollmentInfo":84,"targetDuration":4,"studyType":22,"phases":86,"briefSummary":87,"conditions":88,"keywords":90,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":95,"completionDateStruct":96,"leadSponsor":98,"locationsCount":74},"100618921","comparing-over-the-counter-pain-medicines-for-discomfort-in-crohns-disease-avid-cd-100618921","NCT07337902","Comparing Over the Counter Pain Medicines for Discomfort in Crohn's Disease (AVID-CD)","Acetaminophen Versus Ibuprofen for Discomfort in Crohn's Disease (AVID-CD): An Open-Label Randomized Pilot Trial","AVID-CD","Inclusion Criteria:\n\n* Ages 18-44 years\n* Assigned female at birth\n* Crohn's Disease (CD) diagnosis\n* In stable clinical remission from CD, defined as a short Crohn's Disease Activity Index (CDAI; See Table 3) \\\u003C150 without use of corticosteroids\n* Self-reported primary dysmenorrhea\n* Regular menstrual cycles occurring every 23-35 days\n* Using an appropriate contraceptive method or abstinence\n\nExclusion Criteria:\n\n* Any of the following conditions: endometriosis, adenomyosis, polycystic ovarian syndrome, endometrial fibroids\u002Fpolyps, chronic pelvic inflammatory disease, a history of pelvic surgery including hysterectomy, any other pathological pelvic conditions, or current pregnancy\n* Plans to become pregnant during the study period\n* Use of an oral contraceptive for less than 3 months, on an unstable oral contraceptive dose within the last 3 months, switched from one oral contraceptive to another within the last 3 months or intend to do so during the course of the trial\n* Taking hormone therapy including estrogen or progesterone that is not part of a hormonal contraceptive\n* Known hypersensitivity or contraindication to ibuprofen or acetaminophen\n* Inability to complete REDCap questionnaires (including confusion despite training and\u002For lack of smart phone and\u002For computer access).\n* Not able to speak and read English language.","44 Years",{"count":85,"type":21},24,[24],"The purpose of this pilot study is to prepare for a larger study that will compare the effectiveness and safety of two common pain medications, ibuprofen and acetaminophen, to help treat period cramps in women with Crohn's disease. The goal of this study is to identify any challenges in running a larger study. The investigators will track how many people sign up for the study, how well participants follow the study plan, how many people stay in the study, and whether they are able to complete all the study activities, such as taking the medication, submitting samples, and filling out surveys.\n\nDuring the study, participants will undergo a screening visit that includes a blood draw, physical exam, pregnancy test, stool testing, and complete surveys about Crohn's disease and menstrual cycles. Once this visit is complete, the rest of the study will occur at home.\n\nParticipants will be assigned to take either ibuprofen or acetaminophen to help treat period cramps for four menstrual cycles in a row. Participants will take ibuprofen for two cycles and acetaminophen for two cycles. Participants will know which medication is being taken at any given time, but the order in which they take the medications will be randomly assigned.\n\nBefore each menstrual cycle, participants will submit a stool sample and fill out a short (\\\u003C1 minute) electronic survey. When participants develop period cramps, they will take the assigned medication for three days and fill out short (\\\u003C1 minute) electronic surveys about their cramps. After participants finish taking the medication for three days, they will submit another stool sample and fill out two more short (\\\u003C1 minute) electronic surveys. After have completing this process for four menstrual cycles, a remote interview with a researcher to give feedback on the study will be conducted.",[89,27],"Crohn's Disease (CD)",[91],"Crohn's Disease","2026-03-18",{"date":94,"type":36},"2026-03-23",{"date":92,"type":36},{"date":97,"type":21},"2028-07",{"name":99,"class":43},"University of North Carolina, Chapel Hill",{"id":101,"slug":102,"hasResults":11,"nctId":103,"briefTitle":104,"officialTitle":104,"acronym":105,"eligibilityCriteria":106,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":107,"targetDuration":4,"studyType":22,"phases":109,"briefSummary":110,"conditions":111,"keywords":112,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":115,"lastUpdatePostDateStruct":116,"startDateStruct":118,"completionDateStruct":120,"leadSponsor":122,"locationsCount":4},"100622042","evaluation-of-the-effectiveness-of-manual-lymphatic-drainage-in-young-women-with-primary-dysmenorrhea-100622042","NCT07378475","Evaluation of the Effectiveness of Manual Lymphatic Drainage in Young Women With Primary Dysmenorrhea","EDLMDP","Inclusion Criteria:\n\n* Female participants aged 18-25 years\n* Confirmed diagnosis of primary dysmenorrhea\n* Regular menstrual cycles\n* Ability to provide informed consent\n\nExclusion Criteria:\n\n* Secondary dysmenorrhea\n* Use of hormonal contraceptives\n* Presence of pelvic pathology (endometriosis, polycystic ovary syndrome, fibroids)\n* Irritable bowel syndrome\n* Use of analgesics or anti-inflammatory drugs within 12 hours prior to intervention\n* Any therapy for dysmenorrhea in the previous month\n* Pregnancy or suspected pregnancy\n* Irregular menstrual cycles",{"count":108,"type":21},20,[24],"This pilot clinical trial aims to evaluate the effectiveness of manual lymphatic drainage (MLD) in reducing symptoms associated with primary dysmenorrhea in young women. Primary dysmenorrhea is a common gynecological condition characterized by intense pelvic pain during menstruation, often accompanied by fatigue, headache, and sleep disturbances. Despite its high prevalence, it is frequently underestimated, negatively impacting quality of life and daily activities.\n\nThe intervention consists of three monthly sessions of MLD performed during the late luteal phase, prior to menstruation. Outcome measures include pain intensity, abdominal circumference, pressure pain threshold, sleep quality, and health-related quality of life.",[27],[113,114],"Manual Lymphatic Drainage","physiotherapy","2026-02-03",{"date":117,"type":36},"2026-02-05",{"date":119,"type":21},"2026-01-30",{"date":121,"type":21},"2026-07-01",{"name":123,"class":43},"Camilo Jose Cela University",{"id":125,"slug":126,"hasResults":11,"nctId":127,"briefTitle":128,"officialTitle":129,"acronym":4,"eligibilityCriteria":130,"healthyVolunteers":131,"sex":16,"minAge":17,"maxAge":132,"enrollmentInfo":133,"targetDuration":4,"studyType":22,"phases":134,"briefSummary":135,"conditions":136,"keywords":139,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":141,"lastUpdatePostDateStruct":142,"startDateStruct":144,"completionDateStruct":146,"leadSponsor":148,"locationsCount":74},"100609054","a-research-study-exploring-how-musculoskeletal-function-and-the-autonomic-nervous-system-relate-to-visceral-pain-in-women-with-and-without-dysmenorrhea-painful-periods-100609054","NCT07209566","A Research Study Exploring How Musculoskeletal Function and the Autonomic Nervous System Relate to Visceral Pain in Women With and Without Dysmenorrhea (Painful Periods).","The Effect of Vaginal Somatovisceral Pain on Hip Extension Mobility and Strength in Women at Mid-cycle With Dysmenorrhea vs. Controls: A Case-control Study","Inclusion Criteria: Non-pregnant women, not taking hormonal birth control, between the ages of 18 and 36 who report regular menstrual cycles are eligible for the study Exclusion Criteria: Participants will be excluded if they are currently pregnant or, have given birth within the preceding six months, are breastfeeding, or are undergoing in-vitro fertilization treatments. Exclusions also include those who have had abdominal, lumbar, or pelvic surgery within the preceding 12 months, suffer from a chronic pain condition, have an active genitourinary infection, are incontinent of bowel or bladder, or have been diagnosed with prolapse of a pelvic organ, severe labral pathology, femoral acetabular impingement (FAI), interstitial cystitis, endometriosis, pelvic inflammatory disease, irritable bowel syndrome, or other pelvic pathology. Participants reporting a cycle length of less than 28 days or longer than 35 days, those with a history of sexual assault, and those who are anovulatory without hormonal BC or amenorrheic will also be excluded.\n\n\\-",true,"35 Years",{"count":53,"type":21},[24],"The purpose of this clinical trial is to determine if women with dysmenorrhea demonstrate an increased musculoskeletal and autonomic nervous system response to a painful visceral stimulus compared to controls. A secondary aim is to determine if interoceptive awareness moderates this relationship. The designed methodology aims to elucidate the intricate connections between the interoceptive and musculoskeletal systems in pain perception among female participants, providing valuable insights into the underlying mechanisms of interoceptive pain and functional musculoskeletal changes.",[137,27,138,57],"Dysmenorrhea","Visceral Pain",[140],"Effect of visceral organ pain on musculoskeletal and autonomic nervous system","2025-09-29",{"date":143,"type":36},"2025-10-07",{"date":145,"type":36},"2025-08-01",{"date":147,"type":21},"2027-04-01",{"name":149,"class":43},"Azusa Pacific University",{"id":151,"slug":152,"hasResults":11,"nctId":153,"briefTitle":154,"officialTitle":155,"acronym":156,"eligibilityCriteria":157,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":158,"enrollmentInfo":159,"targetDuration":4,"studyType":22,"phases":161,"briefSummary":162,"conditions":163,"keywords":166,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":170,"lastUpdatePostDateStruct":171,"startDateStruct":173,"completionDateStruct":175,"leadSponsor":177,"locationsCount":4},"100604882","menstrual-pain-intervention-among-students-100604882","NCT07155291","Menstrual Pain Intervention Among Students","Evaluation of Easy-to-Implement Intervention for Menstrual Pain in a Series of N-of-1 Trials: Study Protocol of the Menstrual Pain Intervention Among Students Study (MPIS)","MPIS","Inclusion Criteria:\n\n* Female students living in Germany\n* Have consistently experienced menstrual pain and other symptoms primarily during menstruation for at least the last three cycles\n* Regular access to a smartphone on which the StudyU (https:\u002F\u002Fwww.studyu.health\u002F) application can be installed\n* Informed consent\n* Proficiency in English or German\n\nExclusion Criteria:\n\n* Age under 18 or over 45 years\n* Participation in a different intervention study during the duration of this study\n* Use of hormonal treatments affecting the menstrual cycle\n* Confirmed or suspected pregnancy\n* Presence of contraindicated disorders or diseases for massage\n* Severe psychiatric conditions impairing informed consent or reliable participation\n* Substance abuse (e.g., alcohol, drugs)\n* Planned surgery within the next four to five months\n* Doctor's advice against proceeding with the intervention","45 Years",{"count":160,"type":21},46,[24],"Dysmenorrhea, or menstrual pain, is a prevalent issue among female students, which negatively influences students' productivity, academic performance, and quality of life.\n\nThis study explores a non-pharmaceutical physiotherapy method that has shown potential to decrease menstrual cramping, but research on its efficacy remains limited. The intervention is a visceral abdominal self-massage.\n\nBecause individuals tend to respond differently to physiotherapy methods, the investigators aim to assess the effect of performing the self-massage regularly on the self-reported perception of menstrual pain and related symptoms of female students in Germany, with a series of N-of-1 trials.\n\nN-of-1 trials lasting up to 60 days are conducted with participants who regularly experience dysmenorrhea. Participants undergo a control (A) and an intervention phase (B), with a probable second control phase (A) depending on the individual cycle lengths and study start. Daily symptoms are recorded via the StudyU smartphone application. The baseline questionnaire collects demographic, lifestyle, and menstrual history information to identify potential effect modifiers. The intervention's effects will be estimated across individual and population levels. Participants will receive access to an analysis of their data.\n\nThe results may benefit individual well-being and contribute to the exploration of a more holistic approach to menstrual health.",[137,27,164,165],"Dysmenorrhea Secondary","Dysmenorrhea Symptom",[167,168,62,169],"Abdominal Self-Massage","Massage Physiotherapy","N-of-1 Trial","2025-08-31",{"date":172,"type":36},"2025-09-04",{"date":174,"type":21},"2025-09",{"date":176,"type":21},"2026-01",{"name":178,"class":43},"University of Potsdam",{"id":180,"slug":181,"hasResults":11,"nctId":182,"briefTitle":183,"officialTitle":184,"acronym":4,"eligibilityCriteria":185,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":186,"enrollmentInfo":187,"targetDuration":4,"studyType":22,"phases":188,"briefSummary":189,"conditions":190,"keywords":191,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":196,"lastUpdatePostDateStruct":197,"startDateStruct":198,"completionDateStruct":200,"leadSponsor":202,"locationsCount":74},"100594642","comparison-of-different-physiotherapy-techniques-in-dysmenorrhea-100594642","NCT07022106","Comparison of Different Physiotherapy Techniques in Dysmenorrhea","Comparison of Myofascial Release and Kinesiotaping Techniques in the Management of Primary Dysmenorrhea","Inclusion Criteria:\n\n* Diagnosis of primary dysmenorrhea,\n* Moderate-to-severe pain during menstrual days 1-3,\n* Regular menstrual cycles for past 6 months\n\nExclusion Criteria:\n\n* Secondary gynaecological conditions,\n* Current use of pain medications,\n* History of pregnancy","30 Years",{"count":160,"type":21},[24],"This study is investigating the effects of myofascial release technique \\& kinesiotape in managing dysmenorrhea",[27],[192,193,194,195],"primary dysmenorrhea","kinesiotape","myofascial release","pain","2025-07-29",{"date":145,"type":36},{"date":199,"type":36},"2025-06-15",{"date":201,"type":21},"2025-10-01",{"name":203,"class":43},"Medipol University",{"id":205,"slug":206,"hasResults":11,"nctId":207,"briefTitle":208,"officialTitle":209,"acronym":4,"eligibilityCriteria":210,"healthyVolunteers":11,"sex":16,"minAge":211,"maxAge":17,"enrollmentInfo":212,"targetDuration":4,"studyType":22,"phases":214,"briefSummary":215,"conditions":216,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":218,"lastUpdatePostDateStruct":219,"startDateStruct":221,"completionDateStruct":222,"leadSponsor":223,"locationsCount":74},"100592355","bioptron-light-therapy-for-dysmenorrhea-in-obese-adolesences-rct-100592355","NCT06992349","Bioptron Light Therapy for Dysmenorrhea in Obese Adolesences: RCT","Evaluating the Efficacy of Bioptron° Light Therapy in Managing Primary Dysmenorrhea Among Obese Adolescence: Double Blinded Randomized Control Trial","Inclusion Criteria:\n\n* 144 female adolescences suffering from primary dysmenorrhea pain determined according to the sample size calculation adapted from (Gu et al., 2022).\n* They will be selected from the outpatient's clinic of the faculty of Physical Therapy Sinai University.\n* Their chronological age ranged from 16 to 18 years old.\n\nExclusion Criteria:\n\n* Those who were taking anti-psychotic or anti-depressant medications, patients with any skin lesion or infection.\n* Gynecological disorders included cervical cancer, ovarian tumors, endometriosis, uterine fibroids, polycystic ovarian syndrome, and other conditions that can affect menstruation.","16 Years",{"count":213,"type":21},144,[24],"Dysmenorrhea is the most common health problem in women in the reproductive age(Bakhsh et al., 2022). The primary dysmenorrhea starts shortly after the menarche the pain lasting 1 to 3 days that start just before or at the onset of menstruation with the absence of other gynecological symptoms (Itani et al., 2022). Primary dysmenorrhea can reduce the quality of life and social activities of women(Esan et al., 2024).\n\nThere is a relationship between body mass composition and primary dysmenorrhea and as the value of body mass index and body fat percentages goes on increasing in females, the severity of primary dysmenorrhea also increased (Wu et al., 2022).\n\nBIOPTRON® Light therapy system is a device that contains an optical unit. This unit emits light with an electromagnetic spectrum produced by the sun, but without the ultraviolet rays and it is significant with four main characteristics which are Polarization, Polychromatic, Incoherence and low energy light (Raeissadat et al., 2014).\n\nThe Purpose of the Study The aim of the study is to investigate the effect of bioptron© light therapy on primary dysmenorrhoea outcomes as pain and quality of life among obese adolescence.",[27,217],"Obesity and Overweight","2025-05-24",{"date":220,"type":36},"2025-05-28",{"date":145,"type":21},{"date":170,"type":21},{"name":224,"class":43},"Alaa Noureldeen Kora",{"id":226,"slug":227,"hasResults":11,"nctId":228,"briefTitle":229,"officialTitle":230,"acronym":231,"eligibilityCriteria":232,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":158,"enrollmentInfo":233,"targetDuration":4,"studyType":22,"phases":234,"briefSummary":235,"conditions":236,"keywords":237,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":240,"lastUpdatePostDateStruct":241,"startDateStruct":243,"completionDateStruct":245,"leadSponsor":247,"locationsCount":74},"100586208","pain-relief-from-dysmenorrhea-employing-tavns-100586208","NCT06912386","Pain Relief From Dysmenorrhea Employing taVNS","A Randomized Two-Way Crossover Comparison Study of Pain Relief From Dysmenorrhea Employing taVNS and Sham Stimulation","taVNS-DYSM","Inclusion Criteria:\n\n* Regular menstrual cycle (28 days ± 7 days);\n* Average moderate menstrual pain (with 4 - 7 NRS scores);\n* History of over-the-counter (OTC) analgesic use for the treatment of menstrual pain (at least 1 IBUPROFEN for the first two days);\n* 4 consecutive monthly menstrual cycles;\n* Non-pregnant status;\n* Agrees to use adequate birth control during the trial;\n* Otherwise, healthy;\n* Agree not to participate in any other clinical trial while enrolled in this trial ;\n* No facial or ear pain, no recent ear trauma, no metal implants including pacemakers;\n* Normal ECG, Heart Rate and Blood Pressure (systolic BP 105-130, diastolic BP 60-90, heart rate per min at rest 60-85);\n\nExclusion Criteria:\n\n* Currently under medications (except for analgesic medication for menstrual cycle);\n* Use of oral contraceptive;\n* Secondary cause for dysmenorrhea (i.e., endometriosis, adenomyosis, uterine fibroids, or infection);\n* Unstable or serious illness (e.g., kidney, liver, GIT, heart conditions, diabetes, thyroid gland function, lung conditions, chronic asthma, diagnosed psychological or mood disorder, hypertension, any bleeding disorders, recent surgery, or concurrent blood thinning treatment);\n* Current malignancy or treatment for malignancy within the previous 2 years;\n* Pregnant or lactating women;\n* Active smokers, nicotine use, or drug (prescription or illegal substances) abuse;\n* Chronic past and\u002For current alcohol use (\\>14 alcoholic drinks per week);\n* Any condition that in the opinion of the investigator, makes the participant unsuitable for inclusion;\n* Unwilling or unable to comply with protocol;\n* Active genitourinary infection in the last four weeks;\n* Unable to read or comprehend the informed consent;\n* Unwilling to complete study procedures;\n* Participated in any other clinical trial during the past 1 month;\n* Personal or family history of seizure, mood, or cardiovascular disorders;\n* Allergic reaction to surface electrodes.",{"count":108,"type":21},[24],"The goal of this clinical trial is to determine if transauricular vagal nerve stimulation (taVNS) is effective in treating moderate dysmenorrhea. The main question it aims to answer is:\n\n• Does taVNS reduce the number of times participants suffering from dysmenorrhea need to use rescue medication during menstruation? Researchers will compare taVNS stimulation with a sham stimulation (a look-alike procedure that does not stimulate the vagus nerve) to assess whether taVNS is effective in treating moderate dysmenorrhea.\n\nParticipants will:\n\n* Undergo taVNS for 2 months and sham stimulation for another 2 months, each for 5 days per month, starting 2 days before the expected beginning of their menstrual cycle.\n* Visit the clinic twice a month for checkups and tests.\n* Keep a diary to record their pain levels and the number of times they use rescue medication.\n* Undergo functional magnetic resonance imagine two times (one after the end of the first use of taVNS and another after the end of the first use of SHAM stimulation).",[27],[137,238,239],"transauricular vagal nerve stimulation","Pain","2025-03-30",{"date":242,"type":36},"2025-04-04",{"date":244,"type":21},"2025-04-01",{"date":246,"type":21},"2025-06-30",{"name":248,"class":43},"University of Electronic Science and Technology of China",{"id":250,"slug":251,"hasResults":11,"nctId":252,"briefTitle":253,"officialTitle":254,"acronym":4,"eligibilityCriteria":255,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":256,"targetDuration":4,"studyType":22,"phases":258,"briefSummary":259,"conditions":260,"keywords":261,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":263,"lastUpdatePostDateStruct":264,"startDateStruct":266,"completionDateStruct":268,"leadSponsor":270,"locationsCount":74},"100574628","taping-and-pmr-effects-in-primary-dysmenorrhea-100574628","NCT06761755","Taping and PMR Effects in Primary Dysmenorrhea","Combined Effects of Kinesiology Taping and Progressive Muscle Relaxation Technique on Pain, Anxiety and Body Awareness in Primary Dysmenorrhea","Inclusion Criteria:\n\n* • Aged between 18-25 years\n\n  * Unmarried female\n  * Taking ≥4 points from Visual Analog Scale during menstrual cycle\n  * Had moderate menstrual pain as measured by WaLLID score\n\nExclusion Criteria:\n\n* • Complaints of low back pain due to any other pathology, any skin infection, sensitive skin or allergic to Kinesio Tape.\n\n  * PCOD, Uterine\u002F ovarian tumor, Acute\u002F chronic pelvic pathology like PID, endometriosis, spinal pathology and deformity\n  * Endometrial polyp, having a pelvic infection, using an intrauterine device, having venous congestion in the internal genital organs.\n  * Who take analgesic",{"count":257,"type":21},30,[24],"The study is randomized controlled trial,The study conducted in two groups. Group A has given the kinesiology taping on the lower abdomen and back for 1-3 days with progressive muscle relaxation technique for 10-20 minutes and a baseline treatment hot pack at a time twice a day from the start of menstruation and Group B has receive the kinesiology taping on the lower abdomen and baseline treatment hot pack without progressive muscle relaxation technique for 1-3 days. The total treatment duration will be 6 weeks. The rationale of this study is to provide empirical evidence regarding the efficacy and safety of kinesiology taping and progressive muscle relaxation. By investigating the potential benefits of this intervention, healthcare professionals can make informed decisions about incorporating K-taping and PMR in primary dysmenorhea. Focusing on the impact of kinesiology taping and progressive muscle relaxation on pain,anxiety, and body awareness aligns with a patient-centered approach to care. The goal is not only to reduce symptoms but also to enhance overall well-being and functional capacity",[27],[262],": Anxiety, dysmenorrhea, pain,","2025-01-01",{"date":265,"type":36},"2025-01-07",{"date":267,"type":36},"2023-12-23",{"date":269,"type":21},"2025-02",{"name":271,"class":43},"Riphah International University",{"id":273,"slug":274,"hasResults":11,"nctId":275,"briefTitle":276,"officialTitle":277,"acronym":4,"eligibilityCriteria":278,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":132,"enrollmentInfo":279,"targetDuration":4,"studyType":22,"phases":281,"briefSummary":282,"conditions":283,"keywords":288,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":292,"lastUpdatePostDateStruct":293,"startDateStruct":295,"completionDateStruct":297,"leadSponsor":299,"locationsCount":74},"100553904","myofascial-release-technique-in-women-with-primary-dysmenorrhea-100553904","NCT06492148","Myofascial Release Technique in Women With Primary Dysmenorrhea","Effect of Myofascial Release Technique on Central Sensitization, Myofascial Trigger Point and Menstrual Symptoms in Women With Primary Dysmenorrhea: Sham-Controlled, Randomized Double-Blind Study","Inclusion Criteria:\n\n* Diagnosed with Primary Dysmenorrhea according to the Primary Dysmenorrhea Consensus Guide,\n* Having regular menstruation in the last 6 months (28±7 days)\n* Those who had menstrual pain between 40 mm and 100 mm according to the Visual Analogue Scale (VAS) in the last 6 months\n\nExclusion Criteria:\n\n* Diagnosed with Secondary Dysmenorrhea,\n* Having given birth,\n* Those with serious gastrointestinal, urogynecological, or autoimmune diseases or other chronic pain syndromes,\n* Undergoing urogynecological surgery,\n* Those who are pregnant or suspected of pregnancy,\n* Those who use analgesics or non-pharmacological agents other than NSAIDs for menstrual pain,\n* Those using intrauterine or oral contraceptives,\n* Those taking extra supplements such as magnesium, which may affect treatment",{"count":280,"type":21},36,[24],"It has been found that women with dysmenorrhea have active trigger points, particularly in the rectus abdominis, oblique abdominal muscles, quadratus lumborum, and paraspinal muscles. The myofascial release technique is a widely used manual therapy method characterized by the application of low-load, long-duration mechanical forces to manipulate the myofascial complex. This technique aims to restore optimal length, alleviate pain, and improve function. This study aims to examine the effect of the myofascial release technique on central sensitization, myofascial trigger points, and menstrual symptoms in women with primary dysmenorrhea.",[27,284,285,286,287],"Central Sensitisation","Myofascial Trigger Point Pain","Menstrual Discomfort","Myofascial Release",[194,289,290,137,291],"trigger point","Central sensitization","sham","2024-11-19",{"date":294,"type":36},"2024-11-21",{"date":296,"type":36},"2024-09-10",{"date":298,"type":21},"2025-09-25",{"name":300,"class":43},"Gazi University"]